Publications

2026

Fluorogenic speed-optimized DNA-PAINT probes enable super-resolution imaging of whole cells

S. Stoller; A. Jha; J. Bewersdorf; F. Schueder 

2026

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Oligomeric assembly of the gatekeeper InvE orchestrates hierarchical type III protein secretion in Salmonella Typhimurium

T. Wang; L. Zhu; E. Guo; C. Wu; F. Schueder et al. 

Proceedings of the National Academy of Sciences. 2026. Vol. 123, num. 5. DOI : 10.1073/pnas.2530441123.

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2025

Nanoscale 3D DNA tracing in non-denatured cells resolves the Cohesin-dependent loop architecture of the genome in situ

K. S. Beckwith; Ø. Ødegård-Fougner; N. R. Morero; C. Barton; F. Schueder et al. 

Nature Communications. 2025. Vol. 16, num. 1. DOI : 10.1038/s41467-025-61689-y.

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2024

VPS13B is localized at the interface between Golgi cisternae and is a functional partner of FAM177A1

B. Ugur; F. Schueder; J. Shin; M. G. Hanna; Y. Wu et al. 

Journal of Cell Biology. 2024. Vol. 223, num. 12. DOI : 10.1083/jcb.202311189.

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Unraveling cellular complexity with transient adapters in highly multiplexed super-resolution imaging

F. Schueder; F. Rivera-Molina; M. Su; Z. Marin; P. Kidd et al. 

Cell. 2024. Vol. 187, num. 7, p. 1769 – 1784.e18. DOI : 10.1016/j.cell.2024.02.033.

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In Situ Imaging of Proteins Using DNA-PAINT Super-Resolution Microscopy

F. Schueder; R. Jungmann 

Imaging Cell Signaling; New York, NY: Humana (United States), 2024. p. 103 – 113.

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2023

Parkinson’s disease kinase LRRK2 coordinates a cell-intrinsic itaconate-dependent defence pathway against intracellular Salmonella

H. Lian; D. Park; M. Chen; F. Schueder; M. Lara-Tejero et al. 

Nature Microbiology. 2023. Vol. 8, num. 10, p. 1880 – 1895. DOI : 10.1038/s41564-023-01459-y.

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Principles of RNA recruitment to viral ribonucleoprotein condensates in a segmented dsRNA virus

S. Strauss; J. Acker; G. Papa; D. Desirò; F. Schueder et al. 

eLife. 2023. Vol. 12. DOI : 10.7554/elife.68670.

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Nanobodies combined with DNA-PAINT super-resolution reveal a staggered titin nanoarchitecture in flight muscles

F. Schueder; P. Mangeol; E. H. Chan; R. Rees; J. Schünemann et al. 

eLife. 2023. Vol. 12. DOI : 10.7554/elife.79344.

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2022

High-precision estimation of emitter positions using Bayesian grouping of localizations

M. Fazel; M. J. Wester; D. J. Schodt; S. R. Cruz; S. Strauss et al. 

Nature Communications. 2022. Vol. 13, num. 1. DOI : 10.1038/s41467-022-34894-2.

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Omics goes spatial epigenomics

F. Schueder; J. Bewersdorf 

Cell. 2022. Vol. 185, num. 23, p. 4253 – 4255. DOI : 10.1016/j.cell.2022.10.014.

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2021

Double‐ to Single‐Strand Transition Induces Forces and Motion in DNA Origami Nanostructures

F. N. Gür; S. Kempter; F. Schueder; C. Sikeler; M. J. Urban et al. 

Advanced Materials. 2021. Vol. 33, num. 37. DOI : 10.1002/adma.202101986.

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Detecting structural heterogeneity in single-molecule localization microscopy data

T. A. Huijben; H. Heydarian; A. Auer; F. Schueder; R. Jungmann et al. 

Nature Communications. 2021. Vol. 12, num. 1. DOI : 10.1038/s41467-021-24106-8.

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Single-molecule localization microscopy

M. Lelek; M. T. Gyparaki; G. Beliu; F. Schueder; J. Griffie et al. 

Nature Reviews Methods Primers. 2021. Vol. 1, num. 1, p. 39. DOI : 10.1038/s43586-021-00038-x.

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3D particle averaging and detection of macromolecular symmetry in localization microscopy

H. Heydarian; M. Joosten; A. Przybylski; F. Schueder; R. Jungmann et al. 

Nature Communications. 2021. Vol. 12, num. 1. DOI : 10.1038/s41467-021-22006-5.

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2020

Complex multicomponent patterns rendered on a 3D DNA-barrel pegboard

S. F. J. Wickham; A. Auer; J. Min; N. Ponnuswamy; J. B. Woehrstein et al. 

Nature Communications. 2020. Vol. 11, num. 1. DOI : 10.1038/s41467-020-18910-x.

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Super‐Resolution Spatial Proximity Detection with Proximity‐PAINT

F. Schueder; J. Lara‐Gutiérrez; D. Haas; K. S. Beckwith; P. Yin et al. 

Angewandte Chemie International Edition. 2020. Vol. 60, num. 2, p. 716 – 720. DOI : 10.1002/anie.202009031.

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DNA‐Barcoded Fluorescence Microscopy for Spatial Omics

F. Schueder; E. M. Unterauer; M. Ganji; R. Jungmann 

PROTEOMICS. 2020. Vol. 20, num. 23. DOI : 10.1002/pmic.201900368.

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Live-cell super-resolved PAINT imaging of piconewton cellular traction forces

J. M. Brockman; H. Su; A. T. Blanchard; Y. Duan; T. Meyer et al. 

Nature Methods. 2020. Vol. 17, num. 10, p. 1018 – 1024. DOI : 10.1038/s41592-020-0929-2.

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2019

Localization microscopy at doubled precision with patterned illumination

J. Cnossen; T. Hinsdale; R. Ø. Thorsen; M. Siemons; F. Schueder et al. 

Nature Methods. 2019. Vol. 17, num. 1, p. 59 – 63. DOI : 10.1038/s41592-019-0657-7.

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An order of magnitude faster DNA-PAINT imaging by optimized sequence design and buffer conditions

F. Schueder; J. Stein; F. Stehr; A. Auer; B. Sperl et al. 

Nature Methods. 2019. Vol. 16, num. 11, p. 1101 – 1104. DOI : 10.1038/s41592-019-0584-7.

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Bayesian Multiple Emitter Fitting using Reversible Jump Markov Chain Monte Carlo

M. Fazel; M. J. Wester; H. Mazloom-Farsibaf; M. B. M. Meddens; A. S. Eklund et al. 

Scientific Reports. 2019. Vol. 9, num. 1. DOI : 10.1038/s41598-019-50232-x.

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Toward Absolute Molecular Numbers in DNA-PAINT

J. Stein; F. Stehr; P. Schueler; P. Blumhardt; F. Schueder et al. 

Nano Letters. 2019. Vol. 19, num. 11, p. 8182 – 8190. DOI : 10.1021/acs.nanolett.9b03546.

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Direct Visualization of Single Nuclear Pore Complex Proteins Using Genetically‐Encoded Probes for DNA‐PAINT

T. Schlichthaerle; M. T. Strauss; F. Schueder; A. Auer; B. Nijmeijer et al. 

Angewandte Chemie. 2019. Vol. 131, num. 37, p. 13138 – 13142. DOI : 10.1002/ange.201905685.

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The nucleolus functions as a phase-separated protein quality control compartment

F. Frottin; F. Schueder; S. Tiwary; R. Gupta; R. Körner et al. 

Science. 2019. Vol. 365, num. 6451, p. 342 – 347. DOI : 10.1126/science.aaw9157.

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Flat-top TIRF illumination boosts DNA-PAINT imaging and quantification

F. Stehr; J. Stein; F. Schueder; P. Schwille; R. Jungmann 

Nature Communications. 2019. Vol. 10, num. 1. DOI : 10.1038/s41467-019-09064-6.

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124-Color Super-resolution Imaging by Engineering DNA-PAINT Blinking Kinetics

O. K. Wade; J. B. Woehrstein; P. C. Nickels; S. Strauss; F. Stehr et al. 

Nano Letters. 2019. Vol. 19, num. 4, p. 2641 – 2646. DOI : 10.1021/acs.nanolett.9b00508.

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Dynamic host–guest interaction enables autonomous single molecule blinking and super-resolution imaging

R. Sasmal; N. Das Saha; F. Schueder; D. Joshi; V. Sheeba et al. 

Chemical Communications. 2019. Vol. 55, num. 96, p. 14430 – 14433. DOI : 10.1039/c9cc07153a.

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2018

Nanometer‐scale Multiplexed Super‐Resolution Imaging with an Economic 3D‐DNA‐PAINT Microscope

A. Auer; T. Schlichthaerle; J. B. Woehrstein; F. Schueder; M. T. Strauss et al. 

ChemPhysChem. 2018. Vol. 19, num. 22, p. 3024 – 3034. DOI : 10.1002/cphc.201800630.

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Template-free 2D particle fusion in localization microscopy

H. Heydarian; F. Schueder; M. T. Strauss; B. van Werkhoven; M. Fazel et al. 

Nature Methods. 2018. Vol. 15, num. 10, p. 781 – 784. DOI : 10.1038/s41592-018-0136-6.

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Site‐Specific Labeling of Affimers for DNA‐PAINT Microscopy

T. Schlichthaerle; A. S. Eklund; F. Schueder; M. T. Strauss; C. Tiede et al. 

Angewandte Chemie International Edition. 2018. Vol. 57, num. 34, p. 11060 – 11063. DOI : 10.1002/anie.201804020.

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Quantifying absolute addressability in DNA origami with molecular resolution

M. T. Strauss; F. Schueder; D. Haas; P. C. Nickels; R. Jungmann 

Nature Communications. 2018. Vol. 9, num. 1. DOI : 10.1038/s41467-018-04031-z.

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2017

Multiplexed 3D super-resolution imaging of whole cells using spinning disk confocal microscopy and DNA-PAINT

F. Schueder; J. Lara-Gutiérrez; B. J. Beliveau; S. K. Saka; H. M. Sasaki et al. 

Nature Communications. 2017. Vol. 8, num. 1. DOI : 10.1038/s41467-017-02028-8.

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Programmable self-assembly of three-dimensional nanostructures from 10,000 unique components

L. L. Ong; N. Hanikel; O. K. Yaghi; C. Grun; M. T. Strauss et al. 

Nature. 2017. Vol. 552, num. 7683, p. 72 – 77. DOI : 10.1038/nature24648.

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Super-resolution microscopy with DNA-PAINT

J. Schnitzbauer; M. T. Strauss; T. Schlichthaerle; F. Schueder; R. Jungmann 

Nature Protocols. 2017. Vol. 12, num. 6, p. 1198 – 1228. DOI : 10.1038/nprot.2017.024.

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Universal Super‐Resolution Multiplexing by DNA Exchange

F. Schueder; M. T. Strauss; D. Hoerl; J. Schnitzbauer; T. Schlichthaerle et al. 

Angewandte Chemie International Edition. 2017. Vol. 56, num. 14, p. 4052 – 4055. DOI : 10.1002/anie.201611729.

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DNA-barcoded labeling probes for highly multiplexed Exchange-PAINT imaging

S. S. Agasti; Y. Wang; F. Schueder; A. Sukumar; R. Jungmann et al. 

Chemical Science. 2017. Vol. 8, num. 4, p. 3080 – 3091. DOI : 10.1039/c6sc05420j.

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2016

DNA nanotechnology and fluorescence applications

T. Schlichthaerle; M. T. Strauss; F. Schueder; J. B. Woehrstein; R. Jungmann 

Current Opinion in Biotechnology. 2016. Vol. 39, p. 41 – 47. DOI : 10.1016/j.copbio.2015.12.014.

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2015

Anle138b and related compounds are aggregation specific fluorescence markers and reveal high affinity binding to α-synuclein aggregates

A. A. Deeg; A. M. Reiner; F. Schmidt; F. Schueder; S. Ryazanov et al. 

Biochimica et Biophysica Acta (BBA) – General Subjects. 2015. Vol. 1850, num. 9, p. 1884 – 1890. DOI : 10.1016/j.bbagen.2015.05.021.

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Routing of individual polymers in designed patterns

J. B. Knudsen; L. Liu; A. L. Bank Kodal; M. Madsen; Q. Li et al. 

Nature Nanotechnology. 2015. num. 10, p. 892 – 898. DOI : 10.1038/nnano.2015.190.

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DNA-Based Self-Assembly of Fluorescent Nanodiamonds

T. Zhang; A. Neumann; J. Lindlau; Y. Wu; G. Pramanik et al. 

Journal of the American Chemical Society. 2015. Vol. 137, num. 31, p. 9776 – 9779. DOI : 10.1021/jacs.5b04857.

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