Journal Articles

Inflammation clues in STING protein structure

A. Ablasser 

Nature. 2019-03-21. DOI : 10.1038/d41586-019-00707-8.


cGAS in action: Expanding roles in immunity and inflammation

A. Ablasser; Z. J. Chen 



Journal Articles

Phase separation focuses DNA sensing

A. Ablasser 

Science. 2018-08-17. DOI : 10.1126/science.aau6019.

Targeting STING with covalent small-molecule inhibitors

S. Haag; M. Gulen; L. Reymond; A. Gibelin; L. Abrami et al. 

NATURE. 2018. DOI : 10.1038/s41586-018-0287-8.

Human cGAS Has a Slightly Different Taste for dsDNA

A. Decout; A. Ablasser 

IMMUNITY. 2018. DOI : 10.1016/j.immuni.2018.08.005.


Innate immunosensing of DNA in cellular senescence

S. Glück; A. Ablasser 



Journal Articles

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

S. Glück; B. Guey; M. F. Gulen; K. Wolter; T-W. Kang et al. 

Nature Cell Biology. 2017-09-19. DOI : 10.1038/ncb3586.

Signalling strength determines proapoptotic functions of STING

M. F. Gulen; U. Koch; S. M. Haag; F. Schuler; L. Apetoh et al. 

Nature Communications. 2017. DOI : 10.1038/s41467-017-00573-w.


Journal Articles

ReGLUation of cGAS

A. Ablasser 

Nature Immunology. 2016. 


The role of cGAS in innate immunity and beyond

A. Ablasser; M. F. Gulen 


Book Chapters

Inflammasome Activation and Function During Infection with Mycobacterium tuberculosis

A. Ablasser; A. Dorhoi 

Inflammasome Signaling And Bacterial Infections; Cham: Springer Int Publishing Ag, 2016. p. 183-197.


Journal Articles

Inside Job: Viruses Transfer cGAMP between Cells

M. F. Gulen; A. Ablasser 

Cell Host & Microbe. 2015. DOI : 10.1016/j.chom.2015.08.008.

Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1

R. Wassermann; M. F. Gulen; C. Sala; S. G. Perin; Y. Lou et al. 

Cell Host & Microbe. 2015. DOI : 10.1016/j.chom.2015.05.003.


Journal Articles

OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids

V. Hornung; R. Hartmann; A. Ablasser; K-P. Hopfner 

Nature Reviews Immunology. 2014. DOI : 10.1038/nri3719.

TREX1 Deficiency Triggers Cell-Autonomous Immunity in a cGAS-Dependent Manner

A. Ablasser; I. Hemmerling; J. L. Schmid-Burgk; R. Behrendt; A. Roers et al. 

Journal of immunology. 2014. DOI : 10.4049/jimmunol.1400737.


Journal Articles

DNA sensing unchained

A. Ablasser; V. Hornung 

Cell research. 2013. DOI : 10.1038/cr.2013.28.

Species-specific detection of the antiviral small-molecule compound CMA by STING

T. Cavlar; T. Deimling; A. Ablasser; K-P. Hopfner; V. Hornung 

The EMBO journal. 2013. DOI : 10.1038/emboj.2013.86.

cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING

A. Ablasser; M. Goldeck; T. Cavlar; T. Deimling; G. Witte et al. 

Nature. 2013. DOI : 10.1038/nature12306.

Structural mechanism of cytosolic DNA sensing by cGAS

F. Civril; T. Deimling; C. C. de Oliveira Mann; A. Ablasser; M. Moldt et al. 

Nature. 2013. DOI : 10.1038/nature12305.

Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP

A. Ablasser; J. L. Schmid-Burgk; I. Hemmerling; G. L. Horvath; T. Schmidt et al. 

Nature. 2013. DOI : 10.1038/nature12640.

Self-priming determines high type I IFN production by plasmacytoid dendritic cells

S. Kim; V. Kaiser; E. Beier; M. Bechheim; M. Guenthner-Biller et al. 

European journal of immunology. 2013. DOI : 10.1002/eji.201343806.


Nucleic acid driven sterile inflammation

A. Ablasser; C. Hertrich; R. Waßermann; V. Hornung 




Induction of type I IFNs by intracellular DNA-sensing pathways

T. Cavlar; A. Ablasser; V. Hornung 



Journal Articles

Where, in antiviral defense, does IFIT1 fit?

A. Ablasser; V. Hornung 

Nature immunology. 2011. DOI : 10.1038/ni.2061.


Inflammasomes: current understanding and open questions

F. Bauernfeind; A. Ablasser; E. Bartok; S. Kim; J. Schmid-Burgk et al. 



Journal Articles

Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome

S. Kim; F. Bauernfeind; A. Ablasser; G. Hartmann; K. A. Fitzgerald et al. 

European journal of immunology. 2010. DOI : 10.1002/eji.201040425.


An unexpected role for RNA in the recognition of DNA by the innate immune system

F. Bauernfeind; A. Ablasser; S. Kim; E. Bartok; V. Hornung 



Journal Articles

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

V. Hornung; A. Ablasser; M. Charrel-Dennis; F. Bauernfeind; G. Horvath et al. 

Nature. 2009. DOI : 10.1038/nature07725.

TLR8-driven IL-12-dependent reciprocal and synergistic activation of NK cells and monocytes by immunostimulatory RNA

M. Berger; A. Ablasser; S. Kim; I. Bekeredjian-Ding; T. Giese et al. 

Journal of immunotherapy. 2009. DOI : 10.1097/CJI.0b013e318198bd2a.

Selection of molecular structure and delivery of RNA oligonucleotides to activate TLR7 versus TLR8 and to induce high amounts of IL-12p70 in primary human monocytes

A. Ablasser; H. Poeck; D. Anz; M. Berger; M. Schlee et al. 

Journal of immunology (Baltimore, Md. : 1950). 2009. DOI : 10.4049/jimmunol.0803001.

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate

A. Ablasser; F. Bauernfeind; G. Hartmann; E. Latz; K. A. Fitzgerald et al. 

Nature immunology. 2009. DOI : 10.1038/ni.1779.


Journal Articles

T cell-independent, TLR-induced IL-12p70 production in primary human monocytes

I. Bekeredjian-Ding; S. I. Roth; S. Gilles; T. Giese; A. Ablasser et al. 

Journal of immunology (Baltimore, Md. : 1950). 2006. 


Journal Articles

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

V. Hornung; M. Guenthner-Biller; C. Bourquin; A. Ablasser; M. Schlee et al. 

Nature medicine. 2005. DOI : 10.1038/nm1191.