2026
Journal Articles
High-throughput screening of drug libraries identifies a new synergistic drug combination for the treatment of retinoblastoma
PLOS One. 2026. Vol. 21, num. 2. DOI : 10.1371/journal.pone.0339334.Unconventional chalcogen-containing azolylidene metal complexes as potential anticancer therapeutics
Chemical Science. 2026. DOI : 10.1039/d5sc05555e.2025
Journal Articles
Imaging mitochondrial membrane potential via concentration-dependent fluorescence lifetime changes
Nature Communications. 2025. Vol. 16, num. 1. DOI : 10.1038/s41467-025-66042-x.Peroxisome Staining in Mammalian Cells Using Peroxisome-Specific Probes
Journal of Visualized Experiments (JoVE). 2025. Vol. 2025, num. 226, p. e69405. DOI : 10.3791/69405.An all-in-one pipeline for the in vitro discovery and in vivo testing of Plasmodium falciparum malaria transmission blocking drugs
Nature communications. 2025. Vol. 16, num. 1. DOI : 10.1038/s41467-025-62014-3.Two‐Color Timestamping of Gene Expression with a Chemigenetic Reporter System
ChemBioChem. 2025. DOI : 10.1002/cbic.202500494.Solvent Redistribution Method To Determine Solubility and Aggregation: High Throughput, Accuracy, and Sustainability
The Journal of Physical Chemistry B. 2025. DOI : 10.1021/acs.jpcb.5c03073.Identification of glutathione transferase (GST P1) inhibitors via a high-throughput screening assay and implications as alternative treatment options for breast cancers
PLOS One. 2025. Vol. 20, num. 7. DOI : 10.1371/journal.pone.0319904.A Silicon Rhodamine-fused Glibenclamide to Label and Detect Malaria-infected Red Blood Cells
CHEMBIOCHEM. 2025. DOI : 10.1002/cbic.202400628.Automated fast label-free quantification of cardiomyocyte dynamics with raw holograms for cardiotoxicity screening
BIOMEDICAL OPTICS EXPRESS. 2025. num. 2, p. 398 – 414. DOI : 10.1364/BOE.542362.Targeting protein-ligand neosurfaces with a generalizable deep learning tool
NATURE. 2025. DOI : 10.1038/s41586-024-08435-4.Aurora kinase B is required for growth and expansion of medulloblastoma cells in the tissue context
Neoplasia (New York, N.Y.). 2025. Vol. 59. DOI : 10.1016/j.neo.2024.101078.Working Papers
A human cell-free translation screen identifies the NT-2 mycotoxin as a ribosomal peptidyl transferase inhibitor
2025
HAK-Actin, U-ExM-Compatible Probe to Image the Actin Cytoskeleton
2025
Patents
Compounds for use in the treatment of inflammatory diseases
WO2025247879.
2025.2024
Journal Articles
Preclinical spheroid models identify BMX as a therapeutic target for metastatic MYCN nonamplified neuroblastoma
JCI INSIGHT. 2024. Vol. 9, num. 14. DOI : 10.1172/jci.insight.169647.Antibody-peptide conjugates deliver covalent inhibitors blocking oncogenic cathepsins
Nature Chemical Biology. 2024. DOI : 10.1038/s41589-024-01627-z.Fluorescent fatty acid conjugates for live cell imaging of peroxisomes
Nature Communications. 2024. Vol. 15, num. 4314. DOI : 10.1038/s41467-024-48679-2.Gentle Rhodamines for Live-Cell Fluorescence Microscopy
ACS Central Science. 2024. DOI : 10.1021/acscentsci.4c00616.2023
Journal Articles
Phosphoproteomics and morphology of stored human red blood cells treated by protein tyrosine phosphatases inhibitor
Blood Advances. 2023. Vol. 8, num. 1, p. 1 – 13. DOI : 10.1182/bloodadvances.2023009964.Chemical Probe for Imaging of Polo-like Kinase 4 and Centrioles
Jacs Au. 2023. DOI : 10.1021/jacsau.3c00271.In vitro-transfusional model for red-blood-cell study: the advantage of lowering hematocrit
Blood Transfusion. 2023. Vol. 21, num. 4, p. 277 – 288. DOI : 10.2450/2022.0086-22.Tubulin engineering by semi-synthesis reveals that polyglutamylation directs detyrosination
Nature Chemistry. 2023. DOI : 10.1038/s41557-023-01228-8.Translational screening platform to evaluate chemotherapy in combination with focal therapy for retinoblastoma
Cancer Science. 2023. DOI : 10.1111/cas.15878.Automated Dual-Mode Cell Monitoring To Simultaneously Explore Calcium Dynamics and Contraction-Relaxation Kinetics within Drug-Treated Stem Cell-Derived Cardiomyocytes
Acs Sensors. 2023. DOI : 10.1021/acssensors.3c00073.Conference Papers
Repurposing drug screen of patient-derived malignant pleural mesothelioma cells reveals potential anti-cancer activity
2023. p. S117 – S118.2022
Journal Articles
A covalently linked probe to monitor local membrane properties surrounding plasma membrane proteins
Journal of Cell Biology (JCB). 2022. Vol. 222, num. 3, p. e202206119. DOI : 10.1083/jcb.202206119.High-content, arrayed compound screens with rhinovirus, influenza A virus and herpes simplex virus infections
Scientific Data. 2022. Vol. 9, num. 610, p. 1 – 12. DOI : 10.1038/s41597-022-01733-4.Fluorescent D-Amino Acids for Super-resolution Microscopy of the Bacterial Cell Wall
Acs Chemical Biology. 2022. Vol. 17, num. 9, p. 2418 – 2424. DOI : 10.1021/acschembio.2c00496.Synthesis and direct assay of large macrocycle diversities by combinatorial late-stage modification at picomole scale
Nature Communications. 2022. Vol. 13, num. 1, p. 3823. DOI : 10.1038/s41467-022-31428-8.Phage Display Selected Cyclic Peptide Inhibitors of Kallikrein-Related Peptidases 5 and 7 and Their In Vivo Delivery to the Skin
Journal Of Medicinal Chemistry. 2022. Vol. 65, num. 14, p. 9735 – 9749. DOI : 10.1021/acs.jmedchem.2c00306.Novel High-Throughput Fluorescence-Based Assay for the Identification of Nematocidal Compounds That Target the Blood-Feeding Pathway
Pharmaceuticals. 2022. Vol. 15, num. 6, p. 669. DOI : 10.3390/ph15060669.Identification of New Vulnerabilities in Conjunctival Melanoma Using Image-Based High Content Drug Screening
Cancers. 2022. Vol. 14, num. 6, p. 1575. DOI : 10.3390/cancers14061575.Identification of broad anti-coronavirus chemical agents for repurposing against SARS-CoV-2 and variants of concern
Current Research in Virological Science. 2022. Vol. 3, p. 100019. DOI : 10.1016/j.crviro.2022.100019.Conference Papers
A Label-Free, High-Throughput Phenotypic Screen Of Adipocytic Differentiation Modulators To Accelerate Hematopoietic Recovery
2022. 51st Annual Scientific Meeting of the International-Society-for-Experimental-Hematology (ISEH), Edinburgh, SCOTLAND, Sep 01-04, 2022. p. S38 – S38.2021
Journal Articles
Highly Potent Host-Specific Small-Molecule Inhibitor of Paramyxovirus and Pneumovirus Replication with High Resistance Barrier
Mbio. 2021. Vol. 12, num. 6, p. e02621 – 21. DOI : 10.1128/mBio.02621-21.Picomole-Scale Synthesis and Screening of Macrocyclic Compound Libraries by Acoustic Liquid Transfer
Angewandte Chemie International Edition. 2021. Vol. 60, num. 40, p. 21702 – 21707. DOI : 10.1002/anie.202107815.Image- and Fluorescence-Based Test Shows Oxidant-Dependent Damages in Red Blood Cells and Enables Screening of Potential Protective Molecules
International Journal of Molecular Sciences. 2021. Vol. 22, num. 8, p. 4293. DOI : 10.3390/ijms22084293.Antiviral Screen against Canine Distemper Virus-Induced Membrane Fusion Activity
Viruses. 2021. Vol. 13, num. 1, p. 128. DOI : 10.3390/v13010128.Patents
Cathepsin inhibitors and uses thereof
WO2021191412; EP3884948.
2021.2020
Journal Articles
The FDA-Approved Drug Nelfinavir Inhibits Lytic Cell-Free but Not Cell-Associated Nonlytic Transmission of Human Adenovirus
Antimicrobial Agents and Chemotherapy. 2020. Vol. 64, num. 9, p. e01002 – 20. DOI : 10.1128/AAC.01002-20.A high-content image-based drug screen of clinical compounds against cell transmission of adenovirus
Scientific Data. 2020. Vol. 7, num. 1, p. 265. DOI : 10.1038/s41597-020-00604-0.Macrocycle synthesis strategy based on step-wise “adding and reacting” three components enables screening of large combinatorial libraries
Chemical Science. 2020. Vol. 11, num. 30, p. 7858 – 7863. DOI : 10.1039/D0SC01944E.High-throughput automated organoid culture via stem-cell aggregation in microcavity arrays
Nature Biomedical Engineering. 2020. Vol. 4, p. 863 – 874. DOI : 10.1038/s41551-020-0565-2.Loss of Bacterial Cell Pole Stabilization in Caulobacter crescentus Sensitizes to Outer Membrane Stress and Peptidoglycan-Directed Antibiotics
mBio. 2020. Vol. 11, num. 3, p. e00538 – 20. DOI : 10.1128/mBio.00538-20.The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration
Proceedings Of The National Academy Of Sciences Of The United States Of America (PNAS). 2020. p. 201913904. DOI : 10.1073/pnas.1913904117.Marker-Free Automatic Quantification of Drug-Treated Cardiomyocytes with Digital Holographic Imaging
Acs Photonics. 2020. Vol. 7, num. 1, p. 105 – 113. DOI : 10.1021/acsphotonics.9b01152.2019
Journal Articles
A ligand-based system for receptor-specific delivery of proteins
Scientific Reports. 2019. Vol. 9, p. 19214. DOI : 10.1038/s41598-019-55797-1.Image-Based Marker-Free Screening of GABA(A) Agonists, Antagonists, and Modulators
Slas Discovery. 2019. p. 2472555219887142. DOI : 10.1177/2472555219887142.Photoactivation of silicon rhodamines via a light-induced protonation
Nature Communications. 2019. Vol. 10, p. 4580. DOI : 10.1038/s41467-019-12480-3.Thiol-to-amine cyclization reaction enables screening of large libraries of macrocyclic compounds and the generation of sub-kilodalton ligands
Science Advances. 2019. Vol. 5, num. 8, p. eaaw2851. DOI : 10.1126/sciadv.aaw2851.Screening-based approach to discover effective platinum-based chemotherapies for cancers with poor prognosis
Plos One. 2019. Vol. 14, num. 1, p. e0211268. DOI : 10.1371/journal.pone.0211268.An optimized and validated 384-well plate assay to test platelet function in a high-throughput screening format
Platelets. 2019. Vol. 30, num. 5, p. 563 – 571. DOI : 10.1080/09537104.2018.1514106.A Universal Assay for Aminopeptidase Activity and Its Application for Dipeptidyl Peptidase-4 Drug Discovery
Analytical Chemistry. 2019. Vol. 91, num. 1, p. 1098 – 1104. DOI : 10.1021/acs.analchem.8b04672.Patents
Sting inhibitors
WO2019201939; EP3556362.
2019.Sting inhibitors
WO2019122202; EP3502102.
2019.Sting inhibitors
WO2019122202; EP3502102.
2019.2018
Journal Articles
Using Laser-Induced Rydberg Spectroscopy diagnostic for direct measurements of the local electric field in the edge region of NSTX/NSTX-U: Modeling
Review Of Scientific Instruments. 2018. Vol. 89, num. 10, p. 10C106. DOI : 10.1063/1.5038877.Quantification of stored red blood cell fluctuations by time-lapse holographic cell imaging
Biomedical Optics Express. 2018. Vol. 9, num. 10, p. 4714 – 4729. DOI : 10.1364/BOE.9.004714.2017
Journal Articles
Computational design of environmental sensors for the potent opioid fentanyl
eLife. 2017. Vol. 6. DOI : 10.7554/eLife.28909.Repositioning approved drugs for the treatment of problematic cancers using a screening approach
Plos One. 2017. Vol. 12, num. 2, p. e0171052. DOI : 10.1371/journal.pone.0171052.Red blood cells ageing markers: a multi-parametric analysis
Blood Transfusion. 2017. Vol. 15, num. 3, p. 239 – S2. DOI : 10.2450/2017.0318-16.Luciferases with tunable emission wavelengths
Angewandte Chemie International Edition. 2017. Vol. 56, num. 46, p. 14556 – 14560. DOI : 10.1002/anie.201708277.2016
Journal Articles
Growth control switch by a DNA-damage-inducible toxin–antitoxin system in Caulobacter crescentus
Nature Microbiology. 2016. Vol. 1, num. 4, p. 16008. DOI : 10.1038/nmicrobiol.2016.8.Automated tracking of temporal displacements of a red blood cell obtained by time-lapse digital holographic microscopy
Applied Optics. 2016. Vol. 55, num. 3, p. A86 – A94. DOI : 10.1364/Ao.55.000A86.Screening out irrelevant cell-based models of disease
Nature Reviews Drug Discovery. 2016. Vol. 15, num. 11, p. 751 – 769. DOI : 10.1038/nrd.2016.175.Conference Papers
Development Of A Novel First-In-Class Oral Inhibitor Of The Notch Pathway
2016. 21st Congress of the European-Hematology-Association, Copenhagen, DENMARK, JUN 09-12, 2016. p. 29 – 29.2015
Journal Articles
Automated multi-parameter measurement of cardiomyocytes dynamics with digital holographic microscopy
Optics Express. 2015. Vol. 23, num. 10, p. 13333 – 13347. DOI : 10.1364/OE.23.013333.Wnt directs the endosomal flux of LDL-derived cholesterol and lipid droplet homeostasis
Embo Reports. 2015. Vol. 16, num. 6, p. 741 – 752. DOI : 10.15252/embr.201540081.Conference Papers
Identification of CDC-48 inhibitors in C. elegans
2015. 40th Congress of the Federation-of-European-Biochemical-Societies (FEBS) – The Biochemical Basis of Life, Berlin, GERMANY, JUL 04-09, 2015. p. 389 – 389.Book Chapters
Digital Holographic Imaging for Label-Free Phenotypic Profiling, Cytotoxicity, and Chloride Channels Target Screening
Label-Free Biosensor Methods in Drug Discovery; New York: Springer, 2015. p. 307 – 325.2014
Journal Articles
Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors
European Journal Of Medicinal Chemistry. 2014. Vol. 84, p. 284 – 301. DOI : 10.1016/j.ejmech.2014.06.078.Developing the Biomolecular Screening Facility at the EPFL into the Chemical Biology Screening Platform for Switzerland
Combinatorial Chemistry & High Throughput Screening. 2014. Vol. 17, num. 4, p. 369 – 376. DOI : 10.2174/1386207317666140323194716.Non-specific SIRT inhibition as a mechanism for the cytotoxicity of ginkgolic acids and urushiols
Toxicology Letters. 2014. Vol. 229, num. 2, p. 374 – 380. DOI : 10.1016/j.toxlet.2014.07.002.Anticytolytic Screen Identifies Inhibitors of Mycobacterial Virulence Protein Secretion
Cell Host & Microbe. 2014. Vol. 16, num. 4, p. 538 – 548. DOI : 10.1016/j.chom.2014.09.008.Digital holographic microscopy: a quantitative label-free microscopy technique for phenotypic screening
Combinatorial chemistry & high throughput screening. 2014. Vol. 17, num. 1, p. 80 – 8. DOI : 10.2174/13862073113166660062.Conference Papers
Loss of Protein Tyr-phosphorylation During in vitro Storage of Human Erythrocytes: Impact on RBC Morphology
2014. AABB Annual Meeting, Philadelphia, PA, OCT 25-28, 2014. p. 49A – 50A.2013
Journal Articles
Label-Free Cytotoxicity Screening Assay by Digital Holographic Microscopy
ASSAY and Drug Development Technologies. 2013. Vol. 11, num. 2, p. 101 – 107. DOI : 10.1089/adt.2012.476.2012
Journal Articles
Enumeration of 166 Billion Organic Small Molecules in the Chemical Universe Database GDB-17
Journal Of Chemical Information And Modeling. 2012. Vol. 52, num. 11, p. 2864 – 2875. DOI : 10.1021/ci300415d.2011
Journal Articles
Exploring the Chemical Space of Known and Unknown Organic Small Molecules at www.gdb.unibe.ch
CHIMIA. 2011. Vol. 65, p. 863 – 867. DOI : 10.2533/chimia.2011.863.2010
Journal Articles
Identification and characterization of novel classes of macrophage migration inhibitory factor (MIF) inhibitors with distinct mechanisms of action
Journal of Biological Chemistry. 2010. Vol. 285, num. 34, p. 26581 – 98. DOI : 10.1074/jbc.M110.113951.Leads for antitubercular compounds from kinase inhibitor library screens
Tuberculosis. 2010. Vol. 90, num. 6, p. 354 – 60. DOI : 10.1016/j.tube.2010.09.001.An integrative in silico methodology for the identification of modulators of macrophage migration inhibitory factor (MIF) tautomerase activity
Bioorganic & medicinal chemistry. 2010. Vol. 18, num. 14, p. 5425 – 40. DOI : 10.1016/j.bmc.2010.05.010.Optimization of microfluidic single cell trapping for long-term on-chip culture
Lab on a Chip. 2010. Vol. 10, num. 7, p. 857 – 863. DOI : 10.1039/b918055a.Patents
Preparation of nucleic acid templates for solid phase amplification
EP2918686; EP1957668; WO2007060456; US8168388; US2010041561; EP1957668; WO2007060456; GB0524069.
2010.2009
Journal Articles
A new class of isothiocyanate-based irreversible inhibitors of macrophage migration inhibitory factor
Biochemistry. 2009. Vol. 48, num. 41, p. 9858 – 70. DOI : 10.1021/bi900957e.Patents
Preparation of templates for nucleic acid sequencing
ES2398808; EP2298930; US10710046; US2018353926; US9999866; US2017021325; US9498763; US2015343410; US9085802; US2014349891; US8715966; ES2398808; EP2298930; US2012208194; EP1910559; HK1154636; EP2298930; US2009118128; EP1910559; WO2007010251; WO2007010251; GB0514936.
2009.2008
Journal Articles
Accurate whole human genome sequencing using reversible terminator chemistry
Nature. 2008. Vol. 456, num. 7218, p. 53 – 9. DOI : 10.1038/nature07517.A new class of cleavable fluorescent nucleotides: synthesis and optimization as reversible terminators for DNA sequencing by synthesis
Nucleic Acids Research. 2008. Vol. 36, num. 4, p. e25. DOI : 10.1093/nar/gkn021.Patents
Method of Nucleotide Detection
EP1828412; US9970055; US2016208324; US9303290; US9217178; US2014378323; EP1828412; US2008280773; EP1828412; WO2006064199; GB0514933; GB0427236.
2008.2007
Journal Articles
Low- to high-throughput analysis of telomerase modulators with Telospot
Nature Methods. 2007. Vol. 4, num. 10, p. 851 – 853. DOI : 10.1038/nmeth1099.Interfering residues narrow the spectrum of MLV restriction by human TRIM5alpha
PLOS Pathogens. 2007. Vol. 3, num. 12, p. e200. DOI : 10.1371/journal.ppat.0030200.Patents
Improved method of nucleotide detection
EP1828412; US9970055; US2016208324; US9303290; US9217178; US2014378323; EP1828412; US2008280773; EP1828412; WO2006064199; GB0514933; GB0427236.
2007.Conversion of amine- to carboxyl groups on solid surfaces
US7704543; US2007042109; EP1692090; WO2005030695.
2007.2006
Journal Articles
BTA, a novel reagent for DNA attachment on glass and efficient generation of solid-phase amplified DNA colonies
Nucleic Acids Research. 2006. Vol. 34, num. 3, p. e22. DOI : 10.1093/nar/gnj023.Aryldithioethyloxycarbonyl (Ardec): A new family of amine protecting groups removable under mild reducing conditions and their applications to peptide synthesis
Chemistry – A European Journal. 2006. Vol. 12, num. 13, p. 3655 – 3671. DOI : 10.1002/chem.200501538.2004
Journal Articles
A microfluidic platform using molecular beacon-based temperature calibration for thermal dehybridization of surface-bound DNA
Analytical Chemistry. 2004. Vol. 76, num. 6, p. 1778 – 1787. DOI : 10.1021/ac034377+.2003
Patents
Nucleotide detection by fluorescence resonance energy transfer and methods thereof
BR0303224; NO20034592; NO20034592; AU2003226829; WO03068986.
2003.