We have an opening in the group for a curious, independent and motivated person who would like to explore the balance of cell-intrinsic timing and extrinsic signaling factors in the segmentation clock. This person will build on our recent work in Rohde et al., eLife https://doi.org/10.7554/eLife.93764.2.
Questions addressed by the project include: What temporal behaviors are encoded within cells of the segmentation clock? What is the molecular basis of these cell-intrinsic programs? Which signals from other cells or cues from the embryonic environment influence the intrinsic behavior? What dynamics in these noisy signals are relevant for information transfer, and how are they decoded by individual or groups of cells?
We use the zebrafish as a model system, combining genetic engineering, time-lapse microscopy of single cells and embryos, image processing, various omics approaches, biochemistry, data analysis and modeling to understand the biology. We are looking for people with a mix of experimental and computational skills. If this sounds interesting to you, then please apply to the Timing, Oscillators, Patterns lab.