EDCB Published theses

It is our pleasure to present the theses undertaken in the frame of the EPFL PhD Program in Computational and Quantitative Biology.

2025

Leveraging chromatin modules to explore the impact of regulatory variation on disease

O. Pushkarev / B. Deplancke (Dir.)  

Lausanne, EPFL, 2025. 

Revealing and exploiting coevolution through protein language models

D. Sgarbossa / A-F. R. Bitbol (Dir.)  

Lausanne, EPFL, 2025. 

Non-equilibrium control of biomolecular condensates

A. Shelest / P. De Los Rios (Dir.)  

Lausanne, EPFL, 2025. 

Computational design of complex protein folds and soluble analogs of membrane proteins

C. A. Goverde / B. E. Ferreira De Sousa Correia (Dir.)  

Lausanne, EPFL, 2025. 

The Regulation of Transcription Factors Binding Site Occupancies by Their Concentrations

R. Mizeret / D. M. Suter (Dir.)  

Lausanne, EPFL, 2025. 

Leveraging social media data and large language models for understanding public health behaviours in the context of infectious diseases and vaccination

L. Espinosa Montalbán / M. Salathé (Dir.)  

Lausanne, EPFL, 2025. 

Dynamics and Coordination of Protein Synthesis and Protein Decay in Mammalian Cells

B. J. C. A. H. Martin / D. M. Suter (Dir.)  

Lausanne, EPFL, 2025. 

SPAD Image Sensors with Embedded Intelligence

Y. Lin / E. Charbon; C. Bruschini (Dir.)  

Lausanne, EPFL, 2025. 

Computational approaches for spatialomics data: construction, integration and analysis of biomolecular atlases

H. H. E. Schede / G. D’Angelo; G. La Manno (Dir.)  

Lausanne, EPFL, 2025. 

Transcription Factor Target Search on Chromatin via Electrostatic Interactions

S. Sakong / D. Suter; B. Fierz (Dir.)  

Lausanne, EPFL, 2025. 

Protein Organisation at Different Scales: Amyloid Disaggregation, Chaperone Networks and Engineered Allostery

D. Cois / P. De Los Rios (Dir.)  

Lausanne, EPFL, 2025. 

Investigation of the bone marrow niche in clonal hematopoiesis and myelodysplastic syndrome

M. Kholmatov / B. Deplancke; J. Zaugg (Dir.)  

Lausanne, EPFL, 2025. 

Learning the language of the genome: AI- and data-driven decoding of genetic variants and disease mechanisms

A. Saadat Varnosfaderanii / J. Fellay (Dir.)  

Lausanne, EPFL, 2025. 

Mapping Brain Morphology with Micro-CT and Topological Data Analysis: From Drosophila to General Applications

S. S. Bourgeat / B. McCabe; A. M. Jaksic (Dir.)  

Lausanne, EPFL, 2025. 

Light-directed evolution of dynamic biological systems

V. Gligorovski / S. J. Rahi (Dir.)  

Lausanne, EPFL, 2025. 

2024

Study of disease-associated proteins using integrative structural biology: the case of GOLPH3 and PREPL

A. Theodoropoulou / M. Dal Peraro (Dir.)  

Lausanne, EPFL, 2024. 

Deciphering the nature of cell state transitions in single cells using quantitative modeling of temporal dynamics

A. R. Lederer / G. La Manno (Dir.)  

Lausanne, EPFL, 2024. 

Label-Efficient Deep Learning Methods for Event Detection, Object Segmentation and Cell Tracking in Biological Microscopy Images

B. Gallusser / M. Dal Peraro; M. Weigert (Dir.)  

Lausanne, EPFL, 2024. 

Predicting protein interactions using geometric deep learning on protein surfaces

F. Sverrisson / B. E. Ferreira De Sousa Correia; M. Bronstein (Dir.)  

Lausanne, EPFL, 2024. 

Unraveling behavioral individuality in Drosophila melanogaster: An automated high-throughput screening approach

R. Manna / K. Hess Bellwald; A. M. Jaksic (Dir.)  

Lausanne, EPFL, 2024.