Total synthesis of natural product

The architecturally complex molecules provide the driving force for the development of new synthetic strategies/new reactions. In return, the so-developed new synthetic technologies can often find application in the synthesis of other seemingly unrelated molecular targets. Exploring the synergism between target pursuits and methodology/strategy development is the key principle that guided our work in the field of natural product synthesis.

Below are the selected natural products that have been synthesized in our group : 

Selected publications:

  1. Li, G.; Piemontesi, C.; Wang, Q.; Zhu, J. “Stereoselective Total Synthesis of Eburnane-Type Alkaloids Enabled by Conformation-Directed Cyclization and Rearrangement” Angew. Chem. Int. Ed. 2019, 58, 2870-2874.
  2. Torres-Ochoa, R.; Buyck, T.; Wang, Q; Zhu, J. “Heteroannulation of Arynes with a-Amino Imides: Synthesis of 2,2-Disubstituted Indolin-3-ones and Application to the Enantioselective Total Synthesis of (+)-Hinckdentine A” Angew. Chem. Int. Ed. 2018, 57, 5679-5683.
  3. Piemontesi, C.; Wang, Q.; Zhu, J. ” Enantioselective Synthesis of (+)-Peganumine A” J. Am. Chem. Soc. 2016, 138, 11148-11151.
  4. Piemontesi, C.; Wang, Q.; Zhu, J. “Enantioselective Total Synthesis of (–)-Terengganensine A” Angew. Chem. Int. Ed. 2016, 55, 6556-6560.
  5. Ren, W.; Wang, Q.; Zhu, J. “Total Synthesis of (±)-Strictamine” Angew. Chem. Int. Ed. 2016, 55, 3500-3503.
  6. Dagoneau, D.; Xu, Z.; Wang, Q.; Zhu, J. “Enantioselective Total Syntheses of (-)-Rhazinilam, (-)-Leucomidine B, and (+)-Leuconodine F” Angew. Chem. Int. Ed. 2016, 55, 760-763.
  7. Xu, Z.; Bao, X.; Wang, Q.; Zhu, J. “An Enantioselective Total Synthesis of (–)-Isoschizogamine” Angew. Chem. Int. Ed. 2015, 54, 14937-14940.
  8. Xu, Z.; Wang, Q.; Zhu, J. “Total Syntheses of (-)-Mersicarpine, (-)-Scholarisine G, (+)-Melodinine E, (-)-Leuconoxine, (-)-Leuconolam, (-)-Leuconodine A, (+)-Leuconodine F and (-)-Leuconodine C. Self-Induced Diastereomeric Anisochronism (SIDA) Phenomenon for Scholarisine G, Leuconodines A and C” J. Am. Chem. Soc. 2015, 137, 6712-6724.
  9. Erb, W.; Grassot, J.-M.; Linder, D.; Neuville, L.; Zhu, J. “Enantioselective Synthesis of Putative Lipiarmycin Aglycon Related to Fidaxomicin/Tiacumicin B” Angew. Chem. Int. Ed. 2015, 54, 1929-1932.
  10. Wagnières, O.; Xu, Z.; Wang, Q.; Zhu, J. “Unified Strategy to Monoterpene Indole Alkaloids: Total Syntheses of (±)-Goniomitine, (±)-1,2-Dehydroaspidospermidine, (±)-Aspidospermidine, (±)-Vincadifformine and (±)-Kopsihainanine A” J. Am. Chem. Soc. 2014, 136, 15102-15108.