Inflammatory mitochondrial nucleic acids as drivers of pathophysiology

C. G. Peace; A. Hooftman; D. G. Ryan 

Amidation of glutamate residues in mycobacterial peptidoglycan is essential for cell wall cross-linking

M. T. Shaku; K. L. Ocius; A. J. Apostolos; M. M. Pires; M. S. Vannieuwenhze et al. 

Africa-specific human genetic variation near CHD1L associates with HIV-1 load

P. J. J. McLaren; I. Porreca; G. Iaconis; H. P. Mok; S. Mukhopadhyay et al. 

cGAS-STING drives ageing-related inflammation and neurodegeneration

M. F. Gulen; N. Samson; A. Keller; M. Schwabenland; C. Liu et al. 

Variation in African genomes linked to control of HIV

P. J. McLaren; J. Fellay 

Pseudomonas aeruginosa type IV pili actively induce mucus contraction to form biofilms in tissue-engineered human airways

T. Rossy; T. Distler; L. Meirelles; J. Pezoldt; J. Kim et al. 

Protein target highlights in CASP15: Analysis of models by structure providers

L. T. Alexander; J. Durairaj; A. Kryshtafovych; L. A. Abriata; Y. Bayo et al. 

A metagenome-wide association study of HIV disease progression in HIV controllers

L. M. Real; M. E. Saez; A. Corma-Gomez; A. Gonzalez-Perez; C. Thorball et al. 

Ecology-relevant bacteria drive the evolution of host antimicrobial peptides in Drosophila

M. A. Hanson; L. Grollmus; B. Lemaitre 

Prevalence of CFTR variants in primary immunodeficiency patients with bronchiectasis is an important modifying cofactor

D. Lawless; H. L. Allen; J. E. D. Thaventhiran; S. Goddard; O. S. Burren et al. 

Hits and Misses: Digital Contact Tracing in a Pandemic

M. Garry; R. Zajac; L. Hope; M. Salathe; L. Levine et al. 

Autoantibodies neutralizing type I IFNs underlie West Nile virus encephalitis in & SIM;40% of patients

A. Gervais; F. Rovida; M. A. Avanzini; S. Croce; A. Marchal et al. 

Fluid flow structures gut microbiota biofilm communities by distributing public goods

J. P. H. Wong; M. F-Stettler; S. C. Zeeman; T. J. Battin; A. Persat et al. 

ER-to-lysosome-associated degradation in a nutshell: mammalian, yeast, and plant ER-phagy as induced by misfolded proteins

M. Rudinskiy; M. Molinari 

Biofilm formation on human immune cells is a multicellular predation strategy of Vibrio cholerae

L. Vidakovic; S. Mikhaleva; H. Jeckel; V. Nisnevich; K. Strenger et al. 

Multiancestry sex-stratified genomic associations with HIV viral load and controller status from the ICGH

C. Vergara; J. F. Tuff; J. Int Collaboration Genomics HIV ICGH; J. Fellay; P. Duggal et al. 

Poloxamers Have Vaccine-Adjuvant Properties by Increasing Dissemination of Particulate Antigen at Distant Lymph Nodes

M. Lamrayah; C. Phelip; R. Rovera; C. Coiffier; N. Lazhar et al. 

Association of a Polygenic Risk Score With Osteoporosis in People Living With HIV: The Swiss HIV Cohort Study

J. M. Schwenke; C. W. Thorball; I. C. Schoepf; L. Ryom; B. Hasse et al. 

Secondary structure of the human mitochondrial genome affects formation of deletions

V. Shamanskiy; A. A. Mikhailova; E. O. Tretiakov; K. Ushakova; A. G. Mikhailova et al. 

Epigenetic ageing accelerates before antiretroviral therapy and decelerates after viral suppression in people with HIV in Switzerland: a longitudinal study over 17 years

I. C. Schoepf; A. Esteban-Cantos; C. W. Thorball; B. Rodes; P. Reiss et al. 

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

D. Matuozzo; E. Talouarn; A. Marchal; P. Zhang; J. Manry et al. 

Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range

D. Ni; P. Turelli; B. Beckert; S. Nazarov; E. Uchikawa et al. 

Antimicrobial peptides do not directly contribute to aging in Drosophila, but improve lifespan by preventing dysbiosis

M. A. Hanson; B. Lemaitre 

Back-to-Africa introductions of Mycobacterium tuberculosis as the main cause of tuberculosis in Dar es Salaam, Tanzania

M. Zwyer; L. Rutaihwa; E. Windels; J. Hella; F. Menardo et al. 

Uptake-independent killing of macrophages by extracellular Mycobacterium tuberculosis aggregates

C. Toniolo; N. Dhar; J. D. McKinney 

COVID-Twitter-BERT: A natural language processing model to analyse COVID-19 content on Twitter

M. Muller; M. Salathe; P. E. Kummervold 

Live Birth of a Healthy Child in a Couple with Identical mtDNA Carrying a Pathogenic c.471_477delTTTAAAAinsG Variant in the MOCS2 Gene

M. Tofilo; N. Voronova; L. Nigmatullina; E. Kuznetsova; V. Timonina et al. 

An Advanced Alkaline Al-Air Fuel Cell Using L-Ascorbic Acid Interface Layer upon Al Anode via Gradient Anti-corrosion

M. Wei; K. Wang; Y. Zuo; H. Wang; P. Zhang et al. 

Two antagonistic response regulators control Pseudomonas aeruginosa polarization during mechanotaxis

M. J. Kuhn; H. Macmillan; L. Tala; Y. Inclan; R. Patino et al. 

Material Substrate Physical Properties Control Pseudomonas aeruginosa Biofilm Architecture

A. Cont; J. Vermeil; A. Persat 

Associations of genetic and infectious risk factors with coronary heart disease

F. Hodel; Z. M. Xu; C. W. Thorball; R. de la Harpe; P. Letang-Mathieu et al. 

Species-specific regulation of XIST by the JPX/FTX orthologs

O. Rosspopoff; E. Cazottes; C. Huret; A. Loda; A. J. Collier et al. 

Leukocyte Count and Coronary Artery Disease Events in People With Human Immunodeficiency Virus: A Longitudinal Study

E. F. Avery; J. N. Kleynhans; B. Ledergerber; I. C. Schoepf; C. W. Thorball et al. 

Combining European and US risk prediction models with polygenic risk scores to refine cardiovascular prevention: the CoLaus|PsyCoLaus Study

R. de La Harpe; C. W. Thorball; C. Redin; S. Fournier; O. Mueller et al. 

Dynamics of CLIMP-63 S-acylation control ER morphology

P. A. Sandoz; R. A. Denhardt-Eriksson; L. Abrami; L. A. Abriata; G. Spreemann et al. 

Take a walk on the KRAB side

O. Rosspopoff; D. Trono 

Genetic features and genomic targets of human KRAB-zinc finger proteins

J. de Tribolet-Hardy; C. W. Thorball; R. Forey; E. Planet; J. Duc et al. 

Host-Pathogen Interactions Through the Genomic Lens

KRAB zinc finger proteins link heterochromatin maintenance to replicative stress and inflammation in diffuse large B-cell lymphoma

Efficient and sensitive profiling of RNA–protein interactions using TLC-CLIP

C. Ernst; J. Duc; D. Trono 

DNA modifications impact natural transformation of Acinetobacter baumannii

N. Vesel; C. Iseli; N. Guex; A. Lemopoulos; M. Blokesch 

Sporadic type VI secretion in seventh pandemic Vibrio cholerae

A. Proutière; N. C. Drebes Dorr; L. Bader; S. Stutzmann; L. C. Metzger et al. 

The immunopeptidome landscape associated with T cell infiltration, inflammation and immune editing in lung cancer

A. I. Kraemer; C. Chong; F. Huber; H. Pak; B. J. Stevenson et al. 

Bacterial colonization in realistic environments: how mechanics impact biofilm formation in the wild and during infection

Machine Learning in Protein Science De Novo Design of Site-Specific Protein Binders Using Surface Fingerprints

A. Van Hall-Beauvais; P. Gainza; S. Wehrle; A. Scheck; A. Marchand et al. 

Biofilm morphogenesis on soft hydrogels

Tracking spatiotemporal localisation and interactions of the innate immune sensor STING

Recombinant bacteria resistant to horizontal gene transfer and phage infection

M. Blokesch; M. J. Jaskolska; D. W. Adams 

Induction of a strong and long-lasting neutralizing immune response by dPreS1-TLR2 agonist nanovaccine against hepatitis B virus

M. Lamrayah; F. Charriaud; M. Desmares; C. Coiffier; S. Megy et al. 

Visual masking deficits in schizophrenia: a view into the genetics of the disease through an endophenotype

A. Shaqiri; F. Hodel; J. R. da Cruz; M. Roinishvili; E. Chkonia et al. 

Selective involvement of UGGT variant: UGGT2 in protecting mouse embryonic fibroblasts from saturated lipid-induced ER stress

H-H. Hung; Y. Nagatsuka; T. Solda; V. K. Kodali; K. Iwabuchi et al. 

Microbiome-mediated fructose depletion restricts murine gut colonization by vancomycin-resistant Enterococcus

S. Isaac; A. Flor-Duro; G. Carruana; L. Puchades-Carrasco; A. Quirant et al. 

The cGAS-STING pathway and cancer

N. Samson; A. Ablasser 

Seroprevalence of anti-SARS-CoV-2 antibodies and cross-variant neutralization capacity after the Omicron BA.2 wave in Geneva, Switzerland: a population-based study

M-E. Zaballa; J. Perez-Saez; C. de Mestral; N. Pullen; J. Lamour et al. 

In vitro synergistic action of TAT-RasGAP 317-326 peptide with antibiotics against Gram-negative pathogens

G. Vizzarro; N. Jacquier 

Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation

M. Schmitt; F. Ceteci; J. Gupta; M. Pesic; T. W. Bottger et al. 

Phase separation in viral infections

H. Li; C. Ernst; M. Kolonko-Adamska; B. Greb-Markiewicz; J. Man et al. 

Variability of Primary Sjogren’s Syndrome Is Driven by Interferon alpha and Interferon alpha Blood Levels Are Associated With the Class II HLA-DQ Locus

D. Trutschel; P. Bost; X. Mariette; V. Bondet; A. Llibre et al. 

How to: Diagnose inborn errors of intrinsic and innate immunity to viral, bacterial, mycobacterial, and fungal infections

F. Conti; M. Moratti; M. Giannella; S. Ferrari; A. Borghesi 

The combined impact of persistent infections and human genetic variation on C-reactive protein levels

F. Hodel; O. Naret; C. Bonnet; N. Brenner; N. Bender et al. 

A satellite DNA array barcodes chromosome 7 and regulates totipotency via ZFP819

L. P. Fernandes; R. Enriquez-Gasca; P. A. Gould; J. H. Holt; L. Conde et al. 

Clathrin-associated AP-1 control stermination of STING signalling

Y. Liu; P. Xu; S. Rivara; C. Liu; J. Ricci et al. 

Global and gene-specific translational regulation in Escherichia coli across different conditions

D. Zhang; S. H-J. Li; C. G. King; N. S. Wingreen; Z. Gitai et al. 

ClimateBench v1.0: A Benchmark for Data-Driven Climate Projections

D. Watson-Parris; Y. Rao; D. Olivie; O. Seland; P. Nowack et al. 

A mitochondria-specific mutational signature of aging: increased rate of A > G substitutions on the heavy strand

A. G. Mikhailova; A. A. Mikhailova; K. Ushakova; E. O. Tretiakov; D. Iliushchenko et al. 

Preexisting Heterogeneity of Inducible Nitric Oxide Synthase Expression Drives Differential Growth of Mycobacterium tuberculosis in Macrophages

O. Rutschmann; C. Toniolo; J. D. McKinney 

Fluorescent D-Amino Acids for Super-resolution Microscopy of the Bacterial Cell Wall

C. Zhang; L. Reymond; O. Rutschmann; M. A. Meyer; J. Denereaz et al. 

Polygenic Risk Scores for Prediction of Subclinical Coronary Artery Disease in Persons Living With HIV: The Swiss HIV Cohort Study

I. C. Schoepf; C. W. Thorball; H. Kovari; B. Ledergerber; R. R. Buechel et al. 

Clinical detection of ‘cold stress’ is overlooked: an online survey of healthcare workers to explore the gap in neonatal thermal care in low-resource settings

M. Kyokan; V. Jirapaet; F. Rosa-Mangeret; G. B. Pisoni; R. E. Pfister 

Deploying Decentralized, Privacy-Preserving Proximity Tracing

C. Troncoso; D. Bogdanov; E. Bugnion; S. Chatel; C. Cremers et al. 

Monocyte-derived macrophages aggravate pulmonary vasculitis via cGAS/STING/IFN-mediated nucleic acid sensing

N. Kessler; S. F. Viehmann; C. Krollmann; K. Mai; K. M. Kirschner et al. 

Transposon-activated POU5F1B promotes colorectal cancer growth and metastasis

L. Simó-Riudalbas; S. Offner; E. Planet; J. Duc; L. Abrami et al. 

A Phylogeny-aware GWAS Framework to Correct for Heritable Pathogen Effects on Infectious Disease Traits

S. Nadeau; C. W. Thorball; R. Kouyos; H. F. Guenthard; J. Boeni et al. 

Acetate, a metabolic product of Heligmosomoides polygyrus, facilitates intestinal epithelial barrier breakdown in a FFAR2-dependent manner

F. Schalter; M. Frech; K. Duerholz; S. Lucas; K. Sarter et al. 

A Baseline Cellular Antiviral State Is Maintained by cGAS and Its Most Frequent Naturally Occurring Variant rs610913

J. Kazmierski; C. Elsner; K. Doehner; S. Xu; A. Ducroux et al. 

Disproportionate investment in Spiralin B production limits in-host growth and favors the vertical transmission of Spiroplasma insect endosymbionts

F. Masson; S. Rommelaere; F. Schupfer; J-P. Boquete; B. Lemaitre 

Type 1 piliated uropathogenic Escherichia coli hijack the host immune response by binding to CD14

K. Tomasek; A. Leithner; I. Glatzova; M. S. Lukesch; C. C. Guet et al. 

Engineering Agrobacterium tumefaciens Adhesion to Target Cells

X. Pierrat; A. Pham; J. P. H. Wong; Z. Al-Mayyah; A. Persat 

Patient-derived monoclonal antibody neutralizes SARS-CoV-2 Omicron variants and confers full protection in monkeys

C. Fenwick; P. Turelli; D. Ni; L. Perez; K. Lau et al. 

Dynamics of the most common pathogenic mtDNA variant m.3243A > G demonstrate frequency-dependency in blood and positive selection in the germline

M. Franco; S. J. Pickett; Z. Fleischmann; M. Khrapko; A. Cote-L’Heureux et al. 

Improving polygenic prediction with genetically inferred ancestry

O. Naret; Z. Kutalik; F. Hodel; Z. M. Xu; P. Marques-Vidal et al. 

Polar flagellar wrapping and lateral flagella jointly contribute to Shewanella putrefaciens environmental spreading

M. J. Kuehn; D. B. Edelmann; K. M. Thormann 

Er-Phagy: Mechanisms, Regulation, And Diseases Connected To The Lysosomal Clearance Of The Endoplasmic Reticulum

F. Reggiori; M. Molinari 

Host genomics of SARS-CoV-2 infection

C. Redin; C. W. Thorball; J. Fellay 

Transposable elements contribute to the spatiotemporal microRNA landscape in human brain development

C. J. Playfoot; S. Sheppard; E. Planet; D. Trono 

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

J. Manry; P. Bastard; A. Gervais; T. Le Voyer; J. Rosain et al. 

The Food Recognition Benchmark: Using Deep Learning to Recognize Food in Images

S. P. Mohanty; G. Singhal; E. A. Scuccimarra; D. Kebaili; H. Heritier et al. 

Mitochondrial Pseudogenes Suggest Repeated Inter-Species Hybridization among Direct Human Ancestors

K. Popadin; K. Gunbin; L. Peshkin; S. Annis; Z. Fleischmann et al. 

Nuclear Lipid Droplet Birth during Replicative Stress

S. Kumanski; R. Forey; C. Cazevieille; M. Moriel-Carretero 

Autoantibodies against type I IFNs in patients with Ph-negative myeloproliferative neoplasms

O. Borsani; P. Bastard; J. Rosain; A. Gervais; E. Sant’Antonio et al. 

Identifying and Characterizing Trans Women in the Swiss HIV Cohort Study as an Epidemiologically Distinct Risk Group (vol 74, pg 1468, 2022)

H. Nguyen; B. Hampel; D. G. Nunez; M. Battegay; A. Hachfeld et al. 

Local and substrate-specific S-palmitoylation determines subcellular localization of G alpha o

G. P. Solis; A. Kazemzadeh; L. Abrami; J. Valnohova; C. Alvarez et al. 

CD38 Expression by Antigen-Specific CD4 T Cells Is Significantly Restored 5 Months After Treatment Initiation Independently of Sputum Bacterial Load at the Time of Tuberculosis Diagnosis

H. Hiza; J. Hella; A. Arbues; M. Sasamalo; V. Misana et al. 

Single nucleotide polymorphism determines constitutive versus inducible type VI secretion in Vibrio cholerae

N. C. Drebes Dörr; A. Proutière; M. Jaskólska; S. Stutzmann; L. Bader et al. 

Phylogenetic estimation of the viral fitness landscape of HIV-1 set-point viral load

L. Zhao; C. Wymant; F. Blanquart; T. Golubchik; A. Gall et al. 

Solving the mystery of the missing plasmids in seventh pandemic Vibrio cholerae strains

M. Blokesch 

Two defence systems eliminate plasmids from seventh pandemic Vibrio cholerae

M. Jaskólska; D. W. Adams; M. Blokesch 

A polygenic risk score to predict sudden cardiac arrest in patients with cardiovascular disease

E. Porcu; C. Thorball; A. P. Porretta; E. Pruvot; K. Wiskott et al. 

Risk of mitochondrial deletions is affected by the global secondary structure of the mitochondrial genome

V. Shamanskiy; A. A. Mikhailova; K. Ushakova; A. G. Mikhailova; S. Oreshkov et al. 

Increased CHIP prevalence amongst people living with HIV

K. Popadin; A. G. Bick; C. W. Thorball; M. M. Uddin; M. Zanni et al.