Publications

2024

Journal Articles

A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation

F. Martins; O. Rosspopoff; J. Carlevaro-Fita; R. Forey; S. Offner et al. 

Cancer Research. 2024.  p. OF1-OF19. DOI : 10.1158/0008-5472.CAN-23-1237.

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Transposable elements mediate genetic effects altering the expression of nearby genes in colorectal cancer

N. M. R. Lykoskoufis; E. Planet; H. Ongen; D. Trono; E. T. Dermitzakis 

Nature Communications. 2024. Vol. 15, num. 749. DOI : 10.1038/s41467-023-42405-0.

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Ancestral genome reconstruction enhances transposable element annotation by identifying degenerate integrants

W. Matsushima; E. Planet; D. Trono 

Cell Genomics. 2024. Vol. 4, p. 100497. DOI : 10.1016/j.xgen.2024.100497.

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A First-in-Human Randomized Study to Assess the Safety, Tolerability, Pharmacokinetics, and Neutralization Profile of Two Investigational Long-Acting Anti-SARS-CoV-2 Monoclonal Antibodies

N. Moullan; J. Asiago; K. Stecco; S. Hadi; M. Albizem et al. 

Infectious Diseases and Therapy. 2024-01-14. DOI : 10.1007/s40121-023-00908-9.

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2023

Journal Articles

Statistical learning quantifies transposable element-mediated cis-regulation

C. Pulver; D. Grun; J. Duc; S. Sheppard; E. Planet et al. 

Genome Biology. 2023. Vol. 24, num. 258. DOI : 10.1186/s13059-023-03085-7.

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SARS-CoV-2 hijacks a cell damage response, which induces transcription of a more efficient Spike S-acyltransferase

F. S. Mesquita; L. Abrami; L. Bracq; N. Panyain; V. Mercier et al. 

Nature Communications. 2023. Vol. 14, num. 7302. DOI : 10.1038/s41467-023-43027-2.

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New ingredients for old recipes

O. Rosspopoff; F. Martins; D. Trono 

Nature Genetics. 2023. DOI : 10.1038/s41588-023-01591-9.

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Broadly potent anti-SARS-CoV-2 antibody shares 93% of epitope with ACE2 and provides full protection in monkeys

C. Fenwick; P. Turelli; Y. Duhoo; K. Lau; C. Herate et al. 

Journal of Infection. 2023. DOI : 10.1016/j.jinf.2023.10.008.

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Take a walk on the KRAB side

O. Rosspopoff; D. Trono 

Trends in Genetics. 2023. DOI : 10.1016/j.tig.2023.08.003.

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Genetic features and genomic targets of human KRAB-zinc finger proteins

J. de Tribolet-Hardy; C. W. Thorball; R. Forey; E. Planet; J. Duc et al. 

Genome Research. 2023. DOI : 10.1101/gr.277722.123.

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Efficient and sensitive profiling of RNA–protein interactions using TLC-CLIP

C. Ernst; J. Duc; D. Trono 

Nucleic Acids Research. 2023. DOI : 10.1093/nar/gkad466.

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The immunopeptidome landscape associated with T cell infiltration, inflammation and immune editing in lung cancer

A. I. Kraemer; C. Chong; F. Huber; H. Pak; B. J. Stevenson et al. 

Nature Cancer. 2023. DOI : 10.1038/s43018-023-00548-5.

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Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range

D. Ni; P. Turelli; B. Beckert; S. Nazarov; E. Uchikawa et al. 

PLOS Pathogens. 2023-04-05. Vol. 19, num. 4, p. e1011206. DOI : 10.1371/journal.ppat.1011206.

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2022

Journal Articles

Seroprevalence of anti-SARS-CoV-2 antibodies and cross-variant neutralization capacity after the Omicron BA.2 wave in Geneva, Switzerland: a population-based study

M-E. Zaballa; J. Perez-Saez; C. de Mestral; N. Pullen; J. Lamour et al. 

The Lancet Regional Health – Europe. 2022-12-01. Vol. 24, p. 100547. DOI : 10.1016/j.lanepe.2022.100547.

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A satellite DNA array barcodes chromosome 7 and regulates totipotency via ZFP819

L. P. Fernandes; R. Enriquez-Gasca; P. A. Gould; J. H. Holt; L. Conde et al. 

Science Advances. 2022-10-28. Vol. 8, num. 43. DOI : 10.1126/sciadv.abp8085.

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Transposon-activated POU5F1B promotes colorectal cancer growth and metastasis

L. Simó-Riudalbas; S. Offner; E. Planet; J. Duc; L. Abrami et al. 

Nature Communications. 2022-08-20. Vol. 13, num. 1, p. 4913. DOI : 10.1038/s41467-022-32649-7.

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Patient-derived monoclonal antibody neutralizes SARS-CoV-2 Omicron variants and confers full protection in monkeys

C. Fenwick; P. Turelli; D. Ni; L. Perez; K. Lau et al. 

Nature Microbiology. 2022-07-25. DOI : 10.1038/s41564-022-01198-6.

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Transposable elements contribute to the spatiotemporal microRNA landscape in human brain development

C. J. Playfoot; S. Sheppard; E. Planet; D. Trono 

RNA. 2022-06-22.  p. rna.079100.122. DOI : 10.1261/rna.079100.122.

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A cis-acting structural variation at the ZNF558 locus controls a gene regulatory network in human brain development

P. Johansson; P. L. Brattas; C. Douse; P. Hsieh; A. Adami et al. 

Cell Stem Cell. 2022-01-06. Vol. 29, num. 1, p. 52-69. DOI : 10.1016/j.stem.2021.09.008.

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Humoral Responses Against Variants of Concern by COVID-19 mRNA Vaccines in Immunocompromised Patients

M. Obeid; M. Suffiotti; C. Pellaton; H. Bouchaab; A. Cairoli et al. 

Jama Oncology. 2022-03-10. DOI : 10.1001/jamaoncol.2022.0446.

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Human reproduction is regulated by retrotransposons derived from ancient Hominidae-specific viral infections

X. Xiang; Y. Tao; J. DiRusso; F-M. Hsu; J. Zhang et al. 

Nature Communications. 2022-01-24. Vol. 13, num. 1, p. 463. DOI : 10.1038/s41467-022-28105-1.

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Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasma

M. M. Schneider; M. Emmenegger; C. K. Xu; I. C. Morales; G. Meisl et al. 

Life Science Alliance. 2022-02-01. Vol. 5, num. 2, p. e202101270. DOI : 10.26508/lsa.202101270.

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KRAB zinc finger protein ZNF676 controls the transcriptional influence of LTR12-related endogenous retrovirus sequences

A. Iouranova; D. Grun; T. Rossy; J. Duc; A. Coudray et al. 

Mobile Dna. 2022-01-18. Vol. 13, num. 1, p. 4. DOI : 10.1186/s13100-021-00260-0.

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Occupational risk of SARS-CoV-2 infection and reinfection during the second pandemic surge: a cohort study

A. Leidi; A. Berner; R. Dumont; R. Dubos; F. Koegler et al. 

Occupational And Environmental Medicine. 2022. Vol. 79, p. 116-119. DOI : 10.1136/oemed-2021-107924.

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2021

Journal Articles

S-acylation controls SARS-CoV-2 membrane lipid organization and enhances infectivity

F. S. Mesquita; L. Abrami; O. Sergeeva; P. Turelli; E. Qing et al. 

Developmental Cell. 2021-10-25. Vol. 56, num. 20, p. 2790-+. DOI : 10.1016/j.devcel.2021.09.016.

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A highly potent antibody effective against SARS-CoV-2 variants of concern

C. Fenwick; P. Turelli; L. Perez; C. Pellaton; L. Esteves-Leuenberger et al. 

Cell Reports. 2021-10-12. Vol. 37, num. 2, p. 109814. DOI : 10.1016/j.celrep.2021.109814.

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Transposable elements and their KZFP controllers are drivers of transcriptional innovation in the developing human brain

C. J. Playfoot; J. Duc; S. Sheppard; S. Dind; A. Coudray et al. 

Genome Research. 2021-09-01. Vol. 31, num. 9, p. 1531-1545. DOI : 10.1101/gr.275133.120.

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A high-throughput cell- and virus-free assay shows reduced neutralization of SARS-CoV-2 variants by COVID-19 convalescent plasma

C. Fenwick; P. Turelli; C. Pellaton; A. Farina; J. Campos et al. 

Science Translational Medicine. 2021-08-04. Vol. 13, num. 605, p. eabi8452. DOI : 10.1126/scitranslmed.abi8452.

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Large variation in anti-SARS-CoV-2 antibody prevalence among essential workers in Geneva, Switzerland

S. Stringhini; M-E. Zaballa; N. Pullen; C. de Mestral; J. Perez-Saez et al. 

Nature Communications. 2021-06-08. Vol. 12, num. 1, p. 3455. DOI : 10.1038/s41467-021-23796-4.

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Changes in SARS-CoV-2 Spike versus Nucleoprotein Antibody Responses Impact the Estimates of Infections in Population-Based Seroprevalence Studies

C. Fenwick; A. Croxatto; A. T. Coste; F. Pojer; C. Andre et al. 

Journal Of Virology. 2021-02-01. Vol. 95, num. 3, p. e01828-20. DOI : 10.1128/JVI.01828-20.

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2020

Journal Articles

The Human RNA Helicase DDX21 Presents a Dimerization Interface Necessary for Helicase Activity

M. J. Marcaida Lopez; A. Kauzlaric; A. Duperrex; J. Sülzle; M. C. Moncrieffe et al. 

iScience. 2020-11-18. Vol. 23, num. 12, p. 101811. DOI : 10.1016/j.isci.2020.101811.

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Endogenous retroviruses drive KRAB zinc-finger protein family expression for tumor suppression

J. Ito; I. Kimura; A. Soper; A. Coudray; Y. Koyanagi et al. 

Science Advances. 2020-10-01. Vol. 6, num. 43, p. eabc3020. DOI : 10.1126/sciadv.abc3020.

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Primate-restricted KRAB zinc finger proteins and target retrotransposons control gene expression in human neurons

P. Turelli; C. Playfoot; D. Grun; C. Raclot; J. Pontis et al. 

Science Advances. 2020-08-28. Vol. 6, num. 35, p. eaba3200. DOI : 10.1126/sciadv.aba3200.

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Seroprevalence of anti-SARS-CoV-2 IgG antibodies in Geneva, Switzerland (SEROCoV-POP): a population-based study

S. Stringhini; A. Wisniak; G. Piumatti; A. S. Azman; S. A. Lauer et al. 

The Lancet. 2020-06-11. Vol. 396, num. 10247, p. 313 – 319. DOI : 10.1016/S0140-6736(20)31304-0.

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Integrated proteogenomic deep sequencing and analytics accurately identify non-canonical peptides in tumor immunopeptidomes

C. Chong; M. Müller; H. Pak; D. Harnett; F. Huber et al. 

Nature Communications. 2020-03-10. Vol. 11, p. 1239. DOI : 10.1038/s41467-020-14968-9.

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KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage

G. Wolf; A. de Iaco; M-A. Sun; M. Bruno; M. Tinkham et al. 

eLife. 2020-06-01. Vol. 9, p. e56337. DOI : 10.7554/eLife.56337.

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KAP1 targets actively transcribed genomic loci to exert pleomorphic effects on RNA polymerase II activity

A. Kauzlaric; S. M. Jang; M. Morchikh; M. Cassano; E. Planet et al. 

Philosophical Transactions of the Royal Society B: Biological Sciences. 2020-02-10. Vol. 375, num. 1795, p. 20190334. DOI : 10.1098/rstb.2019.0334.

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2019

Journal Articles

DUX is a non-essential synchronizer of zygotic genome activation

A. De Iaco; S. Verp; S. Offner; D. Grun; D. Trono 

Development. 2019-12-05.  p. dev.177725. DOI : 10.1242/dev.177725.

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KAP1 is an antiparallel dimer with a functional asymmetry

G. Fonti; M. J. Marcaida; L. C. Bryan; S. Traeger; A. S. Kalantzi et al. 

Life Science Alliance. 2019-08-01. Vol. 2, num. 4, p. e201900349. DOI : 10.26508/lsa.201900349.

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The interactome of KRAB zinc finger proteins reveals the evolutionary history of their functional diversification

P. Helleboid; M. Heusel; J. Duc; C. Piot; C. W. Thorball et al. 

The EMBO Journal. 2019-08-12.  p. 1-16. DOI : 10.15252/embj.2018101220.

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ZFP30 promotes adipogenesis through the KAP1-mediated activation of a retrotransposon-derived Pparg2 enhancer

W. Chen; P. C. Schwalie; E. V. Pankevich; C. Gubelmann; S. K. Raghav et al. 

Nature Communications. 2019-04-18. Vol. 10, num. 1, p. 1809. DOI : 10.1038/s41467-019-09803-9.

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A Dissection of Oligomerization by the TRIM28 Tripartite Motif and the Interaction with Members of the Krab-ZFP Family

Y. Sun; J. R. Keown; M. M. Black; C. Raclot; N. Demarais et al. 

Journal of Molecular Biology. 2019-06-28. Vol. 431, num. 14, p. 2511-2527. DOI : 10.1016/j.jmb.2019.05.002.

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Hominoid-Specific Transposable Elements and KZFPs Facilitate Human Embryonic Genome Activation and Control Transcription in Naive Human ESCs

J. Pontis; E. Planet; S. Offner; P. Turelli; J. Duc et al. 

Cell Stem Cell. 2019-03-27. Vol. 24, num. 5, p. 724-735. DOI : 10.1016/j.stem.2019.03.012.

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DPPA2 and DPPA4 are necessary to establish a 2C‐like state in mouse embryonic stem cells

A. De Iaco; A. Coudray; J. Duc; D. Trono 

EMBO reports. 2019-04-04.  p. e47382. DOI : 10.15252/embr.201847382.

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Pharmacological induction of a progenitor state for the efficient expansion of primary human hepatocytes

C. Unzu; E. Planet; N. Brandenberg; F. Fusil; M. Cassano et al. 

Hepatology. 2019. Vol. 69, num. 5, p. 2214-2231. DOI : 10.1002/hep.30425.

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ZNF445 is a primary regulator of genomic imprinting

N. Takahashi; A. Coluccio; C. W. Thorball; E. Planet; H. Shi et al. 

Genes & Development. 2019-01-01. Vol. 33, num. 1-2, p. 49-54. DOI : 10.1101/gad.320069.118.

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2018

Journal Articles

Properties of LINE-1 proteins and repeat element expression in the context of amyotrophic lateral sclerosis

G. C. Pereira; L. Sanchez; P. M. Schaughency; A. Rubio-Roldan; J. A. Choi et al. 

Mobile Dna. 2018-12-15. Vol. 9, p. 35. DOI : 10.1186/s13100-018-0138-z.

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HIV-1 Vpr and p21 restrict LINE-1 mobility

K. Kawano; A. J. Doucet; M. Ueno; R. Kariya; W. An et al. 

Nucleic Acids Research. 2018-07-31. Vol. 46, num. 16, p. 8454-8470. DOI : 10.1093/nar/gky688.

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KAP1 facilitates reinstatement of heterochromatin after DNA replication

S. M. Jang; A. Kauzlaric; J-P. Quivy; J. Pontis; B. Rauwel et al. 

Nucleic Acids Research. 2018-06-28. Vol. 46, num. 17, p. 8788-8802. DOI : 10.1093/nar/gky580.

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Individual retrotransposon integrants are differentially controlled by KZFP/KAP1-dependent histone methylation, DNA methylation and TET-mediated hydroxymethylation in naïve embryonic stem cells

A. Coluccio; G. Ecco; J. Duc; S. Offner; P. Turelli et al. 

Epigenetics & Chromatin. 2018-02-26. Vol. 11, num. 1, p. 7. DOI : 10.1186/s13072-018-0177-1.

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2017

Journal Articles

KRAB zinc finger proteins

G. Ecco; M. Imbeault; D. Trono 

Development. 2017. Vol. 144, num. 15, p. 2719-2729. DOI : 10.1242/dev.132605.

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DUX-family transcription factors regulate zygotic genome activation in placental mammals

A. De Iaco; E. Planet; A. Coluccio; S. Verp; J. Duc et al. 

Nature Genetics. 2017. Vol. 49, num. 6, p. 941-945. DOI : 10.1038/ng.3858.

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Polyphenic trait promotes liver cancer in a model of epigenetic instability

M. Cassano; S. Offner; E. Planet; A. Piersigilli; S. M. Jang et al. 

Hepatology. 2017. Vol. 66, num. 1, p. 235-251. DOI : 10.1002/hep.29182.

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The mouse genome displays highly dynamic populations of KRAB-zinc finger protein genes and related genetic units

A. Kauzlaric; G. Ecco; M. Cassano; J. Duc; M. Imbeault et al. 

PLoS One. 2017. Vol. 12, num. 3, p. e0173746. DOI : 10.1371/journal.pone.0173746.

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KRAB zinc-finger proteins contribute to the evolution of gene regulatory networks

M. Imbeault; P-Y. Helleboid; D. Trono 

Nature. 2017. Vol. 543, p. 550-554. DOI : 10.1038/nature21683.

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SMiLE-seq identifies binding motifs of single and dimeric transcription factors

A. Isakova; R. Groux; M. Imbeault; P. Rainer; D. Alpern et al. 

Nature methods. 2017. Vol. 14, p. 316-322. DOI : 10.1038/nmeth.4143.

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2016

Journal Articles

Switzerland and the Digital Health Revolution

D. Trono 

Chimia. 2016. Vol. 70, num. 12, p. 851-852. DOI : 10.2533/chimia.2016.851.

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Lentiviral vectors, two decades later

L. Naldini; D. Trono; I. M. Verma 

Science. 2016. Vol. 353, num. 6304, p. 1101-1102. DOI : 10.1126/science.aah6192.

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Transposable Elements, Polydactyl Proteins, and the Genesis of Human-Specific Transcription Networks

D. Trono 

Cold Spring Harbor symposia on quantitative biology. 2016. Vol. 80, p. 281-8. DOI : 10.1101/sqb.2015.80.027573.

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A Large-Scale Functional Screen to Identify Epigenetic Repressors of Retrotransposon Expression

G. Ecco; H. M. Rowe; D. Trono 

Methods in molecular biology (Clifton, N.J.). 2016. Vol. 1400, p. 403-17. DOI : 10.1007/978-1-4939-3372-3_25.

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Molecular Criteria for Defining the Naive Human Pluripotent State

T. W. Theunissen; M. Friedli; Y. He; E. Planet; R. C. O’Neil et al. 

Cell stem cell. 2016. Vol. 19, num. 4, p. 502-515. DOI : 10.1016/j.stem.2016.06.011.

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Transposable Elements and Their KRAB-ZFP Controllers Regulate Gene Expression in Adult Tissues

G. Ecco; M. Cassano; A. Kauzlaric; J. Duc; A. Coluccio et al. 

Developmental Cell. 2016. Vol. 36, num. 6, p. 611-623. DOI : 10.1016/j.devcel.2016.02.024.

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The evolution of gene expression and binding specificity of the largest transcription factor family in primates

A. Kapopoulou; L. Mathew; A. Wong; D. Trono; J. D. Jensen 

Evolution. 2016. Vol. 70, num. 1, p. 167-180. DOI : 10.1111/evo.12819.

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2015

Journal Articles

Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages

J-E. Dietrich; L. Panavaite; S. Gunther; S. Wennekamp; A. C. Groner et al. 

EMBO reports. 2015. Vol. 16, num. 8, p. 1005-1021. DOI : 10.15252/embr.201540162.

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Release of human cytomegalovirus from latency by a KAP1/TRIM28 phosphorylation switch

B. Rauwel; S. M. Jang; M. Cassano; A. Kapopoulou; I. Barde et al. 

eLife. 2015. Vol. 4, p. e06068. DOI : 10.7554/eLife.06068.

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A KAP1 phosphorylation switch controls MyoD function during skeletal muscle differentiation

K. Singh; M. Cassano; E. Planet; S. Sebastian; S. M. Jang et al. 

Genes & development. 2015. Vol. 29, num. 5, p. 513-25. DOI : 10.1101/gad.254532.114.

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TRIM28 Represses Transcription of Endogenous Retroviruses in Neural Progenitor Cells

L. Fasching; A. Kapopoulou; R. Sachdeva; R. Petri; M. Jönsson et al. 

Cell Reports. 2015. Vol. 10, num. 1, p. 20-28. DOI : 10.1016/j.celrep.2014.12.004.

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2014

Journal Articles

As Time Goes by: KRABs Evolve to KAP Endogenous Retroelements

M. Imbeault; D. Trono 

Developmental Cell. 2014. Vol. 31, num. 3, p. 257-258. DOI : 10.1016/j.devcel.2014.10.019.

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Identification of the transcription factor ZEB1 as a central component of the adipogenic gene regulatory network

C. Gubelmann; P. C. Schwalie; S. K. Raghav; E. Roeder; T. Delessa et al. 

Elife. 2014. Vol. 3, p. e03346. DOI : 10.7554/eLife.03346.

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Dual-regulated Lentiviral Vector for Gene Therapy of X-linked Chronic Granulomatosis

M. Chiriaco; G. Farinelli; V. Capo; E. Zonari; S. Scaramuzza et al. 

Molecular Therapy. 2014. Vol. 22, num. 8, p. 1472-1483. DOI : 10.1038/mt.2014.87.

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Evolutionally dynamic L1 regulation in embryonic stem cells

N. Castro-Diaz; G. Ecco; A. Coluccio; A. Kapopoulou; B. Yazdanpanah et al. 

Genes & development. 2014. Vol. 28, num. 13, p. 1397-409. DOI : 10.1101/gad.241661.114.

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Interplay of TRIM28 and DNA methylation in controlling human endogenous retroelements

P. Turelli; N. Castro-Diaz; F. Marzetta; A. Kapopoulou; C. Raclot et al. 

Genome research. 2014. Vol. 24, num. 8, p. 1260-70. DOI : 10.1101/gr.172833.114.

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Loss of transcriptional control over endogenous retroelements during reprogramming to pluripotency

M. Friedli; P. Turelli; A. Kapopoulou; B. Rauwel; N. Castro-Díaz et al. 

Genome research. 2014. Vol. 24, num. 8, p. 1251-9. DOI : 10.1101/gr.172809.114.

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Control of mitophagie by microRNAs – A key step of erythropoiesis

I. Barde; B. Rauwel; R. M. Marin-Florez; A. Corsinotti; E. Laurenti et al. 

M S-Medecine Sciences. 2014. Vol. 30, num. 1, p. 12-15. DOI : 10.1051/medsci/20143001003.

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2013

Journal Articles

VEGFR-3 Neutralization Inhibits Ovarian Lymphangiogenesis, Follicle Maturation, and Murine Pregnancy

J. M. Rutkowski; J. E. Ihm; S. T. Lee; W. W. Kilarski; V. I. Greenwood et al. 

American Journal Of Pathology. 2013. Vol. 183, num. 5, p. 1596-1607. DOI : 10.1016/j.ajpath.2013.07.031.

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Prototype Foamy Virus Bet Impairs the Dimerization and Cytosolic Solubility of Human APOBEC3G

J. Vasudevan; A. Ayyappan; M. Perkovic; Y. Bulliard; K. Cichutek et al. 

Journal of virology. 2013. Vol. 87, num. 16, p. 9030-9040. DOI : 10.1128/JVI.03385-12.

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A switch between topological domains underlies HoxD genes collinearity in mouse limbs

G. Andrey; T. Montavon; B. Mascrez; F. Gonzalez; D. Noordermeer et al. 

Science (New York, N.Y.). 2013. Vol. 340, num. 6137, p. 1234167. DOI : 10.1126/science.1234167.

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Global and stage specific patterns of krüppel-associated-box zinc finger protein gene expression in murine early embryonic cells

A. Corsinotti; A. Kapopoulou; C. Gubelmann; M. Imbeault; S. de Sio et al. 

PloS One. 2013. Vol. 8, num. 2, p. e56721. DOI : 10.1371/journal.pone.0056721.

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Peripuberty stress leads to abnormal aggression, altered amygdala and orbitofrontal reactivity and increased prefrontal MAOA gene expression

C. Márquez; G. L. Poirier; M. I. Cordero; M. H. Larsen; A. Groner et al. 

Transl Psychiatry. 2013. Vol. 3, p. e216. DOI : 10.1038/tp.2012.144.

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De novo DNA methylation of endogenous retroviruses is shaped by KRAB-ZFPs/KAP1 and ESET

H. M. Rowe; M. Friedli; S. Offner; S. Verp; D. Mesnard et al. 

Development (Cambridge, England). 2013. Vol. 140, num. 3, p. 519-29. DOI : 10.1242/dev.087585.

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TRIM28 repression of retrotransposon-based enhancers is necessary to preserve transcriptional dynamics in embryonic stem cells

H. M. Rowe; A. Kapopoulou; A. Corsinotti; L. Fasching; T. S. Macfarlan et al. 

Genome research. 2013. Vol. 23, p. 452-461. DOI : 10.1101/gr.147678.112.

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2012

Journal Articles

The KRAB-ZFP/KAP1 System Contributes to the Early Embryonic Establishment of Site-Specific DNA Methylation Patterns Maintained during Development

S. Quenneville; P. Turelli; K. Bojkowska; C. Raclot; S. Offner et al. 

Cell Reports. 2012. Vol. 2, num. 4, p. 766-773. DOI : 10.1016/j.celrep.2012.08.043.

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KAP1 regulates gene networks controlling T-cell development and responsiveness

S. de Sio; R. Francesca; I. Barde; S. Offner; A. Kapopoulou et al. 

FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2012. Vol. 26, num. 11, p. 4561-4575. DOI : 10.1096/fj.12-206177.

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MicroRNA-124 Is a Subventricular Zone Neuronal Fate Determinant

M. Akerblom; R. Sachdeva; I. Barde; S. Verp; B. Gentner et al. 

The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012. Vol. 32, num. 26, p. 8879-89. DOI : 10.1523/JNEUROSCI.0558-12.2012.

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Embryonic stem cell potency fluctuates with endogenous retrovirus activity

T. S. Macfarlan; W. D. Gifford; S. Driscoll; K. Lettieri; H. M. Rowe et al. 

Nature. 2012. Vol. 487, num. 7405, p. 57-63. DOI : 10.1038/nature11244.

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Liver-specific ablation of Krüppel-associated box-associated protein 1 in mice leads to male-predominant hepatosteatosis and development of liver adenoma

K. Bojkowska; F. Aloisio; M. Cassano; A. Kapopoulou; F. Santoni De Sio et al. 

Hepatology. 2012. Vol. 56, num. 4, p. 1279-1290. DOI : 10.1002/hep.25767.

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The Kruppel-associated Box Repressor Domain Can Induce Reversible Heterochromatization of a Mouse Locus in Vivo

A. C. Groner; P. Tschopp; L. Challet; J-E. Dietrich; S. Verp et al. 

The Journal of biological chemistry. 2012. Vol. 287, num. 30, p. 25361-9. DOI : 10.1074/jbc.M112.350884.

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Gene therapy: too much splice can spoil the dish

D. Trono 

The Journal of clinical investigation. 2012. Vol. 122, num. 5, p. 1600-1602. DOI : 10.1172/JCI63066.

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KAP1 regulates gene networks controlling mouse B-lymphoid cell differentiation and function

S. de Sio; R. Francesca; J. Massacand; I. Barde; S. Offner et al. 

Blood. 2012. Vol. 119, num. 20, p. 4675-85. DOI : 10.1182/blood-2011-12-401117.

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The ATM substrate KAP1 controls DNA repair in heterochromatin: Regulation by HP1 proteins and Serine 473/824 phosphorylation

D. White; I. U. Rafalska-Metcalf; A. V. Ivanov; A. Corsinotti; H. Peng et al. 

Molecular cancer research : MCR. 2012. Vol. 1, p. 3-10. DOI : 10.1158/1541-7786.MCR-11-0134.

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2011

Journal Articles

A novel lentiviral vector targets gene transfer into human hematopoietic stem cells in marrow from patients with bone marrow failure syndrome and in vivo in humanized mice

C. Frecha; C. Costa; D. Nègre; F. Amirache; D. Trono et al. 

Blood. 2011. Vol. 119, num. 5, p. 1139-50. DOI : 10.1182/blood-2011-04-346619.

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In Embryonic Stem Cells, ZFP57/KAP1 Recognize a Methylated Hexanucleotide to Affect Chromatin and DNA Methylation of Imprinting Control Regions

S. Quenneville; G. Verde; A. Corsinotti; A. Kapopoulou; J. Jakobsson et al. 

Molecular Cell. 2011. Vol. 44, num. 3, p. 361-372. DOI : 10.1016/j.molcel.2011.08.032.

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A gene-rich, transcriptionally active environment and the pre-deposition of repressive marks are predictive of susceptibility to KRAB/KAP1-mediated silencing

S. Meylan; A. C. Groner; G. Ambrosini; N. Malani; S. Quenneville et al. 

BMC genomics. 2011. Vol. 12, num. 1, p. 378. DOI : 10.1186/1471-2164-12-378.

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Measuring In Vivo Protein Half-Life

K. Bojkowska; F. Santoni De Sio; I. Barde; S. Offner; S. Verp et al. 

Chemistry & Biology. 2011. Vol. 18, num. 6, p. 805-815. DOI : 10.1016/j.chembiol.2011.03.014.

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Lentiviral Vector Mediated Transgenesis

I. Barde; S. Verp; S. E. Offner; D. Trono 

Current Protocols in Mouse Biology 1. 2011. Vol. 1, p. 169-184. DOI : 10.1002/9780470942390.mo100169.

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Chromosome Conformation Capture Uncovers Potential Genome-Wide Interactions between Human Conserved Non-Coding Sequences

D. Robyr; M. Friedli; C. Gehrig; M. Arcangeli; M. Marin et al. 

PloS One. 2011. Vol. 6, num. 3, p. e17634. DOI : 10.1371/journal.pone.0017634.

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Profaning the Ultimate Sanctuary: HIV Latency in Hematopoietic Stem Cells

D. Trono; F. Marzetta 

Cell host & microbe. 2011. Vol. 9, num. 3, p. 170-2. DOI : 10.1016/j.chom.2011.03.001.

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Dynamic control of endogenous retroviruses during development

H. M. Rowe; D. Trono 

Virology. 2011. Vol. 411, num. 2, p. 273-87. DOI : 10.1016/j.virol.2010.12.007.

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2010

Journal Articles

Homology-based identification of capsid determinants that protect HIV1 from human TRIM5α restriction

P. V. Maillard; V. Zoete; O. Michielin; D. Trono 

The Journal of biological chemistry. 2010. Vol. 286, num. 10, p. 8128-40. DOI : 10.1074/jbc.M110.187609.

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A systematic enhancer screen using lentivector transgenesis identifies conserved and non-conserved functional elements at the olig1 and olig2 locus

M. Friedli; I. Barde; M. Arcangeli; S. Verp; A. Quazzola et al. 

PloS One. 2010. Vol. 5, num. 12, p. e15741. DOI : 10.1371/journal.pone.0015741.

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Structure-function analysis points to a polynucleotide-accommodating groove essential for APOBEC3A restriction activities

Y. Bulliard; I. Narvaiza; A. Bertero; S. Peddi; U. F. Röhrig et al. 

Journal of virology. 2010. Vol. 85, num. 4, p. 1765-1776. DOI : 10.1128/JVI.01651-10.

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Inducible Gene and shRNA Expression in Resident Hematopoietic Stem Cells In Vivo

E. Laurenti; I. Barde; S. Verp; S. Offner; A. Wilson et al. 

Stem cells (Dayton, Ohio). 2010. Vol. 28, num. 8, p. 1390-1398. DOI : 10.1002/stem.460.

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Genetic Reactivation of Cone Photoreceptors Restores Visual Responses in Retinitis pigmentosa

V. Busskamp; J. Duebel; D. Balya; M. Fradot; T. J. Viney et al. 

Science (New York, N.Y.). 2010. Vol. 329, num. 5990, p. 413-417. DOI : 10.1126/science.1190897.

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KRAB-Zinc Finger Proteins and KAP1 Can Mediate Long-Range Transcriptional Repression through Heterochromatin Spreading

A. C. Groner; S. Meylan; A. Ciuffi; N. Zangger; G. Ambrosini et al. 

PLoS genetics. 2010. Vol. 6, num. 3, p. e1000869. DOI : 10.1371/journal.pgen.1000869.

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The specificity of TRIM5{alpha}-mediated restriction is influenced by its coiled-coil domain

P. V. Maillard; G. Ecco; M. Ortiz; D. Trono 

Journal of virology. 2010. Vol. 84, num. 11, p. 5790-5801. DOI : 10.1128/JVI.02413-09.

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KAP1 controls endogenous retroviruses in embryonic stem cells

H. M. Rowe; J. Jakobsson; D. Mesnard; J. Rougemont; S. Reynard et al. 

Nature. 2010. Vol. 463, num. 7278, p. 237-40. DOI : 10.1038/nature08674.

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2009

Journal Articles

Biosafety in ex vivo gene therapy and conditional ablation of lentivirally transduced hepatocytes in nonhuman primates

O. Menzel; J. Birraux; B. E. Wildhaber; C. Jond; F. Lasne et al. 

Molecular therapy : the journal of the American Society of Gene Therapy. 2009. Vol. 17, num. 10, p. 1754-60. DOI : 10.1038/mt.2009.143.

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Regulation of Episomal Gene Expression by KRAB/KAP1-Mediated Histone Modifications

I. Barde; E. Laurenti; S. Verp; A. C. Groner; C. Towne et al. 

Journal of Virology. 2009. Vol. 83, num. 11, p. 5574-5580. DOI : 10.1128/JVI.00001-09.

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2008

Journal Articles

Antiprion prophylaxis by gene transfer of a soluble prion antagonist

N. Genoud; D. Ott; N. Braun; M. Prinz; P. Schwarz et al. 

American journal of pathology. 2008. Vol. 172, num. 5, p. 1287-96. DOI : 10.2353/ajpath.2008.070836.

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KAP1-mediated epigenetic repression in the forebrain modulates behavioral vulnerability to stress

J. Jakobsson; M. I. Cordero; R. Bisaz; A. C. Groner; V. Busskamp et al. 

Neuron. 2008. Vol. 60, num. 5, p. 818-31. DOI : 10.1016/j.neuron.2008.09.036.

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A human TRIM5alpha B30.2/SPRY domain mutant gains the ability to restrict and prematurely uncoat B-tropic murine leukemia virus

F. Diaz-Griffero; M. Perron; K. McGee-Estrada; R. Hanna; P. V. Maillard et al. 

Virology. 2008. Vol. 378, num. 2, p. 233-42. DOI : 10.1016/j.virol.2008.05.008.

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Characterization of APOBEC3G binding to 7SL RNA

D. Bach; S. Peddy; B. Mangeat; A. Lakkaraju; K. Strub et al. 

Retrovirology. 2008. Vol. 5, num. 1, p. 54. DOI : 10.1186/1742-4690-5-54.

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Genotypic features of lentivirus transgenic mice

M-O. Sauvain; A. P. Dorr; B. Stevenson; A. Quazzola; F. Naef et al. 

Journal of virology. 2008. Vol. 82, num. 14, p. 7111-9. DOI : 10.1128/JVI.00623-08.

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APOBEC3-independent interferon-induced viral clearance in hepatitis B virus transgenic mice

P. Turelli; A. Liagre-Quazzola; B. Mangeat; S. Verp; S. Jost et al. 

Journal of Virology. 2008. Vol. 82, num. 13, p. 6585-6590. DOI : 10.1128/JVI.00216-08.

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2007

Journal Articles

Model Structure of Human APOBEC3G

K-L. Zhang; B. Mangeat; M. Ortiz; V. Zoete; D. Trono et al. 

PLoS ONE. 2007. Vol. 2, num. 4, p. e378. DOI : 10.1371/journal.pone.0000378.

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Lentivirus as a tool for lineage-specific gene manipulations

A. Malashicheva; B. Kanzler; E. Tolkunova; D. Trono; A. Tomilin 

genesis. 2007. Vol. 45, num. 7, p. 456-459. DOI : 10.1002/dvg.20313.

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Molecular mechanism of hepcidin deficiency in a patient with juvenile hemochromatosis

A. Rideau; B. Mangeat; T. Matthes; D. Trono; P. Beris 

Haematologica. 2007. Vol. 92, num. 1, p. 127-8. DOI : 10.3324/haematol.10545.

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Inhibition of HIV-1 multiplication by a modified U7 snRNA inducing Tat and Rev exon skipping

M. B. Asparuhova; G. Marti; S. Liu; F. Serhan; D. Trono et al. 

The journal of gene medicine. 2007. Vol. 9, num. 5, p. 323-34. DOI : 10.1002/jgm.1027.

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Expression of FGF-2 in neural progenitor cells enhances their potential for cellular brain repair in the rodent cortex

A. G. Dayer; B. Jenny; M-O. Sauvain; G. Potter; P. Salmon et al. 

Brain : a journal of neurology. 2007. Vol. 130, num. 11, p. 2962-76. DOI : 10.1093/brain/awm200.

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Interfering residues narrow the spectrum of MLV restriction by human TRIM5alpha

P. Maillard; S. Reynard; F. Serhan; P. Turelli; D. Trono 

PLOS Pathogens. 2007. Vol. 3, num. 12, p. e200. DOI : 10.1371/journal.ppat.0030200.

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2006

Journal Articles

Ataxia-telangiectasia-mutated (ATM) protein can enhance human immunodeficiency virus type 1 replication by stimulating Rev function

Y. Ariumi; D. Trono 

Journal of Virology. 2006. Vol. 80, num. 5, p. 2445-52. DOI : 10.1128/JVI.80.5.2445-2452.2006.

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Ex vivo lentivirus transduction and immediate transplantation of uncultured hepatocytes for treating hyperbilirubinemic Gunn rat

T. H. Nguyen; J. Birraux; B. Wildhaber; A. Myara; F. Trivin et al. 

Transplantation. 2006. Vol. 82, num. 6, p. 794-803. DOI : 10.1097/01.tp.0000234675.56598.35.

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Multipotential nestin and Isl-1 positive mesenchymal stem cells isolated from human pancreatic islets

M. Eberhardt; P. Salmon; M-A. von Mach; J. G. Hengstler; M. Brulport et al. 

Biochemical and Biophysical Research Communications. 2006. Vol. 345, num. 3, p. 1167-1176. DOI : 10.1016/j.bbrc.2006.05.016.

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A versatile tool for conditional gene expression and knockdown

J. Szulc; M. Wiznerowicz; M-O. Sauvain; D. Trono; P. Aebischer 

Nature Methods. 2006. Vol. 3, num. 2, p. 109-116. DOI : 10.1038/nmeth846.

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Tuning silence: conditional systems for RNA interference

M. Wiznerowicz; J. Szulc; D. Trono 

Nature Methods. 2006. Vol. 3, num. 9, p. 682-688. DOI : 10.1038/nmeth914.

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2005

Journal Articles

A simple and highly effective method for the stable transduction of uncultured porcine hepatocytes using lentiviral vector

T. H. Nguyen; T. Khakhoulina; A. Simmons; P. Morel; D. Trono 

Cell Transplantation. 2005. Vol. 14, num. 7, p. 489-96. DOI : 10.3727/000000005783982828.

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Therapeutic lentivirus-mediated neonatal in vivo gene therapy in hyperbilirubinemic Gunn rats

T. H. Nguyen; M. Bellodi-Privato; D. Aubert; V. Pichard; A. Myara et al. 

Molecular therapy : the journal of the American Society of Gene Therapy. 2005. Vol. 12, num. 5, p. 852-9. DOI : 10.1016/j.ymthe.2005.06.482.

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Lentiviral vectors and antiretroviral intrinsic immunity

B. Mangeat; D. Trono 

Human Gene Therapy. 2005. Vol. 16, num. 8, p. 913-920. DOI : 10.1089/hum.2005.16.913.

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Harnessing HIV for therapy, basic research and biotechnology

M. Wiznerowicz; D. Trono 

Trends Biotechnol. 2005. Vol. 23, num. 1, p. 42-7. DOI : 10.1016/j.tibtech.2004.11.001.

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Treatment of fulminant liver failure by transplantation of microencapsulated primary or immortalized xenogeneic hepatocytes

G. Mai; N. T. Huy; P. Morel; J. Mei; D. Bosco et al. 

Transplant Proc. 2005. Vol. 37, num. 1, p. 527-9. DOI : 10.1016/j.transproceed.2005.01.017.

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Editing at the crossroad of innate and adaptive immunity

P. Turelli; D. Trono 

Science. 2005. Vol. 307, num. 5712, p. 1061-5. DOI : 10.1126/science.1105964.

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DNA damage sensors ATM, ATR, DNA-PKcs, and PARP-1 are dispensable for human immunodeficiency virus type 1 integration

Y. Ariumi; P. Turelli; M. Masutani; D. Trono 

Journal of Virology. 2005. Vol. 79, num. 5, p. 2973-8. DOI : 10.1128/JVI.79.5.2973-2978.2005.

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Development of cellular models for ribosomal protein S19 (RPS19)-deficient diamond-blackfan anemia using inducible expression of siRNA against RPS19

K. Miyake; J. Flygare; T. Kiefer; T. Utsugisawa; J. Richter et al. 

Molecular Therapy. 2005. Vol. 11, num. 4, p. 627-37. DOI : 10.1016/j.ymthe.2004.12.001.

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Statins reduce interleukin-6-induced C-reactive protein in human hepatocytes: new evidence for direct antiinflammatory effects of statins

C. Arnaud; F. Burger; S. Steffens; N. R. Veillard; T. H. Nguyen et al. 

Arterioscler Thromb Vasc Biol. 2005. Vol. 25, num. 6, p. 1231-6. DOI : 10.1161/01.ATV.0000163840.63685.0c.

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Deficiency of ribosomal protein S19 in CD34+ cells generated by siRNA blocks erythroid development and mimics defects seen in Diamond-Blackfan anemia

J. Flygare; T. Kiefer; K. Miyake; T. Utsugisawa; I. Hamaguchi et al. 

Blood. 2005. Vol. 105, num. 12, p. 4627-34. DOI : 10.1182/blood-2004-08-3115.

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Transduction of CpG DNA-stimulated primary human B cells with bicistronic lentivectors

K. Kvell; T. H. Nguyen; P. Salmon; F. Glauser; C. Werner-Favre et al. 

Molecular Therapy. 2005. Vol. 12, p. 892-899. DOI : 10.1016/j.ymthe.2005.05.010.

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Novel lentiviral vectors displaying “early acting cytokines” selectively promote survival and transduction of NOD/SCID repopulating human hematopoietic stem cells

E. Verhoeyen; M. Wiznerowicz; D. Olivier; B. Izac; D. Trono et al. 

Blood. 2005. Vol. 106, num. 10, p. 3386-3395. DOI : 10.1182/blood-2004-12-4736.

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Oncogenesis Following Delivery of a Nonprimate Lentiviral Gene Therapy Vector to Fetal and Neonatal Mice

M. Themis; S. N. Waddington; M. Schmidt; C. von Kalle; Y. Wang et al. 

Molecular Therapy. 2005. Vol. 12, p. 763-771. DOI : 10.1016/j.ymthe.2005.07.358.

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2004

Journal Articles

A single amino acid determinant governs the species-specific sensitivity of APOBEC3G to Vif action

B. Mangeat; P. Turelli; S. Liao; D. Trono 

Journal of Biological Chemistry. 2004. Vol. 279, num. 15, p. 14481-14483. DOI : 10.1074/jbc.C400060200.

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Response to Comment on “Inhibition of Hepatitis B Virus Replication by APOBEC3G”

P. Turelli; S. Jost; B. Mangeat; D. Trono 

Science. 2004. Vol. 305, num. 5689, p. 1403. DOI : 10.1126/science.1101974.

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Inhibition of hepatitis B virus replication by APOBEC3G

P. Turelli; B. Mangeat; S. Jost; S. Vianin; D. Trono 

Science. 2004. Vol. 303, num. 5665, p. 1829. DOI : 10.1126/science.1092066.

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Contribution of proteoglycans to human immunodeficiency virus type 1 brain invasion

M. D. Bobardt; P. Salmon; L. Wang; J. D. Esko; D. Gabuzda et al. 

Journal of Virology. 2004. Vol. 78, num. 12, p. 6567-84. DOI : 10.1128/JVI.78.12.6567-6584.2004.

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ARF1 regulates Nef-induced CD4 degradation

J. Fauré; R. Stalder; C. Borel; K. Sobo; V. Piguet et al. 

Current Biology. 2004. Vol. 14, num. 12, p. 1056-1064. DOI : 10.1016/j.cub.2004.06.021.

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Retroviruses under editing crossfire: a second member of the human APOBEC3 family is a Vif-blockable innate antiretroviral factor

D. Trono 

EMBO Rep. 2004. Vol. 5, num. 7, p. 679-80. DOI : 10.1038/sj.embor.7400192.

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Entry and transcription as key determinants of differences in CD4 T-cell permissiveness to human immunodeficiency virus type 1 infection

A. Ciuffi; G. Bleiber; M. Muñoz; R. Martinez; C. Loeuillet et al. 

Journal of Virology. 2004. Vol. 78, num. 19, p. 10747-54. DOI : 10.1128/JVI.78.19.10747-10754.2004.

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Lentivirus-mediated RNA interference of DC-SIGN expression inhibits human immunodeficiency virus transmission from dendritic cells to T cells

J-F. Arrighi; M. Pion; M. Wiznerowicz; T. B. Geijtenbeek; E. Garcia et al. 

Journal of Virology. 2004. Vol. 78, num. 20, p. 10848-55. DOI : 10.1128/JVI.78.20.10848-10855.2004.

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The innate antiretroviral factor APOBEC3G does not affect human LINE-1 retrotransposition in a cell culture assay

P. Turelli; S. Vianin; D. Trono 

Journal of Biological Chemistry. 2004. Vol. 279, num. 42, p. 43371-3. DOI : 10.1074/jbc.C400334200.

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Lentiviral vectors interfering with virus-induced CD4 down-modulation potently block human immunodeficiency virus type 1 replication in primary lymphocytes

H. M. Pham; E. R. Argañaraz; B. Groschel; D. Trono; J. Lama 

Journal of Virology. 2004. Vol. 78, num. 23, p. 13072-13081. DOI : 10.1128/JVI.78.23.13072-13081.

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2003

Journal Articles

Lentivirus-mediated transduction of connexin cDNAs shows level- and isoform-specific alterations in insulin secretion of primary pancreatic beta-cells

D. Caton; A. Calabrese; C. Mas; V. Serre-Beinier; A. Charollais et al. 

Journal of Cell Science. 2003. Vol. 116, num. 11, p. 2285-94. DOI : 10.1242/jcs.00442.

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Hide, shield and strike back: how HIV-infected cells avoid immune eradication

B. M. Peterlin; D. Trono 

Nat Rev Immunol. 2003. Vol. 3, num. 2, p. 97-107. DOI : 10.1038/nri998.

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Lentiviral vector transduction of NOD/SCID repopulating cells results in multiple vector integrations per transduced cell: risk of insertional mutagenesis

N-B. Woods; A. Muessig; M. Schmidt; J. Flygare; K. Olsson et al. 

Blood. 2003. Vol. 101, num. 4, p. 1284-9. DOI : 10.1182/blood-2002-07-2238.

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Efficient transduction of primary human B lymphocytes and nondividing myeloma B cells with HIV-1-derived lentiviral vectors

F. Bovia; P. Salmon; T. Matthes; K. Kvell; T. H. Nguyen et al. 

Blood. 2003. Vol. 101, num. 5, p. 1727-33. DOI : 10.1182/blood-2001-12-0249.

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IL-7 surface-engineered lentiviral vectors promote survival and efficient gene transfer in resting primary T lymphocytes

E. Verhoeyen; V. Dardalhon; O. Ducrey-Rundquist; D. Trono; N. Taylor et al. 

Blood. 2003. Vol. 101, num. 6, p. 2167-74. DOI : 10.1182/blood-2002-07-2224.

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Activity analysis of housekeeping promoters using self-inactivating lentiviral vector delivery into the mouse retina

C. Kostic; F. Chiodini; P. Salmon; M. Wiznerowicz; N. Deglon et al. 

Gene Therapy. 2003. Vol. 10, num. 9, p. 818-21. DOI : 10.1038/sj.gt.3301948.

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Ectopic expression of the beta-cell specific transcription factor Pdx1 inhibits glucagon gene transcription

B. Ritz-Laser; B. R. Gauthier; A. Estreicher; A. Mamin; T. Brun et al. 

Diabetologia. 2003. Vol. 46, num. 6, p. 810-21. DOI : 10.1007/s00125-003-1115-7.

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Virology. Picking the right spot.

D. Trono 

Science. 2003. Vol. 300, num. 5626, p. 1670-1. DOI : 10.1126/science.1086238.

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Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts

B. Mangeat; P. Turelli; G. Caron; M. Friedli; L. Perrin et al. 

Nature. 2003. Vol. 424, num. 6944, p. 99-103. DOI : 10.1038/nature01709.

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Conditional suppression of cellular genes: lentivirus vector-mediated drug-inducible RNA interference

M. Wiznerowicz; D. Trono 

Journal of Virology. 2003. Vol. 77, num. 16, p. 8957-61. DOI : 10.1128/JVI.77.16.8957-8951.2003.

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Lentivector-mediated transfer of Bmi-1 and telomerase in muscle satellite cells yields a duchenne myoblast cell line with long-term genotypic and phenotypic stability

C. Cudré-Mauroux; T. Occhiodoro; S. König; P. Salmon; L. Bernheim et al. 

Human Gene Therapy. 2003. Vol. 14, num. 16, p. 1525-1533. DOI : 10.1089/104303403322495034.

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2002

Journal Articles

Efficient gene transfer into human primary blood lymphocytes by surface-engineered lentiviral vectors that display a T cell-activating polypeptide

M. Maurice; E. Verhoeyen; P. Salmon; D. Trono; S. J. Russell et al. 

Blood. 2002. Vol. 99, num. 7, p. 2342-50. DOI : 10.1182/blood.V99.7.2342.

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Differentiation of the RN33B cell line into forebrain projection neurons after transplantation into the neonatal rat brain

C. Lundberg; U. Englund; D. Trono; A. Björklund; K. Wictorin 

Exp Neurol. 2002. Vol. 175, num. 2, p. 370-87. DOI : 10.1006/exnr.2002.7888.

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Transepithelial transport of HIV-1 by M cells is receptor-mediated

G. Fotopoulos; A. Harari; P. Michetti; D. Trono; G. Pantaleo et al. 

Proceedings Of The National Academy Of Sciences Of The United States Of America. 2002. Vol. 99, num. 14, p. 9410-4. DOI : 10.1073/pnas.142586899.

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Highly efficient lentiviral vector-mediated transduction of nondividing, fully reimplantable primary hepatocytes

T. H. Nguyen; J. Oberholzer; J. Birraux; P. Majno; P. Morel et al. 

Molecular Therapy. 2002. Vol. 6, num. 2, p. 199-209. DOI : 10.1006/mthe.2002.0653.

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Lentiviral vectors pseudotyped with a modified RD114 envelope glycoprotein show increased stability in sera and augmented transduction of primary lymphocytes and CD34+ cells derived from human and nonhuman primates

V. Sandrin; B. Boson; P. Salmon; W. Gay; D. Nègre et al. 

Blood. 2002. Vol. 100, num. 3, p. 823-32. DOI : 10.1182/blood-2001-11-0042.

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Modalities of interleukin-7-induced human immunodeficiency virus permissiveness in quiescent T lymphocytes

O. Ducrey-Rundquist; M. Guyader; D. Trono 

Journal of Virology. 2002. Vol. 76, num. 18, p. 9103-11. DOI : 10.1128/JVI.76.18.9103-9111.2002.

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Role for human immunodeficiency virus type 1 membrane cholesterol in viral internalization

M. Guyader; E. Kiyokawa; L. Abrami; P. Turelli; D. Trono 

Journal of Virology. 2002. Vol. 76, num. 20, p. 10356-64. DOI : 10.1128/JVI.76.20.10356-10364.2002.

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The HIV-1 Nef protein and phagocyte NADPH oxidase activation

F. Vilhardt; O. Plastre; M. Sawada; K. Suzuki; M. Wiznerowicz et al. 

Journal of Biological Chemistry. 2002. Vol. 277, num. 44, p. 42136-43. DOI : 10.1074/jbc.M200862200.

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2001

Journal Articles

Living in oblivion: HIV immune evasion

V. Piguet; D. Trono 

Semin Immunol. 2001. Vol. 13, num. 1, p. 51-7. DOI : 10.1006/smim.2000.0295.

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Cytoplasmic recruitment of INI1 and PML on incoming HIV preintegration complexes: interference with early steps of viral replication

P. Turelli; V. Doucas; E. Craig; B. Mangeat; N. Klages et al. 

Molecular Cell. 2001. Vol. 7, num. 6, p. 1245-54. DOI : 10.1016/S1097-2765(01)00255-6.

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Transduction of CD34+ cells with lentiviral vectors enables the production of large quantities of transgene-expressing immature and mature dendritic cells

P. Salmon; J. F. Arrighi; V. Piguet; B. Chapuis; R. H. Zubler et al. 

J Gene Med. 2001. Vol. 3, num. 4, p. 311-20. DOI : 10.1002/1521-2254(200107/08)3:4<311::AID-JGM198>3.0.CO;2-B.

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Inhibition of HIV-1 in cell culture by oligonucleotide-loaded nanoparticles

M. Berton; P. Turelli; D. Trono; C. A. Stein; E. Allémann et al. 

Pharm Res. 2001. Vol. 18, num. 8, p. 1096-101. DOI : 10.1023/A:1010962507273.

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Organ distribution of gene expression after intravenous infusion of targeted and untargeted lentiviral vectors

K. W. Peng; L. Pham; H. Ye; R. Zufferey; D. Trono et al. 

Gene Therapy. 2001. Vol. 8, num. 19, p. 1456-63. DOI : 10.1038/sj.gt.3301552.

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2000

Journal Articles

Lentivirus vector gene expression during ES cell-derived hematopoietic development in vitro

I. Hamaguchi; N. B. Woods; I. Panagopoulos; E. Andersson; H. Mikkola et al. 

Journal of Virology. 2000. Vol. 74, num. 22, p. 10778-84. DOI : 10.1128/JVI.74.22.10778-10784.2000.

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HIV-based vectors: getting the best out of the worst

D. Trono 

Journal of Gene Medicine. 2000. Vol. 2, p. 61-63. DOI : 10.1002/(sici)1521-2254(200001/02)2:1<61::aid-jgm92>3.0.co;2-1.

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Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson’s disease

N. Déglon; J. L. Tseng; J. Bensadoun; A. D. Zurn; Y. Arsenijevic et al. 

Human Gene Therapy. 2000. Vol. 11, p. 179-90. DOI : 10.1089/10430340050016256.

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Lentiviral vectors: turning a deadly foe into a therapeutic agent

D. Trono 

Gene Therapy. 2000. Vol. 7, num. 1, p. 20-3. DOI : 10.1038/sj.gt.3301105.

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The Nef protein of HIV-1 associates with rafts and primes T cells for activation

J. K. Wang; E. Kiyokawa; E. Verdin; D. Trono 

Proceedings Of The National Academy Of Sciences Of The United States Of America. 2000. Vol. 97, num. 1, p. 394-9. DOI : 10.1073/pnas.97.1.394.

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In vivo protection of nigral dopamine neurons by lentiviral gene transfer of the novel GDNF-family member neublastin/artemin

C. Rosenblad; M. Grønborg; C. Hansen; N. Blom; M. Meyer et al. 

Molecular and Cellular Neurosciences. 2000. Vol. 15, num. 2, p. 199-214. DOI : 10.1006/mcne.1999.0817.

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HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes

V. Piguet; L. Wan; C. Borel; A. Mangasarian; N. Demaurex et al. 

Nature Cell Biology. 2000. Vol. 2, p. 163-7. DOI : 10.1038/35004038.

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Reversal of pathology in the entire brain of mucopolysaccharidosis type VII mice after lentivirus-mediated gene transfer

A. Bosch; E. Perret; N. Desmaris; D. Trono; J. M. Heard 

Human Gene Therapy. 2000. Vol. 11, p. 1139-1150. DOI : 10.1089/10430340050015194.

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A stable system for the high-titer production of multiply attenuated lentiviral vectors

N. Klages; R. Zufferey; D. Trono 

Molecular Therapy. 2000. Vol. 2, num. 2, p. 170-6. DOI : 10.1006/mthe.2000.0103.

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Reversible immortalization of human primary cells by lentivector-mediated transfer of specific genes

P. Salmon; J. Oberholzer; T. Occhiodoro; P. Morel; J. Lou et al. 

Molecular Therapy. 2000. Vol. 2, num. 4, p. 404-14. DOI : 10.1006/mthe.2000.0141.

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A lentiviral vector expressing a fusogenic glycoprotein for cancer gene therapy

R. M. Diaz; A. Bateman; L. Emiliusen; A. Fielding; D. Trono et al. 

Gene Therapy. 2000. Vol. 7, num. 19, p. 1656-63. DOI : 10.1038/sj.gt.3301277.

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Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson’s disease

J. H. Kordower; M. E. Emborg; J. Bloch; S. Y. Ma; Y. Chu et al. 

Science. 2000. Vol. 290, num. 5492, p. 767-73. DOI : 10.1126/science.290.5492.767.

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The plasma membrane as a combat zone in the HIV battlefield

R. W. Doms; D. Trono 

Genes & Development. 2000. Vol. 14, num. 21, p. 2677-88. DOI : 10.1101/gad.833300.

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High-level transgene expression in human hematopoietic progenitors and differentiated blood lineages after transduction with improved lentiviral vectors

P. Salmon; V. Kindler; O. Ducrey; B. Chapuis; R. H. Zubler et al. 

Blood. 2000. Vol. 96, p. 3392-3398. DOI : 10.1182/blood.V96.10.3392.

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Lentivirus gene transfer in murine hematopoietic progenitor cells is compromised by a delay in proviral integration and results in transduction mosaicism and heterogeneous gene expression in progeny cells

H. Mikkola; N. B. Woods; M. Sjögren; H. Helgadottir; I. Hamaguchi et al. 

Journal of Virology. 2000. Vol. 74, num. 24, p. 11911-8. DOI : 10.1128/JVI.74.24.11911-11918.2000.

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Lentiviral gene transfer into primary and secondary NOD/SCID repopulating cells

N. B. Woods; C. Fahlman; H. Mikkola; I. Hamaguchi; K. Olsson et al. 

Blood. 2000. Vol. 96, num. 12, p. 3725-33. DOI : 10.1182/blood.V96.12.3725.

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1999

Journal Articles

Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking

A. Mangasarian; V. Piguet; J. K. Wang; Y. L. Chen; D. Trono 

Journal of Virology. 1999. Vol. 73, p. 1964-73. DOI : 10.1128/JVI.73.3.1964-1973.1999.

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The Nef protein of primate lentiviruses

V. Piguet; D. Trono 

Rev Med Virol. 1999. Vol. 9, num. 2, p. 111-20. DOI : 10.1002/(SICI)1099-1654(199904/06)9:2<111::AID-RMV245>3.0.CO;2-P.

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Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors

R. Zufferey; J. E. Donello; D. Trono; T. J. Hope 

Journal of Virology. 1999. Vol. 73, num. 4, p. 2886-92. DOI : 10.1128/JVI.73.4.2886-2892.1999.

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The downregulation of CD4 and MHC-I by primate lentiviruses: a paradigm for the modulation of cell surface receptors

V. Piguet; O. Schwartz; S. Le Gall; D. Trono 

Immunol Rev. 1999. Vol. 168, p. 51-63. DOI : 10.1111/j.1600-065X.1999.tb01282.x.

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Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes

V. Piguet; F. Gu; M. Foti; N. Demaurex; J. Gruenberg et al. 

Cell. 1999. Vol. 97, num. 1, p. 63-73. DOI : 10.1016/S0092-8674(00)80715-1.

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Lentivirus-mediated Bcl-2 expression in betaTC-tet cells improves resistance to hypoxia and cytokine-induced apoptosis while preserving in vitro and in vivo control of insulin secretion

P. Dupraz; C. Rinsch; W. F. Pralong; E. Rolland; R. Zufferey et al. 

Gene Therapy. 1999. Vol. 6, num. 6, p. 1160-9. DOI : 10.1038/sj.gt.3300922.

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Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner

J. Lama; A. Mangasarian; D. Trono 

Current Biology. 1999. Vol. 9, num. 12, p. 622-31. DOI : 10.1016/S0960-9822(99)80284-X.

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Transgene expression in the guinea pig cochlea mediated by a lentivirus-derived gene transfer vector

J. J. Han; A. N. Mhatre; M. Wareing; R. Pettis; W. Q. Gao et al. 

Human Gene Therapy. 1999. Vol. 10, num. 11, p. 1867-73. DOI : 10.1089/10430349950017545.

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The HIV Nef protein alters Ca(2+) signaling in myelomonocytic cells through SH3-mediated protein-protein interactions

M. Foti; L. Cartier; V. Piguet; D. P. Lew; J. L. Carpentier et al. 

Journal of Biological Chemistry. 1999. Vol. 274, p. 34765-72. DOI : 10.1074/jbc.274.49.34765.

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1998

Journal Articles

Human immunodeficiency virus type 1 matrix protein interacts with cellular protein HO3

J. Lama; D. Trono 

Journal of Virology. 1998. Vol. 72, p. 1671-1676. DOI : 10.1128/JVI.72.2.1671-1676.1998.

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The proteolytic cleavage of human immunodeficiency virus type 1 Nef does not correlate with its ability to stimulate virion infectivity

Y. L. Chen; D. Trono; D. Camaur 

Journal of Virology. 1998. Vol. 72, p. 3178-3184. DOI : 10.1128/JVI.72.4.3178-3184.1998.

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Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the mu chain of adaptor complexes

V. Piguet; Y. L. Chen; A. Mangasarian; M. Foti; J. L. Carpentier et al. 

EMBO Journal. 1998. Vol. 17, num. 9, p. 2472-81. DOI : 10.1093/emboj/17.9.2472.

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A third-generation lentivirus vector with a conditional packaging system

T. Dull; R. Zufferey; M. Kelly; R. J. Mandel; M. Nguyen et al. 

Journal of Virology. 1998. Vol. 72, num. 11, p. 8463-8471. DOI : 10.1128/JVI.72.11.8463-8471.1998.

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When accessories turn out to be essential

D. Trono 

Nature Medicine. 1998. Vol. 4, num. 12, p. 1368-9. DOI : 10.1038/3953.

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Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery

R. Zufferey; T. Dull; R. J. Mandel; A. Bukovsky; D. Quiroz et al. 

Journal of Virology. 1998. Vol. 72, num. 12, p. 9873-9880. DOI : 10.1128/JVI.72.12.9873-9880.1998.

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1997

Journal Articles

The multifaceted role of HIV Nef

A. Mangasarian; D. Trono 

Research in Virology. 1997. Vol. 148, p. 30-33. DOI : 10.1016/S0923-2516(97)81909-7.

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The HIV-1 Nef protein acts as a connector with sorting pathways in the Golgi and at the plasma membrane

A. Mangasarian; M. Foti; C. Aiken; D. Chin; J. L. Carpentier et al. 

Immunity. 1997. Vol. 6, num. 1, p. 67-77. DOI : 10.1016/S1074-7613(00)80243-5.

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Nef and PAK: virulence factor and cellular accomplice

D. Trono; J. K. Wang 

Chem Biol. 1997. Vol. 4, num. 1, p. 13-5. DOI : 10.1016/S1074-5521(97)90232-5.

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The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix

S. Swingler; P. Gallay; D. Camaur; J. Song; A. Abo et al. 

Journal of Virology. 1997. Vol. 71, p. 4372-4737. DOI : 10.1128/jvi.71.6.4372-4377.1997.

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Second-messenger regulation of receptor association with clathrin-coated pits: a novel and selective mechanism in the control of CD4 endocytosis.

M. Foti; J. L. Carpentier; C. Aiken; D. Trono; D. P. Lew et al. 

Molecular Biology of the Cell. 1997. Vol. 8, p. 1377-89. DOI : 10.1091/mbc.8.7.1377.

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Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo

R. Zufferey; D. Nagy; R. J. Mandel; L. Naldini; D. Trono 

Nat Biotechnol. 1997. Vol. 15, num. 9, p. 871-5. DOI : 10.1038/nbt0997-871.

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Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector

U. Blömer; L. Naldini; T. Kafri; D. Trono; I. M. Verma et al. 

Journal of Virology. 1997. Vol. 71, p. 6641-6649. DOI : 10.1128/jvi.71.9.6641-6649.1997.

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Human immunodeficiency virus matrix tyrosine phosphorylation: characterization of the kinase and its substrate requirements

D. Camaur; P. Gallay; S. Swingler; D. Trono 

Journal of Virology. 1997. Vol. 71, p. 6834-6841. DOI : 10.1128/jvi.71.9.6834-6841.1997.

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HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway

P. Gallay; T. Hope; D. Chin; D. Trono 

Proceedings Of The National Academy Of Sciences Of The United States Of America. 1997. Vol. 94, num. 18, p. 9825-30. DOI : 10.1073/pnas.94.18.9825.

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Nef-mediated clathrin-coated pit formation

M. Foti; A. Mangasarian; V. Piguet; D. P. Lew; K. H. Krause et al. 

Journal of Cell Biology. 1997. Vol. 139, num. 1, p. 37-47. DOI : 10.1083/jcb.139.1.37.

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