Welcome to the Laboratory of Asymmetric Catalysis and Synthesis (LCSA) headed by Professor Nicolai Cramer. We are a young and dynamic research team working on challenges in asymmetric metal-catalyzed reactions and the synthesis of bioactive natural products.
LATEST NEWS
29.04.2025: Arthur’s preprint on the iridium(III)-catalyzed ionic hydrogenation of pyridines to multi-substituted piperidines. It’s now available in ChemRxiv. Congrats Arthur!
28.04.2025: Check out Lenin’s work on the enantioselective cobalt(III)-catalyzed [4+1] annulation of benzamides in JACS. Congrats Lenin!
07.04.2025: Andrea joined the group as a new PhD student. Welcome to the LCSA, Andrea!
07.04.2025: Check out Sripati’s paper on the enantioselective acyl-trifluoromethylation of
olefins by bulky thiazolium carbene catalysis in Nature Communications. Congrats!
28.02.2025: Adrien Madron du Vigné successfully defended his PhD thesis. Congrats Adrien!
10.12.2024: Sripati’s impressive work on tunable thiazolium carbenes for enantioselective radical three-component dicarbofunctionalizations is now available on JACS.
06.12.2024: Recent work of the enantiospecific synthesis of planar chiral rhodium and iridium cyclopentadienyl complexes by Sebastian and Aragorn can be found in JACS. Congrats!
28.08.2024: Check out this Yi-Xuan’s preprint on accessing carbon, boron and germanium spiro stereocenters in a unified catalytic enantioselective approach in ChemRxiv.
28.08.2024: Yi-Xuan Cao successfully defended his PhD thesis. Congrats Yi-Xuan!
24.07.2024: Adrien’s new publication on streamlined synthetic assembly of α-chiral CAAC ligands and catalytic performance of their copper and ruthenium complexes is now available in Chemical Science. Check it out!
01.01.2024: Giuseppe joined the group as a SNSF Ambizione Fellow and Navadheer joined the group as a new PhD student. Welcome to the LCSA, Giuseppe and Navadheer!
LATEST PUBLICATIONS
A. Despois, N. Cramer, ChemRxiv 2025, doi:10.26434/chemrxiv-2025-78q6b: “Iridium(III)-Catalyzed Ionic Hydrogenation of Pyridines to Multi-Substituted Piperidines”
L. K. Verdhi, M. D. Wodrich, N. Cramer, J. Am. Chem. Soc. 2025, 147, 15041-15049: “Enantioselective Cobalt(III)-Catalyzed [4 + 1] Annulation of Benzamides: Cyclopropenes as One-Carbon Synthons”
S. Jana, M. D. Wodrich, N. Cramer, Nat. Commun. 2025, 16, 3293-3301: “Enantioselective acyl-trifluoromethylation of olefins by bulky thiazolium carbene catalysis”
S. Jana, N. Cramer, J. Am. Chem. Soc. 2024, 146, 35199-35207: “Tunable Thiazolium Carbenes for Enantioselective Radical Three-Component Dicarbofunctionalizations“
Y. S. Ye, A. Laverny, M. D. Wodrich, R. Laplaza, F. Fadaei-Tirani, R. Scopelliti, C. Corminboeuf, N. Cramer, J. Am. Chem. Soc. 2024, 146, 34786-34795: “Enantiospecific Synthesis of Planar Chiral Rhodium and Iridium Cyclopentadienyl Complexes: Enabling Streamlined and Computer-Guided Access to Highly Selective Catalysts for Asymmetric C–H Functionalizations“
Y.-X. Cao, A.-S. Chauvin, S. Tong, L. Alama, N. Cramer, ChemRxiv 2024, doi:10.26434/chemrxiv-2024-3w4p4: “Accessing Carbon, Boron and Germanium Spiro Stereocenters in a Unified Catalytic Enantioselective Approach“
A. Madron du Vigné, N. Cramer, Chem. Sci. 2024, 15, 13864-13871: “Streamlined synthetic assembly of α-chiral CAAC ligands and catalytic performance of their copper and ruthenium complexes“
Y. Zhang, J.-J. Zhang, L. Lou, R. Lin, N. Cramer, S.-G. Wang and Z. Chen, Chem. Soc. Rev. 2024, 53, 3457-3484: “Recent advances in Rh(I)-catalyzed enantioselective C–H functionalization“
G. Zhang, M. D. Wodrich, N. Cramer, Science 2024, 383, 395-401: “Catalytic enantioselective reductive Eschenmoser-Claisen rearrangements“