Welcome to the Laboratory of Asymmetric Catalysis and Synthesis (LCSA) headed by Professor Nicolai Cramer. We are a young and dynamic research team working on challenges in asymmetric metal-catalyzed reactions and the synthesis of bioactive natural products.
LATEST NEWS
29.09.2026: Vitalii’s development of an atroposelective Pd(0)-catalyzed direct intermolecular C─H arylation of thiazole N-oxides to provide access to heterobiaryls has been published in ACIE. Congratulations, Vitalii!
07.09.2026: Recent work on cobalt-catalyzed enantioselective intermolecular C–H carboamination with racemic allenes by Lenin can be found in JACS. Congrats!
13.07.2026: Arthur’s new publication on the iridium-catalyzed ionic hydrogenation of multi-aza heterocycles is now available in ACIE. Check it out!
08.06.2026: One of our more peculiar findings, Bram’s discovery of stable 16-electron chiral Cp cobalt complexes, is now available in Organometallics. Congrats for finishing the PhD with a paper hattrick!
22.04.2026: The core mission of Bram’s PhD, developing a combinatorial synthesis of highly tunable pentasubstituted chiral Cp ligands, has been successful and can now be found in JACS. Bravo!
02.02.2026: Erik joined the group as a new PhD student. Welcome to the LCSA, Erik!
09.01.2026: Bram’s development of a unified synthesis platform for structurally diverse 1,2,3-trisubstituted cyclopentadienyl ligands and their catalytically potent complexes has been published in JACS. Congratulations, Bram!
05.01.2026: Clara joined the group as a new PhD student. Welcome to the LCSA, Clara!
LATEST PUBLICATIONS
V. Small, N. Cramer, Angew. Chem. Int. Ed. 2026, e6888467: “Atroposelective Pd(0)-Catalyzed Direct Intermolecular C─H Arylation of Thiazole N-Oxides Provides Access to Heterobiaryls”
L. K. Verdhi, N. Cramer, J. Am. Chem. Soc. 2026, xxx, xxxxx-xxxxx: “Cobalt-Catalyzed Enantioselective Intermolecular C–H Carboamination with Racemic Allenes”
A. Despois, N. Cramer, Angew. Chem. Int. Ed. 2026, 65, e4341513: “Iridium-Catalyzed Ionic Hydrogenation of Multi-Aza Heterocycles”
B. Van Den Bossche, N. Cramer, Organometallics 2026, 45, 1333-1338: “Speciation of Bulky Chiral Cyclopentadienyl Cobalt(III) Complexes: Isolation of Air-Stable 16-Electron Species”
B. Van Den Bossche, N. Cramer, J. Am. Chem. Soc. 2026, 148, 18468-18481: “Modular Assembly of Chiral Cp* Clones Unlocks Performant Catalysts for Enantioselective C–H Functionalizations”
B. Van Den Bossche, N. Cramer, J. Am. Chem. Soc. 2026, 148, 3775-3787: “Unified Synthesis Platform for 1,2,3-Trisubstituted Cyclopentadienyl Ligands Decouples Sterics from Electronics”