Welcome to the Computational Systems Biology lab
Our lab is interested in quantitative, systems biology, and more generally the link between physics and biology. We work on various problems including circadian rhythms, transcriptional bursting, developmental patterning, gene regulation, and single cell imaging. To study these systems we combine theoretical, computational and experimental methods.
Current research areas:
- Circadian gene regulatory networks in mammals
- Chronobiology of the liver
- Circadian oscillators in single cells
- Interactions of circadian oscilators and cell cycle
- Transcriptional bursting and noise in mammalian gene transcription
Would you like to join us for your PhD or Post-doc?
See Openings.
Please contact [email protected]
Recent Highlights
Clock-dependent chromatin topology modulates circadian transcription and behavior
Mermet et al., Genes Development 2018. The circadian clock in animals orchestrates widespread oscillatory gene expression programs, which underlie 24-h rhythms in behavior and physiology.
Modulation of transcriptional burst frequency by histone acetylation
Nicolas et al., PNAS 2018. Many mammalian genes are transcribed during short bursts of variable frequencies and sizes that substantially contribute to cellto-cell variability. However,
Transcription factor activity rhythms and tissue-specific chromatin interactions explain circadian gene expression across organs.
Yeung et al., Genome Research 2018. Temporal control of physiology requires the interplay between gene networks involved in daily timekeeping and tissue function across different organs.