Naef lab - UPNAE Laboratory of Computational and Systems Biology
Current Research Areas
> Circadian gene regulatory networks in mammals
> Chronobiology of the liver
> Circadian oscillators in single cells
> Interactions of circadian oscilators and cell cycle
> Transcriptional bursting and noise in mammalian gene transcription
Would you like to join us for your PhD or Post-doc? See Openings.
Please contact [email protected]
Recent Highlights
Clock-dependent chromatin topology modulates circadian transcription and behavior
Mermet et al., Genes Development 2018. The circadian clock in animals orchestrates widespread oscillatory gene expression programs, which underlie 24-h rhythms in behavior and physiology.
Modulation of transcriptional burst frequency by histone acetylation
Nicolas et al., PNAS 2018. Many mammalian genes are transcribed during short bursts of variable frequencies and sizes that substantially contribute to cellto-cell variability. However,
Transcription factor activity rhythms and tissue-specific chromatin interactions explain circadian gene expression across organs.
Yeung et al., Genome Research 2018. Temporal control of physiology requires the interplay between gene networks involved in daily timekeeping and tissue function across different organs.
See all our previous Research Highlights
Contact
Laboratory of Computational and Systems Biology
Head of laboratory: Prof. Felix Naef
♦ Office AAB 040
♦ Phone: +41 21 693 16 21
♦ Email: [email protected]
Administrative Assistant: Sophie Barret
♦ Office AAB 038
♦ Phone: +41 21 693 83 58
♦ Email: [email protected]
Mailing Address:
EPFL SV IBI UPNAE
Prof. Felix Naef
AAB 040
Station 15
CH-1015 Lausanne