Ultrasound-assisted gene therapy mitigates Leigh syndrome pathology

M. Faideau; R. Clément; S. Rigollet; G. Benegiamo; C. Cresson et al. 

An oral, liver-restricted LXR inverse agonist for dyslipidemia: preclinical development and phase 1 trial

X. Li; G. Benegiamo; A. Vijayakumar; N. SRODA; M. Kimura et al. 

Mitophagy in the pathogenesis and management of disease

Q. Wang; Y. Sun; T. Y. Li; J. Auwerx 

Genetic and dietary determinants of gut microbiome-bile acid interactions in the BXD genetic reference population

X. Li; A. Perino; J. Sulc; A. Jalil; G. von Alvensleben et al. 

A consensus guide to preclinical indirect calorimetry experiments

A. S. Banks; D. B. Allison; T. Alquier; Ansarullah; S. N. Austad et al. 

A Multiomic Network Approach to Uncover Disease Modifying Mechanisms of Inborn Errors of Metabolism

A. Bender; P. Ranea-Robles; E. G. Williams; M. Mirzaian; J. A. Heimel et al. 

A lysosomal surveillance response to stress extends healthspan

T. Y. Li; A. W. Gao; R. Yang; Y. Sun; Y. Lei et al. 

Porphyran from discolored nori prevents metabolic syndrome through microbiota-bile acid-ceramide pathway

Y. Yokoyama; Y. Takashina; J. D. Morel; T. Taworntawat; N. Kitamura et al. 

Age-associated nicotinamide adenine dinucleotide decline drives CAR-T cell failure

H. C. Hope; J. de Sostoa; P. Ginefra; M. Andreatta; Y-H. Chiang et al. 

NAD⁺ boosting increases atherosclerotic plaques and inflammation in Apoe knockout mice

Y. J. Wang; D. S. Gaul; E. Gorica; J. Pahla; Z. Wang et al. 

Plasmalogen remodeling modulates macrophage response to cytotoxic oxysterols and atherosclerotic plaque vulnerability

A. Jalil; T. Pilot; T. Bourgeois; A. Laubriet; X. Li et al. 

Delivery of A Chemically Modified Noncoding RNA Domain Improves Dystrophic Myotube Function

Z. Niasse-Sy; B. Zhao; A. Lenardic; H. T. T. Luong; O. Bar-Nur et al. 

ACMSD inhibition corrects fibrosis, inflammation, and DNA damage in MASLD/MASH

Y. J. Liu; M. Kimura; X. Li; J. Sulc; Q. Wang et al. 

The protein deacetylase SIRT2 exerts metabolic control over adaptive β cell proliferation

M. Wortham; B. Ramms; C. Zeng; J. R. Benthuysen; S. Sai et al. 

Herbal terpenoids activate autophagy and mitophagy through modulation of bioenergetics and protect from metabolic stress, sarcopenia and epigenetic aging

G. Civiletto; D. Brunetti; G. Lizzo; K. Muller; G. E. Jacot et al. 

Safe and Orally Bioavailable Inhibitor of Serine Palmitoyltransferase Improves Age-Related Sarcopenia

J. Poisson; I. Daskalaki; V. Potluri; J. D. Morel; S. Rodriguez-Lopez et al. 

The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research

S. Deota; J. S. Pendergast; U. Kolthur-Seetharam; K. A. Esser; F. Gachon et al. 

Mitochondrial genetics, signalling and stress responses

Y. J. Liu; J. Sulc; J. Auwerx 

Skin health and biological aging

D. Furman; J. Auwerx; A. L. Bulteau; G. Church; V. Couturaud et al. 

Genetic mapping of lifespan and mitochondrial stress response in C. elegans

J. Auwerx; X. Li; W. Li; A. Gao; Y. Zhu et al. 

Genetic Modulation of Lifespan: Dynamic Effects, Sex Differences, and Body Weight Trade-offs

D. Arends; D. G. Ashbrook; S. Roy; L. Lu; Z. Sloan et al. 

Endometrial NCOR1 Deficiency as a Contributor to Implantation Failure in Endometriosis-Related Infertility

L. T. K. Nguyen; D. N. Tran; J. Auwerx; H. Kumar; S. L. Young et al. 

Failure of metabolic checkpoint control during late-stage granulopoiesis drives neutropenia in reticular dysgenesis

W. Wang; M. Arreola; T. Mathews; A. DeVilbiss; Z. Zhao et al. 

Wars1 downregulation in hepatocytes induces mitochondrial stress and disrupts metabolic homeostasis

F. Pontanari; H. Demagny; A. Faure; X. Li; G. Benegiamo et al. 

High-content phenotypic analysis of a C. elegans recombinant inbred population identifies genetic and molecular regulators of lifespan

A. W. Gao; G. El Alam; Y. Zhu; W. Li; J. Sulc et al. 

Skeletal Muscle SIRT3 Deficiency Contributes to Pulmonary Vascular Remodeling in Pulmonary Hypertension Due to Heart Failure With Preserved Ejection Fraction

J. R. Jheng; Y. Bai; K. Noda; J. R. Huot; T. Cook et al. 

Targeting senescence induced by age or chemotherapy with a polyphenol-rich natural extract improves longevity and healthspan in mice

S. Zumerle; M. Sarill; M. Saponaro; M. Colucci; L. Contu et al. 

Systems genetics of metabolic health in the BXD mouse genetic reference population

X. Li; J. D. Morel; J. Sulc; A. De Masi; A. Lalou et al. 

Cyclo His-Pro Attenuates Muscle Degeneration in Murine Myopathy Models

A. De Masi; N. Zanou; K. Strotjohann; D. Lee; T. I. Lima et al. 

Hippo-YAP/TAZ signalling coordinates adipose plasticity and energy balance by uncoupling leptin expression from fat mass

S. Choi; J-G. Kang; Y. T. H. Tran; S-H. Jeong; K-Y. Park et al. 

Embracing cancer complexity: Hallmarks of systemic disease

C. Swanton; E. Bernard; C. Abbosh; F. Andre; J. Auwerx et al. 

Inhibition of SIRT7 overcomes sorafenib acquired resistance by suppressing ERK1/2 phosphorylation via the DDX3X-mediated NLRP3 inflammasome in hepatocellular carcinoma

Y. Kim; K-Y. Jung; Y. H. Kim; P. Xu; B. E. Kang et al. 

Loss of hepatic Sirt7 accelerates diethylnitrosamine (DEN)-induced formation of hepatocellular carcinoma by impairing DNA damage repair

Y. Kim; B. E. Kang; K. Gariani; J. Gariani; J. Lee et al. 

Drug Screening in C. elegans to identify new pharmacological mitochondrial stress inducers

Cellpose training data and scripts from “Inhibition of CERS1 in aging skeletal muscle exacerbates age-related muscle impairments”

M. Wohlwend; O. Burri; J. Auwerx 

Genetic and dietary modulators of the inflammatory response in the gastrointestinal tract of the BXD mouse genetic reference population

X. Li; J-D. H. Morel; G. Benegiamo; J. G. A. Poisson; A. Bachmann et al. 

Inhibition of CERS1 in skeletal muscle exacerbates age-related muscle dysfunction

M. Wohlwend; P-P. U. Laurila; L. Goeminne; T. Imamura de Lima; A. Lalou et al. 

Lysosomes mediate the mitochondrial UPR via mTORC1-dependent ATF4 phosphorylation

T. Y. Li; Q. Wang; A. W. Gao; X. Li; Y. Sun et al. 

Gene network based analysis identifies a coexpression module involved in regulating plasma lipids with high-fat diet response

F. Xu; J. Ziebarth; L. J. E. Goeminne; J. Gao; E. G. Williams et al. 

Cyclo(His-Pro): A further step in the management of steatohepatitis

A. De Masi; X. Li; D. Lee; J. Jeon; Q. Wang et al. 

Induction of mitochondrial recycling reverts age-associated decline of the hematopoietic and immune systems

M. Girotra; Y-H. Chiang; M. Charmoy; P. Ginefra; H. C. Hope et al. 

Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male mice

A. Park; K-e. Kim; I. Park; S. H. Lee; K-Y. Park et al. 

Inhibiting de novo ceramide synthesis restores mitochondrial and protein homeostasis in muscle aging

T. I. Lima; P-P. Laurila; M. Wohlwend; J. D. Morel; L. J. E. Goeminne et al. 

Upregulation of the ERR γ-VDAC1 axis underlies the molecular pathogenesis of pancreatitis

D. Chanda; T. Thoudam; I. S. Sinam; C. W. Lim; M. Kim et al. 

Mitochondria: A “pacemaker”for species-specific development

Y. J. Liu; J. Auwerx 

Hepatic lipid overload triggers biliary epithelial cell activation via E2Fs

E. Yildiz; G. El Alam; A. Perino; A. Jalil; P-D. Denechaud et al. 

Sodium ferrous citrate and 5-aminolevulinic acid improve type 2 diabetes by maintaining muscle and mitochondrial health

N. Kitamura; S. Zhang; J-D. Morel; U. Nagano; T. Taworntawat et al. 

The genetic background shapes the susceptibility to mitochondrial dysfunction and NASH progression

G. Benegiamo; G. V. G. von Alvensleben; S. Rodriguez-Lopez; L. J. E. Goeminne; A. M. Bachmann et al. 

Mitochondrial and NAD plus metabolism predict recovery from acute kidney injury in a diverse mouse population

J. -D. Morel; M. B. Sleiman; T. Y. Li; G. von Alvensleben; A. M. Bachmann et al. 

GPS2-mediated regulation of the adipocyte secretome modulates adipose tissue remodeling at the onset of diet-induced obesity

J. English; J. Orofino; C. T. Cederquist; I. Paul; H. Li et al. 

ACMSD INHIBITION REDUCES HEPATIC INFLAMMATION AND FIBROSIS IN A MURINE THERMONEUTRALITY MODEL OF NASH

Y. Liu; M. Kimura; S. Rodriguez-Lopez; A. M. L. Scantlebery; K. Strotjohann et al. 

INHIBITING SARM1 IS MORE EFFICACIOUS THAN NICOTINAMIDE RIBOSIDE SUPPLEMENTATION FOR THE TREATMENT OF A MOUSE MODEL WITH NAFLD/NASH

Y. Liu; A. M. L. Scantlebery; K. Strotjohann; S. Rodriguez-Lopez; X. Li et al. 

CycloZ reduces inflammation in bleomycin-induced idiopathic pulmonary fibrosis model mice.

S. Baek; D. Lee; J. Jeon; O. Park; X. Li et al. 

CycloZ improves pulmonary fibrosis in bleomycin-induced idiopathic pulmonary fibrosis model mice by modulating the pathogenic transcriptome.

D. Lee; J. Jeon; S. Baek; O. Park; X. Li et al. 

Mitophagy in human health, ageing and disease

A. Picca; J. Faitg; J. Auwerx; L. Ferrucci; D. D’Amico 

Identifying genetic and dietary modulators of metabolic disorders using systems genetics

Characterization of Cyclo His-Pro for the prevention and treatment of liver disease and muscular dystrophy

Tetracycline derivative induced mitohormesis mediates disease tolerance against viral infections

J. Auwerx; A. J. L. Mottis; M. Nelson 

Machine learning-derived gut microbiome signature predicts fatty liver disease in the presence of insulin resistance

B. E. Kang; A. Park; H. Yang; Y. Jo; T. G. Oh et al. 

SIRT7 suppresses energy expenditure and thermogenesis by regulating brown adipose tissue functions in mice

T. Yoshizawa; Y. Sato; S. U. Sobuz; T. Mizumoto; T. Tsuyama et al. 

Sphingolipids accumulate in aged muscle, and their reduction counteracts sarcopenia

P-P. Laurila; M. Wohlwend; T. I. de Lima; P. Luan; S. Herzig et al. 

V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans

T. Y. Li; A. W. Gao; X. Li; H. Li; Y. J. Liu et al. 

COX7A2L genetic variants determine cardiorespiratory fitness in mice and human

G. Benegiamo; M. B. Sleiman; M. Wohlwend; S. Rodriguez-Lopez; L. J. E. Goeminne et al. 

Integrative systems analysis identifies genetic and dietary modulators of bile acid homeostasis

H. Li; A. Perino; Q. Huang; G. V. G. Von Alvensleben; A. Banaei-Esfahani et al. 

Non-genomic activation of the AKT-mTOR pathway by the mitochondrial stress response in thyroid cancer

W. K. L. Doolittle; S. Park; S. G. Lee; S. Jeong; G. Lee et al. 

The Slc25a47 locus is a novel determinant of hepatic mitochondrial function implicated in liver fibrosis

N. Bresciani; H. Demagny; V. Lemos; F. Pontanari; X. Li et al. 

Sex- and age-dependent genetics of longevity in a heterogeneous mouse population

M. Bou Sleiman; S. Roy; A. W. Gao; M. C. Sadler; G. V. G. von Alvensleben et al. 

Tetracycline-induced mitohormesis mediates disease tolerance against influenza

A. Mottis; T. Y. Li; G. El Alam; A. Rapin; E. Katsyuba et al. 

Estrogen-related receptor gamma regulates mitochondrial and synaptic genes and modulates vulnerability to synucleinopathy

S. N. Fox; L. J. McMeekin; C. H. Savage; K. L. Joyce; S. M. Boas et al. 

Genetic background and sex control the outcome of high-fat diet feeding in mice

A. M. Bachmann; J-D. Morel; G. El Alam; S. Rodríguez-López; T. Imamura de lima et al. 

Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults

A. Singh; D. D’Amico; P. A. Andreux; A. M. Fouassier; W. Blanco-Bose et al. 

Sirtuin 7 Deficiency Reduces Inflammation and Tubular Damage Induced by an Episode of Acute Kidney Injury

A. Sanchez-Navarro; M. A. Martinez-Rojas; A. Albarran-Godinez; R. Perez-Villalva; J. Auwerx et al. 

Article Multi-omics analysis identifies essential regulators of mitochondrial stress response in two wild-type C. elegans strains

A. W. Gao; G. El Alam; A. Lalou; T. Y. Li; M. Molenaars et al. 

The mouse metallomic landscape of aging and metabolism

J-D. Morel; L. Sauzeat; L. J. E. Goeminne; P. Jha; E. Williams et al. 

Inhibition of sphingolipid de novo synthesis counteracts muscular dystrophy

P-P. Laurila; P. Luan; M. Wohlwend; N. Zanou; B. Crisol et al. 

eNAMPT actions through nucleus accumbens NAD + /SIRT1 link increased adiposity with sociability deficits programmed by peripuberty stress

L. Morató; S. Astori; I. Zalachoras; J. Rodrigues; S. Ghosal et al. 

ENHANCEMENT OF DE NOVO NAD plus BIOSYNTHESIS BY NOVEL ACMSD INHIBITORS IMPROVES MITOCHONDRIAL FUNCTION IN iPSC-DERIVED HUMAN LIVER ORGANOID MODELS OF STEATOHEPATITIS

Y. Liu; M. Kimura; A. Vijayakumar; E. Murakami; T. Takebe et al. 

The Genetic Background Shapes Disease Susceptibility And Reveals A Specific Role For Mitochondrial Dysfunction In The Progression From Nafld To Nash

G. Benegiamo; G. Von Alvensleben; Y. Liu; S. Rodriguez-Lopez; A. Bachmann et al. 

Cyclo (His-Pro) Prevents Diet-Induced Fatty Liver Disease

A. De Masi; Xiaoxu Li; Qi Wang; A. Mottis; A. Rapin et al. 

Pleiotropic effects of mitochondria in aging

T. Lima; T. Y. Li; A. Mottis; J. Auwerx 

The role of nicotinamide riboside metabolism in pancreatic beta cells

Products and methods for promoting myogenesis

M. Wohlwend; J. Auwerx; U. Wisløff; J. B. Moreira 

Acute RyR1 Ca2+ leak enhances NADH-linked mitochondrial respiratory capacity

N. Zanou; H. Dridi; S. Reiken; T. I. de Lima; C. Donnelly et al. 

The exercise-induced long noncoding RNA CYTOR promotes fast-twitch myogenesis in aging

M. Wohlwend; P-P. Laurila; K. William; M. Romani; T. Lima et al. 

GCN5 maintains muscle integrity by acetylating YY1 to promote dystrophin expression

G. C. Addicks; H. Zhang; D. Ryu; G. Vasam; A. E. Green et al. 

Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression

T. Hu; S. K. Shukla; E. Vernucci; C. He; D. Wang et al. 

Phalloidin Staining of Actin Filaments for Visualization of Muscle Fibers in Caenorhabditis elegans

M. Romani; J. Auwerx 

Gene-by-environment modulation of lifespan and weight gain in the murine BXD family

S. Roy; M. B. Sleiman; P. Jha; J. F. Ingels; C. J. Chapman et al. 

Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population

A. Singh; D. D’Amico; P. A. Andreux; G. Dunngalvin; T. Kern et al. 

Nicotinamide Riboside Enhances In Vitro Beta-adrenergic Brown Adipose Tissue Activity in Humans

E. B. M. Nascimento; M. P. B. Moonen; C. M. E. Remie; K. Gariani; J. A. Jorgensen et al. 

Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy

P. Luan; D. D’Amico; P. A. Andreux; P-P. Laurila; M. Wohlwend et al. 

SIRT7 modulates the stability and activity of the renal K-Cl cotransporter KCC4 through deacetylation

L. G. Noriega; Z. Melo; R. D. Rajaram; A. Mercado; A. R. Tovar et al. 

Differential roles of GDF15 and FGF21 in systemic metabolic adaptation to the mitochondrial integrated stress response

S. G. Kang; M. J. Choi; S-B. Jung; H. K. Chung; J. Y. Chang et al. 

A platform for experimental precision medicine: The extended BXD mouse family

D. G. Ashbrook; D. Arends; P. Prins; M. K. Mulligan; S. Roy et al. 

TGR5 Regulates Macrophage Inflammation in Nonalcoholic Steatohepatitis by Modulating NLRP3 Inflammasome Activation

Y. Shi; W. Su; L. Zhang; C. Shi; J. Zhou et al. 

Pharmacological and genetic perturbation establish SIRT5 as a promising target in breast cancer

Y. L. N. Abril; I. R. Fernandez; J. Y. Hong; Y-L. Chiang; D. A. Kutateladze et al. 

NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle

M. Romani; V. Sorrentino; C. Oh; H. Li; T. Imamura de Lima et al. 

TGR5/Cathepsin E signaling regulates macrophage innate immune activation in liver ischemia and reperfusion injury

H. Zhou; S. Zhou; Y. Shi; Q. Wang; S. Wei et al. 

Differential role of nicotinamide adenine dinucleotide deficiency in acute and chronic kidney disease

A. Faivre; E. Katsyuba; T. Verissimo; M. Lindenmeyer; R. D. Rajaram et al. 

Pancreatic Sirtuin 3 Deficiency Promotes Hepatic Steatosis by Enhancing 5-Hydroxytryptamine Synthesis in Mice With Diet-Induced Obesity

X. Ming; A. C. K. Chung; D. Mao; H. Cao; B. Fan et al. 

Impact of the Natural Compound Urolithin A on Health, Disease, and Aging

D. D’Amico; P. A. Andreux; P. Valdes; A. Singh; C. Rinsch et al. 

Genetic, metabolic, and molecular insights into the diverse outcomes of diet-induced obesity in mouse

Enhancing mitochondrial quality control to fight neuromuscular degeneration in aging and disease

Treatment and prevention of aging related-disease and/or aging by the inhibition of sphingolipids

P-P. Laurila; J. Auwerx 

Enoxacin induces oxidative metabolism and mitigates obesity by regulating adipose tissue miRNA expression

A. L. Rocha; T. I. de Lima; G. P. de Souza; R. O. Correa; D. L. Ferrucci et al. 

Inhibition of mitophagy drives macrophage activation and antibacterial defense during sepsis

D. Patoli; F. Mignotte; V. Deckert; A. Dusuel; A. Dumont et al. 

The Gene-Regulatory Footprint of Aging Highlights Conserved Central Regulators

M. B. Sleiman; P. Jha; R. Houtkooper; R. W. Williams; X. Wang et al. 

Asperuloside Improves Obesity and Type 2 Diabetes through Modulation of Gut Microbiota and Metabolic Signaling

A. Nakamura; Y. Yokoyama; K. Tanaka; G. Benegiamo; A. Hirayama et al. 

TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington’s disease models

R. N. Hegde; A. Chiki; L. Petricca; P. Martufi; N. Arbez et al. 

Macrophage NCOR1 Deficiency Ameliorates Myocardial Infarction and Neointimal Hyperplasia in Mice

L-J. Du; J-Y. Sun; W-C. Zhang; Y-L. Wang; H. Zhu et al. 

PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle

H. Yoon; J. B. Spinelli; E. Zaganjor; S. J. Wong; N. J. German et al. 

Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans

C. M. E. Remie; K. H. M. Roumans; M. P. B. Moonen; N. J. Connell; B. Havekes et al. 

Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age

D. Brigger; C. Riether; R. van Brummelen; K. I. Mosher; A. Shiu et al. 

Growth differentiation factor 15 protects against the aging-mediated systemic inflammatory response in humans and mice

J. S. Moon; L. J. E. Goeminne; J. T. Kim; J. W. Tian; S-H. Kim et al. 

Confounding factors from inducible systems for spatiotemporal gene expression regulation

R. C. I. Wuest; R. H. Houtkooper; J. Auwerx 

Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism

K. Williams; L. R. Ingerslev; J. Bork-Jensen; M. Wohlwend; A. N. Hansen et al. 

Gene replacement therapy provides benefit in an adult mouse model of Leigh syndrome

R. Reynaud-Dulaurier; G. Benegiamo; E. Marrocco; R. Al-Tannir; E. M. Surace et al. 

Evaluation of the NAD(+) biosynthetic pathway in ALS patients and effect of modulating NAD(+) levels in hSOD1-linked ALS mouse models

B. A. Harlan; K. M. Killoy; M. Pehar; L. Liu; J. Auwerx et al. 

Long noncoding RNA SNHG12 integrates a DNA-PK-mediated DNA damage response and vascular senescence

S. Haemmig; D. Yang; X. Sun; D. Das; S. Ghaffari et al. 

Nicotinamide Pathway-Dependent Sirt1 Activation Restores Calcium Homeostasis to Achieve Neuroprotection in Spinocerebellar Ataxia Type 7

C. A. Stoyas; D. D. Bushart; P. M. Switonski; J. M. Ward; A. Alaghatta et al. 

Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress

A. E. Dikalova; A. Pandey; L. Xiao; L. Arslanbaeva; T. Sidorova et al. 

Sirt6 deletion in bone marrow-derived cells increases atherosclerosis – Central role of macrophage scavenger receptor 1

T. Arsiwala; J. Pahla; L. J. van Tits; L. Bisceglie; D. S. Gaul et al. 

NCoR1 Protects Mice From Dextran Sodium Sulfate Induced Colitis by Guarding Colonic Crypt Cells From Luminal Insult

E. Mennillo; X. Yang; M. Paszek; J. Auwerx; C. Benner et al. 

A conserved role of CBP/p300 in mitochondrial stress response and longevity

J. Auwerx; T. Li 

Mouse Systems Genetics as a Prelude to Precision Medicine

H. Li; J. Auwerx 

NAD(+) homeostasis in health and disease

E. Katsyuba; M. Romani; D. Hofer; J. Auwerx 

Metabolic rescue of muscle and muscle stem cells in muscle disease

The Detection of Early Epigenetic Inheritance of Mitochondrial Stress in C. Elegans with a Microfluidic Phenotyping Platform

H. B. Atakan; K. S. Hof; M. Cornaglia; J. Auwerx; M. A. M. Gijs 

N-acetylaspartate availability is essential for juvenile survival on fat-free diet and determines metabolic health

D. C. Hofer; G. Zirkovits; H. J. Pelzmann; K. Huber; A. R. Pessentheiner et al. 

A biosensor for measuring NAD(+) levels at the point of care

Q. Yu; N. Pourmandi; L. Xue; C. Gondrand; S. Fabritz et al. 

Identifying gene function and module connections by the integration of multispecies expression compendia

H. Li; D. Rukina; F. P. A. David; T. Y. Li; C-M. Oh et al. 

Mitochondrial haplotypes affect metabolic phenotypes in the Drosophila Genetic Reference Panel

R. P. J. Bevers; M. Litovchenko; A. Kapopoulou; V. S. Braman; M. R. Robinson et al. 

Opposing action of NCoR1 and PGC-1 alpha in mitochondrial redox homeostasis

T. I. Lima; D. S. P. S. F. Guimaraes; A. G. Oliveira; H. Araujo; C. H. G. Sponton et al. 

Diet modulates cecum bacterial diversity and physiological phenotypes across the BXD mouse genetic reference population

M. E. Perez-Munoz; A. M. McKnite; E. G. Williams; J. Auwerx; R. W. Williams et al. 

Automated Platform for Long-Term Culture and High-Content Phenotyping of Single C. elegans Worms

H. B. Atakan; R. Xiang; M. Cornaglia; L. Mouchiroud; E. Katsyuba et al. 

Nuclear receptor corepressor 1 represses cardiac hypertrophy

C. Li; X-N. Sun; B-Y. Chen; M-R. Zeng; L-J. Du et al. 

The gut microbiota influences skeletal muscle mass and function in mice

S. Lahiri; H. Kim; I. Garcia-Perez; M. M. Reza; K. A. Martin et al. 

Cross-species functional modules link proteostasis to human normal aging

A. Komljenovic; H. Li; V. Sorrentino; Z. Kutalik; J. Auwerx et al. 

The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans

P. A. Andreux; W. Blanco-Bose; D. Ryu; F. Burdet; M. Ibberson et al. 

MicroRNA-382 silencing induces a mitonuclear protein imbalance and activates the mitochondrial unfolded protein response in muscle cells

D. Dahlmans; A. Houzelle; P. Andreux; X. Wang; J. A. Jorgensen et al. 

Autophagy regulates lipid metabolism through selective turnover of NCoR1

T. Saito; A. Kuma; Y. Sugiura; Y. Ichimura; M. Obata et al. 

Niacin: an old lipid drug in a new NAD(+) dress

M. Romani; D. C. Hofer; E. Katsyuba; J. Auwerx 

Mild inborn errors of metabolism in commonly used inbred mouse strains

J. Leandro; S. Violante; C. A. Argmann; J. Hagen; T. Dodatko et al. 

The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance

N. Vannini; V. Campos; M. Girotra; V. Trachsel; S. Rojas-Sutterlin et al. 

The nuclear receptor corepressor NCoR1 regulates hematopoiesis and leukemogenesis in vivo

X. Wan; L. Liu; P. Zhou; X. Hui; Q. He et al. 

The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging

D. D’Amico; A. Mottis; F. Potenza; V. Sorrentino; H. Li et al. 

Regulation of NAD plus biosynthesis pathway in chronic kidney disease

A. Faivre; A. Mottis; R. D. Rajaram; D. Legouis; M. Lindenmeyer et al. 

Inhibition of Mitophagy Triggers Classical Activation of Macrophages

D. Patoli; V. Deckert; A. Rieu; A. Dusuel; A. Jalil et al. 

Mitocellular communication: Shaping health and disease

A. Mottis; S. Herzig; J. Auwerx 

The virtuous cycle of human genetics and mouse models in drug discovery

J. H. Nadeau; J. Auwerx