Telomeric chromatin in health and disease

The physical ends of chromosomes, known as telomeres, play critical roles in cancer development, other age-related disorders and short telomere syndromes. Telomeres protect chromosomes from degradation and rearrangements that are typically seen in cancer. Telomeres also serve as cellular clocks. They shorten in the absence of telomerase limiting cellular lifespan. In most tumors, telomerase is upregulated in order to counteract telomere shortening. Through the expression of telomerase, human cancer cells acquire an immortal phenotype.

Research

Our laboratory combines telomeric chromatin analysis by mass spectrometry, biochemistry and molecular genetics to study the dynamics of telomere structure, function and replication in human cells under normal and pathological situations. Our work may allow manipulation of telomere functions in tumors and other diseased tissues in the future.

Contact

Head of the Laboratory: Prof. Joachim Lingner
Office : SV 1824
Phone : +41 21 693 07 21


Administration: Nicole de Montmollin
Office: SV 1823
Phone: + 41 21 693 07 22


Mailing Address
EPFL SV ISREC UPLIN
SV 1824 (Bâtiment SV)
Station 19
CH-1015 Lausanne
Ph: [+41 (0)21 69]3 0721