Publications

2025

Journal Articles

The ‘mono‐side’ of cutaneous adverse drug reactions

F. Martins; R. André; E. Planet; S. Menzinger; L. T. Trellu et al. 

Journal of the European Academy of Dermatology and Venereology. 2025. DOI : 10.1111/jdv.70128.

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Injury-induced intestinal stem cell renewal requires capillary morphogenesis gene 2

L. Bracq; A. Chuat; B. Kunz; O. Burri; R. Guiet et al. 

EMBO Molecular Medicine. 2025. DOI : 10.1038/s44321-025-00295-3.

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Cancer cells subvert the primate-specific KRAB zinc finger protein ZNF93 to control APOBEC3B

R. Forey; C. Raclot; C. Pulver; O. Rosspopoff; S. Offner et al. 

Proceedings of the National Academy of Sciences. 2025. Vol. 122, num. 34. DOI : 10.1073/pnas.2505021122.

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Evolutionarily recent transcription factors partake in human cell cycle regulation

C. Pulver; R. Forey; A. R. Lederer; M. Begnis; O. Rosspopoff et al. 

Cell Genomics. 2025.  p. 100923. DOI : 10.1016/j.xgen.2025.100923.

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Working Papers

Identification of the Lipid Oxygen Radical Defense pathway and its epigenetic control

F-G. van der Goot; F. Sarmento Mesquita; L. Abrami; R. Forey; B. Kunz et al. 

2025

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2024

Journal Articles

Single-cell transcriptome analysis reveals atypical monocytes circulating ahead of acute graft-versus-host disease clinical onset

F. Martins; E. Planet; D. Marino; M. Ansari; D. Trono 

JOURNAL OF LEUKOCYTE BIOLOGY. 2024. DOI : 10.1093/jleuko/qiae229.

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Clusters of lineage-specific genes are anchored by ZNF274 in repressive perinucleolar compartments

M. Begnis; J. Duc; S. Offner; D. Grun; S. Sheppard et al. 

Science Advances. 2024. Vol. 10, num. 37. DOI : 10.1126/sciadv.ado1662.

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Single-mitosis dissection of acute and chronic DNA mutagenesis and repair

P. A. Ginno; H. Borgers; C. Ernst; A. Schneider; M. Behm et al. 

Nature Genetics. 2024. DOI : 10.1038/s41588-024-01712-y.

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The dynamic genetic determinants of increased transcriptional divergence in spermatids

J. Panten; T. Heinen; C. Ernst; N. Eling; R. E. Wagner et al. 

Nature Communications. 2024. Vol. 15, num. 1, p. 1272. DOI : 10.1038/s41467-024-45133-1.

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A First-in-Human Randomized Study to Assess the Safety, Tolerability, Pharmacokinetics, and Neutralization Profile of Two Investigational Long-Acting Anti-SARS-CoV-2 Monoclonal Antibodies

N. Moullan; J. Asiago; K. Stecco; S. Hadi; M. Albizem et al. 

Infectious Diseases and Therapy. 2024. DOI : 10.1007/s40121-023-00908-9.

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Transposable elements mediate genetic effects altering the expression of nearby genes in colorectal cancer

N. M. R. Lykoskoufis; E. Planet; H. Ongen; D. Trono; E. T. Dermitzakis 

Nature Communications. 2024. Vol. 15, num. 749. DOI : 10.1038/s41467-023-42405-0.

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A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation

F. Martins; O. Rosspopoff; J. Carlevaro-Fita; R. Forey; S. Offner et al. 

Cancer Research. 2024.  p. OF1 – OF19. DOI : 10.1158/0008-5472.CAN-23-1237.

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Ancestral genome reconstruction enhances transposable element annotation by identifying degenerate integrants

W. Matsushima; E. Planet; D. Trono 

Cell Genomics. 2024. Vol. 4, p. 100497. DOI : 10.1016/j.xgen.2024.100497.

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2023

Journal Articles

Poloxamers Have Vaccine-Adjuvant Properties by Increasing Dissemination of Particulate Antigen at Distant Lymph Nodes

M. Lamrayah; C. Phelip; R. Rovera; C. Coiffier; N. Lazhar et al. 

Molecules. 2023. Vol. 28, num. 12, p. 4778. DOI : 10.3390/molecules28124778.

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Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range

D. Ni; P. Turelli; B. Beckert; S. Nazarov; E. Uchikawa et al. 

PLOS Pathogens. 2023. Vol. 19, num. 4, p. e1011206. DOI : 10.1371/journal.ppat.1011206.

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Species-specific regulation of XIST by the JPX/FTX orthologs

O. Rosspopoff; E. Cazottes; C. Huret; A. Loda; A. J. Collier et al. 

Nucleic Acids Research. 2023. DOI : 10.1093/nar/gkad029.

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Induction of a strong and long-lasting neutralizing immune response by dPreS1-TLR2 agonist nanovaccine against hepatitis B virus

M. Lamrayah; F. Charriaud; M. Desmares; C. Coiffier; S. Megy et al. 

Antiviral Research. 2023. Vol. 209, p. 105483. DOI : 10.1016/j.antiviral.2022.105483.

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Statistical learning quantifies transposable element-mediated cis-regulation

C. Pulver; D. Grun; J. Duc; S. Sheppard; E. Planet et al. 

Genome Biology. 2023. Vol. 24, num. 258. DOI : 10.1186/s13059-023-03085-7.

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Genetic features and genomic targets of human KRAB-zinc finger proteins

J. de Tribolet-Hardy; C. W. Thorball; R. Forey; E. Planet; J. Duc et al. 

Genome Research. 2023. DOI : 10.1101/gr.277722.123.

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Efficient and sensitive profiling of RNA–protein interactions using TLC-CLIP

C. Ernst; J. Duc; D. Trono 

Nucleic Acids Research. 2023. DOI : 10.1093/nar/gkad466.

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Take a walk on the KRAB side

O. Rosspopoff; D. Trono 

Trends in Genetics. 2023. DOI : 10.1016/j.tig.2023.08.003.

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The immunopeptidome landscape associated with T cell infiltration, inflammation and immune editing in lung cancer

A. I. Kraemer; C. Chong; F. Huber; H. Pak; B. J. Stevenson et al. 

Nature Cancer. 2023. DOI : 10.1038/s43018-023-00548-5.

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Broadly potent anti-SARS-CoV-2 antibody shares 93% of epitope with ACE2 and provides full protection in monkeys

C. Fenwick; P. Turelli; Y. Duhoo; K. Lau; C. Herate et al. 

Journal of Infection. 2023. DOI : 10.1016/j.jinf.2023.10.008.

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New ingredients for old recipes

O. Rosspopoff; F. Martins; D. Trono 

Nature Genetics. 2023. DOI : 10.1038/s41588-023-01591-9.

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SARS-CoV-2 hijacks a cell damage response, which induces transcription of a more efficient Spike S-acyltransferase

F. S. Mesquita; L. Abrami; L. Bracq; N. Panyain; V. Mercier et al. 

Nature Communications. 2023. Vol. 14, num. 7302. DOI : 10.1038/s41467-023-43027-2.

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Conference Papers

Machine Learning in Protein Science De Novo Design of Site-Specific Protein Binders Using Surface Fingerprints

A. Van Hall-Beauvais; P. Gainza; S. Wehrle; A. Scheck; A. Marchand et al. 

2023. 36th Annual Symposium of the Protein-Society, San Francisco, CA, Jul 07-10, 2022.

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2022

Journal Articles

Seroprevalence of anti-SARS-CoV-2 antibodies and cross-variant neutralization capacity after the Omicron BA.2 wave in Geneva, Switzerland: a population-based study

M-E. Zaballa; J. Perez-Saez; C. de Mestral; N. Pullen; J. Lamour et al. 

The Lancet Regional Health – Europe. 2022. Vol. 24, p. 100547. DOI : 10.1016/j.lanepe.2022.100547.

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A satellite DNA array barcodes chromosome 7 and regulates totipotency via ZFP819

L. P. Fernandes; R. Enriquez-Gasca; P. A. Gould; J. H. Holt; L. Conde et al. 

Science Advances. 2022. Vol. 8, num. 43. DOI : 10.1126/sciadv.abp8085.

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Transposon-activated POU5F1B promotes colorectal cancer growth and metastasis

L. Simó-Riudalbas; S. Offner; E. Planet; J. Duc; L. Abrami et al. 

Nature Communications. 2022. Vol. 13, num. 1, p. 4913. DOI : 10.1038/s41467-022-32649-7.

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Patient-derived monoclonal antibody neutralizes SARS-CoV-2 Omicron variants and confers full protection in monkeys

C. Fenwick; P. Turelli; D. Ni; L. Perez; K. Lau et al. 

Nature Microbiology. 2022. DOI : 10.1038/s41564-022-01198-6.

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Transposable elements contribute to the spatiotemporal microRNA landscape in human brain development

C. J. Playfoot; S. Sheppard; E. Planet; D. Trono 

RNA. 2022.  p. rna.079100.122. DOI : 10.1261/rna.079100.122.

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Nuclear Lipid Droplet Birth during Replicative Stress

S. Kumanski; R. Forey; C. Cazevieille; M. Moriel-Carretero 

Cells. 2022. Vol. 11, num. 9, p. 1390. DOI : 10.3390/cells11091390.

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Humoral Responses Against Variants of Concern by COVID-19 mRNA Vaccines in Immunocompromised Patients

M. Obeid; M. Suffiotti; C. Pellaton; H. Bouchaab; A. Cairoli et al. 

Jama Oncology. 2022. DOI : 10.1001/jamaoncol.2022.0446.

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Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasma

M. M. Schneider; M. Emmenegger; C. K. Xu; I. C. Morales; G. Meisl et al. 

Life Science Alliance. 2022. Vol. 5, num. 2, p. e202101270. DOI : 10.26508/lsa.202101270.

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Human reproduction is regulated by retrotransposons derived from ancient Hominidae-specific viral infections

X. Xiang; Y. Tao; J. DiRusso; F-M. Hsu; J. Zhang et al. 

Nature Communications. 2022. Vol. 13, num. 1, p. 463. DOI : 10.1038/s41467-022-28105-1.

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KRAB zinc finger protein ZNF676 controls the transcriptional influence of LTR12-related endogenous retrovirus sequences

A. Iouranova; D. Grun; T. Rossy; J. Duc; A. Coudray et al. 

Mobile Dna. 2022. Vol. 13, num. 1, p. 4. DOI : 10.1186/s13100-021-00260-0.

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A cis-acting structural variation at the ZNF558 locus controls a gene regulatory network in human brain development

P. Johansson; P. L. Brattas; C. Douse; P. Hsieh; A. Adami et al. 

Cell Stem Cell. 2022. Vol. 29, num. 1, p. 52 – 69. DOI : 10.1016/j.stem.2021.09.008.

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Occupational risk of SARS-CoV-2 infection and reinfection during the second pandemic surge: a cohort study

A. Leidi; A. Berner; R. Dumont; R. Dubos; F. Koegler et al. 

Occupational And Environmental Medicine. 2022. Vol. 79, p. 116 – 119. DOI : 10.1136/oemed-2021-107924.

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Conference Papers

The interplay between regulatory variants, transposable elements and gene expression in the context of colorectal cancer

N. M. R. Lykoskoufis; H. Ongen; E. Planet; D. Trono; E. T. Dermitzakis 

2022.  p. 387 – 388.

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Reviews

Phase separation in viral infections

H. Li; C. Ernst; M. Kolonko-Adamska; B. Greb-Markiewicz; J. Man et al. 

Trends In Microbiology. 2022. Vol. 30, num. 12, p. 1217 – 1231. DOI : 10.1016/j.tim.2022.06.005.

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2021

Journal Articles

S-acylation controls SARS-CoV-2 membrane lipid organization and enhances infectivity

F. S. Mesquita; L. Abrami; O. Sergeeva; P. Turelli; E. Qing et al. 

Developmental Cell. 2021. Vol. 56, num. 20, p. 2790 – +. DOI : 10.1016/j.devcel.2021.09.016.

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A highly potent antibody effective against SARS-CoV-2 variants of concern

C. Fenwick; P. Turelli; L. Perez; C. Pellaton; L. Esteves-Leuenberger et al. 

Cell Reports. 2021. Vol. 37, num. 2, p. 109814. DOI : 10.1016/j.celrep.2021.109814.

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Transposable elements and their KZFP controllers are drivers of transcriptional innovation in the developing human brain

C. J. Playfoot; J. Duc; S. Sheppard; S. Dind; A. Coudray et al. 

Genome Research. 2021. Vol. 31, num. 9, p. 1531 – 1545. DOI : 10.1101/gr.275133.120.

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A high-throughput cell- and virus-free assay shows reduced neutralization of SARS-CoV-2 variants by COVID-19 convalescent plasma

C. Fenwick; P. Turelli; C. Pellaton; A. Farina; J. Campos et al. 

Science Translational Medicine. 2021. Vol. 13, num. 605, p. eabi8452. DOI : 10.1126/scitranslmed.abi8452.

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Large variation in anti-SARS-CoV-2 antibody prevalence among essential workers in Geneva, Switzerland

S. Stringhini; M-E. Zaballa; N. Pullen; C. de Mestral; J. Perez-Saez et al. 

Nature Communications. 2021. Vol. 12, num. 1, p. 3455. DOI : 10.1038/s41467-021-23796-4.

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Homoeolog Inference Methods Requiring Bidirectional Best Hits or Synteny Miss Many Pairs

N. Glover; S. Sheppard; C. Dessimoz 

Genome Biology And Evolution. 2021. Vol. 13, num. 6, p. evab077. DOI : 10.1093/gbe/evab077.

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Changes in SARS-CoV-2 Spike versus Nucleoprotein Antibody Responses Impact the Estimates of Infections in Population-Based Seroprevalence Studies

C. Fenwick; A. Croxatto; A. T. Coste; F. Pojer; C. Andre et al. 

Journal of Virology. 2021. Vol. 95, num. 3, p. e01828 – 20. DOI : 10.1128/JVI.01828-20.

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Characterization of myelodysplastic syndromes progressing to acute lymphoblastic leukemia

F. Martins; M. Kruszewski; I. Scarpelli; J. Schoumans; O. Spertini et al. 

Annals Of Hematology. 2021. Vol. 100, p. 63 – 78. DOI : 10.1007/s00277-020-04114-2.

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Conference Papers

Transposon-activated POU5F1B promotes colorectal cancer growth and metastasis.

L. Simo-Riudalbas; E. Planet; S. Offner; J. Duc; L. Abrami et al. 

2021. DOI : 10.1158/1538-7445.AM2021-2853.

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2020

Journal Articles

The Human RNA Helicase DDX21 Presents a Dimerization Interface Necessary for Helicase Activity

M. J. Marcaida Lopez; A. Kauzlaric; A. Duperrex; J. Sülzle; M. C. Moncrieffe et al. 

iScience. 2020. Vol. 23, num. 12, p. 101811. DOI : 10.1016/j.isci.2020.101811.

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Whole-exome Sequencing for the Identification of Rare Variants in Primary Immunodeficiency Genes in Children With Sepsis: A Prospective, Population-based Cohort Study

A. Borghesi; J. Trueck; S. Asgari; V. Sancho-Shimizu; P. K. A. Agyeman et al. 

Clinical Infectious Diseases. 2020. Vol. 71, num. 10, p. E614 – E623. DOI : 10.1093/cid/ciaa290.

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Large magnetoresistance and nonzero Berry phase in the nodal-line semimetal MoO2

Q. Chen; Z. Lou; S. Zhang; B. Xu; Y. Zhou et al. 

Physical Review B. 2020. Vol. 102, num. 16, p. 165133. DOI : 10.1103/PhysRevB.102.165133.

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Endogenous retroviruses drive KRAB zinc-finger protein family expression for tumor suppression

J. Ito; I. Kimura; A. Soper; A. Coudray; Y. Koyanagi et al. 

Science Advances. 2020. Vol. 6, num. 43, p. eabc3020. DOI : 10.1126/sciadv.abc3020.

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Primate-restricted KRAB zinc finger proteins and target retrotransposons control gene expression in human neurons

P. Turelli; C. Playfoot; D. Grun; C. Raclot; J. Pontis et al. 

Science Advances. 2020. Vol. 6, num. 35, p. eaba3200. DOI : 10.1126/sciadv.aba3200.

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Seroprevalence of anti-SARS-CoV-2 IgG antibodies in Geneva, Switzerland (SEROCoV-POP): a population-based study

S. Stringhini; A. Wisniak; G. Piumatti; A. S. Azman; S. A. Lauer et al. 

The Lancet. 2020. Vol. 396, num. 10247, p. 313 – 319. DOI : 10.1016/S0140-6736(20)31304-0.

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KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage

G. Wolf; A. de Iaco; M-A. Sun; M. Bruno; M. Tinkham et al. 

eLife. 2020. Vol. 9, p. e56337. DOI : 10.7554/eLife.56337.

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Integrated proteogenomic deep sequencing and analytics accurately identify non-canonical peptides in tumor immunopeptidomes

C. Chong; M. Müller; H. Pak; D. Harnett; F. Huber et al. 

Nature Communications. 2020. Vol. 11, p. 1239. DOI : 10.1038/s41467-020-14968-9.

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KAP1 targets actively transcribed genomic loci to exert pleomorphic effects on RNA polymerase II activity

A. Kauzlaric; S. M. Jang; M. Morchikh; M. Cassano; E. Planet et al. 

Philosophical Transactions of the Royal Society B: Biological Sciences. 2020. Vol. 375, num. 1795, p. 20190334. DOI : 10.1098/rstb.2019.0334.

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The combination of stereotactic radiosurgery with immune checkpoint inhibition or targeted therapy in melanoma patients with brain metastases: a retrospective study

F. Martins; L. Schiappacasse; M. Levivier; C. Tuleasca; M. A. Cuendet et al. 

Journal Of Neuro-Oncology. 2020. Vol. 146, num. 1, p. 181 – 193. DOI : 10.1007/s11060-019-03363-0.

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2019

Journal Articles

DUX is a non-essential synchronizer of zygotic genome activation

A. De Iaco; S. Verp; S. Offner; D. Grun; D. Trono 

Development. 2019.  p. dev.177725. DOI : 10.1242/dev.177725.

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The H3K9 Methylation Writer SETDB1 and Its Reader MPP8 Cooperate to Silence Satellite DNA Repeats in Mouse Embryonic Stem Cells

P. Cruz-Tapias; P. Robin; J. Pontis; L. Del Maestro; S. Ait-Si-Ali 

Genes. 2019. Vol. 10, num. 10, p. 750. DOI : 10.3390/genes10100750.

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The interactome of KRAB zinc finger proteins reveals the evolutionary history of their functional diversification

P. Helleboid; M. Heusel; J. Duc; C. Piot; C. W. Thorball et al. 

The EMBO Journal. 2019.  p. 1 – 16. DOI : 10.15252/embj.2018101220.

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RasGRP1 is a potential biomarker for stratifying anti-EGFR therapy response in colorectal cancer

O. M. Gbenedio; C. Bonnans; D. Grun; C-Y. Wang; A. J. Hatch et al. 

Jci Insight. 2019. Vol. 4, num. 15, p. e127552. DOI : 10.1172/jci.insight.127552.

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KAP1 is an antiparallel dimer with a functional asymmetry

G. Fonti; M. J. Marcaida; L. C. Bryan; S. Traeger; A. S. Kalantzi et al. 

Life Science Alliance. 2019. Vol. 2, num. 4, p. e201900349. DOI : 10.26508/lsa.201900349.

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Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART

N. Bachmann; C. von Siebenthal; V. Vongrad; T. Turk; K. Neumann et al. 

Nature Communications. 2019. Vol. 10, p. 3193. DOI : 10.1038/s41467-019-10884-9.

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A Dissection of Oligomerization by the TRIM28 Tripartite Motif and the Interaction with Members of the Krab-ZFP Family

Y. Sun; J. R. Keown; M. M. Black; C. Raclot; N. Demarais et al. 

Journal of Molecular Biology. 2019. Vol. 431, num. 14, p. 2511 – 2527. DOI : 10.1016/j.jmb.2019.05.002.

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ZFP30 promotes adipogenesis through the KAP1-mediated activation of a retrotransposon-derived Pparg2 enhancer

W. Chen; P. C. Schwalie; E. V. Pankevich; C. Gubelmann; S. K. Raghav et al. 

Nature Communications. 2019. Vol. 10, num. 1, p. 1809. DOI : 10.1038/s41467-019-09803-9.

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DPPA2 and DPPA4 are necessary to establish a 2C‐like state in mouse embryonic stem cells

A. De Iaco; A. Coudray; J. Duc; D. Trono 

EMBO Reports. 2019.  p. e47382. DOI : 10.15252/embr.201847382.

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Hominoid-Specific Transposable Elements and KZFPs Facilitate Human Embryonic Genome Activation and Control Transcription in Naive Human ESCs

J. Pontis; E. Planet; S. Offner; P. Turelli; J. Duc et al. 

Cell Stem Cell. 2019. Vol. 24, num. 5, p. 724 – 735. DOI : 10.1016/j.stem.2019.03.012.

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ZNF445 is a primary regulator of genomic imprinting

N. Takahashi; A. Coluccio; C. W. Thorball; E. Planet; H. Shi et al. 

Genes & Development. 2019. Vol. 33, num. 1-2, p. 49 – 54. DOI : 10.1101/gad.320069.118.

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Pharmacological induction of a progenitor state for the efficient expansion of primary human hepatocytes

C. Unzu; E. Planet; N. Brandenberg; F. Fusil; M. Cassano et al. 

Hepatology. 2019. Vol. 69, num. 5, p. 2214 – 2231. DOI : 10.1002/hep.30425.

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Conference Papers

PAX5 as a model to study the evolution of transcription factors’ regulatory networks

F. Martins; A. Coudray; D. Trono 

2019.  p. 30S – 31S.

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Reviews

Adverse effects of immune-checkpoint inhibitors: epidemiology, management and surveillance

F. Martins; L. Sofiya; G. P. Sykiotis; F. Lamine; M. Maillard et al. 

Nature Reviews Clinical Oncology. 2019. Vol. 16, num. 9, p. 563 – 580. DOI : 10.1038/s41571-019-0218-0.

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2018

Journal Articles

Properties of LINE-1 proteins and repeat element expression in the context of amyotrophic lateral sclerosis

G. C. Pereira; L. Sanchez; P. M. Schaughency; A. Rubio-Roldan; J. A. Choi et al. 

Mobile Dna. 2018. Vol. 9, p. 35. DOI : 10.1186/s13100-018-0138-z.

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HIV-1 Vpr and p21 restrict LINE-1 mobility

K. Kawano; A. J. Doucet; M. Ueno; R. Kariya; W. An et al. 

Nucleic Acids Research. 2018. Vol. 46, num. 16, p. 8454 – 8470. DOI : 10.1093/nar/gky688.

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KAP1 facilitates reinstatement of heterochromatin after DNA replication

S. M. Jang; A. Kauzlaric; J-P. Quivy; J. Pontis; B. Rauwel et al. 

Nucleic Acids Research. 2018. Vol. 46, num. 17, p. 8788 – 8802. DOI : 10.1093/nar/gky580.

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Individual retrotransposon integrants are differentially controlled by KZFP/KAP1-dependent histone methylation, DNA methylation and TET-mediated hydroxymethylation in naïve embryonic stem cells

A. Coluccio; G. Ecco; J. Duc; S. Offner; P. Turelli et al. 

Epigenetics & Chromatin. 2018. Vol. 11, num. 1, p. 7. DOI : 10.1186/s13072-018-0177-1.

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2017

Journal Articles

DUX-family transcription factors regulate zygotic genome activation in placental mammals

A. De Iaco; E. Planet; A. Coluccio; S. Verp; J. Duc et al. 

Nature Genetics. 2017. Vol. 49, num. 6, p. 941 – 945. DOI : 10.1038/ng.3858.

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The mouse genome displays highly dynamic populations of KRAB-zinc finger protein genes and related genetic units

A. Kauzlaric; G. Ecco; M. Cassano; J. Duc; M. Imbeault et al. 

PLoS One. 2017. Vol. 12, num. 3, p. e0173746. DOI : 10.1371/journal.pone.0173746.

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KRAB zinc-finger proteins contribute to the evolution of gene regulatory networks

M. Imbeault; P-Y. Helleboid; D. Trono 

Nature. 2017. Vol. 543, p. 550 – 554. DOI : 10.1038/nature21683.

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Polyphenic trait promotes liver cancer in a model of epigenetic instability

M. Cassano; S. Offner; E. Planet; A. Piersigilli; S. M. Jang et al. 

Hepatology. 2017. Vol. 66, num. 1, p. 235 – 251. DOI : 10.1002/hep.29182.

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KRAB zinc finger proteins

G. Ecco; M. Imbeault; D. Trono 

Development. 2017. Vol. 144, num. 15, p. 2719 – 2729. DOI : 10.1242/dev.132605.

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SMiLE-seq identifies binding motifs of single and dimeric transcription factors

A. Isakova; R. Groux; M. Imbeault; P. Rainer; D. Alpern et al. 

Nature methods. 2017. Vol. 14, p. 316 – 322. DOI : 10.1038/nmeth.4143.

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Reviews

A KRABsody for Embryo-Placental Development

D. Trono 

Developmental Cell. 2017. Vol. 41, num. 6, p. 578 – 580. DOI : 10.1016/j.devcel.2017.06.005.

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2016

Journal Articles

Transposable Elements and Their KRAB-ZFP Controllers Regulate Gene Expression in Adult Tissues

G. Ecco; M. Cassano; A. Kauzlaric; J. Duc; A. Coluccio et al. 

Developmental Cell. 2016. Vol. 36, num. 6, p. 611 – 623. DOI : 10.1016/j.devcel.2016.02.024.

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The evolution of gene expression and binding specificity of the largest transcription factor family in primates

A. Kapopoulou; L. Mathew; A. Wong; D. Trono; J. D. Jensen 

Evolution. 2016. Vol. 70, num. 1, p. 167 – 180. DOI : 10.1111/evo.12819.

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Switzerland and the Digital Health Revolution

D. Trono 

Chimia. 2016. Vol. 70, num. 12, p. 851 – 852. DOI : 10.2533/chimia.2016.851.

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Lentiviral vectors, two decades later

L. Naldini; D. Trono; I. M. Verma 

Science. 2016. Vol. 353, num. 6304, p. 1101 – 1102. DOI : 10.1126/science.aah6192.

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Human Hepatocyte-Derived Induced Pluripotent Stem Cells: MYC Expression, Similarities to Human Germ Cell Tumors, and Safety Issues

C. Unzu; M. Friedli; A. Bosman; M. E. Jaconi; B. E. Wildhaber et al. 

Stem Cells International. 2016. Vol. 2016, p. 1 – 16. DOI : 10.1155/2016/4370142.

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Transposable Elements, Polydactyl Proteins, and the Genesis of Human-Specific Transcription Networks

D. Trono 

Cold Spring Harbor symposia on quantitative biology. 2016. Vol. 80, p. 281 – 8. DOI : 10.1101/sqb.2015.80.027573.

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A Large-Scale Functional Screen to Identify Epigenetic Repressors of Retrotransposon Expression

G. Ecco; H. M. Rowe; D. Trono 

Methods in molecular biology (Clifton, N.J.). 2016. Vol. 1400, p. 403 – 17. DOI : 10.1007/978-1-4939-3372-3_25.

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Molecular Criteria for Defining the Naive Human Pluripotent State

T. W. Theunissen; M. Friedli; Y. He; E. Planet; R. C. O’Neil et al. 

Cell stem cell. 2016. Vol. 19, num. 4, p. 502 – 515. DOI : 10.1016/j.stem.2016.06.011.

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2015

Journal Articles

Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages

J-E. Dietrich; L. Panavaite; S. Gunther; S. Wennekamp; A. C. Groner et al. 

EMBO Reports. 2015. Vol. 16, num. 8, p. 1005 – 1021. DOI : 10.15252/embr.201540162.

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A KAP1 phosphorylation switch controls MyoD function during skeletal muscle differentiation

K. Singh; M. Cassano; E. Planet; S. Sebastian; S. M. Jang et al. 

Genes & Development. 2015. Vol. 29, num. 5, p. 513 – 25. DOI : 10.1101/gad.254532.114.

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Release of human cytomegalovirus from latency by a KAP1/TRIM28 phosphorylation switch

B. Rauwel; S. M. Jang; M. Cassano; A. Kapopoulou; I. Barde et al. 

eLife. 2015. Vol. 4, p. e06068. DOI : 10.7554/eLife.06068.

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TRIM28 Represses Transcription of Endogenous Retroviruses in Neural Progenitor Cells

L. Fasching; A. Kapopoulou; R. Sachdeva; R. Petri; M. Jönsson et al. 

Cell Reports. 2015. Vol. 10, num. 1, p. 20 – 28. DOI : 10.1016/j.celrep.2014.12.004.

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Reviews

The Developmental Control of Transposable Elements and the Evolution of Higher Species

M. Friedli; D. Trono 

Annual review of cell and developmental biology. 2015. Vol. 31, p. 429 – 451. DOI : 10.1146/annurev-cellbio-100814-125514.

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Drawing a fine line on endogenous retroelement activity

N. Castro-Diaz; M. Friedli; D. Trono 

Mobile genetic elements. 2015. Vol. 5, num. 1, p. 1 – 6. DOI : 10.1080/2159256X.2015.1006109.

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2014

Journal Articles

As Time Goes by: KRABs Evolve to KAP Endogenous Retroelements

M. Imbeault; D. Trono 

Developmental Cell. 2014. Vol. 31, num. 3, p. 257 – 258. DOI : 10.1016/j.devcel.2014.10.019.

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Dual-regulated Lentiviral Vector for Gene Therapy of X-linked Chronic Granulomatosis

M. Chiriaco; G. Farinelli; V. Capo; E. Zonari; S. Scaramuzza et al. 

Molecular Therapy. 2014. Vol. 22, num. 8, p. 1472 – 1483. DOI : 10.1038/mt.2014.87.

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