Our publications



Journal Articles

The CRL5-SPSB3 ubiquitin ligase targets nuclear cGAS for degradation

P. Xu; Y. Liu; C. Liu; B. Guey; L. Li et al. 

Nature. 2024-02-28. DOI : 10.1038/s41586-024-07112-w.


Journal Articles

cGAS-STING drives ageing-related inflammation and neurodegeneration

M. F. Gulen; N. Samson; A. Keller; M. Schwabenland; C. Liu et al. 

Nature. 2023-08-02. Vol. 620, p. 374–380. DOI : 10.1038/s41586-023-06373-1.


Journal Articles

Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation

M. Schmitt; F. Ceteci; J. Gupta; M. Pesic; T. W. Bottger et al. 

Nature. 2022-11-16. Vol. 612, p. 347–353. DOI : 10.1038/s41586-022-05426-1.

Clathrin-associated AP-1 control stermination of STING signalling

Y. Liu; P. Xu; S. Rivara; C. Liu; J. Ricci et al. 

Nature. 2022-10-19. Vol. 610, num. 7933, p. 761-767. DOI : 10.1038/s41586-022-05354-0.

Monocyte-derived macrophages aggravate pulmonary vasculitis via cGAS/STING/IFN-mediated nucleic acid sensing

N. Kessler; S. F. Viehmann; C. Krollmann; K. Mai; K. M. Kirschner et al. 

Journal Of Experimental Medicine. 2022-08-23. Vol. 219, num. 10, p. e20220759. DOI : 10.1084/jem.20220759.

The cGAS–STING pathway drives type I IFN immunopathology in COVID-19

J. D. Domizio; M. F. Gulen; F. Saidoune; V. V. Thacker; A. Yatim et al. 

Nature. 2022. Vol. 603, num. 7899, p. 145-151. DOI : 10.1038/s41586-022-04421-w.


Journal Articles

DNA hypomethylation leads to cGAS-induced autoinflammation in the epidermis

M. A. Beck; H. Fischer; L. M. Grabner; T. Groffics; M. Winter et al. 

Embo Journal. 2021-09-29.  p. e108234. DOI : 10.15252/embj.2021108234.

The spatial organization of cGAS-TREX1 interactions

P. Juricic; A. Ablasser 

Developmental Cell. 2021-04-05. Vol. 56, num. 7, p. 876-877. DOI : 10.1016/j.devcel.2021.03.016.

DNA sensor in standby mode during mitosis

A. Ablasser 

Science. 2021-03-19. Vol. 371, num. 6535, p. 1204-1205. DOI : 10.1126/science.abg7422.

m6A methylation potentiates cytosolic dsDNA recognition in a sequence-specific manner

M. Balzarolo; S. Engels; A. J. de Jong; K. Franke; T. K. van den Berg et al. 

Open Biology. 2021-03-10. Vol. 11, num. 3, p. 210030. DOI : 10.1098/rsob.210030.


Journal Articles

COPA silences STING

S. Rivara; A. Ablasser 

Journal Of Experimental Medicine. 2020-11-01. Vol. 217, num. 11, p. e20201517. DOI : 10.1084/jem.20201517.

Structural mechanism of cGAS inhibition by the nucleosome

G. R. Pathare; A. Decout; S. Glück; S. Cavadini; K. Makasheva et al. 

Nature. 2020. Vol. 587, p. 668–672. DOI : 10.1038/s41586-020-2750-6.

BAF restricts cGAS on nuclear DNA to prevent innate immune activation

B. Guey; M. Wischnewski; A. Decout; K. Makasheva; M. Kaynak et al. 

Science. 2020-08-14. Vol. 369, num. 6505, p. 823-828. DOI : 10.1126/science.aaw6421.

Editorial overview ‘Network news: Reporting from the frontlines of cell signaling’

A. Ablasser; J. Thorner 

Current Opinion In Cell Biology. 2020-04-01. Vol. 63, p. III-V. DOI : 10.1016/j.ceb.2020.02.013.


Journal Articles

Latest advances in aging research and drug discovery

D. Bakula; A. Ablasser; A. Aguzzi; A. Antebi; N. Barzilai et al. 

Aging-Us. 2019-11-30. Vol. 11, num. 22, p. 9971-9981. DOI : 10.18632/aging.102487.

A carrier for cyclic dinucleotides

B. Guey; A. Ablasser 

Nature Immunology. 2019-10-10. Vol. 20, num. 11, p. 1418–1420. DOI : 10.1038/s41590-019-0521-z.

Intracellular bacteria engage a STING-TBK1-MVB12b pathway to enable paracrine cGAS-STING signalling

R. Nandakumar; R. Tschismarov; F. Meissner; T. Prabakaran; A. Krissanaprasit et al. 

Nature Microbiology. 2019-04-01. Vol. 4, num. 4, p. 701-713. DOI : 10.1038/s41564-019-0367-z.

Virology: Poxins Soothe the STING

A. Decout; A. Ablasser 

Current Biology. 2019-05-06. Vol. 29, num. 9, p. R332-R334. DOI : 10.1016/j.cub.2019.03.031.

Inflammation clues in STING protein structure

A. Ablasser 

Nature. 2019-03-21. Vol. 567, num. 7748, p. 321-322. DOI : 10.1038/d41586-019-00707-8.


Journal Articles

Phase separation focuses DNA sensing

A. Ablasser 

Science. 2018-08-17. Vol. 361, num. 6403, p. 646-647. DOI : 10.1126/science.aau6019.

Targeting STING with covalent small-molecule inhibitors

S. Haag; M. Gulen; L. Reymond; A. Gibelin; L. Abrami et al. 

Nature. 2018. Vol. 559, num. 7713, p. 269-273. DOI : 10.1038/s41586-018-0287-8.


Journal Articles

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

S. Glück; B. Guey; M. F. Gulen; K. Wolter; T-W. Kang et al. 

Nature Cell Biology. 2017-09-19. Vol. 19, num. 9, p. 1061-1070. DOI : 10.1038/ncb3586.

Signalling strength determines proapoptotic functions of STING

M. F. Gulen; U. Koch; S. M. Haag; F. Schuler; L. Apetoh et al. 

Nature Communications. 2017. Vol. 8, num. 1, p. 427. DOI : 10.1038/s41467-017-00573-w.


Journal Articles

ReGLUation of cGAS

A. Ablasser 

Nature Immunology. 2016. Vol. 17, num. 4, p. 347-349. DOI : 10.1038/ni.3397.


Journal Articles

Inside Job: Viruses Transfer cGAMP between Cells

M. F. Gulen; A. Ablasser 

Cell Host & Microbe. 2015. Vol. 18, num. 3, p. 263-265. DOI : 10.1016/j.chom.2015.08.008.