Publications

2025

Journal Articles

Automated fast label-free quantification of cardiomyocyte dynamics with raw holograms for cardiotoxicity screening

I. Moon; E. Ahmadzadeh; Y. Kim; B. Rappaz; G. Turcatti 

BIOMEDICAL OPTICS EXPRESS. 2025. num. 2, p. 398 – 414. DOI : 10.1364/BOE.542362.

Targeting protein-ligand neosurfaces with a generalizable deep learning tool

A. Marchand; S. Buckley; A. Schneuing; M. Pacesa; M. Elia et al. 

NATURE. 2025. DOI : 10.1038/s41586-024-08435-4.

Aurora kinase B is required for growth and expansion of medulloblastoma cells in the tissue context

A. Gries; K. Santhana Kumar; F. Kuttler; Ö. Özalp; V. Akle et al. 

Neoplasia (New York, N.Y.). 2025. Vol. 59. DOI : 10.1016/j.neo.2024.101078.

2024

Journal Articles

Preclinical spheroid models identify BMX as a therapeutic target for metastatic MYCN nonamplified neuroblastoma

S. Sundaramoorthy; D. F. Colombo; R. Sanalkumar; L. Broye; K. B. Bourloud et al. 

JCI INSIGHT. 2024. Vol. 9, num. 14. DOI : 10.1172/jci.insight.169647.

Gentle Rhodamines for Live-Cell Fluorescence Microscopy

T. Liu; J. Kompa; J. Ling; N. Lardon; Y. Zhang et al. 

ACS Central Science. 2024. DOI : 10.1021/acscentsci.4c00616.

2023

Journal Articles

Phosphoproteomics and morphology of stored human red blood cells treated by protein tyrosine phosphatases inhibitor

M. Bardyn; D. Crettaz; B. Rappaz; R. Hamelin; F. Armand et al. 

Blood Advances. 2023. Vol. 8, num. 1, p. 1 – 13. DOI : 10.1182/bloodadvances.2023009964.

In vitro-transfusional model for red-blood-cell study: the advantage of lowering hematocrit

E. Langst; D. Crettaz; J. Delobel; R. Renella; M. S. Bardyn et al. 

Blood Transfusion. 2023. Vol. 21, num. 4, p. 277 – 288. DOI : 10.2450/2022.0086-22.

Translational screening platform to evaluate chemotherapy in combination with focal therapy for retinoblastoma

I. L. Sinenko; F. Kuttler; V. Simeonov; A. Moulin; P. Aouad et al. 

Cancer Science. 2023. DOI : 10.1111/cas.15878.

Automated Dual-Mode Cell Monitoring To Simultaneously Explore Calcium Dynamics and Contraction-Relaxation Kinetics within Drug-Treated Stem Cell-Derived Cardiomyocytes

K. Jaferzadeh; B. Rappaz; Y. Kim; B-K. Kim; I. Moon et al. 

Acs Sensors. 2023. DOI : 10.1021/acssensors.3c00073.

Conference Papers

Repurposing drug screen of patient-derived malignant pleural mesothelioma cells reveals potential anti-cancer activity

A. Laure; A. Rigutto; M. Manovah; M. Chambon; G. Turcatti et al. 

2023.  p. S117 – S118.

2022

Journal Articles

High-content, arrayed compound screens with rhinovirus, influenza A virus and herpes simplex virus infections

D. Olszewski; F. Georgi; L. Murer; V. Andriasyan; F. Kuttler et al. 

Scientific Data. 2022. Vol. 9, num. 610, p. 1 – 12. DOI : 10.1038/s41597-022-01733-4.

Novel High-Throughput Fluorescence-Based Assay for the Identification of Nematocidal Compounds That Target the Blood-Feeding Pathway

A. Marchand; J. W. M. Van Bree; A. C. Taki; M. Moyat; G. Turcatti et al. 

Pharmaceuticals. 2022. Vol. 15, num. 6, p. 669. DOI : 10.3390/ph15060669.

Identification of New Vulnerabilities in Conjunctival Melanoma Using Image-Based High Content Drug Screening

K. Nardou; M. Nicolas; F. Kuttler; K. Cisarova; E. Celik et al. 

Cancers. 2022. Vol. 14, num. 6, p. 1575. DOI : 10.3390/cancers14061575.

Identification of broad anti-coronavirus chemical agents for repurposing against SARS-CoV-2 and variants of concern

L. Murer; R. Volle; V. Andriasyan; A. Petkidis; A. Gomez-Gonzalez et al. 

Current Research in Virological Science. 2022. Vol. 3, p. 100019. DOI : 10.1016/j.crviro.2022.100019.

2021

Journal Articles

Highly Potent Host-Specific Small-Molecule Inhibitor of Paramyxovirus and Pneumovirus Replication with High Resistance Barrier

N. Shrestha; F. M. Gall; C. Mathieu; M. M. Hierweger; M. Bruegger et al. 

Mbio. 2021. Vol. 12, num. 6, p. e02621 – 21. DOI : 10.1128/mBio.02621-21.

Picomole-Scale Synthesis and Screening of Macrocyclic Compound Libraries by Acoustic Liquid Transfer

G. Sangouard; A. Zorzi; Y. Wu; E. Ehret; M. Schuettel et al. 

Angewandte Chemie International Edition. 2021. Vol. 60, num. 40, p. 21702 – 21707. DOI : 10.1002/anie.202107815.

Image- and Fluorescence-Based Test Shows Oxidant-Dependent Damages in Red Blood Cells and Enables Screening of Potential Protective Molecules

M. Bardyn; J. Allard; D. Crettaz; B. Rappaz; G. Turcatti et al. 

International Journal of Molecular Sciences. 2021. Vol. 22, num. 8, p. 4293. DOI : 10.3390/ijms22084293.

Antiviral Screen against Canine Distemper Virus-Induced Membrane Fusion Activity

N. Shrestha; F. M. Gall; J. Vesin; M. Chambon; G. Turcatti et al. 

Viruses. 2021. Vol. 13, num. 1, p. 128. DOI : 10.3390/v13010128.

Patents

Cathepsin inhibitors and uses thereof

E. Oricchio; E. Battistello; M. Santin; L. Reymond 

WO2021191412; EP3884948.

2021.

2020

Journal Articles

The FDA-Approved Drug Nelfinavir Inhibits Lytic Cell-Free but Not Cell-Associated Nonlytic Transmission of Human Adenovirus

F. Georgi; V. Andriasyan; R. Witte; L. Murer; S. Hemmi et al. 

Antimicrobial Agents and Chemotherapy. 2020. Vol. 64, num. 9, p. e01002 – 20. DOI : 10.1128/AAC.01002-20.

A high-content image-based drug screen of clinical compounds against cell transmission of adenovirus

F. Georgi; F. Kuttler; L. Murer; V. Andriasyan; R. Witte et al. 

Scientific Data. 2020. Vol. 7, num. 1, p. 265. DOI : 10.1038/s41597-020-00604-0.

High-throughput automated organoid culture via stem-cell aggregation in microcavity arrays

N. Brandenberg; S. Hoehnel; F. Kuttler; K. Homicsko; C. Ceroni et al. 

Nature Biomedical Engineering. 2020. Vol. 4, p. 863 – 874. DOI : 10.1038/s41551-020-0565-2.

Loss of Bacterial Cell Pole Stabilization in Caulobacter crescentus Sensitizes to Outer Membrane Stress and Peptidoglycan-Directed Antibiotics

S-U. Vallet; L. H. Hansen; F. C. Bistrup; S. A. Laursen; J. Bortoli Chapalay et al. 

mBio. 2020. Vol. 11, num. 3, p. e00538 – 20. DOI : 10.1128/mBio.00538-20.

Marker-Free Automatic Quantification of Drug-Treated Cardiomyocytes with Digital Holographic Imaging

K. Jaferzadeh; B. Rappaz; F. Kuttler; B. K. Kim; I. Moon et al. 

Acs Photonics. 2020. Vol. 7, num. 1, p. 105 – 113. DOI : 10.1021/acsphotonics.9b01152.

2019

Journal Articles

Image-Based Marker-Free Screening of GABA(A) Agonists, Antagonists, and Modulators

B. Rappaz; P. Jourdain; D. Banfi; F. Kuttler; P. Marquet et al. 

Slas Discovery. 2019.  p. 2472555219887142. DOI : 10.1177/2472555219887142.

Thiol-to-amine cyclization reaction enables screening of large libraries of macrocyclic compounds and the generation of sub-kilodalton ligands

S. S. Kale; M. Bergeron-Brlek; Y. Wu; M. G. Kumar; M. V. Pham et al. 

Science Advances. 2019. Vol. 5, num. 8, p. eaaw2851. DOI : 10.1126/sciadv.aaw2851.

Screening-based approach to discover effective platinum-based chemotherapies for cancers with poor prognosis

H. P. Varbanov; F. Kuttler; D. Banfi; G. Turcatti; P. J. Dyson 

Plos One. 2019. Vol. 14, num. 1, p. e0211268. DOI : 10.1371/journal.pone.0211268.

A Universal Assay for Aminopeptidase Activity and Its Application for Dipeptidyl Peptidase-4 Drug Discovery

A. A. Bazhin; M. Chambon; J. Vesin; J. Bortoli; J. W. Collins et al. 

Analytical Chemistry. 2019. Vol. 91, num. 1, p. 1098 – 1104. DOI : 10.1021/acs.analchem.8b04672.

An optimized and validated 384-well plate assay to test platelet function in a high-throughput screening format

A. M. Lima; M. E. Bragina; O. Burri; J. B. Chapalay; F. P. Costa-Fraga et al. 

Platelets. 2019. Vol. 30, num. 5, p. 563 – 571. DOI : 10.1080/09537104.2018.1514106.

Patents

Sting inhibitors

A. Ablasser; S. Haag; L. Reymond 

WO2019201939; EP3556362.

2019.

2018

Journal Articles

Quantification of stored red blood cell fluctuations by time-lapse holographic cell imaging

K. Jaferzadeh; I. Moon; M. Bardyn; M. Prudent; J-D. Tissot et al. 

Biomedical Optics Express. 2018. Vol. 9, num. 10, p. 4714 – 4729. DOI : 10.1364/BOE.9.004714.

2017

Journal Articles

Red blood cells ageing markers: a multi-parametric analysis

M. Bardyn; B. Rappaz; K. Jaferzadeh; D. Crettaz; J-D. Tissot et al. 

Blood Transfusion. 2017. Vol. 15, num. 3, p. 239 – S2. DOI : 10.2450/2017.0318-16.

Repositioning approved drugs for the treatment of problematic cancers using a screening approach

H. P. Varbanov; F. Kuttler; D. Banfi; G. Turcatti; P. J. Dyson 

Plos One. 2017. Vol. 12, num. 2, p. e0171052. DOI : 10.1371/journal.pone.0171052.

2016

Journal Articles

Growth control switch by a DNA-damage-inducible toxin–antitoxin system in Caulobacter crescentus

C. L. Kirkpatrick; D. Martins; P. Redder; A. Frandi; J. Mignolet et al. 

Nature Microbiology. 2016. Vol. 1, num. 4, p. 16008. DOI : 10.1038/nmicrobiol.2016.8.

Automated tracking of temporal displacements of a red blood cell obtained by time-lapse digital holographic microscopy

I. Moon; F. Yi; B. Rappaz 

Applied Optics. 2016. Vol. 55, num. 3, p. A86 – A94. DOI : 10.1364/Ao.55.000A86.

Screening out irrelevant cell-based models of disease

P. Horvath; N. Aulner; M. Bickle; A. M. Davies; E. Del Nery et al. 

Nature Reviews Drug Discovery. 2016. Vol. 15, num. 11, p. 751 – 769. DOI : 10.1038/nrd.2016.175.

Conference Papers

Development Of A Novel First-In-Class Oral Inhibitor Of The Notch Pathway

R. Lehal; V. Frismantas; V. Reinmuller; G. Turcatti; J. P. Bourquin et al. 

2016. 21st Congress of the European-Hematology-Association, Copenhagen, DENMARK, JUN 09-12, 2016. p. 29 – 29.

2015

Journal Articles

Automated multi-parameter measurement of cardiomyocytes dynamics with digital holographic microscopy

B. Rappaz; I. Moon; F. Yi; B. Javidi; P. Marquet et al. 

Optics Express. 2015. Vol. 23, num. 10, p. 13333 – 13347. DOI : 10.1364/OE.23.013333.

Wnt directs the endosomal flux of LDL-derived cholesterol and lipid droplet homeostasis

C. C. Scott; S. Vossio; F. Vacca; B. Snijder; J. Larios et al. 

Embo Reports. 2015. Vol. 16, num. 6, p. 741 – 752. DOI : 10.15252/embr.201540081.

Conference Papers

Identification of CDC-48 inhibitors in C. elegans

A. F. Conchas; F. Schwager; M. Chambon; G. Turcatti; M. Gotta 

2015. 40th Congress of the Federation-of-European-Biochemical-Societies (FEBS) – The Biochemical Basis of Life, Berlin, GERMANY, JUL 04-09, 2015. p. 389 – 389.

Book Chapters

Digital Holographic Imaging for Label-Free Phenotypic Profiling, Cytotoxicity, and Chloride Channels Target Screening

B. Rappaz; F. Kuttler; B. Breton; G. Turcatti 

Label-Free Biosensor Methods in Drug Discovery; New York: Springer, 2015. p. 307 – 325.

2014

Journal Articles

Anticytolytic Screen Identifies Inhibitors of Mycobacterial Virulence Protein Secretion

J. Rybniker; J. M. Chen; C. Sala; R. C. Hartkoorn; A. Vocat et al. 

Cell Host & Microbe. 2014. Vol. 16, num. 4, p. 538 – 548. DOI : 10.1016/j.chom.2014.09.008.

Digital holographic microscopy: a quantitative label-free microscopy technique for phenotypic screening

B. Rappaz; B. Breton; E. Shaffer; G. Turcatti 

Combinatorial chemistry & high throughput screening. 2014. Vol. 17, num. 1, p. 80 – 8. DOI : 10.2174/13862073113166660062.

Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors

U. F. Roehrig; S. R. Majjigapu; M. Chambon; S. Bron; L. Pilotte et al. 

European Journal Of Medicinal Chemistry. 2014. Vol. 84, p. 284 – 301. DOI : 10.1016/j.ejmech.2014.06.078.

Non-specific SIRT inhibition as a mechanism for the cytotoxicity of ginkgolic acids and urushiols

L. Ryckewaert; L. Sacconnay; P-A. Carrupt; A. Nurisso; C. Simões-Pires 

Toxicology Letters. 2014. Vol. 229, num. 2, p. 374 – 380. DOI : 10.1016/j.toxlet.2014.07.002.

Developing the Biomolecular Screening Facility at the EPFL into the Chemical Biology Screening Platform for Switzerland

G. Turcatti 

Combinatorial Chemistry & High Throughput Screening. 2014. Vol. 17, num. 4, p. 369 – 376. DOI : 10.2174/1386207317666140323194716.

Conference Papers

Loss of Protein Tyr-phosphorylation During in vitro Storage of Human Erythrocytes: Impact on RBC Morphology

M. Prudent; B. Rappaz; R. Hamelin; J. Delobel; M. Mueller et al. 

2014. AABB Annual Meeting, Philadelphia, PA, OCT 25-28, 2014. p. 49A – 50A.

2013

Journal Articles

Label-Free Cytotoxicity Screening Assay by Digital Holographic Microscopy

J. Kühn; E. Shaffer; J. Mena; B. Breton; J. Parent et al. 

ASSAY and Drug Development Technologies. 2013. Vol. 11, num. 2, p. 101 – 107. DOI : 10.1089/adt.2012.476.

2012

Journal Articles

Enumeration of 166 Billion Organic Small Molecules in the Chemical Universe Database GDB-17

L. Ruddigkeit; R. Van Deursen; L. C. Blum; J-L. Reymond 

Journal Of Chemical Information And Modeling. 2012. Vol. 52, num. 11, p. 2864 – 2875. DOI : 10.1021/ci300415d.

2011

Journal Articles

Exploring the Chemical Space of Known and Unknown Organic Small Molecules at www.gdb.unibe.ch

J-L. Reymond; L. C. Blum; R. van Deursen 

CHIMIA. 2011. Vol. 65, p. 863 – 867. DOI : 10.2533/chimia.2011.863.

2010

Journal Articles

Leads for antitubercular compounds from kinase inhibitor library screens

S. Magnet; R. C. Hartkoorn; R. Székely; J. Pató; J. A. Triccas et al. 

Tuberculosis. 2010. Vol. 90, num. 6, p. 354 – 60. DOI : 10.1016/j.tube.2010.09.001.

Identification and characterization of novel classes of macrophage migration inhibitory factor (MIF) inhibitors with distinct mechanisms of action

H. Ouertatani-Sakouhi; F. El-Turk; B. Fauvet; M-K. Cho; D. Pinar Karpinar et al. 

The Journal of biological chemistry. 2010. Vol. 285, num. 34, p. 26581 – 98. DOI : 10.1074/jbc.M110.113951.

Optimization of microfluidic single cell trapping for long-term on-chip culture

S. Kobel; A. Valero; J. Latt; P. Renaud; M. Lutolf 

Lab on a Chip. 2010. Vol. 10, num. 7, p. 857 – 863. DOI : 10.1039/b918055a.

An integrative in silico methodology for the identification of modulators of macrophage migration inhibitory factor (MIF) tautomerase activity

F. El Turk; B. Fauvet; H. Ouertatani-Sakouhi; A. Lugari; S. Betzi et al. 

Bioorganic & medicinal chemistry. 2010. Vol. 18, num. 14, p. 5425 – 40. DOI : 10.1016/j.bmc.2010.05.010.

Patents

Preparation of nucleic acid templates for solid phase amplification

N. Gormley; J. Boutell; G. Turcatti; C. Barnes 

EP2918686; EP1957668; WO2007060456; US8168388; US2010041561; EP1957668; WO2007060456; GB0524069.

2010.

2009

Journal Articles

A new class of isothiocyanate-based irreversible inhibitors of macrophage migration inhibitory factor

H. Ouertatani-Sakouhi; F. El-Turk; B. Fauvet; T. Roger; D. Le Roy et al. 

Biochemistry. 2009. Vol. 48, num. 41, p. 9858 – 70. DOI : 10.1021/bi900957e.

Patents

Preparation of templates for nucleic acid sequencing

X. Liu; J. Milton; G. Smith; C. Barnes; I. Rasolonjatovo et al. 

ES2398808; EP2298930; US10710046; US2018353926; US9999866; US2017021325; US9498763; US2015343410; US9085802; US2014349891; US8715966; ES2398808; EP2298930; US2012208194; EP1910559; HK1154636; EP2298930; US2009118128; EP1910559; WO2007010251; WO2007010251; GB0514936.

2009.

2008

Journal Articles

A new class of cleavable fluorescent nucleotides: synthesis and optimization as reversible terminators for DNA sequencing by synthesis

G. Turcatti; A. Romieu; M. Fedurco; A. Tairi 

Nucleic Acids Research. 2008. Vol. 36, num. 4, p. e25. DOI : 10.1093/nar/gkn021.

Accurate whole human genome sequencing using reversible terminator chemistry

D. R. Bentley; S. Balasubramanian; H. P. Swerdlow; G. P. Smith; J. Milton et al. 

Nature. 2008. Vol. 456, num. 7218, p. 53 – 9. DOI : 10.1038/nature07517.

Patents

Method of Nucleotide Detection

M. Fedurco; A. Romieu; G. Turcatti 

EP1828412; US9970055; US2016208324; US9303290; US9217178; US2014378323; EP1828412; US2008280773; EP1828412; WO2006064199; GB0514933; GB0427236.

2008.

2007

Journal Articles

Interfering residues narrow the spectrum of MLV restriction by human TRIM5alpha

P. Maillard; S. Reynard; F. Serhan; P. Turelli; D. Trono 

PLOS Pathogens. 2007. Vol. 3, num. 12, p. e200. DOI : 10.1371/journal.ppat.0030200.

Low- to high-throughput analysis of telomerase modulators with Telospot

G. Cristofari; P. Reichenbach; P. O. Regamey; D. Banfi; M. Chambon et al. 

Nature Methods. 2007. Vol. 4, num. 10, p. 851 – 853. DOI : 10.1038/nmeth1099.

Patents

Conversion of amine- to carboxyl groups on solid surfaces

M. Fedurco; A. Romieu; G. Turcatti 

US7704543; US2007042109; EP1692090; WO2005030695.

2007.

Improved method of nucleotide detection

M. Fedurco; A. Romieu; G. Turcatti 

EP1828412; US9970055; US2016208324; US9303290; US9217178; US2014378323; EP1828412; US2008280773; EP1828412; WO2006064199; GB0514933; GB0427236.

2007.

2006

Journal Articles

BTA, a novel reagent for DNA attachment on glass and efficient generation of solid-phase amplified DNA colonies

M. Fedurco; A. Romieu; S. Williams; I. Lawrence; G. Turcatti 

Nucleic Acids Research. 2006. Vol. 34, num. 3, p. e22. DOI : 10.1093/nar/gnj023.

Aryldithioethyloxycarbonyl (Ardec): A new family of amine protecting groups removable under mild reducing conditions and their applications to peptide synthesis

M. Lapeyre; J. Leprince; M. Massonneau; H. Oulyadi; P. Y. Renard et al. 

Chemistry – A European Journal. 2006. Vol. 12, num. 13, p. 3655 – 3671. DOI : 10.1002/chem.200501538.

2004

Journal Articles

A microfluidic platform using molecular beacon-based temperature calibration for thermal dehybridization of surface-bound DNA

A. Dodge; G. Turcatti; I. Lawrence; N. F. De Rooij; E. Verpoorte 

Analytical Chemistry. 2004. Vol. 76, num. 6, p. 1778 – 1787. DOI : 10.1021/ac034377+.

2003

Patents

Nucleotide detection by fluorescence resonance energy transfer and methods thereof

G. Turcatti 

BR0303224; NO20034592; NO20034592; AU2003226829; WO03068986.

2003.

2001

Journal Articles

Synthesis and characterization of fluorescent and photoactivatable MIP-1alpha ligands and interactions with chemokine receptors CCR1 and CCR5

S. Zoffmann; G. Turcatti; J. L. Galzi; M. Dahl; A. Chollet 

Journal of Medicinal Chemistry. 2001. Vol. 44, num. 2, p. 215 – 222. DOI : 10.1021/jm000982i.

2000

Journal Articles

Solid phase DNA amplification: characterisation of primer attachment and amplification mechanisms

C. Adessi; G. Matton; G. Ayala; G. Turcatti; J. J. Mermod et al. 

Nucleic acids research. 2000. Vol. 28, num. 20, p. e87. DOI : 10.1093/nar/28.20.e87.

Patents

Methods of nucleic acid amplification and sequencing

C. Adessi; E. Kawashima; P. Mayer; J-J. Mermod; G. Turcatti 

US10370652; US2016319274; US9297006; US2014228254; US8652810; EP1634963; EP1117827; US2008160580; US7115400; DE69928683; EP1634963; DE69928683; AT311474; EP1117827; AU771073; EA004271; HU0105052; NZ510599; HK1042525; JP2002525125; AR021833; EE200100195; HU0105052; PL347125; BG105363; CN1325458; SK4292001; EA200100402; ZA200102420; CZ20011183; KR20010085860; EP1117827; TR200100911; BR9914159; NO20011303; NO20011303; AU6108899; CA2344575; WO0018957.

2000.

1999

Journal Articles

Fluorescent pseudo-peptide linear vasopressin antagonists: Design, synthesis, and applications

T. Durroux; M. Peter; G. Turcatti; A. Chollet; M. N. Balestre et al. 

Journal of Medicinal Chemistry. 1999. Vol. 42, num. 7, p. 1312 – 1319. DOI : 10.1021/jm9804782.

Biophysical approaches to G protein-coupled receptors: Structure, function and dynamics

A. Chollet; G. Turcatti 

Journal of Computer-Aided Molecular Design. 1999. Vol. 13, num. 3, p. 209 – 219. DOI : 10.1023/A:1008052002695.

1998

Journal Articles

Mapping the binding sites of peptide and non-peptide molecules to G protein-coupled receptors by fluorescence

A. Chollet; G. Turcatti 

Letters in Peptide Science. 1998. Vol. 5, num. 2-3, p. 79 – 82. DOI : 10.1007/BF02443443.

Conference Papers

Probing ligand-receptor recognition in G protein-coupled receptors through biosynthetic incorporation of fluorescent amino acids at specific sites and measurement of distances by fluorescence energy transfer

A. Chollet; G. Turcatti; K. Nemeth; H. Vogel 

1998. 2nd Conference on Fluorescence Microscopy and Fluorescent Probes, Prague, Apr. 9-12, 1997. p. 87 – 92.

1997

Journal Articles

Characterization of non-peptide antagonist and peptide agonist binding sites of the NK1 receptor with fluorescent ligands

G. Turcatti; S. Zoffmann; J. A. Lowe Iii; S. E. Drozda; G. Chassaing et al. 

Journal of Biological Chemistry. 1997. Vol. 272, num. 34, p. 21167 – 21175. DOI : 10.1074/jbc.272.34.21167.

Fluorescent labeling of NK2 receptor at specific sites in vivo and fluorescence energy transfer analysis of NK2 ligand-receptor complexes

G. Turcatti; K. Nemeth; M. D. Edgerton; J. Knowles; H. Vogel et al. 

Receptors and Channels. 1997. Vol. 5, num. 3-4, p. 201 – 207.

1996

Journal Articles

Probing the structure and function of the tachykinin neurokinin-2 receptor through biosynthetic incorporation of fluorescent amino acids at specific sites

G. Turcatti; K. Nemeth; M. D. Edgerton; U. Meseth; F. Talabot et al. 

Journal of Biological Chemistry. 1996. Vol. 271, num. 33, p. 19991 – 19998. DOI : 10.1074/jbc.271.33.19991.

1995

Journal Articles

Probing the Binding Domain of the NK2 Receptor with Fluorescent Ligands: Evidence That Heptapeptide Agonists and Antagonists Bind Differently

G. Turcatti; H. Vogel; A. Chollet 

Biochemistry. 1995. Vol. 34, num. 12, p. 3972 – 80. DOI : 10.1021/bi00012a015.

1994

Journal Articles

Purification, cDNA cloning and heterologous expression of human phosphomannose isomerase

A. E. I. Proudfoot; G. Turcatti; T. N. C. Wells; M. A. Payton; D. J. Smith 

European Journal of Biochemistry. 1994. Vol. 219, num. 1-2, p. 415 – 423. DOI : 10.1111/j.1432-1033.1994.tb19954.x.

Synthesis and characterization of selective fluorescent ligands for the neurokinin NK2 receptor

C. G. Bradshaw; K. Ceszkowski; G. Turcatti; I. J. M. Beresford; A. Chollet 

Journal of Medicinal Chemistry. 1994. Vol. 37, num. 13, p. 1991 – 1995. DOI : 10.1021/jm00039a012.

1993

Journal Articles

Role of cysteine62 in DNA recognition by the p50 subunit of NF-kappa B

J. R. Matthews; W. Kaszubska; G. Turcatti; T. N. C. Wells; R. T. Hay 

Nucleic Acids Research. 1993. Vol. 21, num. 8, p. 1727 – 1734. DOI : 10.1093/nar/21.8.1727.

Biochemical characterization and solubilization of human NK2 receptor expressed in Chinese hamster ovary cells

G. Turcatti; K. Ceszkowski; A. Chollet 

Journal of Receptor Research. 1993. Vol. 13, num. 1-4, p. 639 – 652. DOI : 10.3109/10799899309073684.

1992

Journal Articles

Partial characterization of natural and recombinant human soluble CD23

K. Rose; G. Turcatti; P. Graber; S. Pochon; P. O. Regamey et al. 

Biochemical Journal. 1992. Vol. 286, num. 3, p. 819 – 824. DOI : 10.1042/bj2860819.

Purification and characterization of biologically active human recombinant 37 kDa soluble CD23 (sFc epsilon RII) expressed in insect cells

P. Graber; K. U. Jansen; S. Pochon; J. Shields; N. Aubonney et al. 

Journal of Immunological Methods. 1992. Vol. 149, num. 2, p. 215 – 226. DOI : 10.1016/0022-1759(92)90253-P.

1991

Journal Articles

Purification and partial characterization of rat factor D

B. C. Baker; C. J. Campbell; C. J. Grinham; G. Turcatti 

Biochemical Journal. 1991. Vol. 279, num. 3, p. 775 – 779. DOI : 10.1042/bj2790775.

Human interleukin-5 expressed in Escherichia coli: Assignment of the disulfide bridges of the purified unglycosylated protein

A. E. I. Proudfoot; J. G. Davies; G. Turcatti; P. T. Wingfield 

FEBS Letters. 1991. Vol. 283, num. 1, p. 61 – 64. DOI : 10.1016/0014-5793(91)80553-F.

1990

Journal Articles

Tumor necrosis factor inhibitor: purification, NH2-terminal amino acid sequence and evidence for anti-inflammatory and immunomodulatory activities

P. Seckinger; E. Vey; G. Turcatti; P. Wingfield; J. M. Dayer 

European Journal of Immunology. 1990. Vol. 20, num. 5, p. 1167 – 1174.

Structure and partial amino acid sequence of calf thymus DNA topoisomerase II: Comparison with other type II enzymes

C. A. Austin; H. A. Barot; E. E. C. Margerrison; G. Turcatti; P. Wingfield et al. 

Biochemical and Biophysical Research Communications. 1990. Vol. 170, num. 2, p. 763 – 768. DOI : 10.1016/0006-291X(90)92156-T.

1989

Journal Articles

Purification and characterization of a methionine-specific aminopeptidase from Salmonella typhimurium

P. Wingfield; P. Graber; G. Turcatti; N. R. Movva; M. Pelletier et al. 

European Journal of Biochemistry. 1989. Vol. 180, num. 1, p. 23 – 32. DOI : 10.1111/j.1432-1033.1989.tb14610.x.

1988

Journal Articles

Characterization of recombinant-derived granulocyte-colony stimulating factor (G-CSF)

P. Wingfield; R. Benedict; G. Turcatti; B. Allet; J. J. Mermod et al. 

Biochemical Journal. 1988. Vol. 256, num. 1, p. 213 – 218. DOI : 10.1042/bj2560213.

Insulin proteinase liberates from glucagon a fragment known to have enhanced activity against Ca2+ + Mg2+-dependent ATPase

K. Rose; L. A. Savoy; A. V. Muir; J. G. Davies; R. E. Offord et al. 

Biochemical Journal. 1988. Vol. 256, num. 3, p. 847 – 851. DOI : 10.1042/bj2560847.