After obtaining his Ph.D. at ETH Zürich, Rolf Gruetter went in 1990 to Yale University for a PostDoc, then after a second PostDoc at University of Bern, he became 1994 Assistant Professor at the University of Minnesota’s Center for MR Reserch, ultimately being promoted to tenured full Professor. He joined the Schoolof Basic Sciences of EPFL in 2004.
Metabolic reactions are the end-product of protein and gene expression and often at the heart of many diseases. Our lab is interested in the non-invasive measurement of metabolic processes and function. We are developing new approaches (multi-
nuclear spin physics and metabolic modeling, among others) allowing to measure metabolic reactions in vivo hitherto inaccessible, in the context of biomedical problems of interest in rodent models of health and disease (neurochemistry and diabetes research, among others), as well as with human volunteer subjects.
Selected Publications since 2014
- Boillat, Y. et al. “Metabolite Concentration Changes Associated with Positive and Negative BOLD Responses in the Human Visual Cortex: A Functional MRS Study at 7 Tesla”. J Cereb Blood Flow Metab 0271678X19831022 (2019). https://doi.org/10.1177/0271678X19831022
- Bastiaansen, J. A. M. et al. “Probing Cardiac Metabolism by Hyperpolarized 13C MR Using an Exclusively Endogenous Substrate Mixture and Photo-Induced Nonpersistent Radicals”. Magn Reson Med 79, 2451–2459 (2018). https://doi.org/10.1002/mrm.27122
- Lai, M. et al. “In Vivo 13C MRS in the Mouse Brain at 14.1 Tesla and Metabolic Flux Quantification under Infusion of [1,6-13C2]Glucose”. J. Cereb. Blood Flow Metab. 38, 1701–1714 (2018). https://doi.org/10.1177/0271678X17734101
- Dehghani, M. et al. “Diffusion-Weighted MRS of Acetate in the Rat Brain”. NMR in Biomedicine 30, e3768 (2017). https://doi.org/10.1002/nbm.3768
- Mishkovsky, M. et al. “Measuring Glucose Cerebral Metabolism in the Healthy Mouse Using Hyperpolarized 13C Magnetic Resonance”. Sci Rep 7, 11719 (2017). https://doi.org/10.1038/s41598-017-12086-z
- Narsude, M. et al. “Three-Dimensional Echo Planar Imaging with Controlled Aliasing: A Sequence for High Temporal Resolution Functional MRI”. Magnetic Resonance in Medicine 75, 2350–2361 (2016). https://doi.org/10.1002/mrm.25835
- Sonnay, S. et al. “Compartmentalised Energy Metabolism Supporting Glutamatergic Neurotransmission in Response to Increased Activity in the Rat Cerebral Cortex: A 13C MRS Study in Vivo at 14.1 T”. J Cereb Blood Flow Metab 36, 928–940 (2016). https://doi.org/10.1177/0271678X16629482
- Khabipova, D. et al. “A Modulated Closed Form Solution for Quantitative Susceptibility Mapping–a Thorough Evaluation and Comparison to Iterative Methods Based on Edge Prior Knowledge”. Neuroimage 107, 163–174 (2015). https://doi.org/10.1016/j.neuroimage.2014.11.038
- Jorge, J. et al. “Simultaneous EEG-FMRI at Ultra-High Field: Artifact Prevention and Safety Assessment”. Neuroimage 105, 132–144 (2015). https://doi.org/10.1016/j.neuroimage.2014.10.055
- Lanz, B. et al. “Image-Derived Input Function from the Vena Cava for 18F-FDG PET Studies in Rats and Mice”. J. Nucl. Med. 55, 1380–1388 (2014). https://doi.org/10.2967/jnumed.113.127381