A CTCF-dependent mechanism underlies the Hox timer relation to a segmented body plan

H. Rekaik; D. Duboule 

Sequential and directional insulation by conserved CTCF sites underlies the Hox timer in stembryos

H. Rekaik; L. Lopez-Delisle; A. Hintermann; B. Mascrez; C. Bochaton et al. 

Programming of Multicellular Patterning with Mechano-Chemically Microstructured Cell Niches

P. L. H. Newman; Q. Yip; P. Osteil; T. A. Anderson; J. Q. J. Sun et al. 

Context-dependent enhancer function revealed by targeted inter-TAD relocation

C. C. Bolt; L. Lopez-Delisle; A. Hintermann; B. Mascrez; A. Rauseo et al. 

The (unusual) heuristic value of Hox gene clusters; a matter of time?

D. Duboule 

Differential impact of TGF beta/SMAD signaling activity elicited by Activin A and Nodal on endoderm differentiation of epiblast stem cells

H. Knowles; N. Santucci; J. Studdert; H. N. Goh; K. Kaufman-Francis et al. 

Transgenic Model Systems Have Revolutionized the Study of Disease

A. Mayran; C. C. Bolt 

Sequential in cis mutagenesis in vivo reveals various functions for CTCF sites at the mouse HoxD cluster

A. R. Amandio; L. Beccari; L. Lopez-Delisle; B. Mascrez; J. Zakany et al. 

Mesomelic dysplasias associated with the HOXD locus are caused by regulatory reallocations

C. C. Bolt; L. Lopez-Delisle; B. Mascrez; D. Duboule 

Induction of a chromatin boundary in vivo upon insertion of a tad border

A. Willemin; L. Lopez-Delisle; C. C. Bolt; M-L. Gadolini; D. Duboule et al. 

Analysis of Polycerate Mutants Reveals the Evolutionary Co-option of HOXD1 for Horn Patterning in Bovidae

A. Allais-Bonnet; A. Hintermann; M-C. Deloche; R. Cornette; P. Bardou et al. 

pyGenomeTracks: reproducible plots for multivariate genomic datasets

L. Lopez-Delisle; L. Rabbani; J. Wolff; V. Bhardwaj; R. Backofen et al. 

Chromatin topology and the timing of enhancer function at the HoxD locus

E. Rodriguez-Carballo; L. Lopez-Delisle; A. Willemin; L. Beccari; S. Gitto et al. 

A complex regulatory landscape involved in the development of mammalian external genitals

A. R. Amandio; L. Lopez-Delisle; C. C. Bolt; B. Mascrez; D. Duboule 

Fryns type mesomelic dysplasia of the upper limbs caused by inverted duplications of the HOXD gene cluster

C. Le Caignec; O. Pichon; A. Briand; B. de Courtivron; C. Bonnard et al. 

Comparative Transcriptomics Analyses across Species, Organs, and Developmental Stages Reveal Functionally Constrained lncRNAs

F. Darbellay; A. Necsulea 

Commentary on paper by Leroy C. Stevens (1960)

D. Duboule 

Impact of genome architecture on the functional activation and repression of Hox regulatory landscapes

E. Rodriguez-Carballo; L. Lopez-Delisle; N. Yakushiji-Kaminatsui; A. Ullate-Agote; D. Duboule 

Tail Bud Progenitor Activity Relies on a Network Comprising Gdf11, Lin28, and Hox13 Genes

R. Aires; L. de Lemos; A. Novoa; A. D. Jurberg; B. Mascrez et al. 

An extended regulatory landscape drives Tbx18 activity in a variety of prostate-associated cell lineages

S. Negi; C. C. Bolt; H. Zhang; L. Stubbs 

Constrained Transcriptional Polarity In The Organization Of Mammalian Hox Gene Clusters

F. Darbellay; C. Bochaton; L. Lopez-Delisle; B. Mascrez; P. Tschopp et al. 

Analysis of long-range gene regulation at the HoxD locus

Do RET somatic mutations play a role in Hirschsprung disease? Response

B. K. Kragesteen; D. Duboule; S. Mundlos; M. Spielmann 

Similarities and differences in the regulation of HoxD genes during chick and mouse limb development

N. Yakushiji-Kaminatsui; L. Lopez-Delisle; C. C. Bolt; G. Andrey; L. Beccari et al. 

Multi-axial self-organization properties of mouse embryonic stem cells into gastruloids

L. Beccari; N. Moris; M. Girgin; D. A. Turner; P. Baillie-Johnson et al. 

Heterogeneous combinatorial expression of Hoxd genes in single cells during limb development

P. J. Fabre; M. Leleu; B. Mascrez; Q. Lo Giudice; J. Cobb et al. 

The ALK receptor in sympathetic neuron development and neuroblastoma

I. Janoueix-Lerosey; L. Lopez-Delisle; O. Delattre; H. Rohrer 

Noncoding copy-number variations are associated with congenital limb malformation

R. Flottmann; B. Kragesteen; S. Geuer; M. Socha; L. Allou et al. 

Coordinated Hoxd genes expression during embryogenesis is dependent on a strict disposition of genes and polarized regulators within the HoxD cluster

The HoxD cluster is a dynamic and resilient TAD boundary controlling the segregation of antagonistic regulatory landscapes.

E. Rodriguez-Carballo; L. Lopez-Delisle; Y. Zhan; P. J. Fabre; L. Beccari et al. 

Control of growth and gut maturation by &ITHoxD&IT genes and the associated lncRNA &ITHaglr&IT

J. Zakany; F. Darbellay; B. Mascrez; A. Necsulea; D. Duboule 

Large scale genomic reorganization of topological domains at the HoxD locus

P. J. Fabre; M. Leleu; B. H. Mormann; L. Lopez-Delisle; D. Noordermeer et al. 

Integration of Shh and Fgf signaling in controlling Hox gene expression in cultured limb cells

A. R. Rodrigues; N. Yakushiji-Kaminatsui; Y. Atsuta; G. Andrey; P. Schorderet et al. 

Hotair Is Dispensible for Mouse Development

A. R. Amandio; A. Necsulea; E. Joye; B. Mascrez; D. Duboule 

Control of Hoxd gene transcription in the mammary bud by hijacking a preexisting regulatory landscape

R. Schep; A. Necsulea; E. Rodriguez-Carballo; I. Guerreiro; G. Andrey et al. 

Reorganisation of Hoxd regulatory landscapes during the evolution of a snake-like body plan

I. Guerreiro; S. Gitto; A. Novoa; J. Codourey; H. Thi Hanh Nguyen et al. 

A role for HOX13 proteins in the regulatory switch between TADs at the HoxD locus

L. Beccari; N. Yakushiji-Kaminatsui; J. M. Woltering; A. Necsulea; N. Lonfat et al. 

Dynamic Reorganization of Extremely Long-Range Promoter-Promoter Interactions between Two States of Pluripotency

O. Joshi; S-Y. Wang; T. Kuznetsova; Y. Atlasi; T. Peng et al. 

Nanoscale spatial organization of the HoxD gene cluster in distinct transcriptional states

P. J. Fabre; A. Benke; E. Joye; T. H. Nguyen Huynh; S. Manley et al. 

Tetrapod axial evolution and developmental constraints; Empirical underpinning by a mouse model

J. M. Woltering; D. Duboule 

Structure, function and evolution of topologically associating domains (TADs) at HOX loci

N. Lonfat; D. Duboule 

Assessing Recent Selection and Functionality at Long Noncoding RNA Loci in the Mouse Genome

R. A. W. Wiberg; D. L. Halligan; R. W. Ness; A. Necsulea; H. Kaessmann et al. 

Clustering of mammalian Hox genes with other H3K27me3 targets within an active nuclear domain

M. Vieux-Rochas; P. J. Fabre; M. Leleu; D. Duboule; D. Noordermeer 

Convergent evolution of complex regulatory landscapes and pleiotropy at Hox loci

N. Lonfat; T. Montavon; F. Darbellay; S. Gitto; D. Duboule 

Considerations when investigating IncRNA function in vivo

A. R. Bassett; A. Akhtar; D. P. Barlow; A. P. Bird; N. Brockdorff et al. 

Attenuated sensing of SHH by Ptch1 underlies evolution of bovine limbs

J. Lopez-Rios; A. Duchesne; D. Speziale; G. Andrey; K. A. Peterson et al. 

Temporal dynamics and developmental memory of 3D chromatin architecture at Hox gene loci

D. Noordermeer; M. Leleu; P. Schorderet; E. Joye; F. Chabaud et al. 

Evolving Hox Activity Profiles Govern Diversity in Locomotor Systems

H. Jung; E. Mazzoni; N. Soshnikova; O. Hanley; B. Venkatesh et al. 

SnapShot: Hox Gene Regulation

G. Andrey; D. Duboule 

The evolution of lncRNA repertoires and expression patterns in tetrapods

A. Necsulea; M. Soumillon; M. Warnefors; A. Liechti; T. Daish et al.