Welcome to the Laboratory of Asymmetric Catalysis and Synthesis (LCSA) headed by Professor Nicolai Cramer. We are a young and dynamic research team working on challenges in asymmetric metal-catalyzed reactions and the synthesis of bioactive natural products.
We are delighted to invite you to participate in the 23rd IUPAC International Symposium on Organometallic Chemistry Directed towards Organic Synthesis (OMCOS-23) that will be held in Lausanne from July 19-23, 2027, at the SwissTech Convention Center, Lausanne, Switzerland.
LATEST NEWS
29.09.2026: Vitalii’s development of an atroposelective Pd(0)-catalyzed direct intermolecular C─H arylation of thiazole N-oxides to provide access to heterobiaryls has been published in ACIE. Congratulations, Vitalii!
07.09.2026: Recent work on cobalt-catalyzed enantioselective intermolecular C–H carboamination with racemic allenes by Lenin can be found in JACS. Congrats!
13.07.2026: Arthur’s new publication on the iridium-catalyzed ionic hydrogenation of multi-aza heterocycles is now available in ACIE. Check it out!
08.06.2026: One of our more peculiar findings, Bram’s discovery of stable 16-electron chiral Cp cobalt complexes, is now available in Organometallics. Congrats for finishing the PhD with a paper hattrick!
22.04.2026: The core mission of Bram’s PhD, developing a combinatorial synthesis of highly tunable pentasubstituted chiral Cp ligands, has been successful and can now be found in JACS. Bravo!
02.02.2026: Erik joined the group as a new PhD student. Welcome to the LCSA, Erik!
09.01.2026: Bram’s development of a unified synthesis platform for structurally diverse 1,2,3-trisubstituted cyclopentadienyl ligands and their catalytically potent complexes has been published in JACS. Congratulations, Bram!
05.01.2026: Clara joined the group as a new PhD student. Welcome to the LCSA, Clara!
LATEST PUBLICATIONS
V. Small, N. Cramer, Angew. Chem. Int. Ed. 2026, e6888467: “Atroposelective Pd(0)-Catalyzed Direct Intermolecular C─H Arylation of Thiazole N-Oxides Provides Access to Heterobiaryls”
L. K. Verdhi, N. Cramer, J. Am. Chem. Soc. 2026, xxx, xxxxx-xxxxx: “Cobalt-Catalyzed Enantioselective Intermolecular C–H Carboamination with Racemic Allenes”
A. Despois, N. Cramer, Angew. Chem. Int. Ed. 2026, 65, e4341513: “Iridium-Catalyzed Ionic Hydrogenation of Multi-Aza Heterocycles”
B. Van Den Bossche, N. Cramer, Organometallics 2026, 45, 1333-1338: “Speciation of Bulky Chiral Cyclopentadienyl Cobalt(III) Complexes: Isolation of Air-Stable 16-Electron Species”
B. Van Den Bossche, N. Cramer, J. Am. Chem. Soc. 2026, 148, 18468-18481: “Modular Assembly of Chiral Cp* Clones Unlocks Performant Catalysts for Enantioselective C–H Functionalizations”
B. Van Den Bossche, N. Cramer, J. Am. Chem. Soc. 2026, 148, 3775-3787: “Unified Synthesis Platform for 1,2,3-Trisubstituted Cyclopentadienyl Ligands Decouples Sterics from Electronics”