Publications

2026

Journal Articles

Regulation of Type VI secretion systems of Burkholderia during transition to intracellular lifestyle

H. C. Cheung; D. J. Wuest; M. T. W. Plum; P. Reist Iscar; M. Basler 

EMBO Reports. 2026. DOI : 10.1038/s44319-026-00905-2.

Growth in confinement promotes Pseudomonas aeruginosa tolerance to antibiotics

S. Monnappa; Z. Al‐Mayyah; M. S. Sakar; A. Persat 

Proceedings of the National Academy of Sciences. 2026. Vol. 123, num. 22. DOI : 10.1073/pnas.2605176123.

Reviews

Microscale droplets for mechanical measurement and mechanotransduction in artificial and living systems

Y. Su; N. Su; S. Kim; A. Persat; H. Bayley et al. 

Nature Reviews Physics. 2026. DOI : 10.1038/s42254-026-00977-y.

Theses

From Functional Genomics to Tissue Models: Investigating Pseudomonas aeruginosa-Macrophage Interactions

T. Distler / A. L. A. Persat (Dir.)  

Lausanne, EPFL, 2026. 

Mechanoadaptation of bacterial physiology and antibiotic tolerance in confined environments

S. M. Kuppanda Jafri / A. L. A. Persat; M. S. Sakar (Dir.)  

Lausanne, EPFL, 2026. 

Working Papers

Intranuclear niche: actin-tail mediated nuclear entry by intracellular pathogens

H. C. Cheung; P. Reist Iscar; M. T. W. Plum; M. Basler 

2026

Total Synthesis and Preliminary Biological Evaluation of the Natural Glycolipids Cupacinoside and Dalberoside

C. Adamson; L. Li; E. W. L. Ng; H-Y. Huang; A. Persat et al. 

2026

A natural glycolipid exposes the outer membrane interface as a tunable regulator of bacterial surface attachment.

H-Y. Huang; E. N. Astorga-Simon; C. Adamson; Y. Oiao; P. P. Navarro et al. 

2026

A structural trade-off balances mechanical resilience and supramolecular adaptability in type IV pili

C-N. Tsai; L. Le Blanc; F. M. F. Elgebely; Z. Al-Mayyah; M. Nilges et al. 

2026

Pyocyanin disrupts airway regeneration to favor chronic Pseudomonas aeruginosa infection

L. A. Meirelles; A. Grigoryan; L. Le Blanc; D. Liaskos; E. Vayena et al. 

2026

Pseudomonas aeruginosa balances cytotoxicity and motility to counter phagocytosis by macrophages

T. Distler; C-N. Tsai; A. Weimann; Z. Al-Mayyah; L. A. Meirelles et al. 

2026

2025

Journal Articles

Antagonistic response regulators spatially regulate receptor methylation in the Pseudomonas aeruginosa Pil-Chp surface sensing system

R. Patino; M. J. Kühn; H. Macmillan; Y. F. Inclan; I. Chavez et al. 

Cell Reports. 2025. Vol. 44, num. 4, p. 115536. DOI : 10.1016/j.celrep.2025.115536.

Decoding host-microbe interactions with engineered human organoids

L. A. Meirelles; A. Persat 

EMBO JOURNAL. 2025. DOI : 10.1038/s44318-025-00387-3.

Working Papers

Adaptation of Enterococcus faecalis to intestinal mucus revealed by a human colonic organoid model

S. Mikhaleva; P-K. Hsiao; A. Kurmashev; C. M. Anderson; C. Colomer‐Winter et al. 

2025

Patents

Bacterial anti-adhesion compound and use thereof

A. PERSAT; H-Y. HUANG 

WO2025252699.

2025.

2024

Journal Articles

Pseudomonas aeruginosa faces a fitness trade-off between mucosal colonization and antibiotic tolerance during airway infection

L. Andrade Meirelles; E. Vayena; A. Debache; L. E. Schmidt; T. Rossy et al. 

Nature microbiology. 2024. Vol. 9, num. 12, p. 3284 – 3303. DOI : 10.1038/s41564-024-01842-3.

Bacteroides thetaiotaomicron metabolic activity decreases with polysaccharide molecular weight

J. P. H. Wong; N. Chillier; M. Fischer-Stettler; S. C. Zeeman; T. J. Battin et al. 

Mbio. 2024. DOI : 10.1128/mbio.02599-23.

Revitalizing antibiotic discovery and development through in vitro modelling of in-patient conditions

J. Sollier; M. Basler; P. Broz; P. S. Dittrich; K. Drescher et al. 

Nature Microbiology. 2024. DOI : 10.1038/s41564-023-01566-w.

2023

Journal Articles

Archaeal type IV pili stabilize Haloferax volcanii biofilms in flow

P. D. Odermatt; P. Nussbaum; S. Monnappa; L. Tala; Z. Li et al. 

Current Biology. 2023. Vol. 33, num. 15, p. 3265 – 3271. DOI : 10.1016/j.cub.2023.06.055.

Pseudomonas aeruginosa type IV pili actively induce mucus contraction to form biofilms in tissue-engineered human airways

T. Rossy; T. Distler; L. Meirelles; J. Pezoldt; J. Kim et al. 

Plos Biology. 2023. Vol. 21, num. 8, p. e3002209. DOI : 10.1371/journal.pbio.3002209.