Laboratory of Asymmetric Catalysis and Synthesis ‒


Welcome to the Laboratory of Asymmetric Catalysis and Synthesis headed by Professor Nicolai Cramer. We are a young and dynamic research team working on challenges in the areas of asymmetric metal-catalyzed reactions and the synthesis of bioactive natural products.


15.06.2023: Sebastian started as a new postdoctoral researcher. Welcome Sebastian!

29.03.2023: Check out SwissCat+: the future of catalyst discovery and optimisation in Chimia!

29.03.2023: Recent work of the NCCR’s in silico catalyst optimisation can be found in Chimia.

24.03.2023: Aragorn Laverny successfully defended his PhD thesis. Congrats Aragorn!

23.02.2023: Check out Guoting’s paper on the DAP-catalyzed asymmetric Aza-Mislow-Evans Rearrangement in ACIE. Congrats!

22.02.2023: Yi-Xuan’s and Matthew’s impressive work on asymmetric Nickel Catalysis is now available on ChemRxiv. Congrats!

01.02.2023: Wilfrido Almaraz joined the group as a new PhD student. Welcome at the LCSA Wilfrido!

01.01.2023: The LCSA wishes everyone a happy and successful new year. We welcome Dr. Sripati Jana as our new postdoctoral researcher!

01.11.2022: Dagmara Maye rejoined the group as a PhD student. Dr. Lenin Verdhi joined the group as a new Postdoc. Welcome Dagmara and Lenin!

03.10.2022: Jason Denizot joined the group as a new PhD student. Dr. Zigmars Leitis joined the group for a visiting research stay. Welcome Jason and Zigmars!

16.09.2022: Adrien’s work on CAAC Transition-Metal Complexes is published in Organometallics. Congrats!

01.08.2022: Anastasiia Vorobei rejoined the group as a new PhD student. Welcome back Anastasiia!

10.05.2022: Ouidad research on merging CpxRh C-H activation and Cp*Ir reductive amination is published in ACS Catalysis. Congrats Ouidad, Dan and Coralie!

14.04.2022: Johannes and Lukasz’s work DAP-catalyzed radical cyclization is published in ACIE. Congrats!

01.03.2022: Kristers Ozols successfully defended his PhD thesis. Congrats Kristers!

01.03.2022: Géraldine Kiechler and Dagmara Maye joined the group for the their Master thesis.

14.02.2022: Johannes and Lukasz’s joined effort on DAP-catalyzed radical cyclization appeared on ChemRxiv. Congrats!

10.01.2022: Felix Seeberger joined the group as visiting PhD student. Welcome Felix!


P. Laveille, P. Miéville, S. Chatterjee, E. Clerc, J.-C. Cousty, F. de Nanteuil, E. Lam, E. Mariano, A. Ramirez, U. Randrianarisoa, K. Villat, C. Copéret, N. Cramer, Chimia 2023, 77, 154-158: “Swiss Cat+, a Data-driven Infrastructure for Accelerated Catalysts Discovery and Optimization”

M. D. Wodrich, R. Laplaza, N. Cramer, M. Reiher, C. Corminboeuf, Chimia 2023, 77, 139-143: “Toward in silico Catalyst Optimization”

Y.-X. Cao, M. D. Wodrich, N. Cramer, ChemRxiv, DOI: 10.26434/chemrxiv-2023-5dbsv-v2: Nickel-Catalyzed Direct Stereoselective Alpha-Allylation of Ketones with Non-conjugated Dienes”

G. Zhang, N. Cramer, Angew. Chem. Int. Ed. 2023, e202301076: “Reductive Asymmetric Aza-Mislow-Evans Rearrangement by 1,3,2-Diazaphospholene Catalysis”

A. Madron du Vigné, N. Cramer, Organometallics 2022, DOI: 10.1021/acs.organomet.2c00351: “Chiral Cyclic Alkyl Amino Carbene (CAAC) Transition-Metal Complexes: Synthesis, Structural Analysis, and Evaluation in Asymmetric Catalysis”

O. Lahtigui, D. Forster, C. Duchemin, N. Cramer, ACS Catal. 2022, DOI: 10.1021/acscatal.2c01827: Enantioselective Access to 3-Azabicyclo[3.1.0]hexanes by CpxRhIII Catalyzed C–H Activation and Cp*IrIII Transfer Hydrogenation

M. D. WodrichM. ChangS. GallaratiŁ. WoźniakN. CramerC. Corminboeuf, Chem. Eur. J. 2022, e202200399: “Mapping Catalyst-Solvent Interplay in CompetingCarboamination/Cyclopropanation Reactions”

J. Klett, L. Wozniak, N. Cramer, Angew. Chem. Int. Ed. 2022, e202202306, DOI:10.1002/anie.202202306: “1,3,2-Diazaphospholene-Catalyzed Reductive Cyclizations of Organohalides”

J.-F. Tan, C. T. Bormann, K. Severin, N. Cramer, Chem. Sci. 2022, DOI: 10.1039/D2SC00294A: Chemo and regiodivergent access to fluorinated 1alkyl and 1acyl triazenes from alkynyl triazenes”

E. Braconi, N. Cramer, Angew. Chem. Int. Ed. 2022, 61e202112148: “Crossed Regio- and Enantioselective Iron-Catalyzed [4+2]-Cycloadditions of Unactivated Dienes”

J. Mas-Rosello, N. Cramer, Chem. Eur. J. 2022, e202103683: “Catalytic reduction of oximes to hydroxylamines: current methods, challenges and opportunities”