LCSA – Laboratory of Asymmetric Catalysis and Synthesis

Lab Key visual — Asymmetric catalysis. – Metal-catalyzed bond activations. – Natural product synthesis.

Welcome to the Laboratory of Asymmetric Catalysis and Synthesis headed by Professor Nicolai Cramer. We are a young and dynamic research team working on challenges in the areas of asymmetric metal-catalyzed reactions and the synthesis of bioactive natural products.

LATEST NEWS

30.08.2018: Daria’s work on the enantioselective Pd-catalyzed synthesis of 1H-isoindoles got published in ACIE, congrats!!!

25.07.2018: The paper from Yun-Suk, Lukasz and Julia on iridium-catalyzed atropselective biaryl synthesis appeared in ACIE, congrats!!!

20.07.2018: Mischa successfully defended his Master Thesis on the synthesis of phalloidins, congrats!

02.07.2018: Chris, Elena and Jenny’s work on atropoenantioselective cyclization appeared in ACIE, big congrats!

01.05.2018: Dr. Ana Pascual Escudero joins the group for a postdoc. Welcome Ana!

01.04.2018: Dr. Gints Smits comes to the LCSA for a short visits. Weclome back!

16.3.2018: Johannes paper on enantioselective Ni-catalyzed pyridone functionalization appeared in JACS, congrats!!

12.03.2018: Shuo-Guo and Sung Hwan’s paper on a 2-step chiral Cp-ligand family appeared in Angewandte Chemie, congrats!

01.03.2018: Dr. Maria Frias joins the group for a postdoc. Welcome!

20.02.2018: Jack and Solène’s work on asymmetric diazaphospholene catalysis appeared in Angewandte Chemie, congrats!

19.02.2018: Mischa Schüttel started his Master thesis on natural product synthesis, welcome back to EPFL!

01.02.2018: Dr. Marcus Brauns joins the group for a postdoc, welcome to Lausanne.

01.02.2018: Vitalii Smal from Saclay joins the group for his Master work, welcome!

15.01.2018: Yang’s kinetic resolution to generate P-chiral compounds appeared in Chem. Science, congrats!

02.01.2018: Dr. Lukasz Wozniak joins the group for his postdoc. Welcome!

01.11.2017: After defending her Master in Italy, Elena Braconi is back in the group for her PhD thesis, welcome back!

01.10.2017: Kristers Ozols joins the group for his PhD thesis, welcome Kristers!

26.09.2017: Daria’s work on enantioselective ketene aminal phosphate C-H functionalization is published in ACS Catalysis, congrats!

01.09.2017: Jin Fay Tan starts his PhD in the group, welcome to Lausanne!

LATEST PUBLICATIONS

Y.-S. Jang, Ł. Woźniak, J. Pedroni, N. Cramer, Angew. Chem. Int. Ed. 2018, DOI:10.1002/anie.201807749: “Access to P- and Axially-Chiral Biaryl Phosphine Oxides by Enantioselective Cp^xIr^III-Catalyzed C-H Arylations”

C. G. Newton, E. Braconi, J. Kuziola, M. D. Wodrich, N. Cramer, Angew. Chem. Int. Ed. 2018, DOI: 10.1002/anie.201806527: “Axially Chiral Dibenzazepinones via a Pd(0)-Catalyzed Atropo-enantioselective C-H Arylation”

J. Diesel, A. Finogenova, N. Cramer, J. Am. Chem. Soc. 2018, DOI:10.1021/jacs.8b01181: “Nickel-Catalyzed Enantioselective Pyridone C-H Functionalizations Enabled by a Bulky N-Heterocyclic Carbene Ligand”

S.-G. Wang, S. H. Park, N. Cramer, Angew. Chem. Int. Ed. 2018, DOI:10.1002/anie.201802244: “A Readily Accessible Class of Chiral Cp Ligands and their Application in Ru(II)-Catalyzed Enantioselective Syntheses of Dihydrobenzoindoles”

S. Miaskiewicz, J. H. Reed, P. A. Donets, C. C. Oliveira, N. Cramer, Angew. Chem. Int. Ed. 2018, DOI:10.1002/anie.201801300: “Chiral 1,3,2-Diazaphospholenes as Catalytic Molecular Hydrides for Enantioselective Conjugate Reductions”

Y. Sun, N. Cramer, Chem. Sci. 2018, DOI:10.1039/c7sc05411d: “Tailored trisubstituted chiral Cp^xRh^III catalysts for kinetic resolutions of phosphinic amides”

D. Grosheva, N. Cramer, ACS Catalysis 2017, 7, 7417-7420: “Ketene Aminal Phosphates: Competent Substrates for Enantioselective Pd(0)-Catalyzed C-H Functionalizations”

Y.-S. Jang, M. Dieckmann, N. Cramer, Angew. Chem. Int. Ed. 2017, 56, 15088-15092: “Cooperative Effects between Chiral Cp^xIr^III Catalysts and Chiral Carboxylic Acids in Enantioselective C-H Amidations of Phosphine Oxides”