The lab continues to investigate mechanistic and therapeutic implications of the Cancer Stem Cell concept, seeking to identify targetable mechanisms of cancer progression. New approaches of immunotherapy are currently developed which aim to eradicate established tumors by elimination of Cancer Stem Cells and immune check point blockade. Furthermore, in the last couple of years a focus has been the development of new therapeutics based on drug screens, therapeutic antibodies and antibody drug conjugates isolated and produced in the lab. The laboratory is currently studying mouse models of breast, lung, pancreas and colon cancer with an emphasis on metastatic disease. Topics of investigation include mechanisms of: niche induction, stromal reprogramming, and immune evasion. Additional research topics include the development of microfluidic platforms for the isolation and analysis of Cancer Stem Cells.