Fellay Lab – Human Genomics of Infection and Immunity
We use large-scale genomics and bioinformatics to explore the impact of genetic variation on immune parameters and host-pathogen interactions. Our ambition is to shed new light on basic biological mechanisms and to pave the way toward more personalized approaches to medicine. At the crossroad between basic science and the clinical world, we are committed to translational genomic research, aiming at identifying, validating, and bringing to clinical use genetic markers of susceptibility to infectious diseases.
Learning how to control HIV from African genomes
A study on almost four thousand people of African descent has identified a gene that acts as natural defense against HIV by limiting its replication in certain white blood cells. An international effort co-led by EPFL, Canada’s National Microbiology Laboratory, and Imperial College London, it paves the way for new treatment strategies and underscores the importance of studying diverse ancestral populations to better address their specific medical needs and global health disparities.
Oral bacteria may increase heart disease risk
Researchers at EPFL have found that infection with a common bacterium that is linked to periodontal disease, oral cancers, and bad breath may cause a small increase in the risk of cardiovascular disease.
“Scientists can never make statements with 100% certainty”
EPFL professor Jacques Fellay, who served on the Swiss National Covid-19 Task Force, has been selected for a new advisory committee that the government set up recently so policymakers and scientists can continue their joint efforts.