FluoTag-EMSA: a fast and accessible quantitative method to assess RNA-binding specificity using 3′-tagged hybrid duplexes

B. Rothé; D. B. Constam 

Kallikrein-8 mediates furin-independent Activin-A precursor processing to stimulate tumor growth in melanoma

M. Bulliard; K. Pinjusic; L. Iacobucci; C. Schmuziger; N. Fournier et al. 

M⁶A methylation inhibits recruitment of the Dand5 3’UTR to the left-right determinant Bicc1

B. Rothé; M. Mendel; S. Fortier; D. B. Constam 

Stepwise release of Activin-A from its inhibitory prodomain is modulated by cysteines and requires furin coexpression to promote melanoma growth

K. Pinjusic; M. Bulliard; B. Rothé; S. Ansaryan; Y. C. Liu et al. 

Tumor-educated Gr1+CD11b+cells drive breast cancer metastasis via OSM/IL-6/JAK-induced cancer cell plasticity

S. Peyvandi; M. Bulliard; A. Yilmaz; A. Kauzlaric; R. Marcone et al. 

Inhibition of anti-tumor immunity by melanoma cell-derived Activin-A depends on STING

K. Pinjusic; G. Ambrosini; J. Lourenco; N. Fournier; C. Iseli et al. 

The role of LRRK2 in lung adenocarcinoma

Bicc1 ribonucleoprotein complexes specifying organ laterality are licensed by ANKS6-induced structural remodeling of associated ANKS3

B. Rothe; Y. Ikawa; Z. Zhang; T. A. Katoh; E. Kajikawa et al. 

Antagonistic interactions among structured domains in the multivalent Bicc1-ANKS3-ANKS6 protein network govern phase transitioning of target mRNAs

B. Rothe; S. Fortier; C. Gagnieux; C. Schmuziger; D. B. Constam 

Hyperthermic Intrathoracic Chemotherapy (HITOC) Improves Malignant Pleural Mesothelioma Control Through a Tumor Specific Cytotoxic Immune Response

S. Cavin; Y. Hao; A. Gkasti; L. E. Chriqui; D. Marie et al. 

New roles of Bicc1 in cilia formation, cell adhesion, and in adult kidneys

Regulation and function of a hemicleaved Activin-A processing intermediate in melanoma

Activin-A impairs CD8 T cell-mediated immunity and immune checkpoint therapy response in melanoma

K. Pinjusic; O. A. Dubey; O. Egorova; S. Nassiri; E. Meylan et al. 

Immunosuppressive roles of Activin-A in melanoma and characterization of its precursor cleavage

Time-Resolved Scanning Ion Conductance Microscopy for Three-Dimensional Tracking of Nanoscale Cell Surface Dynamics

S. M. Leitao; B. Drake; K. Pinjusic; X. Pierrat; V. Navikas et al. 

Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex

K. Minegishi; B. Rothe; K. R. Komatsu; H. Ono; Y. Ikawa et al. 

The box C/D snoRNP assembly factor Bcd1 interacts with the histone chaperone Rtt106 and controls its transcription dependent activity

B. Bragantini; C. Charron; M. Bourguet; A. Paul; D. Tiotiu et al. 

Role of the RNA-binding protein Bicaudal-C1 and interacting factors in cystic kidney diseases

B. Rothe; C. Gagnieux; L. C. Leal-Esteban; D. B. Constam 

The yeast C/D box snoRNA U14 adopts a “weak” K-turn like conformation recognized by the Snu13 core protein in solution

M-E. Chagot; M. Quinternet; B. Rothe; B. Charpentier; J. Coutant et al. 

A novel cell-based sensor detecting the activity of individual basic proprotein convertases

K. Loew; K. Hardes; C. Fedeli; N. G. Seidah; D. B. Constam et al. 

Comment on “Human dignity and gene editing”

D. B. Constam 

Role of Activin-A signaling in melanoma

Crystal Structure of Bicc1 SAM Polymer and Mapping of Interactions between the Ciliopathy-Associated Proteins Bicc1, ANKS3, and ANKS6

B. Rothe; C. Leettola; L. Leal-Esteban; D. Cascio; S. Fortier et al. 

Role of Bicaudal C1 in renal gluconeogenesis and its novel interaction with the CTLH complex

L. Leal-Esteban; B. Rothe; S. Fortier; M. Isenschmid; D. Constam 

Compartment-Specific Biosensors Reveal a Complementary Subcellular Distribution of Bioactive Furin and PC7

P. Ginefra; B. Filippi; P. Donovan; S. Bessonnard; D. Constam 

Novel compartment-specific biosensors reveal a complementary subcellular distribution of bioactive Furin and PC7

Paracrine Activin-A Signaling Promotes Melanoma Growth and Metastasis through Immune Evasion

P. Donovan; O. A. Dubey; S. Kallioinen; K. W. Rogers; K. Muehlethaler et al. 

Functional analysis of Bicc1 and novel interacting proteins in renal tubule cell metabolism and polycystic kidneys

Epiblast-specific loss of HCF-1 leads to failure in anterior-posterior axis specification

S. Minocha; S. Bessonnard; T-L. Sung; C. Moret; D. B. Constam et al. 

Bicc1 Polymerization Regulates the Localization and Silencing of Bound mRNA

B. Rothe; L. Leal-Esteban; F. Bernet; S. Urfer; N. Doerr et al. 

ProNodal acts via FGFR3 to govern duration of Shh expression in the prechordal mesoderm

P. S. Ellis; S. Burbridge; S. Soubes; K. Ohyama; N. Ben-Haim et al. 

Urine Fetuin-A is a biomarker of autosomal dominant polycystic kidney disease progression

N. Piazzon; F. Bernet; L. Guihard; W. N. Leonhard; S. Urfer et al. 

Bicaudal C1 promotes pancreatic NEUROG3+ endocrine progenitor differentiation and ductal morphogenesis

L. A. Lemaire; J. Goulley; Y. H. Kim; S. Carat; P. Jacquemin et al. 

PC7 and the related proteases Furin and Pace4 regulate E-cadherin function during blastocyst formation

S. Bessonnard; D. Mesnard; D. B. Constam 

Regulation of the mRNA silencing activity of Bicaudal-C

Bicaudal C1 promotes pancreatic NEUROG3+ endocrine progenitor differentiation and ductal morphogenesis

Pathogen-free husbandry conditions alleviate behavioral deficits and neurodegeneration in AD10 anti-NGF mice

S. Tzanoulinou; R. Brandi; I. Arisi; M. D’Onofrio; S. M. Urfer et al. 

Nodal.Gdf1 Heterodimers with Bound Prodomains Enable Serum-independent Nodal Signaling and Endoderm Differentiation

C. Fuerer; M. C. Nostro; D. B. Constam 

Regulation of TGF beta and related signals by precursor processing

D. B. Constam 

De novo DNA methylation of endogenous retroviruses is shaped by KRAB-ZFPs/KAP1 and ESET

H. M. Rowe; M. Friedli; S. Offner; S. Verp; D. Mesnard et al. 

Furin Is the Primary in Vivo Convertase of Angiopoietin-like 3 and Endothelial Lipase in Hepatocytes

R. Essalmani; D. Susan-Resiga; A. Chamberland; M-C. Asselin; M. Canuel et al. 

Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice

W. C. Wetsel; R. M. Rodriguiz; J. Guillemot; E. Rousselet; R. Essalmani et al. 

Bicc1 links the regulation of cAMP signaling in polycystic kidneys to microRNA-induced gene silencing

N. Piazzon; C. Maisonneuve; I. Guilleret; S. Rotman; D. B. Constam 

Cellular Heterogeneity During Embryonic Stem Cell Differentiation to Epiblast Stem Cells Is Revealed by the ShcD/RaLP Adaptor Protein

M. Y. Turco; L. Furia; A. Dietze; L. F. Diaz; S. Ronzoni et al. 

Automated design of ligands to polypharmacological profiles

J. Besnard; G. F. Ruda; V. Setola; K. Abecassis; R. M. Rodriguiz et al. 

Activin Signalling in Human Melanoma Cells

Two mutations in human BICC1 resulting in Wnt pathway hyperactivity associated with cystic renal dysplasia

M. R-C. Kraus; S. Clauin; Y. Pfister; M. Di Maïo; T. Ulinski et al. 

The microenvironment patterns the pluripotent mouse epiblast through paracrine Furin and Pace4 proteolytic activities

D. Mesnard; M. Donnison; C. Fuerer; P. L. Pfeffer; D. B. Constam 

Furin Is the Major Processing Enzyme of the Cardiac-specific Growth Factor Bone Morphogenetic Protein 10

D. Susan-Resiga; R. Essalmani; J. Hamelin; M-C. Asselin; S. Benjannet et al. 

The Role of Nodal Processing in Pluripotent Progenitors

Visualization of proprotein convertase activity in living cells and tissues

D. Mesnard; D. Constam 

KAP1 controls endogenous retroviruses in embryonic stem cells

H. M. Rowe; J. Jakobsson; D. Mesnard; J. Rougemont; S. Reynard et al. 

Imaging proprotein convertase activities and their regulation in the implanting mouse blastocyst

D. Mesnard; D. B. Constam 

Role of Bicaudal-C in Left-Right Axis Formation and Kidney Morphogenesis

Bicaudal C, a novel regulator of Dvl signaling abutting RNA-processing bodies, controls cilia orientation and leftward flow

C. Maisonneuve; I. Guilleret; P. Vick; T. Weber; P. Andre et al. 

Riding shotgun: a dual role for the epidermal growth factor-Cripto/FRL-1/Cryptic protein Cripto in Nodal trafficking

D. B. Constam 

Intracellular trafficking and signaling in development

D. B. Constam 

Running the gauntlet: an overview of the modalities of travel employed by the putative morphogen Nodal

D. B. Constam 

VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5

D. Szumska; G. Pieles; R. Essalmani; M. Bilski; D. Mesnard et al. 

Cripto recruits Furin and PACE4 and controls Nodal trafficking during proteolytic maturation

M. Blanchet; J. Le Good; D. Mesnard; V. Oorschot; S. Baflast et al. 

Cripto localizes nodal at the limiting membrane of early endosomes

M. Blanchet; J. Le Good; V. Oorschot; S. Baflast; G. Minchiotti et al. 

Cripto promotes A-P axis specification independently of its stimulatory effect on Nodal autoinduction

D. D’Andrea; G. L. Liguori; J. A. Le Good; E. Lonardo; O. Andersson et al. 

Role of paracrine Furin activity during gastrulation

D. Mesnard; M. Donnison; P. L. Pfeffer; D. B. Constam 

Evolution of the mechanisms and molecular control of endoderm formation

A. Grapin-Botton; D. Constam 

Nodal specifies embryonic visceral endoderm and sustains pluripotent cells in the epiblast before overt axial patterning

D. Mesnard; M. Guzman-Ayala; D. B. Constam 

The nodal precursor acting via activin receptors induces mesoderm by maintaining a source of its convertases and BMP4

N. Ben-Haim; C. Lu; M. Guzman-Ayala; L. Pescatore; D. Mesnard et al. 

Nodal stability determines signaling range

J. A. Le Good; K. Joubin; A. J. Giraldez; N. Ben-Haim; S. Beck et al. 

Nodal protein processing and fibroblast growth factor 4 synergize to maintain a trophoblast stem cell microenvironment

M. Guzman-Ayala; N. Ben-Haim; S. Beck; D. B. Constam 

Asymmetric Nodal expression in the mouse is governed by the combinatorial activities of two distinct regulatory elements

S. D. Vincent; D. P. Norris; J. A. Le Good; D. B. Constam; E. J. Robertson 

A gene network establishing polarity in the early mouse embryo

S-L. Ang; D. B. Constam 

Endoderm development

A. Grapin-Botton; D. Constam 

Watch thy neighbor: Proprotein convertases activate TGFß-related signals across tissue boundaries

D. Constam 

Extraembryonic proteases regulate Nodal signalling during gastrulation

S. Beck; J. A. Le Good; M. Guzman; N. Ben Haim; K. Roy et al. 

Tissue-specific requirements for the proprotein convertase furin/SPC1 during embryonic turning and heart looping

D. B. Constam; E. J. Robertson 

SPC4/PACE4 regulates a TGFbeta signaling network during axis formation

D. B. Constam; E. J. Robertson 

Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases

D. B. Constam; E. J. Robertson 

Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase Furin

A. J. Roebroek; L. Umans; I. G. Pauli; E. J. Robertson; F. van Leuven et al. 

Cloning of the human puromycin-sensitive aminopeptidase and evidence for expression in neurons

A. R. Tobler; D. B. Constam; A. Schmitt-Gräff; U. Malipiero; R. Schlapbach et al. 

SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis

D. B. Constam; M. Calfon; E. J. Robertson 

Neurons induced to express major histocompatibility complex class I antigen are killed via the perforin and not the Fas (APO-1/CD95) pathway

A. Rensing-Ehl; U. Malipiero; M. Irmler; J. Tschopp; D. Constam et al. 

Puromycin-sensitive aminopeptidase: Sequence analysis, expression, and functional characterization

D. B. Constam; A. R. Tobler; A. Rensing-Ehl; I. Kemler; L. B. Hersh et al. 

Transforming growth factor-beta 2 induces apoptosis of murine T cell clones without down-regulating bcl-2 mRNA expression

M. Weller; D. B. Constam; U. Malipiero; A. Fontana 

Transient production of TGF-beta 2 by postnatal cerebellar neurons and its effect on neuroblast proliferation

D. B. Constam; P. Schmid; A. Aguzzi; M. Schachner; A. Fontana 

Differential expression of transforming growth factor-beta 1, -beta 2, and -beta 3 by glioblastoma cells, astrocytes, and microglia

D. B. Constam; J. Philipp; U. V. Malipiero; P. ten Dijke; M. Schachner et al. 

Purification and partial characterization of an intracellular NADH: quinone oxidoreductase from Phanerochaete chrysosporium

D. Constam; A. Muheim; W. Zimmermann; A. Fiechter 

Astrocyte-derived TGF-beta 2 and NGF differentially regulate neural recognition molecule expression by cultured astrocytes

B. Saad; D. B. Constam; R. Ortmann; M. Moos; A. Fontana et al.