EDBB Published theses

It is our pleasure to present the theses undertaken in the frame of the EPFL PhD Program in Biotechnology & Bioengineering.

2025

Multimodal Imaging Platform for Spatiotemporal Interrogation of Dynamics in Single Cells and Spheroids

S. Ansaryan / H. Altug (Dir.)  

Lausanne, EPFL, 2025. 

Rational cytokine and receptor engineering for enhanced safety and efficacy of cancer immunotherapy

L. Bonati / L. Tang; B. E. Ferreira De Sousa Correia (Dir.)  

Lausanne, EPFL, 2025. 

Towards Conformational Targeting of Alpha-Synuclein Fibrils

A. S. S. Z. M. Sadek / B. E. Ferreira De Sousa Correia; H. Lashuel (Dir.)  

Lausanne, EPFL, 2025. 

Next-generation in vitro liver models through stem cell-derived organoids and bioengineering

B. S. Elçi / M. Lütolf; K. Schoonjans (Dir.)  

Lausanne, EPFL, 2025. 

Exploring the Role of Unstable L-Forms in the Survival of Uropathogenic Escherichia coli Under Fosfomycin Exposure

F. Normandeau / J. McKinney; N. Dhar (Dir.)  

Lausanne, EPFL, 2025. 

Gravitational and acoustic micromanipulation platforms for high-content histological analysis of organoids and spheroids

E. Vuille-Dit-Bille / M. S. Sakar; G. Weder (Dir.)  

Lausanne, EPFL, 2025. 

Programmable supramolecular nanoarchitectures for targeting biological patterns

A. Kononenko / M. M. C. Bastings (Dir.)  

Lausanne, EPFL, 2025. 

Decoding single-cell heterogeneity and plasticity

W. Liu / B. Deplancke (Dir.)  

Lausanne, EPFL, 2025. 

Advancing high-resolution microscopes to enable time-lapse nano-characterization of pathogenic micro-organisms in-vitro

E. Braun / J. McKinney; G. Fantner (Dir.)  

Lausanne, EPFL, 2025. 

PURE system optimization and exploration of self-regeneration for synthetic cell applications

R. Bava Ganesh / S. Maerkl (Dir.)  

Lausanne, EPFL, 2025. 

Translational AI in Digital Health: Applications in Plant Disease Detection, Food Recognition, Postprandial Glycemic Response Forecasting and Musculoskeletal Modeling

S. P. Mohanty / M. Salathé (Dir.)  

Lausanne, EPFL, 2025. 

Droplet microfluidic platforms for multiplexed library-against-library antibody screening

L. Kolmar / C. Merten (Dir.)  

Lausanne, EPFL, 2025. 

Bioengineering of morphologically and functionally accurate in vitro intestinal models

J. J. Langer / M. Lütolf; K. Schoonjans (Dir.)  

Lausanne, EPFL, 2025. 

Computational Design of Protein Switches

S. M. Buckley / B. E. Ferreira De Sousa Correia (Dir.)  

Lausanne, EPFL, 2025. 

Mapping the Operative Space for Polymer-Biostabilized DNA Origami

H. J. Rodríguez Franco / M. M. C. Bastings (Dir.)  

Lausanne, EPFL, 2025. 

Soft microelectrode arrays for 3D in vitro brain models

E. Martinelli / S. Lacour (Dir.)  

Lausanne, EPFL, 2025. 

Heartbeat on repeat: noncanonical KZFP and its transposable element targets shape cardiac cell specification

D. Milovanovic / D. Trono (Dir.)  

Lausanne, EPFL, 2025. 

Experimental Characterization of an Adhesion GPCR Mechanotransduction

G. Gambardella / P. D. Barth; A. L. A. Persat (Dir.)  

Lausanne, EPFL, 2025. 

2024

Accessible and highly observable gastrointestinal organoid model systems for studying host-pathogen interactions

M. Hofer / M. Lütolf (Dir.)  

Lausanne, EPFL, 2024. 

Bioengineering functional organoid models across scales

T. Hübscher / M. Lütolf (Dir.)  

Lausanne, EPFL, 2024. 

Advancing Cell-Free Synthetic Biology: From sustained PURE protein synthesis to an isothermal one-pot DNA replication system

L. S. Grasemann / S. Maerkl (Dir.)  

Lausanne, EPFL, 2024. 

The Slc25a47-Wars1 locus: characterization of its role in metabolic homeostasis and stress pathways

F. Pontanari / K. Schoonjans (Dir.)  

Lausanne, EPFL, 2024. 

Exploring ion and analyte transport in beta-barrel forming biological nanopores

S. F. Mayer / M. Dal Peraro; A. Radenovic (Dir.)  

Lausanne, EPFL, 2024. 

Advancements in Nanomechanical Characterization and Biomolecular Imaging with Atomic force Microscopy

V. Cencen / G. Fantner (Dir.)  

Lausanne, EPFL, 2024. 

Single-cell analysis of the interactions between Mycobacterium tuberculosis and macrophages

O. Rutschmann / J. McKinney (Dir.)  

Lausanne, EPFL, 2024. 

Characterization of the gut-bone marrow axis through bile acid signaling

A. Alonso Calleja / K. Schoonjans; O. M. Naveiras Torres-Quiroga (Dir.)  

Lausanne, EPFL, 2024. 

Dielectrophoretic Manipulation of Biological Species: Novel Microfluidic Approaches to Study Cell-Cell Interactions and the Role of Alpha-Synuclein in Neurodegeneration

T. J. Ryser / C. Guiducci; H. Lashuel (Dir.)  

Lausanne, EPFL, 2024. 

ER+ breast cancer in 3D scaffold ex vivo for transcriptomics-based functional drug screening and personalized medicine

Y. Zhang / C. Brisken; C. Merten (Dir.)  

Lausanne, EPFL, 2024. 

Engineering Split HaloTag for Advanced Fluorescence Microscopy

Y-H. Lin / K. Johnsson (Dir.)  

Lausanne, EPFL, 2024. 

Development and evaluation of a near-infrared photovoltaic implant for wireless neural stimulation

D. I. Medagoda / S. Lacour; D. Ghezzi (Dir.)  

Lausanne, EPFL, 2024. 

Unraveling behavior and cortical signals to guide the development of soft neuroprostheses for auditory restoration and spreading depolarization

E. C. M. Revol / S. Lacour (Dir.)  

Lausanne, EPFL, 2024. 

Targeting Cellular Senescence and NAD+ Metabolism Disruption in Early-Stage Chronic Kidney Disease

L. C. Chanvillard / J. Feige; K. Schoonjans (Dir.)  

Lausanne, EPFL, 2024. 

Drug Screening in C. elegans to identify new pharmacological mitochondrial stress inducers

A. Lalou / J. Auwerx (Dir.)  

Lausanne, EPFL, 2024. 

Exploring the therapeutic potential of Huntingtin native state stabilization through targeting its interacting partners

E. Morro / H. Lashuel (Dir.)  

Lausanne, EPFL, 2024. 

Multi-motif scaffolding for de novo pathogen antigen mimetics by deep generative learning

K. M. Castro Gilabert / B. Correia (Dir.)  

Lausanne, EPFL, 2024. 

Engineering novel protein interactions with therapeutic potential using deep learning-guided surface design

A. Marchand / B. E. Ferreira De Sousa Correia (Dir.)  

Lausanne, EPFL, 2024. 

Targeting TDP-43 Proteinopathies in Neurodegeneration by its Native-State Stabilization

L. Yang / H. Lashuel (Dir.)  

Lausanne, EPFL, 2024. 

Quantitative characterization of the inorganic phosphate gene regulatory networks in S. cerevisiae and bottom up engineering an orthogonal gene network

S. Cheng / S. Maerkl (Dir.)  

Lausanne, EPFL, 2024. 

Resolving bacterial cell biology: from replisome dynamics to cell wall synthesis

C. Zhang / S. Manley (Dir.)  

Lausanne, EPFL, 2024. 

Unraveling mitochondrial dynamics: exploring asymmetries and function through advanced microscopy

J. H. B. Winter / S. Manley (Dir.)  

Lausanne, EPFL, 2024. 

2023

Exploring the interplay of molecular pattern and valency for selective interactions at the bio-interface

K. Paloja / M. M. C. Bastings (Dir.)  

Lausanne, EPFL, 2023. 

Development of new volcano-shaped microelectrodes for single cell electrochemistry, electrophysiology and impedance studies

N. G. Maïno / P. Renaud; A. Bertsch (Dir.)  

Lausanne, EPFL, 2023. 

Nanotechnology enabled modulation of T cell immunity for cancer treatment

X. Hu / L. Tang (Dir.)  

Lausanne, EPFL, 2023. 

Advancing atomic force microscopy through open source instrumentation

M. Kangül / G. Fantner (Dir.)  

Lausanne, EPFL, 2023. 

Bioengineering human mini-intestines with in vivo-like complexity and function

O. Mitrofanova / M. Lütolf (Dir.)  

Lausanne, EPFL, 2023. 

The Effects of Spatial Organization and Fluid Flow on the Social Interactions in Microbial Communities

J. P. H. Wong / A. L. A. Persat; T. I. Battin (Dir.)  

Lausanne, EPFL, 2023. 

Engineering Hydrogel-coated Neural Interfaces for Chronic Deep Brain Recording

N. S. A. Alwahab / S. Lacour (Dir.)  

Lausanne, EPFL, 2023. 

Compliance-matching vascular grafts with personalization potential

G. Rovas / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2023. 

Bacterial colonization in realistic environments: how mechanics impact biofilm formation in the wild and during infection

T. Rossy / A. L. A. Persat (Dir.)  

Lausanne, EPFL, 2023. 

Engineering Innate and Adaptive Immunity for Enhanced Cancer Immunotherapy

M. Gao / L. Tang (Dir.)  

Lausanne, EPFL, 2023. 

Novel quantitative bioengineered tools to track human bone marrow niche cellular constituents in health and disease

R. Sarkis / B. Deplancke; O. M. Naveiras Torres-Quiroga (Dir.)  

Lausanne, EPFL, 2023. 

Characterization of Cyclo His-Pro for the prevention and treatment of liver disease and muscular dystrophy

A. De Masi / J. Auwerx (Dir.)  

Lausanne, EPFL, 2023. 

Tracking spatiotemporal localisation and interactions of the innate immune sensor STING

S. M. E. Rivara / A. Ablasser (Dir.)  

Lausanne, EPFL, 2023. 

Cross-anatomical single-cell definition and characterization of human adipose progenitor niche

R. Ferrero / B. Deplancke (Dir.)  

Lausanne, EPFL, 2023. 

Identifying genetic and dietary modulators of metabolic disorders using systems genetics

X. Li / J. Auwerx (Dir.)  

Lausanne, EPFL, 2023. 

How are cells instructed to form somite boundaries by the zebrafish segmentation clock?

O. F. Venzin / A. C. Oates (Dir.)  

Lausanne, EPFL, 2023. 

Label-free plasmonic microarray for multiplexed analysis of cells and tumor organoids

Y-C. Liu / H. Altug (Dir.)  

Lausanne, EPFL, 2023. 

Countering T cell exhaustion and senescence for enhanced adoptive T cell therapies against solid tumors

Y. Zhao / L. Tang (Dir.)  

Lausanne, EPFL, 2023. 

Time-Resolved Scanning Ion Conductance Microscopy and Single-Molecule Spectroscopy

S. Mendes Leitão / G. Fantner (Dir.)  

Lausanne, EPFL, 2023. 

2022

Sensor-integrated ultraflexible endovascular devices

L. F. Pancaldi-Giubbini / M. S. Sakar (Dir.)  

Lausanne, EPFL, 2022. 

In vitro endoderm emergence and self-organisation in the absence of extraembryonic tissues and embryonic architecture

S. D. Vianello / M. Lütolf (Dir.)  

Lausanne, EPFL, 2022. 

Hunting for the wavefront: investigation of somite boundary positioning in zebrafish

A. Bercowsky Rama / A. C. Oates (Dir.)  

Lausanne, EPFL, 2022. 

Engineering T Cell Trafficking and Function for Enhanced Cancer Immunotherapy

Y. Xie / L. Tang (Dir.)  

Lausanne, EPFL, 2022. 

Understanding the mechanisms of non-thermal plasma treatments on seeds

A. Waskow / I. Furno (Dir.)  

Lausanne, EPFL, 2022. 

Identification of genes required for host-cell adhesion and antibiotic persistence of uropathogenic Escherichia coli via high-content screening

T. M. Simonet / J. McKinney (Dir.)  

Lausanne, EPFL, 2022. 

Dissecting the role of biliary epithelial cells during non-alcoholic fatty liver disease progression

E. Yildiz / K. Schoonjans (Dir.)  

Lausanne, EPFL, 2022. 

Molecular Regulation of Muscle Stem Cell Fate during Skeletal Muscle Regeneration and Aging

S. Ancel / J. Feige; B. Deplancke (Dir.)  

Lausanne, EPFL, 2022. 

Development of a Transient Neural Interface for Minimally Invasive Recording and Stimulation

A. Fanelli / D. Ghezzi (Dir.)  

Lausanne, EPFL, 2022. 

Multidisciplinary Investigation of the Gut-Brain Ecosystem in a Model of Alzheimer’s Disease

A. L. Planchette / A. Radenovic; A. J. Macpherson (Dir.)  

Lausanne, EPFL, 2022. 

Systematic analysis of biomolecular binding reactions using microfluidic systems

A. Shahein / S. Maerkl (Dir.)  

Lausanne, EPFL, 2022. 

Towards automating de novo protein design for novel functionalities: controlling protein folds and protein-protein interactions

Z. Harteveld / B. E. Ferreira De Sousa Correia (Dir.)  

Lausanne, EPFL, 2022. 

Fabrication and validation of an intraneural interface tailored for optic nerve stimulation

E. Borda / D. Ghezzi (Dir.)  

Lausanne, EPFL, 2022. 

Characterization of Pseudomonas aeruginosa mechanosensing through label-free imaging of type IV pili

L. A-L. Talà / A. L. A. Persat (Dir.)  

Lausanne, EPFL, 2022. 

DNA-based biomaterials for nanoscale controlled modulation of immune cells

A. Comberlato / M. M. C. Bastings (Dir.)  

Lausanne, EPFL, 2022. 

Rational design of protein switches: applications in synthetic biology and cancer immunotherapy

S. Shui / B. E. Ferreira De Sousa Correia (Dir.)  

Lausanne, EPFL, 2022. 

Targeting molecular surfaces to engineer novel protein-based immunogens and inhibitors

S. Wehrle / B. E. Ferreira De Sousa Correia (Dir.)  

Lausanne, EPFL, 2022. 

Dissecting the role of the asparagine synthesis in acute liver injury

Y. Sun / K. Schoonjans (Dir.)  

Lausanne, EPFL, 2022. 

Engineering synthetic adhesins for biophysical investigation and rewiring of host-microbe interactions

X. J-Y. Pierrat / A. L. A. Persat (Dir.)  

Lausanne, EPFL, 2022. 

Methods for acute and long-term imaging of the ventral nerve cord in behaving adult Drosophila

L. J. Hermans / P. P. Ramdya; M. S. Sakar (Dir.)  

Lausanne, EPFL, 2022. 

2021

Microtissue models for studying the dynamics of host-pathogen interactions in the urinary bladder

K. Sharma / J. McKinney; N. Dhar (Dir.)  

Lausanne, EPFL, 2021. 

On the exploration of novel methodological approaches for immunogen design: case studies in influenza and hepatitis C

A. Scheck / B. E. Ferreira De Sousa Correia (Dir.)  

Lausanne, EPFL, 2021. 

Towards engineering an artificial neural tube

J. Park / M. Lütolf (Dir.)  

Lausanne, EPFL, 2021. 

Mechanical principles of engineering fibrous tissues with programmable shape

E. Mailand / M. S. Sakar (Dir.)  

Lausanne, EPFL, 2021. 

Single-cell lipidomics reveals a role for cell-to-cell sphingolipid heterogeneity in fibroblast activation

L. Capolupo / G. D’Angelo (Dir.)  

Lausanne, EPFL, 2021. 

Non-invasive monitoring of key hemodynamical and cardiac parameters using physics-based modelling and artificial intelligence

V. Bikia / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2021. 

Towards an artificial cell: Development of a system which self-regenerates the protein components of the PURE system in microfluidic reactors

B. Lavickova / S. Maerkl (Dir.)  

Lausanne, EPFL, 2021. 

Enhancing mitochondrial quality control to fight neuromuscular degeneration in aging and disease

M. Romani / J. Auwerx (Dir.)  

Lausanne, EPFL, 2021. 

An autonomous microfluidic device for identification and analysis of individual clinically-relevant mammalian cells

F. L. C. R. Jammes / S. Maerkl (Dir.)  

Lausanne, EPFL, 2021. 

Wireless soft microscale actuators and robotic devices to study mechanobiology

R. F. Penacho Parreira / M. S. Sakar (Dir.)  

Lausanne, EPFL, 2021. 

Coordination between cell growth, division and chromosome replication cycles in mycobacteria

G. M. Vuaridel / J. McKinney; N. Dhar (Dir.)  

Lausanne, EPFL, 2021. 

Towards scalable and deterministic single cell gene expression profiling

J. J. Bues / B. Deplancke (Dir.)  

Lausanne, EPFL, 2021. 

The genetic architecture of complex human traits at the dawn of genomic medicine

O. N. M. Naret / J. Fellay (Dir.)  

Lausanne, EPFL, 2021. 

In situ photopolymerizable hydrogels for intracranial aneurysms treatment

O. Poupart / D. Pioletti; C. Moser (Dir.)  

Lausanne, EPFL, 2021. 

Engineering next generation organoids through guided stem cell self-organisation

M. Nikolaev / M. Lütolf (Dir.)  

Lausanne, EPFL, 2021. 

Developing new tools to study and program cell fate at the single-cell level

M. Biocanin / B. Deplancke (Dir.)  

Lausanne, EPFL, 2021. 

Toward a mechanistic understanding of variable chromatin modules

G. Llimos Aubach / B. Deplancke (Dir.)  

Lausanne, EPFL, 2021. 

Microfluidics and cell-free synthetic biology in the development of new diagnostic and therapeutic platforms

G. Michielin / S. Maerkl (Dir.)  

Lausanne, EPFL, 2021. 

Biophysical applications of correlative scanning probe and super-resolution microscopy

V. Navikas / A. Radenovic (Dir.)  

Lausanne, EPFL, 2021. 

Post-translational regulation of neuronal differentiation

J. S. Loomba / G. D’Angelo (Dir.)  

Lausanne, EPFL, 2021. 

KRAB zinc finger protein-mediated control of transposon-embedded regulatory sequences from human germline to early embryos

A. Iouranova / D. Trono; P. Turelli (Dir.)  

Lausanne, EPFL, 2021. 

Decoding of error-related potentials in continuous feedback protocols for personalized human computer interaction

F. Iwane / A. Billard; J. d. R. Millán Ruiz (Dir.)  

Lausanne, EPFL, 2021. 

Genetic, metabolic, and molecular insights into the diverse outcomes of diet-induced obesity in mouse

A. M. Bachmann / J. Auwerx (Dir.)  

Lausanne, EPFL, 2021. 

Organisation and dynamics of mitochondria and their RNA.

T. H. R. Rey / S. Manley (Dir.)  

Lausanne, EPFL, 2021. 

Reprogramming G Protein-Coupled Receptor Structure, Function And Signaling By Computational Design

D. Kéri / P. D. Barth (Dir.)  

Lausanne, EPFL, 2021. 

Circadian dynamics of RNA localisation in the mammalian liver

C. Y. S. Hurni / F. Naef (Dir.)  

Lausanne, EPFL, 2021. 

Development and applications of hyperpolarized 13C and 1H MR spectroscopy of cerebral metabolism at ultra-high field

E. I. Flatt / R. Gruetter (Dir.)  

Lausanne, EPFL, 2021. 

Co-regulation of endothelial and myogenic cell fates through intercellular crosstalk in skeletal muscle

U. Lee / J. Feige; B. D. Cosgrove (Dir.)  

Lausanne, EPFL, 2021. 

2020

Development of novel methods and tools to decipher the huntingtin post-translation modifications code

A. Chiki / H. Lashuel (Dir.)  

Lausanne, EPFL, 2020. 

Gait analysis in children with cerebral palsy: bridging the gap between the laboratory and real life

L. Carcreff / K. Aminian; S. Armand (Dir.)  

Lausanne, EPFL, 2020. 

Metabolic rescue of muscle and muscle stem cells in muscle disease

P. Luan / J. Auwerx (Dir.)  

Lausanne, EPFL, 2020. 

Multidisciplinary Approach to Treat Erectile Dysfunction

M. N. Sturny / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2020. 

Sensor and the Beast: Generalised Methods to Recognise Animal Behaviour and Quantify Energy Expenditure Using Inertial Sensors, and Applications

P. Chakravarty / K. Aminian (Dir.)  

Lausanne, EPFL, 2020. 

Characterization of Protein-Membrane Interfaces through a Synergistic Computational-Experimental Approach

A. Prunotto / M. Dal Peraro (Dir.)  

Lausanne, EPFL, 2020. 

Hemodynamics of ageing, ventricular-arterial coupling and noninvasive assessment of key hemodynamical and cardiac quantities

S. Z. Pagoulatou / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2020. 

Beneficial axis of the renin-angiotensin system: from applications to drug discovery

M. Bragina / N. Stergiopulos; M. Dal Peraro (Dir.)  

Lausanne, EPFL, 2020. 

Microfluidic devices for the study of cell-cell, cell-particle and particle-particle interactions

M. C. M. Duchamp / P. Renaud; A. Harari (Dir.)  

Lausanne, EPFL, 2020. 

Quantitative approaches to unravel bone marrow adipocyte site-specificity and its implication in hematopoiesis

J. C. P. Tratwal / O. M. Naveiras Torres-Quiroga (Dir.)  

Lausanne, EPFL, 2020. 

Bioengineering Methods to Improve in vitro Adoptive Cell Therapy based on Tumor-Infiltrating Lymphocytes

F. R. Rivest / M. Lütolf; L. L. Sohn (Dir.)  

Lausanne, EPFL, 2020. 

Microfluidic iMITOMI platform to study the architecture of low-affinity transcription factor binding site clusters

I. Istomin / S. Maerkl (Dir.)  

Lausanne, EPFL, 2020. 

High-throughput microfluidic platforms for characterizing and engineering cell-free gene regulatory circuits

Z. N. Swank / S. Maerkl (Dir.)  

Lausanne, EPFL, 2020. 

In vitro modeling of early mouse development

M. U. Girgin / M. Lütolf (Dir.)  

Lausanne, EPFL, 2020. 

Functional de novo Protein Design for Targeted Vaccines and Synthetic Biology Applications

C. Yang / B. E. Ferreira De Sousa Correia (Dir.)  

Lausanne, EPFL, 2020. 

Time-lapse high-resolution microscopy to study the morphogenesis of microorganisms

M. T. M. Hannebelle / G. Fantner; J. McKinney (Dir.)  

Lausanne, EPFL, 2020. 

2019

Microchannel-based technologies for nerve interfacing

S. Gribi / S. Lacour (Dir.)  

Lausanne, EPFL, 2019. 

Expanding beyond the natural protein repertoire to engineer targeted vaccines and diagnostics

F. Sesterhenn / B. E. Ferreira De Sousa Correia (Dir.)  

Lausanne, EPFL, 2019. 

Optical projection tomography for whole organ imaging

D. Nguyen / T. Lasser; D. N. A. Van De Ville (Dir.)  

Lausanne, EPFL, 2019. 

Application of anti-amyloid beta immunization using encapsulated cell technology in mouse models of Alzheimer’s disease

V. Laversenne / B. Schneider; P. Aebischer (Dir.)  

Lausanne, EPFL, 2019. 

Modeling hematopoietic stem cell dynamics in bioengineered niches

S. Giger / M. Lütolf (Dir.)  

Lausanne, EPFL, 2019. 

Structural and functional characterisation of the KRAB-domain associated protein 1

G. Fonti / M. Dal Peraro (Dir.)  

Lausanne, EPFL, 2019. 

The role of OCT4 and SOX2 in regulating chromatin accessibility and cell fate across the cell cycle in embryonic stem cells

T. E. Friman / D. M. Suter (Dir.)  

Lausanne, EPFL, 2019. 

Elucidating regulatory mechanisms shaping the transcriptome and proteome of the gut immune response in Drosophila melanogaster

M. V. Frochaux / B. Deplancke (Dir.)  

Lausanne, EPFL, 2019. 

Single-cell studies of Mycobacterium smegmatis cell cycle using time-lapse fluorescence microscopy

J. X. Y. Ven / J. McKinney (Dir.)  

Lausanne, EPFL, 2019. 

Tailoring the Mechanical Properties of Tissue Engineering Scaffolds made from Decellularized Cartilage

J. Antons / D. Pioletti; L. A. Laurent-Applegate (Dir.)  

Lausanne, EPFL, 2019. 

Bioengineering human bone marrow models to elucidate the triggers of the stem cell niche

Q. Vallmajó Martín / M. Lütolf; M. Ehrbar (Dir.)  

Lausanne, EPFL, 2019. 

Bioengineering the Human Muscle Stem-Cell Niche for Therapeutic Applications

O. Mashinchian / J. Feige; M. Lütolf (Dir.)  

Lausanne, EPFL, 2019. 

Label-free plasmonic biosensors for real-time live cell analysis

X. Li / H. Altug (Dir.)  

Lausanne, EPFL, 2019. 

Engineering Dynamic Hydrogels For In Vitro Organoid Culture

D. L. P. Blondel / M. Lütolf (Dir.)  

Lausanne, EPFL, 2019. 

Soft multimodal neural interfaces for unravelling sensory neurological circuits

F. P. G. Michoud / S. Lacour (Dir.)  

Lausanne, EPFL, 2019. 

Metabolic and microenvironmental strategies to accelerate hematopoietic recovery post-aplasia

V. Ledebur de Antas de Campos / O. M. Naveiras Torres-Quiroga (Dir.)  

Lausanne, EPFL, 2019. 

2D nanopores: fabrication, energy harvesting and field-effect sensing

M. Graf / A. Radenovic (Dir.)  

Lausanne, EPFL, 2019. 

Characterization of Coenzyme Q Biosynthesis Proteins through Integrative Modeling at the Protein-Membrane Interface

D. Aydin / M. Dal Peraro (Dir.)  

Lausanne, EPFL, 2019. 

Anti-angiogenic immunotherapy for lung cancer

E. Kadioglu / M. De Palma (Dir.)  

Lausanne, EPFL, 2019. 

The onset of cardiovascular disease in mice: an image-based, computational-experimental approach

L. Aslanidou / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2019. 

Integrated microfluidic tools for the characterization of protein/DNA interactions in vitro and in vivo

R. Dainese / B. Deplancke (Dir.)  

Lausanne, EPFL, 2019. 

Tissue-specific circadian transcriptional regulation

J. Yeung / F. Naef (Dir.)  

Lausanne, EPFL, 2019. 

2018

Advancing immunotherapy for HPV-related cancers: Improving therapeutic vaccination approaches and understanding the immunosuppressive role of myeloid cells

G. Galliverti / M. Swartz; D. Hanahan (Dir.)  

Lausanne, EPFL, 2018. 

Likelihood-free Inference of Population Genetic Parameters from Time-Sampled Genetic Data

H. Shim / F. G. van der Goot Grunberg (Dir.)  

Lausanne, EPFL, 2018. 

New roles of the lymphatic endothelium in modulating adaptive immunity: implications for immune tolerance and cancer immunotherapy

L. C. F. Potin / M. Swartz; D. Hanahan (Dir.)  

Lausanne, EPFL, 2018. 

Constrained optimization applied to multiscale integrative modeling

G. E. Tamo / M. Dal Peraro (Dir.)  

EPFL, 2018. 

Single-cell division and killing dynamics of bacteria exposed to isocratic and time-dependent concentrations of antibiotic

K. E. Schneider / J. McKinney; N. Dhar (Dir.)  

Lausanne, EPFL, 2018. 

In vitro fate mapping of stem cell development at the single cell level

V. Trachsel / M. Lütolf (Dir.)  

Lausanne, EPFL, 2018. 

Mid-Infrared plasmonic nanoantennas for ultrasensitive detection of proteins and their secondary structure

D. Etezadi / H. Altug (Dir.)  

Lausanne, EPFL, 2018. 

Circadian clock- and feeding-dependent regulation of translation initiation and elongation in the liver

C. A. Gobet / F. Naef; K. Sakamoto (Dir.)  

Lausanne, EPFL, 2018. 

Computational and Statistical analyses of Molecular Evolution and Demography using Large-scale Sequencing Data

A. Kapopoulou / B. Deplancke; J. D. Jensen (Dir.)  

Lausanne, EPFL, 2018. 

More Medicines for Tuberculosis: Fuelling Drug Discovery against Mycobacterium tuberculosis

S-Y. C. Foo / S. Cole (Dir.)  

Lausanne, EPFL, 2018. 

Quantitative analysis of gene expression and transcriptional memory in mouse embryonic stem cells

A. Mandic / D. M. Suter (Dir.)  

Lausanne, EPFL, 2018. 

Ultra high magnetic field for glial contribution into brain metabolism studied by MR spectroscopy and CEST methods for molecular imaging of glycogen

E. M. C. Vinckenbosch / R. Gruetter (Dir.)  

Lausanne, EPFL, 2018. 

What is the role of fish intestine as environment-organism barrier? Mechanistic investigations using fish intestinal cells on a chip

C. Drieschner / P. Renaud; K. Schirmer (Dir.)  

Lausanne, EPFL, 2018. 

Quantitative single cell dynamics of signaling and transcriptional response in mammalian cells

O. Tidin / D. M. Suter; F. Naef (Dir.)  

Lausanne, EPFL, 2018. 

Genetic determinants of healthy human immune variance: from humoral response to microbiome diversity

P. Scepanovic / J. Fellay; B. Deplancke (Dir.)  

Lausanne, EPFL, 2018. 

Modeling and analysis of parts and devices of genetic regulation

Y. Berset / V. Hatzimanikatis; J. R. van der Meer (Dir.)  

Lausanne, EPFL, 2018. 

The phenotypic impact of naturally occurring genetic and molecular mitochondrial variation in a Drosophila Genetic Reference Population

R. P. J. Bevers / B. Deplancke (Dir.)  

Lausanne, EPFL, 2018. 

Electronic dura mater soft, multimodal neural interfaces : technology, integration and implementation to surface implants

A. E. Hirsch / S. Lacour (Dir.)  

Lausanne, EPFL, 2018. 

Novel tools to dissect stem cell metabolism at single cell level

G. Nikitin / M. Lütolf; A. Meibom (Dir.)  

Lausanne, EPFL, 2018. 

Quantitative analysis of SOX2 and OCT4 expression in pluripotency and differentiation

D. Strebinger / D. M. Suter (Dir.)  

Lausanne, EPFL, 2018. 

Development of microfluidic tools and methods for the biochemical characterization of scFv and Cas9 affinity reagents and their applications in molecular detection

E. E. Petrova / S. Maerkl (Dir.)  

Lausanne, EPFL, 2018. 

Introducing tolerance to foreign and partly foreign proteins by erythrocyte binding and artificial glycosylations

K. L. Brünggel / M. Lütolf; J. A. Hubbell (Dir.)  

EPFL, 2018. 

Mitochondrial stress signalling and its impacts on physiology

A. J. L. Mottis / J. Auwerx (Dir.)  

Lausanne, EPFL, 2018. 

2017

Exploring the potency of normal and pathological human thymic epithelial cells

T. M. C. Arlabosse / Y. Barrandon (Dir.)  

Lausanne, EPFL, 2017. 

Advanced technologies to control stem-cell based organogenesis

N. Brandenberg / M. Lütolf (Dir.)  

Lausanne, EPFL, 2017. 

Microfluidic and Electrokinetic Manipulation of Single Cells

S. Kilchenmann / C. Guiducci (Dir.)  

Lausanne, EPFL, 2017. 

Group Decisions Influence Emergence and Regulation of Leaders during Collective Migration of Epithelial Cells

M. Vishwakarma / J. A. Hubbell; J. Spatz (Dir.)  

Lausanne, EPFL, 2017. 

A Microfluidic Platform Enables Large-Scale Single-Cell Screening to Identify Genes Involved in Bacterial Persistence

A. Verpoorte / J. McKinney; S. Maerkl (Dir.)  

Lausanne, EPFL, 2017. 

Role of ACMSD in regulation of NAD+ metabolism and mitochondrial function

E. Katsyuba / J. Auwerx (Dir.)  

Lausanne, EPFL, 2017. 

Computational methods and modeling of cellular function for the optimization of protein production and the study of cellular disease states

J. R. Pinto Vieira / V. Hatzimanikatis (Dir.)  

Lausanne, EPFL, 2017. 

Regulation of Endoplasmic Reticulum Architecture by Protein S-Palmitoylation

P. A. Sandoz / F. G. van der Goot Grunberg (Dir.)  

Lausanne, EPFL, 2017. 

Lipid membrane characterization with second harmonic scattering : surface potentials, ionization, membrane asymmetry and hydration

C. U. Lütgebaucks / S. Roke (Dir.)  

Lausanne, EPFL, 2017. 

Novel systems biology approaches for design and analysis of palmitoylation networks reveal its regulatory effects on protein stability, activity and localization

T. Dallavilla / V. Hatzimanikatis; F. G. van der Goot Grunberg (Dir.)  

Lausanne, EPFL, 2017. 

AAV based gene therapy for rare diseases : targeting astrocytes for functional recovery in Amyotrophic Lateral Sclerosis

C. C. Rochat / P. Aebischer; B. Schneider (Dir.)  

Lausanne, EPFL, 2017. 

Cell lineage tracing in human tissues using somatic mitochondrial mutations

P. Refinetti / S. Morgenthaler; P. O. Ekstrom (Dir.)  

Lausanne, EPFL, 2017. 

Investigating the Biological Mechanisms underlying the Initiation of Autoimmunity against Beta Cell Antigens in Type 1 Diabetes

C. Cianciaruso / J. A. Hubbell; S. Baekkeskov Hanahan (Dir.)  

Lausanne, EPFL, 2017. 

Fighting preterm birth with novel surgical tools and biomaterials engineering

Y. R. Devaud / M. Lütolf; M. Ehrbar (Dir.)  

Lausanne, EPFL, 2017. 

Deciphering the subcapsular epithelial cells in human fetal and postnatal thymus

D. S. E. Hemon / Y. Barrandon (Dir.)  

Lausanne, EPFL, 2017. 

The therapeutic role of NAD+ modulation in fatty liver disease

K. L. Gariani / J. Auwerx (Dir.)  

Lausanne, EPFL, 2017. 

Microfluidic platforms for high-throughput mammalian cell printing, transfection, and dosage-dependent studies

K. P. Woodruff / S. Maerkl (Dir.)  

Lausanne, EPFL, 2017. 

The role of the polyglutamine and N-terminal domains in regulating the aggregation and structural properties of Huntingtin Exon 1

S. Vieweg / H. Lashuel (Dir.)  

Lausanne, EPFL, 2017. 

Elucidating the role of lymphatic vessels within the tumor microenvironment of breast cancer

I. M. van Mier / M. Swartz; M. De Palma (Dir.)  

Lausanne, EPFL, 2017. 

Human and eco-toxicological impacts of organometallic halide perovskites

R. I. Benmessaoud / L. Forró; H. Lashuel (Dir.)  

Lausanne, EPFL, 2017. 

Gene regulatory dynamics underlying brown fat cell differentiation

R. N. Pradhan / B. Deplancke (Dir.)  

Lausanne, EPFL, 2017. 

In vitro modeling of complex microenvironmental regulation of stem cells

Y. Tabata / M. Lütolf (Dir.)  

Lausanne, EPFL, 2017. 

Inferring the age and strength of mutations evolving under positive selection

N. L. Ormond / J. D. Jensen (Dir.)  

Lausanne, EPFL, 2017. 

Nanocapillaries combined with optical tweezers as a single molecule technique for studying DNA-protein complexes

R. Bulushev / A. Radenovic (Dir.)  

Lausanne, EPFL, 2017. 

Evaluation of oxidation-sensitive polymersomes as vaccine nanocarriers to enhance humoral responses against arenavirus envelope glycoproteins

C. Galan Navarro / M. Dal Peraro; M. Swartz (Dir.)  

Lausanne, EPFL, 2017. 

A Microfluidic Brain Interface for In Vivo Recording of Neurochemical Activity

G. C. Y. Petitpierre / P. Renaud (Dir.)  

Lausanne, EPFL, 2017. 

Selective electrical and optical neuromodulation of the central nervous system with conformable microfabricated implants

A. A. Guex / S. Lacour (Dir.)  

Lausanne, EPFL, 2017. 

2016

Instrumented shoes for daily activity monitoring in healthy and at risk populations

C. Moufawad El Achkar / K. Aminian (Dir.)  

Lausanne, EPFL, 2016. 

BCI based on Neural Correlates of Anticipatory Behavior during Driving

Z. Khaliliardali / J. d. R. Millán Ruiz (Dir.)  

Lausanne, EPFL, 2016. 

Protrusion-retraction switches and traction forces in spontaneous cell polarization

A. C. Bornert / A. Verkhovsky (Dir.)  

Lausanne, EPFL, 2016. 

Nanoscopy in nonlinear scanning fluorescence imaging systems

G. P. J. Laporte / D. Psaltis (Dir.)  

Lausanne, EPFL, 2016. 

Therapeutic Proteins Engineered for Super-Affinity to the Extracellular Matrix in Regenerative Medicine

P. S. M. Briquez / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2016. 

New immunomodulatory roles of lymphatic endothelium and implications for immunotherapy

E. Vokali / M. Swartz (Dir.)  

Lausanne, EPFL, 2016. 

Role of microRNAs in tumor-associated macrophages

C. M. Baer / M. De Palma (Dir.)  

Lausanne, EPFL, 2016. 

Mechanical and Functional Study of Cell Physiology at the Nanoscale

P. D. Odermatt / G. Fantner (Dir.)  

Lausanne, EPFL, 2016. 

Stem cell niche engineering through photopatterning and microfluidics

L. Kolb / M. Lütolf (Dir.)  

Lausanne, EPFL, 2016. 

Engineering Lymphangiogenesis : Implications for Cancer Immunotherapy and Beyond

M. A. Fankhauser / M. Swartz (Dir.)  

Lausanne, EPFL, 2016. 

Integrating Gene Synthesis and MITOMI for Rapid Protein Engineering

M. C. Blackburn / S. Maerkl (Dir.)  

Lausanne, EPFL, 2016. 

Host and pathogen genomics of severe pediatric infections

S. Asgari / J. Fellay (Dir.)  

Lausanne, EPFL, 2016. 

Engineering the Extra Domain A of fibronectin as a vaccine adjuvant and study of its role in tissue regeneration

Z. Julier / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2016. 

Tunable and cell-responsive 3D poly(ethylene glycol) microenvironments for the development of tissue models

S. E. Metzger / J. A. Hubbell; M. Ehrbar (Dir.)  

Lausanne, EPFL, 2016. 

Protein engineering approaches for direct antigen targeting in CD8+ T cell inducing vaccines

V. Panagiotou / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2016. 

Microdevices for Locomotion in Complex Biological Fluids

T. Qiu / J. A. Hubbell; P. Fischer (Dir.)  

Lausanne, EPFL, 2016. 

Novel interventions to recover the regenerative capacity of aged skeletal muscle by targeting the interactions in the stem cell niche

L. Lukjanenko / J. Feige; J. Auwerx (Dir.)  

Lausanne, EPFL, 2016. 

Engineering nanoparticle-based vaccines: Implications for the quality of humoral and cellular immunity

M. Rincón-Restrepo / M. Swartz; S. Hirosue (Dir.)  

Lausanne, EPFL, 2016. 

Microwell and impedance-based approaches to isolate single cells for life sciences

G. Muller / Y. Barrandon; P. Renaud (Dir.)  

Lausanne, EPFL, 2016. 

From the early steps of whisker formation to its evolutionary disappearance: the (curious) case of Prdm1 and its regulation

P. G. Manti / Y. Barrandon (Dir.)  

Lausanne, EPFL, 2016. 

Mitochondrial unfolded protein response, its molecular mechanism and physiological impact

V. Jovaisaite / J. Auwerx (Dir.)  

Lausanne, EPFL, 2016. 

Allosteric regulation and targeting of Abl SH2-kinase interface and other cytoplasmic tyrosine kinases

A. J. Lamontanara / O. Hantschel (Dir.)  

Lausanne, EPFL, 2016. 

Towards brain-on-a-chip : microfluidic and microelectrode array platforms for morphological and electrophysiological observations on the propagation of Alzheimer’s disease

Y. Ren / P. Renaud (Dir.)  

Lausanne, EPFL, 2016. 

In vivo mechanical loading combined with cell therapy in a bone tissue engineering scaffold

T. C. Hausherr / D. Pioletti (Dir.)  

Lausanne, EPFL, 2016. 

Deciphering the Role of LRH-1 in Liver Intermediary Metabolism and Cancer

P. Xu / K. Schoonjans (Dir.)  

Lausanne, EPFL, 2016. 

Unraveling the KRAB/KAP1 control of transposable elements in pluripotent and somatic cells

G. Ecco / D. Trono; P. Turelli (Dir.)  

Lausanne, EPFL, 2016. 

Mechanisms of tolerance induction by erythrocyte-targeted antigens

A. J. Grimm / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2016. 

Quantitative Single-Cell Analysis of Host-Pathogen Interactions

M. J-H. Delincé / J. McKinney (Dir.)  

Lausanne, EPFL, 2016. 

Metabolic control of muscle and muscle stem cell function

H. Zhang / J. Auwerx (Dir.)  

Lausanne, EPFL, 2016. 

Bioengineering approaches in immunotherapy : from basic to translational applications

M. Damo / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2016. 

2015

Interactions of Peripheral Nerve Cells with Soft Micropillar Interfaces

C. X. Paulou / S. Lacour (Dir.)  

Lausanne, EPFL, 2015. 

Implementation and Characterization of Dynamic Genetic Networks in Vitro

H. M. Niederholtmeyer / S. Maerkl (Dir.)  

Lausanne, EPFL, 2015. 

Recapitulating De Novo Alpha-Synuclein Fibrillization in a Novel Neuronal Model of Parkinson’s Disease

M-B. Fares / H. Lashuel (Dir.)  

Lausanne, EPFL, 2015. 

Microfluidic engineering of artificial stem cell niches

S. Allazetta / M. Lütolf (Dir.)  

Lausanne, EPFL, 2015. 

Reconstruction and systems analysis of metabolism in apicomplexan parasites Toxoplasma gondii and Plasmodium falciparum

S. Tymoshenko / V. Hatzimanikatis; D. Soldati-Favre (Dir.)  

Lausanne, EPFL, 2015. 

Tissue engineering for prenatal applications

A-S. J. Kiveliö / J. A. Hubbell; M. Ehrbar (Dir.)  

Lausanne, EPFL, 2015. 

Transposable elements and their KRAB/KAP1 controllers broadly regulate transcription in adult human cells

F. Marzetta / D. Trono; P. Turelli (Dir.)  

Lausanne, EPFL, 2015. 

Bioengineering approaches to emulate the stem cell niche

S. Höhnel / M. Lütolf (Dir.)  

Lausanne, EPFL, 2015. 

Analytical Methods, Correlative Microscopy and Software Tools for Quantitative Single Molecule Localization Microscopy

A. Shivanandan / A. Radenovic; I. Sbalzarini (Dir.)  

Lausanne, EPFL, 2015. 

Deciphering Metabolic Regulation of Hematopoietic Stem Cell Fate

M. Girotra / M. Lütolf (Dir.)  

Lausanne, EPFL, 2015. 

Functional Perturbation of the Gab2 Multiprotein Complex by High-affinity SH2-binding Monobodies in Chronic Myelogenous Leukemia

E. B. Gencer Akçok / O. Hantschel (Dir.)  

Lausanne, EPFL, 2015. 

Superresolution Reconstruction for Magnetic Resonance Spectroscopic Imaging Exploiting Low-Rank Spatio-Spectral Structure

J. A. Kasten / D. Van De Ville; F. Lazeyras (Dir.)  

Lausanne, EPFL, 2015. 

Connectivity Analysis of Brain States and Applications in Brain-Computer Interfaces

H. Zhang / J. d. R. Millán Ruiz (Dir.)  

Lausanne, EPFL, 2015. 

Modeling and Engineering Proteins Thermostability

H. Pezeshgi Modarres / M. Dal Peraro (Dir.)  

Lausanne, EPFL, 2015. 

Quantification of low molecular weight drugs : from the selection of nucleic acid-based capture molecules to the characterization in patient samples

A. Ferretti / C. Guiducci (Dir.)  

Lausanne, EPFL, 2015. 

Bio-engineered collagen-fibrin scaffolds for enhancing urological tissue regeneration

E. Vardar / J. A. Hubbell; P. Frey (Dir.)  

Lausanne, EPFL, 2015. 

Study of transposon-mediated cell pool and cell line generation in CHO cells

S. Balasubramanian / F. M. Wurm; D. Hacker (Dir.)  

Lausanne, EPFL, 2015. 

Quantitative single-cell analysis of S. cerevisiae using a microfluidic live-cell imaging platform

J. Becker / F. Naef; S. Maerkl (Dir.)  

Lausanne, EPFL, 2015. 

2014

Development of plasmid-based expression technology for rapid and sustained production of recombinant proteins in insect cells

X. Shen / F. M. Wurm; D. Hacker (Dir.)  

Lausanne, EPFL, 2014. 

Active Transport Mechanisms by Lymphatic Endothelium and their Modulation by Inflammatory Mediators

V. Triacca / M. Swartz (Dir.)  

Lausanne, EPFL, 2014. 

Novel non-invasive techniques for hemodynamic monitoring

O. Vardoulis / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2014. 

Pharmacological and biochemical assessment of γ-secretase-mediated APP processing involved in Alzheimer’s disease

M. Dimitrov / P. Fraering (Dir.)  

Lausanne, EPFL, 2014. 

Engineering the lymphatic microenvironment for investigating tumor invasion, immune cell traficking and parasite infection under relevant biomechanical conditions

M. Pisano / M. Swartz (Dir.)  

Lausanne, EPFL, 2014. 

The Engineering of a Scalable Disposable Orbitally Shaken Bioreactor System for Animal Cell Cultivation and Therapeutic Protein Production

D. T. Monteil Jr / F. M. Wurm; D. Hacker (Dir.)  

Lausanne, EPFL, 2014. 

Label-free Analytics by Transmission Localized-SPR and its Application to Small Molecules Monitoring in Serum

G. Cappi / C. Guiducci; L. Benini (Dir.)  

Lausanne, EPFL, 2014. 

Dissecting the DNA binding principles of transcription factor monomers and heterodimers

A. Isakova / B. Deplancke (Dir.)  

Lausanne, EPFL, 2014. 

Automated long-term single cell analysis of Schizosaccharomyces pombe on a microfluidic microchemostat array

J-B. Nobs / S. Maerkl (Dir.)  

Lausanne, EPFL, 2014. 

Experimental and theoretical studies on the effects of smooth muscle on the mechanical response and remodeling of arteries

A. Agianniotis / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2014. 

A systems approach to elucidate the genetic architecture of molecular phenotypes

S. M. Waszak / B. Deplancke (Dir.)  

Lausanne, EPFL, 2014. 

Reversible attachment of Cell-Penetrating Peptides for the efficient delivery of α-synuclein to HeLa cells and primary cortical neurons

C. Desobry / H. Lashuel (Dir.)  

Lausanne, EPFL, 2014. 

New Tools for Hydrogel-Based 3D Bioprinting

A. Negro / M. Lütolf (Dir.)  

Lausanne, EPFL, 2014. 

Modeling of transcription mechanisms in mammals from kinetic measurements in single cells

B. Zoller / F. Naef (Dir.)  

Lausanne, EPFL, 2014. 

Genetic analysis of the decaprenyl-phospho-D-arabinofuranose pathway in Mycobacterium tuberculosis

G. S. Kolly / S. Cole (Dir.)  

Lausanne, EPFL, 2014. 

An integrative genomics approach toward deciphering the regulatory logic of phase-specific circadian transcription in the mouse liver

I. Krier / B. Deplancke; J. Rougemont (Dir.)  

Lausanne, EPFL, 2014. 

Engineering lymphangiogenesis : methods, characterization and functional consequences

E. Güç / M. Swartz (Dir.)  

Lausanne, EPFL, 2014. 

Tissue Engineering Bone by Matrix-Assisted MSC Recruitment

P. S. Lienemann / M. Lütolf; M. Ehrbar (Dir.)  

Lausanne, EPFL, 2014. 

The Effectual Hitchhiker : Mechanisms and Consequences of Interactions Between Endosymbiotic Spiroplasma and Host Drosophila

J. K. Herren / B. Lemaître (Dir.)  

Lausanne, EPFL, 2014. 

Development of a Bisphosphonate Delivering Hydrogel for the Augmentation of Impaired Peri-Implant Bone

U. Kettenberger / D. Pioletti (Dir.)  

Lausanne, EPFL, 2014. 

From Genes to Organisms : Bioinformatics System Models and Software

T. Schaffter / D. Floreano; M. Affolter (Dir.)  

Lausanne, EPFL, 2014. 

Subject-specific computational fluid dynamics modelling and measurement of cerebrospinal fluid motion in the cervical spine

T. Yiallourou / N. Stergiopulos; B. A. Martin (Dir.)  

Lausanne, EPFL, 2014. 

Thermal gradients on a chip for the local stimulation of biological systems

S. Delasoie-Baranek / P. Renaud (Dir.)  

Lausanne, EPFL, 2014. 

The regulatory circuit of natural competence for transformation in the human pathogen Vibrio cholerae

M. Lo Scrudato / M. Blokesch (Dir.)  

Lausanne, EPFL, 2014. 

Dynamic brain networks explored by structure-revealing methods

N. Leonardi / D. Van De Ville (Dir.)  

Lausanne, EPFL, 2014. 

In vitro Fate Mapping of Single Hematopoietic Stem Cells

A. Roch / M. Lütolf (Dir.)  

Lausanne, EPFL, 2014. 

A New Noninvasively Adjustable Glaucoma Drainage Device

A. Villamarin / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2014. 

Direct Somatic Cell Reprogramming in Synthetic 3D Microenvironments

Y. Okawa / M. Lütolf (Dir.)  

Lausanne, EPFL, 2014. 

Engineering adjuvants for prophylactic and therapeutic subunit vaccines

A. de Titta / M. Swartz; J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2014. 

Structure-function analysis of the EspR virulence regulator of Mycobacterium tuberculosis

B. Blasco / S. Cole (Dir.)  

Lausanne, EPFL, 2014. 

A Systems Approach to Identify Genetic and Environmental Regulators of Metabolism

E. G. Williams / J. Auwerx (Dir.)  

Lausanne, EPFL, 2014. 

2013

Temperature impacts human epidermal stem cell behaviour through thermoTRPs and mTOR signalling

J. A. Mosig Rodriguez / Y. Barrandon (Dir.)  

Lausanne, EPFL, 2013. 

A microfluidic live-cell imaging platform to study large collections of microbial genotypes

N. Dénervaud / S. Maerkl; F. Naef (Dir.)  

Lausanne, EPFL, 2013. 

Targeting and Modulating Tumor-Associated Sites with Novel Nanoparticle-Based Immunotherapies

L. Jeanbart / M. Swartz; J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2013. 

Structure and function of proteins involved in attachment and piercing of the bacterial cell envelope

L. Sycheva / P. Leiman (Dir.)  

Lausanne, EPFL, 2013. 

Role of the bile acid membrane receptor TGR5 in macrophages and metabolism

M. Nomura / J. Auwerx; K. Schoonjans (Dir.)  

Lausanne, EPFL, 2013. 

Computational Studies on Cellular Bioenergetics

K. C. Soh / V. Hatzimanikatis (Dir.)  

Lausanne, EPFL, 2013. 

Flexible Micro/Nanofabricated Systems for Medical Devices and Implants

W. Hasenkamp Carreira / P. Renaud (Dir.)  

Lausanne, EPFL, 2013. 

Systems Biology of 3D Stem Cell-Niche Interactions

A. Ranga / M. Lutolf (Dir.)  

Lausanne, EPFL, 2013. 

Multiscale simulations of protein dynamics

E. Spiga / M. Dal Peraro (Dir.)  

Lausanne, EPFL, 2013. 

Systematic Analysis of Yeast Gene Expression by Synthetic Promoter Libraries

A. S. Rajkumar / S. Maerkl (Dir.)  

Lausanne, EPFL, 2013. 

The Use of Valproic Acid in Transient Gene Expression with HEK-293E Cells

D. Kiseljak / F. M. Wurm (Dir.)  

Lausanne, EPFL, 2013. 

Dissipation as variable in cartilage mechanobiology

P. Abdel-Sayed / D. Pioletti (Dir.)  

Lausanne, EPFL, 2013. 

Generating microarrays for protein interaction studies using microfluidic devices

S. Rockel / S. Maerkl (Dir.)  

Lausanne, EPFL, 2013. 

The Phosphate Specific Transport (Pst) System in Fast- and Slow-Growing Mycobacteria

C. De Piano / J. McKinney (Dir.)  

Lausanne, EPFL, 2013. 

Engineering nanoparticle vaccines : design principles for lymphatic targeting

S. Raghunathan / M. Swartz; J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2013. 

A Simple High Yielding Transient Gene Expression System for CHO Cells

Y. Rajendra / F. M. Wurm; D. Hacker (Dir.)  

Lausanne, EPFL, 2013. 

Metabolic modeling and experimental studies on carbon and energy metabolism of Mycobacterium tuberculosis

M. E. Özdemir / J. McKinney; V. Hatzimanikatis (Dir.)  

Lausanne, EPFL, 2013. 

Discovery and functional characterisation of structural genomic variation in a natural population

A. Massouras / B. Deplancke (Dir.)  

Lausanne, EPFL, 2013. 

Identification of genetic determinants and pharmacological modulators of mitochondrial function

P. Andreux / J. Auwerx (Dir.)  

Lausanne, EPFL, 2013. 

Development and application of experimental tools to elucidate the gene regulatory network underlying adipogenesis

C. Delattre-Gubelmann / B. Deplancke (Dir.)  

Lausanne, EPFL, 2013. 

Epiphyseal Chondro-Progenitor Cell Therapy For Articular Cartilage Regeneration

S. E. Darwiche / D. Pioletti; L. A. Laurent-Applegate (Dir.)  

Lausanne, EPFL, 2013. 

Control of calcification in a biphasic osteochondral construct and enhancing interface integration

J. Hollenstein / D. Pioletti; R. L-Y. Sah (Dir.)  

Lausanne, EPFL, 2013. 

Molecular Modeling of Membrane Embedded Proteins

T. Lemmin / M. Dal Peraro (Dir.)  

Lausanne, EPFL, 2013. 

Development of Novel Nanoparticle-Based Vaccines and Immunotherapies : Tuberculosis, Lung Metastasis and Allergy as Models

M. Ballester / M. Swartz; J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2013. 

2012

Culture and Characterization of Human and Porcine Urothelial Progenitor Cells

H. M. Larsson / J. A. Hubbell; P. Frey (Dir.)  

Lausanne, EPFL, 2012. 

Early Fate Choice Determines in vivo Engraftment and in vitro Behavior of Epidermal Stem Cells

F. Gorostidi / Y. Barrandon (Dir.)  

Lausanne, EPFL, 2012. 

Hydrogel Microfluidics to Control Stem Cell Fate

S. Cosson / M. Lutolf (Dir.)  

Lausanne, EPFL, 2012. 

Structural Studies and Protein Engineering of Human O6-Alkylguanine-DNA Alkyltransferase

B. Mollwitz / K. Johnsson (Dir.)  

Lausanne, EPFL, 2012. 

Improving Immunogenicity of Subunit Vaccines Using Nanocarrier Systems

A. Stano / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2012. 

Immune Engineering Via Differential Antigen Carriers and Co-Stimulatory Molecules

J. Eby / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2012. 

Microtechnologies to Map the Fate of Single Stem Cells and their Progeny

S. Kobel / M. Lutolf; P. Renaud (Dir.)  

Lausanne, EPFL, 2012. 

Molecular Modeling of Bacterial Nanomachineries

M. T. Degiacomi / M. Dal Peraro (Dir.)  

Lausanne, EPFL, 2012. 

Multidisciplinary Analysis of the Metabolic Shift to Lactate Consumption in CHO Cell Culture

F. Zagari / F. Wurm; M. Jordan (Dir.)  

Lausanne, EPFL, 2012. 

Molecular and Functional Characterization of Clonogenic Human Thymic Epithelial Cells

M. Maggioni / Y. Barrandon (Dir.)  

Lausanne, EPFL, 2012. 

Elucidating the role of post-translational modifications of alpha-synuclein using semisynthesis : phosphorylation at Tyrosine 125 and monoubiquitination at Lysine 6

M. Hejjaoui / H. Lashuel (Dir.)  

Lausanne, EPFL, 2012. 

Nanopore sensing of single molecules application to RNAP-DNA complexes, fabrication of graphene-nanopore devices and translocation algorithm analysis

C. Raillon / A. Radenovic; N. Hernandez (Dir.)  

Lausanne, EPFL, 2012. 

Genomics and transcriptomics of the Mycobacterium tuberculosis complex

S. Uplekar / S. Cole; J. Rougemont (Dir.)  

Lausanne, EPFL, 2012. 

Single-Cell Analysis of Mycobacterial Persistence Using Microfabricated Tools

M. Elitas / J. McKinney; S. Maerkl (Dir.)  

Lausanne, EPFL, 2012. 

Therapeutic Immunomodulation of the Lymphoid-like Tumor Environment Using Nanoparticulate Formulations

I. Kourtis / M. Swartz; J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2012. 

Dissecting Gene Regulatory Networks Using Targeted Quantitative Proteomics

J. Simicevic / B. Deplancke (Dir.)  

Lausanne, EPFL, 2012. 

KRAB/KAP1 Regulation of Embryonic Stem Cell Pluripotent Self-renewal

A. Corsinotti / D. Trono (Dir.)  

Lausanne, EPFL, 2012. 

Photopatterning of Synthetic Hydrogels

K. Mosiewicz / M. Lutolf (Dir.)  

Lausanne, EPFL, 2012. 

Toxicity study of nanostructures

L. Horváth / L. Forró; B. Schwaller (Dir.)  

Lausanne, EPFL, 2012. 

2011

In Vivo Studies on the Control of Gene Expression and Protein Degradation

K. Bojkowska / K. Johnsson; D. Trono (Dir.)  

Lausanne, EPFL, 2011. 

Cellular Responses to Bacterial Pore-Forming Toxins

R. M. Gonzalez / F. G. v. d. Goot Grunberg (Dir.)  

Lausanne, EPFL, 2011. 

Hydrogels for Urinary Tract Tissue Engineering

L. A. Micol / J. A. Hubbell; P. Frey (Dir.)  

Lausanne, EPFL, 2011. 

Identification and Functional Response of “Interstitial Cells of Cajal”-like Cells from Rat Mesenteric Artery

A. Formey de Saint Louvent / J-J. Meister; J-L. Bény (Dir.)  

Lausanne, EPFL, 2011. 

Molecular Mechanisms Underlying Hyaline Fibromatosis Syndrome

J. Deuquet Ariosa / F. G. v. d. Goot Grunberg (Dir.)  

Lausanne, EPFL, 2011. 

On the Precision of Circadian Oscillators

T. D’Eysmond / F. Naef (Dir.)  

Lausanne, EPFL, 2011. 

OrbShake Bioreactors for Mammalian Cell Cultures : Engineering and Scale-up

S. Tissot / F. Wurm (Dir.)  

Lausanne, EPFL, 2011. 

The Role of LEKTI in the Fate Determination of Keratinocyte Stem Cells

A. W. Amici / Y. Barrandon (Dir.)  

Lausanne, EPFL, 2011. 

In vitro lymphatic endothelial morphogenesis : molecular vs. biophysical regulation

C. Yong Pullin / M. Swartz (Dir.)  

Lausanne, EPFL, 2011. 

Engineering of Signaling Microenvironments with Fibronectin Domains to Enhance Tissue Regeneration

M. Martino / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2011. 

Force Transmission in Migrating Cells

M. Fournier / A. Verkhovski (Dir.)  

Lausanne, EPFL, 2011. 

Studies on KRAB/KAP1-Mediated Transcriptional Repression

A. C. Groner / D. Trono (Dir.)  

Lausanne, EPFL, 2011. 

Folding and Structure of the Pore Forming Toxin Aerolysin

M. I. Iacovache / F. G. v. d. Goot Grunberg (Dir.)  

Lausanne, EPFL, 2011. 

New/Surface-Modified Biocompatible Polymer for ICD Lead Insulation

R. B. Pisarek / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2011. 

Engineering Erythrocyte Affinity for Improved Pharmacokinetics and Immune Tolerogenesis

S. Kontos / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2011. 

Pressure and Flow Wave Propagation in Patient-Specific Models of the Arterial Tree

P. Reymond / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2011. 

Assessment of Body Motion and Muscle Weakness : Outcome Evaluation in Frail Elderly and DMD Subjects

R. L. Ganea / K. Aminian (Dir.)  

Lausanne, EPFL, 2011. 

Biofunctional Scaffold Design for Soft Tissue Regeneration

K. Lorentz / J. A. Hubbell; P. Frey (Dir.)  

Lausanne, EPFL, 2011. 

2010

Elucidating the Role of Quaternary Structure in Modulating Macrophage Migration Inhibitory Factor (MIF) Functions

F. El Turk / H. Lashuel (Dir.)  

Lausanne, EPFL, 2010. 

Ambulatory Assessment of Foot Kinematics and Kinetics : Outcome Evaluation of Ankle Osteoarthritis Treatments

H. Rouhani / K. Aminian (Dir.)  

Lausanne, EPFL, 2010. 

Rat bladder muscle regeneration induced by local delivery of an engineered insulin-like growth factor 1 in fibrin gels

L. Yang / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2010. 

Small Molecule Based Approaches to Inhibit Macrophage Migration Inhibitory Factor (MIF) Activities and Elucidate its Role in Health and Disease

H. Ouertatani-Sakouhi / H. Lashuel (Dir.)  

Lausanne, EPFL, 2010. 

Dendritic cell chemotaxis in 3D : new tools and insights

U. Haessler / M. Swartz (Dir.)  

Lausanne, EPFL, 2010. 

Biophysical Regulation of Lymphatic Vessel Function : Flow as a Mediator of Immune Cell and Fluid Transport

D. Miteva / M. Swartz (Dir.)  

Lausanne, EPFL, 2010. 

Lentiviral Vector-Mediated Gene Delivery for the Generation of Chinese Hamster Ovary Cell Lines with Improved Productivity and Stability

A. Oberbek / F. Wurm; D. Hacker (Dir.)  

Lausanne, EPFL, 2010. 

Biomechanics of Vascular Wall : the Role of Structural Organization of Elastin and Collagen

R. Saitta-Rezakhaniha / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2010. 

Genomic Context and KRAB/KAP1-mediated Transcriptional Repression

S. Meylan / D. Trono (Dir.)  

Lausanne, EPFL, 2010. 

Identification of genetic insulator elements to increase the safety of viral gene therapy vectors

A. Gaussin / J. A. Hubbell; N. Mermod (Dir.)  

Lausanne, EPFL, 2010. 

Transient Gene Expression in HEK-293E Cells for Recombinant Protein Production : Process Characterization towards GMP Approval

S. Nallet / F. Wurm (Dir.)  

Lausanne, EPFL, 2010. 

The Interplay between Cytidine Deaminases, HIV and Domesticated Genetic Parasites

Y. Bulliard / D. Trono (Dir.)  

Lausanne, EPFL, 2010. 

Arterial remodeling using a constituent-based approach

A. Tsamis / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2010. 

Innate Barriers to Genome Invasion : how TRIM5a Restricts Retroelements

P. Maillard / D. Trono (Dir.)  

Lausanne, EPFL, 2010. 

2009

The tissue reaction to neuroprostheses

A. Mercanzini / P. Renaud (Dir.)  

Lausanne, EPFL, 2009. 

The interplay between the VEGF-C/VEGFR-3 axis and CCL21/CCR7 axis in tumor cell invasion

A. Issa / M. Swartz (Dir.)  

Lausanne, EPFL, 2009. 

Peptide ligands for targeting and retention of nanoparticles and protein therapeutics in articular cartilage

D. A. Rothenfluh / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2009. 

Tissue engineering of the bladder : exploiting a 3D hydrogel for modulation of the smooth muscle cell phenotype

C. Adelöw / J. A. Hubbell; P. Frey (Dir.)  

Lausanne, EPFL, 2009. 

The role of TIF1 gamma during adult murine hematopoiesis

K. Shakhbazov / F. Radtke; A. Trumpp (Dir.)  

Lausanne, EPFL, 2009. 

Fetal cells for intervertebral disc regeneration

A. Quintin / D. Pioletti; L. A. Laurent-Applegate (Dir.)  

Lausanne, EPFL, 2009. 

Studies on lentiviral-mediated transgenesis

M-O. Sauvain / D. Trono (Dir.)  

Lausanne, EPFL, 2009. 

Differential effects of reduced cyclic stretch and perturbed shear stress within the arterial wall

T. Thacher / N. Stergiopulos; R. F. d. Silva (Dir.)  

Lausanne, EPFL, 2009. 

Transient recombinant protein expression in mammalian cells : the role of mRNA level and stability

S. Wulhfard / F. Wurm (Dir.)  

Lausanne, EPFL, 2009. 

Protein-binding microarray technology and ChIP-sequencing for the identification of novel targets of the human tumor suppressor AP2[alpha]

J. Kerschgens / J. A. Hubbell; N. Mermod (Dir.)  

Lausanne, EPFL, 2009. 

Investigation of novel calcium-related events as suspected contributors to neurodegeneration

N. Rudinskiy / R. Luthi-Carter (Dir.)  

Lausanne, EPFL, 2009. 

Orbitally shaken bioreactors for mammalian cell culture : engineering characterization and bioprocess scale-up

X. Zhang / F. Wurm (Dir.)  

Lausanne, EPFL, 2009. 

Immunoisolated cell implants for intracerebral delivery of anti-Aß single chain Fv antibodies in the APP23 Alzheimer’s mouse model

O. Marroquin Belaunzaran / P. Aebischer (Dir.)  

Lausanne, EPFL, 2009. 

Studies on scaffold design for tissue engineering applications : contribution of synthetic, natural and recombinant materials

E-M. Engelhardt / F. Wurm; P. Frey (Dir.)  

Lausanne, EPFL, 2009. 

Stem cell-based cardiovascular tissue engineering

T. Krähenbühl / J. A. Hubbell; R. S. Langer (Dir.)  

Lausanne, EPFL, 2009. 

2008

Role and mechanism of transient receptor potential (TRP) channels in gustatory and chemesthetic sensations associated with dietary molecules

C. Riera / H. Vogel (Dir.)  

Lausanne, EPFL, 2008. 

Development of an in vitro microenvironment for maturing oocytes

J. E. Ihm / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2008. 

Polymeric carriers for therapeutic agents : drug and gene delivery systems by reversible addition-fragmentation transfer (RAFT) polymerization

Y. S. Jo / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2008. 

Mechanical orchestration of tissue remodeling

P-J. Wipff / B. Hinz (Dir.)  

Lausanne, EPFL, 2008. 

Molecular and mechanical regulators of lymphatic biology

J. M. Rutkowski / M. Swartz (Dir.)  

Lausanne, EPFL, 2008. 

Novel applications of poly(ethylene glycol)-bl-poly(propylene sulfide) block copolymers

C. O’Neil / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2008. 

Effects of base-pair sequence, nicks and gaps on DNA minicircle shapes : analysis and experiment

A. Amzallag / J. H. Maddocks (Dir.)  

Lausanne, EPFL, 2008. 

A novel cell culture approach for tissue engineering based on surface expansion

H. Majd / B. Hinz (Dir.)  

Lausanne, EPFL, 2008. 

Accelerating the development time of recombinant mammalian cell lines producing high titers of protein therapeutics

S. Chenuet / F. Wurm (Dir.)  

Lausanne, EPFL, 2008. 

Prevention of micromotion-related periprosthetic bone loss using local release of bisphosphonate : theoretical developments and experimental validations

V. Stadelmann / D. Pioletti (Dir.)  

Lausanne, EPFL, 2008. 

Tissue engineering complex and mechanically active microenvironments for studies in asthma and cancer

A. A. Tomei / M. Swartz (Dir.)  

Lausanne, EPFL, 2008. 

Development of high-titer transient gene expression processes for manufacturing recombinant proteins

G. Backliwal / F. Wurm (Dir.)  

Lausanne, EPFL, 2008. 

Exploiting immunofunctional nanoparticles as vaccines and synthetic pathogens

S. T. Reddy / M. Swartz; J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2008. 

Vascular physiology : effects of vascular smooth muscle alteration on arterial wall biomechanics

S. Roy / N. Stergiopulos (Dir.)  

Lausanne, EPFL, 2008. 

2007

Polynucleotide cytidine deaminases, innate immunity and hepatitis B infection

S. Jost / D. Trono (Dir.)  

Lausanne, EPFL, 2007. 

Effects of dynamic environments on extracellular morphogen gradients

M. E. Fleury / M. Swartz (Dir.)  

Lausanne, EPFL, 2007. 

Bioreactor processes based on disposable materials for the production of recombinant proteins from mammalian cells

M. Stettler / F. Wurm (Dir.)  

Lausanne, EPFL, 2007. 

2005

Development of a novel drug delivery system based on polymeric, thermoresponsive, hydrogel nanoparticles

D. Misirlis / J. A. Hubbell (Dir.)  

Lausanne, EPFL, 2005.