Publications

2024

Journal Articles

Bacteroides thetaiotaomicron metabolic activity decreases with polysaccharide molecular weight

J. P. H. Wong; N. Chillier; M. Fischer-Stettler; S. C. Zeeman; T. J. Battin et al. 

Mbio. 2024-02-20. DOI : 10.1128/mbio.02599-23.

Revitalizing antibiotic discovery and development through in vitro modelling of in-patient conditions

J. Sollier; M. Basler; P. Broz; P. S. Dittrich; K. Drescher et al. 

Nature Microbiology. 2024-01-04. DOI : 10.1038/s41564-023-01566-w.

2023

Journal Articles

Archaeal type IV pili stabilize Haloferax volcanii biofilms in flow

P. D. Odermatt; P. Nussbaum; S. Monnappa; L. Tala; Z. Li et al. 

Current Biology. 2023-08-07. Vol. 33, num. 15, p. 3265-3271. DOI : 10.1016/j.cub.2023.06.055.

Fluid flow structures gut microbiota biofilm communities by distributing public goods

J. P. H. Wong; M. F-Stettler; S. C. Zeeman; T. J. Battin; A. Persat et al. 

Proceedings Of The National Academy Of Sciences Of The United States Of America. 2023-06-20. Vol. 120, num. 25, p. e2217577120. DOI : 10.1073/pnas.2217577120.

Pseudomonas aeruginosa type IV pili actively induce mucus contraction to form biofilms in tissue-engineered human airways

T. Rossy; T. Distler; L. Meirelles; J. Pezoldt; J. Kim et al. 

Plos Biology. 2023-08-01. Vol. 21, num. 8, p. e3002209. DOI : 10.1371/journal.pbio.3002209.

Biofilm formation on human immune cells is a multicellular predation strategy of Vibrio cholerae

L. Vidakovic; S. Mikhaleva; H. Jeckel; V. Nisnevich; K. Strenger et al. 

Cell. 2023-06-08. Vol. 186, num. 12, p. 2690-+. DOI : 10.1016/j.cell.2023.05.008.

Material Substrate Physical Properties Control Pseudomonas aeruginosa Biofilm Architecture

A. Cont; J. Vermeil; A. Persat 

Mbio. 2023-02-14. DOI : 10.1128/mbio.03518-22.

Two antagonistic response regulators control Pseudomonas aeruginosa polarization during mechanotaxis

M. J. Kuhn; H. Macmillan; L. Tala; Y. Inclan; R. Patino et al. 

Embo Journal. 2023-02-16. DOI : 10.15252/embj.2022112165.

Theses

The Effects of Spatial Organization and Fluid Flow on the Social Interactions in Microbial Communities

J. P. H. Wong / A. L. A. Persat; T. I. Battin (Dir.)  

Lausanne, EPFL, 2023. 

Bacterial colonization in realistic environments: how mechanics impact biofilm formation in the wild and during infection

T. Rossy / A. L. A. Persat (Dir.)  

Lausanne, EPFL, 2023. 

Biofilm morphogenesis on soft hydrogels

A. Cont / A. L. A. Persat (Dir.)  

Lausanne, EPFL, 2023. 

2022

Journal Articles

Global and gene-specific translational regulation in Escherichia coli across different conditions

D. Zhang; S. H-J. Li; C. G. King; N. S. Wingreen; Z. Gitai et al. 

Plos Computational Biology. 2022-10-01. Vol. 18, num. 10, p. e1010641. DOI : 10.1371/journal.pcbi.1010641.

Engineering Agrobacterium tumefaciens Adhesion to Target Cells

X. Pierrat; A. Pham; J. P. H. Wong; Z. Al-Mayyah; A. Persat 

Acs Synthetic Biology. 2022-07-26. DOI : 10.1021/acssynbio.2c00069.

Polar flagellar wrapping and lateral flagella jointly contribute to Shewanella putrefaciens environmental spreading

M. J. Kuehn; D. B. Edelmann; K. M. Thormann 

Environmental Microbiology. 2022-07-08. DOI : 10.1111/1462-2920.16107.

GCN2 adapts protein synthesis to scavenging-dependent growth

M. Nofal; T. Wang; L. Yang; C. S. R. Jankowski; S. H-J. Li et al. 

Cell Systems. 2022-02-16. Vol. 13, num. 2, p. 158-+. DOI : 10.1016/j.cels.2021.09.014.

KRAB zinc finger protein ZNF676 controls the transcriptional influence of LTR12-related endogenous retrovirus sequences

A. Iouranova; D. Grun; T. Rossy; J. Duc; A. Coudray et al. 

Mobile Dna. 2022-01-18. Vol. 13, num. 1, p. 4. DOI : 10.1186/s13100-021-00260-0.

Reviews

Wrapped Up: The Motility of Polarly Flagellated Bacteria

K. M. Thormann; C. Beta; M. J. Kuhn 

Annual Review Of Microbiology. 2022-01-01. Vol. 76, p. 349-367. DOI : 10.1146/annurev-micro-041122-101032.

Theses

Characterization of Pseudomonas aeruginosa mechanosensing through label-free imaging of type IV pili

L. A-L. Talà / A. L. A. Persat (Dir.)  

Lausanne, EPFL, 2022. 

Engineering synthetic adhesins for biophysical investigation and rewiring of host-microbe interactions

X. J-Y. Pierrat / A. L. A. Persat (Dir.)  

Lausanne, EPFL, 2022. 

2021

Journal Articles

Time-Resolved Scanning Ion Conductance Microscopy for Three-Dimensional Tracking of Nanoscale Cell Surface Dynamics

S. M. Leitao; B. Drake; K. Pinjusic; X. Pierrat; V. Navikas et al. 

Acs Nano. 2021-11-23. Vol. 15, num. 11, p. 17613-17622. DOI : 10.1021/acsnano.1c05202.

The wall-less bacterium Spiroplasma poulsonii builds a polymeric cytoskeleton composed of interacting MreB isoforms

F. Masson; X. Pierrat; B. Lemaitre; A. Persat 

Iscience. 2021-12-17. Vol. 24, num. 12, p. 103458. DOI : 10.1016/j.isci.2021.103458.

Mechanotaxis directs Pseudomonas aeruginosa twitching motility

M. J. Kuhn; L. Tala; Y. F. Inclan; R. Patino; X. Pierrat et al. 

Proceedings Of The National Academy Of Sciences Of The United States Of America. 2021-07-27. Vol. 118, num. 30, p. e2101759118. DOI : 10.1073/pnas.2101759118.

The Mammalian Membrane Microenvironment Regulates the Sequential Attachment of Bacteria to Host Cells

X. Pierrat; J. Wong; Z. Al-Mayyah; A. Persat; M. R. Parsek 

mBio. 2021-08-03. Vol. 12, num. 4, p. e01392-21. DOI : 10.1128/mBio.01392-21.

Variations of intracellular density during the cell cycle arise from tip-growth regulation in fission yeast

P. D. Odermatt; T. P. Miettinen; J. Lemiere; J. H. Kang; E. Bostan et al. 

Elife. 2021-06-08. Vol. 10, p. e64901. DOI : 10.7554/eLife.64901.

Movement-Related Cortical Potentials in Embodied Virtual Mirror Visual Feedback

G. Garipelli; T. Rossy; D. Perez-Marcos; J. Johr; K. Diserens 

Frontiers In Neurology. 2021-06-15. Vol. 12, p. 646886. DOI : 10.3389/fneur.2021.646886.

Roadmap on emerging concepts in the physical biology of bacterial biofilms: from surface sensing to community formation

G. C. L. Wong; J. D. Antani; P. P. Lele; J. Chen; B. Nan et al. 

Physical Biology. 2021-09-01. Vol. 18, num. 5, p. 051501. DOI : 10.1088/1478-3975/abdc0e.

Monodisperse Selectively Permeable Hydrogel Capsules Made from Single Emulsion Drops

M. Steinacher; A. Cont; H. Du; A. Persat; E. Amstad 

ACS Applied Materials & Interfaces. 2021. Vol. 13, num. 13, p. 15601-15609. DOI : 10.1021/acsami.1c00230.

2020

Journal Articles

Biofilms deform soft surfaces and disrupt epithelia

A. Cont; T. Rossy; Z. Al-Mayyah; A. Persat 

Elife. 2020-10-07. Vol. 9, p. e56533. DOI : 10.7554/eLife.56533.

Catechol Containing Polyelectrolyte Complex Nanoparticles as Local Drug Delivery System for Bortezomib at Bone Substitute Materials

D. Vehlow; J. P. H. Wong; B. Urban; J. Weisspflog; A. Gebert et al. 

Pharmaceutics. 2020-09-01. Vol. 12, num. 9, p. 799. DOI : 10.3390/pharmaceutics12090799.

Reviews

Mechanomicrobiology: how bacteria sense and respond to forces

Y. F. Dufrene; A. Persat 

Nature Reviews Microbiology. 2020-01-20. Vol. 18, p. 227–240. DOI : 10.1038/s41579-019-0314-2.

2019

Journal Articles

Complete inclusion of bioactive molecules and particles in polydimethylsiloxane: a straightforward process under mild conditions

G. Faccio; A. Cont; E. Mailand; E. Zare-Eelanjegh; R. I. Malini et al. 

Scientific Reports. 2019-11-26. Vol. 9, p. 17575. DOI : 10.1038/s41598-019-54155-5.

Vibrio cholerae filamentation promotes chitin surface attachment at the expense of competition in biofilms

B. R. Wucher; T. M. Bartlet; M. Hoyos; K. Papenfort; A. Persat et al. 

Proceedings of the National Academy of Sciences. 2019-07-09. Vol. 116, num. 28, p. 14216-14221. DOI : 10.1073/pnas.1819016116.

Cellular advective-diffusion drives the emergence of bacterial surface colonization patterns and heterogeneity

T. Rossy; C. D. Nadell; A. Persat 

Nature Communications. 2019-06-06. Vol. 10, p. 2471. DOI : 10.1038/s41467-019-10469-6.

Pseudomonas aeruginosa orchestrates twitching motility by sequential control of type IV pili movements

L. Tala; A. Fineberg; P. Kukura; A. Persat 

Nature Microbiology. 2019-05-01. Vol. 4, num. 5, p. 774-780. DOI : 10.1038/s41564-019-0378-9.

2018

Conference Papers

Bacterial Mechanosensing with Type IV Pili

L. Tala; X. Pierrat; A. Persat 

2018-02-02. 62nd Annual Meeting of the Biophysical-Society, San Francisco, CA, Feb 17-21, 2018. p. 3A-3A. DOI : 10.1016/j.bpj.2017.11.045.

2016

Journal Articles

A scaffold protein connects type IV pili with the Chp chemosensory system to mediate activation of virulence signaling in Pseudomonas aeruginosa

Y. F. Inclan; A. Persat; A. Greninger; J. Von Dollen; J. Johnson et al. 

Molecular microbiology. 2016. Vol. 101, num. 4, p. 590-605. DOI : 10.1111/mmi.13410.

Reviews

An Ohmic model for electrokinetic flows of binary asymmetric electrolytes

A. Persat; J. G. Santiago 

Current Opinion In Colloid & Interface Science. 2016. Vol. 24, p. 52-63. DOI : 10.1016/j.cocis.2016.06.001.

2015

Journal Articles

Type IV pili mechanochemically regulate virulence factors in Pseudomonas aeruginosa

A. Persat; Y. F. Inclan; J. N. Engel; H. A. Stone; Z. Gitai 

Proceedings of the National Academy of Sciences of the United States of America. 2015. Vol. 112, num. 24, p. 7563-8. DOI : 10.1073/pnas.1502025112.

Reviews

The mechanical world of bacteria

A. Persat; C. D. Nadell; M. K. Kim; F. Ingremeau; A. Siryaporn et al. 

Cell. 2015. Vol. 161, num. 5, p. 988-97. DOI : 10.1016/j.cell.2015.05.005.

2014

Journal Articles

The curved shape of Caulobacter crescentus enhances surface colonization in flow

A. Persat; H. A. Stone; Z. Gitai 

Nature Communications. 2014. Vol. 5, p. 3824. DOI : 10.1038/ncomms4824.

Bacterial evolution: rewiring modules to get in shape

A. Persat; Z. Gitai 

Current biology : CB. 2014. Vol. 24, num. 11, p. R522-4. DOI : 10.1016/j.cub.2014.04.022.

2011

Journal Articles

MicroRNA profiling by simultaneous selective isotachophoresis and hybridization with molecular beacons

A. Persat; J. G. Santiago 

Analytical chemistry. 2011. Vol. 83, num. 6, p. 2310-6. DOI : 10.1021/ac103225c.

2010

Journal Articles

Quantification of global microRNA abundance by selective isotachophoresis

A. Persat; R. R. Chivukula; J. T. Mendell; J. G. Santiago 

Analytical chemistry. 2010. Vol. 82, num. 23, p. 9631-5. DOI : 10.1021/ac102496m.

2009

Journal Articles

Electrokinetic control of sample splitting at a channel bifurcation using isotachophoresis

A. Persat; J. G. Santiago 

Nes Journal Of Physics. 2009. Vol. 11, p. 075026. DOI : 10.1088/1367-2630/11/7/075026.

Basic principles of electrolyte chemistry for microfluidic electrokinetics. Part II: Coupling between ion mobility, electrolysis, and acid-base equilibria

A. Persat; M. E. Suss; J. G. Santiago 

Lab on a chip. 2009. Vol. 9, num. 17, p. 2454-69. DOI : 10.1039/b906468k.

Basic principles of electrolyte chemistry for microfluidic electrokinetics. Part I: Acid-base equilibria and pH buffers

A. Persat; R. D. Chambers; J. G. Santiago 

Lab on a chip. 2009. Vol. 9, num. 17, p. 2437-53. DOI : 10.1039/b906465f.

Purification of nucleic acids from whole blood using isotachophoresis

A. Persat; L. A. Marshall; J. G. Santiago 

Analytical chemistry. 2009. Vol. 81, num. 22, p. 9507-11. DOI : 10.1021/ac901965v.