Laboratory of Asymmetric Catalysis and Synthesis ‒

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Welcome to the Laboratory of Asymmetric Catalysis and Synthesis headed by Professor Nicolai Cramer. We are a young and dynamic research team working on challenges in the areas of asymmetric metal-catalyzed reactions and the synthesis of bioactive natural products.

LATEST NEWS

01.11.2022: Dagmara Maye rejoined the group as a PhD student. Dr. Lenin Verdhi joined the group as a new Postdoc. Welcome Dagmara and Lenin!

03.10.2022: Jason Denizot joined the group as a new PhD student. Dr. Zigmars Leitis joined the group for a visiting research stay. Welcome Jason and Zigmars!

16.09.2022: Adrien’s work on CAAC Transition-Metal Complexes is published in Organometallics. Congrats!

01.08.2022: Anastasiia Vorobei rejoined the group as a new PhD student. Welcome back Anastasiia!

10.05.2022: Ouidad research on merging CpxRh C-H activation and Cp*Ir reductive amination is published in ACS Catalysis. Congrats Ouidad, Dan and Coralie!

14.04.2022: Johannes and Lukasz’s work DAP-catalyzed radical cyclization is published in ACIE. Congrats!

01.03.2022: Kristers Ozols successfully defended his PhD thesis. Congrats Kristers!

01.03.2022: Géraldine Kiechler and Dagmara Maye joined the group for the their Master thesis.

14.02.2022: Johannes and Lukasz’s joined effort on DAP-catalyzed radical cyclization appeared on ChemRxiv. Congrats!!

10.01.2022: Felix Seeberger joined the group as visiting PhD student. Welcome Felix!

12.11.2021: Elena successfully defended her thesis. Congrats Elena!

03.11.2021: Jin Fay Tan successfully defended his thesis. Congrats Jin Fay!

28.10.2021: Elena’s work on crossed enantioselective iron-catalyzed [4+2]-cycloaddition is published in ACIE. Congrats!

01.10.2022: Ivan Cornu from Konrad Tiefenbachers’ group from Basel joined as visiting PhD student for a joined NCCR catalysis project. Welcome!

13.09.2021: Ana’s work on asymmetric Co(III)-catalyzed three-component C-H functionalizations is published in ACS Catal. Congrats!!

01.09.2021: Seongmin Jeon joined the group as a new PhD student. Welcome Seongmin!

22.06.2021: Lukasz Ir-catalyzed atropselective oxidative C-H arylation is published in ACIE. Congrats!

03.06.2021: Our longstanding collaboration with the Severin group on alkynyl triazenes resulted in another great result, see Chem Sci publication for Jin-Fay. Congrats!

28.04.2021: Qui-Hien Nguyen successfully defended his thesis. Congrats Hien!

23.04.2021: Josep’s full paper on iridium-catalyzed ionic hydrogenation of the Syngenta collaboration is published in ACIE. Congrats Josep and Tomas!

LATEST PUBLICATIONS

A. Madron du Vigné, N. Cramer, Organometallics 2022, DOI: 10.1021/acs.organomet.2c00351: “Chiral Cyclic Alkyl Amino Carbene (CAAC) Transition-Metal Complexes: Synthesis, Structural Analysis, and Evaluation in Asymmetric Catalysis”

O. Lahtigui, D. Forster, C. Duchemin, N. Cramer, ACS Catal. 2022, DOI: 10.1021/acscatal.2c01827: Enantioselective Access to 3-Azabicyclo[3.1.0]hexanes by CpxRhIII Catalyzed C–H Activation and Cp*IrIII Transfer Hydrogenation

M. D. WodrichM. ChangS. GallaratiŁ. WoźniakN. CramerC. Corminboeuf, Chem. Eur. J. 2022, e202200399: “Mapping Catalyst-Solvent Interplay in CompetingCarboamination/Cyclopropanation Reactions”

J. Klett, L. Wozniak, N. Cramer, Angew. Chem. Int. Ed. 2022, e202202306, DOI:10.1002/anie.202202306: “1,3,2-Diazaphospholene-Catalyzed Reductive Cyclizations of Organohalides”

J.-F. Tan, C. T. Bormann, K. Severin, N. Cramer, Chem. Sci. 2022, DOI: 10.1039/D2SC00294A: Chemo and regiodivergent access to fluorinated 1alkyl and 1acyl triazenes from alkynyl triazenes”

E. Braconi, N. Cramer, Angew. Chem. Int. Ed. 2022, 61e202112148: “Crossed Regio- and Enantioselective Iron-Catalyzed [4+2]-Cycloadditions of Unactivated Dienes”

J. Mas-Rosello, N. Cramer, Chem. Eur. J. 2022, e202103683: “Catalytic reduction of oximes to hydroxylamines: current methods, challenges and opportunities”

E. Braconi, N. Cramer, Angew. Chem. Int. Ed. 2021, DOI: 10.1002/anie.202112148: “Crossed Regio- and Enantioselective Iron-Catalyzed [4+2]-Cycloadditions of Unactivated Dienes”

A. G. Herraiz, N. Cramer, ACS Catal. 2021, DOI: 10.1021/acscatal.1c03153: “Cobalt(III)-Catalyzed Diastereo- and Enantioselective Three-Component C–H Functionalization”

L. Wozniak, N. Cramer, Angew. Chem. Int. Ed. 2021, 60, 18532-18536: “Atropo-Enantioselective Oxidation-Enabled Iridium(III)-Catalyzed C–H Arylations with Aryl Boronic Esters”