EDCB Published theses

It is our pleasure to present the theses undertaken in the frame of the EPFL PhD Program in Computational and Quantitative Biology.

2025

Non-equilibrium control of biomolecular condensates

A. Shelest / P. De Los Rios (Dir.)  

Lausanne, EPFL, 2025. 

Protein Organisation at Different Scales: Amyloid Disaggregation, Chaperone Networks and Engineered Allostery

D. Cois / P. De Los Rios (Dir.)  

Lausanne, EPFL, 2025. 

Transcription Factor Target Search on Chromatin via Electrostatic Interactions

S. Sakong / D. Suter; B. Fierz (Dir.)  

Lausanne, EPFL, 2025. 

Revealing and exploiting coevolution through protein language models

D. Sgarbossa / A-F. R. Bitbol (Dir.)  

Lausanne, EPFL, 2025. 

SPAD Image Sensors with Embedded Intelligence

Y. Lin / E. Charbon; C. Bruschini (Dir.)  

Lausanne, EPFL, 2025. 

Learning the language of the genome: AI- and data-driven decoding of genetic variants and disease mechanisms

A. Saadat Varnosfaderanii / J. Fellay (Dir.)  

Lausanne, EPFL, 2025. 

Leveraging chromatin modules to explore the impact of regulatory variation on disease

O. Pushkarev / B. Deplancke (Dir.)  

Lausanne, EPFL, 2025. 

The Regulation of Transcription Factors Binding Site Occupancies by Their Concentrations

R. Mizeret / D. M. Suter (Dir.)  

Lausanne, EPFL, 2025. 

Investigation of the bone marrow niche in clonal hematopoiesis and myelodysplastic syndrome

M. Kholmatov / B. Deplancke; J. Zaugg (Dir.)  

Lausanne, EPFL, 2025. 

Leveraging social media data and large language models for understanding public health behaviours in the context of infectious diseases and vaccination

L. Espinosa Montalbán / M. Salathé (Dir.)  

Lausanne, EPFL, 2025. 

Light-directed evolution of dynamic biological systems

V. Gligorovski / S. J. Rahi (Dir.)  

Lausanne, EPFL, 2025. 

Dynamics and Coordination of Protein Synthesis and Protein Decay in Mammalian Cells

B. J. C. A. H. Martin / D. M. Suter (Dir.)  

Lausanne, EPFL, 2025. 

Computational design of complex protein folds and soluble analogs of membrane proteins

C. A. Goverde / B. E. Ferreira De Sousa Correia (Dir.)  

Lausanne, EPFL, 2025. 

Mapping Brain Morphology with Micro-CT and Topological Data Analysis: From Drosophila to General Applications

S. S. Bourgeat / B. McCabe; A. M. Jaksic (Dir.)  

Lausanne, EPFL, 2025. 

Computational approaches for spatialomics data: construction, integration and analysis of biomolecular atlases

H. H. E. Schede / G. D’Angelo; G. La Manno (Dir.)  

Lausanne, EPFL, 2025. 

2024

Unraveling behavioral individuality in Drosophila melanogaster: An automated high-throughput screening approach

R. Manna / K. Hess Bellwald; A. M. Jaksic (Dir.)  

Lausanne, EPFL, 2024. 

Characterisation of EIF5A perturbations on ribosome dynamics with single-molecule imaging

I. Lamberti / F. Naef (Dir.)  

Lausanne, EPFL, 2024. 

Investigating the intra-molecular and inter-molecular effects of post-translational modifications on intrinsically disordered protein regions and structured protein regions

Z. Zhang / M. Dal Peraro; H. Lashuel (Dir.)  

Lausanne, EPFL, 2024. 

Deciphering the nature of cell state transitions in single cells using quantitative modeling of temporal dynamics

A. R. Lederer / G. La Manno (Dir.)  

Lausanne, EPFL, 2024. 

Study of disease-associated proteins using integrative structural biology: the case of GOLPH3 and PREPL

A. Theodoropoulou / M. Dal Peraro (Dir.)  

Lausanne, EPFL, 2024.