Long term peripheral AAV9-SMN gene therapy promotes survival in a mouse model of spinal muscular atrophy

A. Reilly; R. Yaworski; A. Beauvais; B. L. Schneider; R. Kothary 

Stable isotope labeling and ultra-high-resolution NanoSIMS imaging reveal alpha-synuclein-induced changes in neuronal metabolism in vivo

S. Spataro; B. Maco; S. Escrig; L. Jensen; L. Polerecky et al. 

Recovery of walking after paralysis by regenerating characterized neurons to their natural target region

J. W. Squair; M. Milano; A. de Coucy; M. Gautier; M. A. Skinnider et al. 

AAV9-mediated SMN gene therapy rescues cardiac desmin but not lamin A/C and elastin dysregulation in Smn(2B/-) spinal muscular atrophy mice

S. J. Brown; D. Soltic; S. A. Synowsky; S. L. Shirran; E. Chilcott et al. 

Differential effect of Fas activation on spinal muscular atrophy motoneuron death and induction of axonal growth

S. Benlefki; R. Younes; D. Challuau; N. Bernard-Marissal; C. Hilaire et al. 

Mitofusin-2 in nucleus accumbens D2-MSNs regulates social dominance and neuronal function

S. Ghosal; E. G. Gebara; E. Ramos Fernandez; A. Chioino; J. Grosse et al. 

The role of the NF-kappaB pathway in Amyotrophic lateral sclerosis pathogenesis

Central and peripheral delivered AAV9-SMN are both efficient but target different pathomechanisms in a mouse model of spinal muscular atrophy

A. Reilly; M-O. Deguise; A. Beauvais; R. Yaworski; S. Thebault et al. 

Dopamine and Methamphetamine Differentially Affect Electron Transport Chain Complexes and Parkin in Rat Striatum: New Insight into Methamphetamine Neurotoxicity

V. Bazylianska; A. Sharma; H. Chauhan; B. Schneider; A. Moszczynska 

Astrocyte-targeting RNA interference against mutated superoxide dismutase 1 induces motoneuron plasticity and protects fast-fatigable motor units in a mouse model of amyotrophic lateral sclerosis

C. Rochat; N. Bernard-Marissal; E. Kaellstig; S. Pradervand; F. E. Perrin et al. 

The exercise-induced long noncoding RNA CYTOR promotes fast-twitch myogenesis in aging

M. Wohlwend; P-P. Laurila; K. William; M. Romani; T. Lima et al. 

Proteins associated with the sarcomere and costamere in hearts are dysregulated in two mouse models of spinal muscular atrophy

S. Owen; D. Soltic; S. Synowsky; E. Crompton; R. Yanez-Munoz et al. 

CSP alpha reduces aggregates and rescues striatal dopamine release in alpha-synuclein transgenic mice

L. Calo; E. Hidari; M. Wegrzynowicz; J. W. Dalley; B. L. Schneider et al. 

Parkin regulates drug-taking behavior in rat model of methamphetamine use disorder

A. Sharma; A. Harutyunyan; B. L. Schneider; A. Moszczynska 

Central anorexigenic actions of bile acids are mediated by TGR5

A. Perino; L. A. Velazquez-Villegas; N. Bresciani; Y. Sun; Q. Huang et al. 

The Links between ALS and NF-κB

E. C. Källstig; B. McCabe; B. Schneider 

IL10-and IL35-Secreting MutuDC Lines Act in Cooperation to Inhibit Memory T Cell Activation Through LAG-3 Expression

M. M. Koga; A. Engel; M. Pigni; C. Lavanchy; M. Stevanin et al. 

SMN Depleted Mice Offer a Robust and Rapid Onset Model of Nonalcoholic Fatty Liver Disease

M-O. Deguise; C. Pileggi; Y. De Repentigny; A. Beauvais; A. Tierney et al. 

Single and Dual Vector Gene Therapy with AAV9-PHP.B Rescues Hearing in Tmc1 Mutant Mice

J. Wu; P. Solanes; C. Nist-Lund; S. Spataro; O. Shubina-Oleinik et al. 

Mitofusin-2 in nucleus accumbens regulates anxiety and depression-like behaviors through mitochondrial and neuronal actions

E. Gebara; O. Zanoletti; S. Ghosal; J. Grosse; B. L. Schneider et al. 

Anti-Aβ antibodies bound to neuritic plaques enhance microglia activity and mitigate tau pathology

V. Laversenne; S. Nazeeruddin; E. C. Källstig; P. Colin; C. Voize et al. 

Efficient viral transduction in mouse inner ear hair cells with utricle injection and AAV9-PHP.B

J. Lee; C. Nist-Lund; P. Solanes; H. Goldberg; J. Wu et al. 

Nano-imaging trace elements at organelle levels in substantia nigra overexpressing alpha-synuclein to model Parkinson’s disease

L. Lemelle; A. Simionovici; P. Colin; G. Knott; S. Bohic et al. 

Glutaredoxin 1 Downregulation in the Substantia Nigra Leads to Dopaminergic Degeneration in Mice

A. Verma; A. Ray; D. Bapat; L. Diwakar; R. P. Kommaddi et al. 

Blood Flow to the Spleen is Altered in a Mouse Model of Spinal Muscular Atrophy

M-O. Deguise; A. Beauvais; B. L. Schneider; R. Kothary 

Glutaredoxin1 Diminishes Amyloid Beta-Mediated Oxidation of F-Actin and Reverses Cognitive Deficits in an Alzheimer’s Disease Mouse Model

R. P. Kommaddi; D. S. Tomar; S. Karunakaran; D. Bapat; S. Nanguneri et al. 

Allele-specific gene disruption through discrimination of a single base change by S. aureus Cas9-KKH prevents progressive hearing loss after AAV-mediated gene delivery

B. Gyorgy; C. Nist-Lund; B. Pan; Y. Asai; K. D. Karavitaki et al. 

Delivery of CRISPR/Cas9 using AAV-PHP.B in the inner ear leads to allele-specific inactivation of the mutated Tmc1 allele and protects auditory function in Beethoven mice

P. Solanes; S. Spataro; Y. Asai; B. Pan; C. A. Nist-Lund et al. 

Evolution of the neurochemical profiles in the G93A-SOD1 mouse model of amyotrophic lateral sclerosis

H. Lei; E. A. Dirren; C. Poitry-Yamate; B. Schneider; R. Gruetter et al. 

Scalable Production of AAV Vectors in Orbitally Shaken HEK293 Cells

D. Blessing; G. Vachey; C. Pythoud; M. Rey; V. Padrun et al. 

The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging

D. D’Amico; A. Mottis; F. Potenza; V. Sorrentino; H. Li et al. 

Compositions and methods for delivering nucleic acids to cochlear and vestibular cells

J. R. Holt; Y. Asai; P. A. Solanes Vega; B. Schneider 

Application of anti-amyloid beta immunization using encapsulated cell technology in mouse models of Alzheimer’s disease

Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss

B. Gyorgy; C. Nist-Lund; B. Pan; Y. Asai; K. D. Karavitaki et al. 

A viral vector based in vivo model of tauopathy to explore therapeutic strategies against tau pathology

Altered interplay between endoplasmic reticulum and mitochondria in Charcot-Marie-Tooth type 2A neuropathy

N. Bernard-Marissal; G. van Hameren; M. Juneja; C. Pellegrino; L. Louhivuori et al. 

Cas9/gRNAs Selective Targeting of the Beethoven Tmc-1 Mutant Allele for Treating Progressive Hearing Loss by AAV-Based Delivery

P. Solanes; B. Pan; P. Aebischer; J. R. Holt; B. Schneider 

Sliding Surface Based Schemes for the Tokamak a Configuration Variable

A. Marco; I. Garrido; A. J. Garrido; S. Coda; J. Ahn et al. 

Encapsulation device

A. Lathuilière; N. Bouche; B. Schneider 

Cas9/gRNA selective targeting of the Beethoven tmc-1 mutant allele for treating progressive hearing loss by AAV-based delivery

P. Solanes; Y. Asai; B. Pan; C. A. Nist-Lund; P. Aebischer et al. 

An miRNA-based gene therapy approach to target mutated SOD1 in key cell types in amyotrophic lateral sclerosis (ALS)

V. Vilmont; J. Aebischer; C. Rochat; B. L. Schneider 

Pathogenic commonalities between spinal muscular atrophy and amyotrophic lateral sclerosis: Converging roads to therapeutic development

M. Bowerman; L. M. Murray; F. Scamps; B. L. Schneider; R. Kothary et al. 

PFN2 and GAMT as common molecular determinants of axonal Charcot-Marie-Tooth disease

M. Juneja; A. Azmi; J. Baets; A. Roos; M. Jennings et al. 

Exogenous LRRK2(G2019S) induces parkinsonian-like pathology in a nonhuman primate

N. Mestre-Frances; N. Serratrice; A. Gennetier; G. Devau; S. Cobo et al. 

Endoplasmic reticulum and mitochondria in diseases of motor and sensory neurons: a broken relationship?

N. Bernard-Marissal; R. Chrast; B. Schneider 

Cortico–reticulo–spinal circuit reorganization enables functional recovery after severe spinal cord contusion

L. Asboth; L. Friedli; J. Beauparlant; C. Martinez-Gonzalez; S. Anil et al. 

PM20D1 is a quantitative trait locus associated with Alzheimer’s disease

J. V. Sanchez-Mut; H. Heyn; B. A. Silva; L. Dixsaut; P. Garcia-Esparcia et al. 

G2019S LRRK2 enhances the neuronal transmission of tau in the mouse brain

A. P. T. Nguyen; G. Daniel; P. Valdés; M. S. Islam; B. L. Schneider et al. 

In vivo neurochemical measurements in cerebral tissues using a droplet-based monitoring system

G. Petit-Pierre; P. Colin; E. Laurer; J. Déglon; A. Bertsch et al. 

AAV based gene therapy for rare diseases

Validation of Scalable and Compliant AAV Production

D. R. Blessing; G. Vachey; B. Schneider; F. M. Wurm; N. Deglon 

Bicistronic aav vector for rna interference in als

J. Aebischer; B. Schneider; C. Rochat 

Parkin functionally interacts with PGC-1 proportional to to preserve mitochondria and protect dopaminergic neurons

L. Zheng; N. Bernard-Marissal; N. Moullan; D. D’Amico; J. Auwerx et al. 

Amyloid-beta plaque deposition measured using propagation-based X-ray phase contrast CT imaging

A. Astolfo; A. Lathuiliere; V. Laversenne; B. Schneider; M. Stampanoni 

Encapsulation device

A. Lathuiliere; N. Bouche; B. Schneider 

Characterization Of Motor And Sensory Neuronal Dysfunction In Both In Vitro And In Vivo Models Of Cmt2A Pathology

N. Bernard-Marissal; C. Rochat; J. J. Medard; B. L. Schneider; R. Chrast 

In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons

P. Machler; M. T. Wyss; M. Elsayed; J. Stobart; R. Gutierrez et al. 

Use of a Bicistronic Vector to Silence SOD1 in Motoneurons and Astrocytes for the Treatment of Familial Amyotrophic Lateral Sclerosis

J. Bobela-Aebischer; C. Rochat; N. Bernard-Marissal; P. Aebischer; B. L. Schneider 

Suspension-Adapted HEK 293 Cells in Orbital Shaken Bioreactors for the Production of Adeno-Associated Virus Vectors

D. R. Blessing; B. Schneider; F. M. Wurm; N. Deglon 

A subcutaneous cellular implant for passive immunization against amyloid-beta reduces brain amyloid and tau pathologies

A. Lathuiliere; V. Laversenne; A. Astolfo; E. Kopetzki; H. Jacobsen et al. 

Modulation of AMPK’s activity via genetic tools and food-derived compounds as a novel approach to Parkinson’s disease treatment

Regulation of Memory Formation by the Transcription Factor XBP1

G. Martinez; R. L. Vidal; P. Mardones; F. G. Serrano; A. O. Ardiles et al. 

The effect of the functional interaction between PGC-1α and Parkin on mitochondrial quality control in Parkinson’s disease

Alpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson’s Disease

W. Bobela; P. Aebischer; B. L. Schneider 

SOD1 silencing in motoneurons or glia rescues neuromuscular function in ALS mice

E. Dirren; J. Aebischer; C. Rochat; C. Towne; B. L. Schneider et al. 

Chondroitinase gene therapy improves upper limb function following cervical contusion injury

N. D. James; J. Shea; E. M. Muir; J. Verhaagen; B. L. Schneider et al. 

PGC-1 alpha activity in nigral dopamine neurons determines vulnerability to alpha-synuclein

C. Ciron; L. Zheng; W. Bobela; G. W. Knott; T. C. Leone et al. 

Encapsulated Cellular Implants for Recombinant Protein Delivery and Therapeutic Modulation of the Immune System

A. Lathuiliere; N. Mach; B. L. Schneider 

Transient Production of Recombinant Adeno-Associated Virus (AAV) Vectors for Gene Therapy Applications Using Suspension-Adapted HEK 293 Cells in Orbital Shaken Bioreactors

D. R. Blessing; M. Montavon; M. De Jesus; L. Baldi; B. Schneider et al. 

Tmc gene therapy restores auditory function in deaf mice

C. Askew; C. Rochat; B. Pan; Y. Asai; H. Ahmed et al. 

Pathway-specific reorganization of projection neurons in somatosensory cortex during learning

J. L. Chen; D. J. Margolis; A. Stankov; L. T. Sumanovski; B. L. Schneider et al. 

Marinesco-Sjogren syndrome protein SIL1 regulates motor neuron subtype-selective ER stress in ALS

A. F. De L’Etang; N. Maharjan; M. C. Brana; C. Ruegsegger; R. Rehmann et al. 

Channel-Mediated Lactate Release by K+-Stimulated Astrocytes

T. Sotelo-Hitschfeld; M. I. Niemeyer; P. Maechler; I. Ruminot; R. Lerchundi et al. 

alpha-Synuclein-induced dopaminergic neurodegeneration in a rat model of Parkinson’s disease occurs independent of ATP13A2 (PARK9)

G. Daniel; A. Musso; E. Tsika; A. Fiser; L. Glauser et al. 

Perineuronal net digestion with chondroitinase restores memory in mice with tau pathology

S. Yang; M. Cacquevel; L. M. Saksida; T. J. Bussey; B. L. Schneider et al. 

The adipocyte differentiation protein APMAP is an endogenous suppressor of Aβ production in the brain

S. Mosser; J-R. Alattia; M. Dimitrov; A. Matz; J. Pascual et al. 

Loss of MITF expression during human embryonic stem cell differentiation disrupts retinal pigment epithelium development and optic vesicle cell proliferation

E. E. Capowski; J. M. Simonett; E. M. Clark; L. S. Wright; S. E. Howden et al. 

A Parkinson’s disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity

J. Dusonchet; H. Li; M. Guillily; M. Liu; K. Stafa et al. 

Parkinson’s disease-linked mutations in VPS35 induce dopaminergic neurodegeneration

E. Tsika; L. Glauser; R. Moser; A. Fiser; G. Daniel et al. 

Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1

P. Valdes; G. Mercado; R. L. Vidal; C. Molina; G. Parsons et al. 

Large-Scale Chondroitin Sulfate Proteoglycan Digestion with Chondroitinase Gene Therapy Leads to Reduced Pathology and Modulates Macrophage Phenotype following Spinal Cord Contusion Injury

K. Bartus; N. D. James; A. Didangelos; K. D. Bosch; J. Verhaagen et al. 

FOXO3 determines the accumulation of alpha-synuclein and controls the fate of dopaminergic neurons in the substantia nigra

E. Pino; R. Amamoto; L. Zheng; M. Cacquevel; J-C. Sarria et al. 

Intracerebroventricular Injection of Adeno-Associated Virus 6 and 9 Vectors for Cell Type-Specific Transgene Expression in the Spinal Cord

E. Dirren; C. L. Towne; V. Setola; D. E. J. Redmond; B. L. Schneider et al. 

Genetic engineering of cell lines using lentiviral vectors to achieve antibody secretion following encapsulated implantation

A. Lathuiliere; B. Bohrmann; E. Kopetzki; C. Schweitzer; H. Jacobsen et al. 

A high-capacity cell macroencapsulation system supporting the long-term survival of genetically engineered allogeneic cells

A. Lathuilière; S. Cosson; M. Lütolf; B. Schneider; P. Aebischer 

Measurement of autophagy flux in the nervous system in vivo

K. Castillo; V. Valenzuela; S. Matus; M. Nassif; M. Onate et al. 

Dysregulation of voltage-gated sodium channels by ubiquitin ligase NEDD4-2 in neuropathic pain

C. J. Laedermann; M. Cachemaille; G. Kirschmann; M. Pertin; R-D. Gosselin et al. 

Behaviour-dependent recruitment of long-range projection neurons in somatosensory cortex

J. L. Chen; S. Carta; J. Soldado-Magraner; B. L. Schneider; F. Helmchen 

Overexpression of parkin in the rat nigrostriatal dopamine system protects against methamphetamine neurotoxicity

B. Liu; R. Traini; B. Killinger; B. L. Schneider; A. Moszczynska 

Direct and Retrograde Transduction of Nigral Neurons with AAV6, 8, and 9 and Intraneuronal Persistence of Viral Particles

K. Loew; P. Aebischer; B. L. Schneider 

Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo

A. Oueslati; B. L. Schneider; P. Aebischer; H. A. Lashuel 

AAV-mediated gene therapy against motoneuron diseases

A novel encapsulation device for peripheral implantation of antibody-secreting cells

Focal expression of adeno-associated viral-mutant tau induces widespread impairment in an APP mouse model

E. Dassie; M. R. Andrews; J-C. Bensadoun; M. Cacquevel; B. L. Schneider et al. 

An in vivo ultrahigh field 14.1 T (1) H-MRS study on 6-OHDA and α-synuclein-based rat models of Parkinson’s disease: GABA as an early disease marker

P. Coune; M. Craveiro; M. Gaugler; V. Mlynárik; B. Schneider et al. 

Parkinson’s Disease: Gene Therapies

P. G. Coune; B. L. Schneider; P. Aebischer 

Proton and phosphorus magnetic resonance spectroscopy of a mouse model of Alzheimer’s disease

V. Mlynárik; M. Cacquevel; L. Sun-Reimer; S. Janssens; C. Cudalbu et al. 

Nigrostriatal overabundance of alpha-synuclein leads to decreased vesicle density and deficits in dopamine release that correlate with reduced motor activity

M. N. Gaugler; O. Genc; W. Bobela; S. Mohanna; M. T. Ardah et al. 

Endoplasmic Reticulum Stress Is Important for the Manifestations of alpha-Synucleinopathy In Vivo

E. Colla; P. Coune; Y. Liu; O. Pletnikova; J. C. Troncoso et al. 

α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer

B. Fauvet; M. K. Mbefo; M-B. Fares; C. Desobry; S. Michael et al.