A bioengineered human urothelial organoid model reveals the urine-urothelium interplay in tissue resilience and UPEC recurrence in urinary tract infections

G. R. Paduthol; M. Nikolaev; K. Sharma; J. Blanc; K. Tomasek et al. 

Epithelial Reprogramming by OM-89 Enhances Antibiotic Clearance of Uropathogenic E. coli in a Bladder Organoid Model

K. Tomasek; K. Skurvydaite; G. Paduthol; A. M. Burns; L. Schlunke et al. 

A hermetically closed sample chamber enables time-lapse nano-characterization of pathogenic microorganisms in vitro

E. Braun; S. H. Andany; M. Kanguel; N. S. Asmari; J. D. Mckinney et al. 

Exploring the Role of Unstable L-Forms in the Survival of Uropathogenic Escherichia coli Under Fosfomycin Exposure

Advancing high-resolution microscopes to enable time-lapse nano-characterization of pathogenic micro-organisms in-vitro

UROPOT: study protocol for a randomized, double-blind phase I/II trial for metabolism-based potentiation of antimicrobial prophylaxis in the urological tract

K. Stritt; B. Roth; A. Masnada; F. Hammann; D. Jacot et al. 

Human alveolar lining fl uid from the elderly promotes Mycobacterium tuberculosis intracellular growth and translocation into the cytosol of alveolar epithelial cells

A. M. Olmo-Fontanez; J. M. Scordo; A. Schami; A. Garcia-Vilanova; P. A. Pino et al. 

Open-source microscope add-on for structured illumination microscopy

M. T. M. Hannebelle; E. Raeth; S. M. Leitao; T. Lukes; J. Pospisil et al. 

Single-cell analysis of the interactions between Mycobacterium tuberculosis and macrophages

Amidation of glutamate residues in mycobacterial peptidoglycan is essential for cell wall cross-linking

M. T. Shaku; K. L. Ocius; A. J. Apostolos; M. M. Pires; M. S. Vannieuwenhze et al. 

cGAS-STING drives ageing-related inflammation and neurodegeneration

M. F. Gulen; N. Samson; A. Keller; M. Schwabenland; C. Liu et al. 

Investigating the composition and recruitment of the mycobacterial ImuA’-ImuB-DnaE2 mutasome

S. Gessner; Z. A-M. Martin; M. A. Reiche; J. A. Santos; R. Dinkele et al. 

Uptake-independent killing of macrophages by extracellular Mycobacterium tuberculosis aggregates

C. Toniolo; N. Dhar; J. D. McKinney 

Preexisting Heterogeneity of Inducible Nitric Oxide Synthase Expression Drives Differential Growth of Mycobacterium tuberculosis in Macrophages

O. Rutschmann; C. Toniolo; J. D. McKinney 

Fluorescent D-Amino Acids for Super-resolution Microscopy of the Bacterial Cell Wall

C. Zhang; L. Reymond; O. Rutschmann; M. A. Meyer; J. Denereaz et al. 

Type 1 piliated uropathogenic Escherichia coli hijack the host immune response by binding to CD14

K. Tomasek; A. Leithner; I. Glatzova; M. S. Lukesch; C. C. Guet et al. 

The cGAS–STING pathway drives type I IFN immunopathology in COVID-19

J. D. Domizio; M. F. Gulen; F. Saidoune; V. V. Thacker; A. Yatim et al. 

Identification of genes required for host-cell adhesion and antibiotic persistence of uropathogenic Escherichia coli via high-content screening

Early invasion of the bladder wall by solitary bacteria protects UPEC from antibiotics and neutrophil swarms in an organoid model

K. Sharma; V. V. Thacker; N. Dhar; M. Clapés Cabrer; A. Dubois et al. 

Dynamic persistence of UPEC intracellular bacterial communities in a human bladder-chip model of urinary tract infection

K. Sharma; N. Dhar; V. V. Thacker; T. M. Simonet; F. Signorino-Gelo et al. 

Revealing Antibiotic Tolerance of the Mycobacterium smegmatis Xanthine/Uracil Permease Mutant Using Microfluidics and Single-Cell Analysis

M. Elitas; N. Dhar; J. D. McKinney 

Rapid endotheliitis and vascular damage characterize SARS‐CoV‐2 infection in a human lung‐on‐chip model

V. V. Thacker; V. V. Thacker; K. Sharma; N. Dhar; G. Mancini et al. 

Microfluidic-assisted bioprinting of tissues and organoids at high cell concentrations

L. Serex; K. Sharma; V. Rizov; A. Bertsch; J. D. McKinney et al. 

Modified full-face snorkel masks as reusable personal protective equipment for hospital personnel

L. Kroo; A. Kothari; M. Hannebelle; G. Herring; T. Pollina et al. 

Coordination between cell growth, division and chromosome replication cycles in mycobacteria

Microtissue models for studying the dynamics of host-pathogen interactions in the urinary bladder

A lung-on-chip model of early Mycobacterium tuberculosis infection reveals an essential role for alveolar epithelial cells in controlling bacterial growth

V. V. Thacker; N. Dhar; K. Sharma; R. Barrile; K. Karalis et al. 

Elicitation of efficient, protective immune responses by using DNA vaccines against tuberculosis (vol 23, pg 5655, 2005)

A. Khera; R. Singh; H. Shakila; V. Rao; N. Dhar et al. 

Do chance encounters between heterogeneous cells shape the outcome of tuberculosis infections?

C. Toniolo; O. Rutschmann; J. McKinney 

Bacteria: Driving polar growth

N. Dhar 

Impedance-Based Single-Cell Pipetting

D. Bonzon; G. Muller; J-B. Bureau; N. Uffer; N. Beuchat et al. 

A biphasic growth model for cell pole elongation in mycobacteria

M. T. M. Hannebelle; J. X. Y. Ven; C. Toniolo; H. A. Eskandarian; G. Vuaridel-Thurre et al. 

Overlapping and essential roles for molecular and mechanical mechanisms in mycobacterial cell division

P. D. Odermatt; M. T. M. Hannebelle; H. A. Eskandarian; A. P. Nievergelt; J. D. McKinney et al. 

Computational Analysis of the Mutual Constraints between Single‐Cell Growth and Division Control Models

G. Vuaridel‐Thurre; A. R. Vuaridel; N. Dhar; J. D. McKinney 

Preexisting variation in DNA damage response predicts the fate of single mycobacteria under stress

G. Manina; A. Griego; L. K. Singh; J. D. McKinney; N. Dhar 

Disruption of the SucT acyltransferase in Mycobacterium smegmatis abrogates succinylation of cell envelope polysaccharides

Z. Palcekova; S. K. Angala; J. M. Belardinelli; H. A. Eskandarian; M. Joe et al. 

Increased drug permeability of a stiffened mycobacterial outer membrane in cells lacking MFS transporter Rv1410 and lipoprotein LprG

M. Hohl; S. Remm; H. A. Eskandarian; M. Dal Molin; F. M. Arnold et al. 

Time-Lapse Atomic Force Microscopy Reveals New End Take Off (Neto) Dynamics in Mycobacteria

M. T. M. Hannebelle; J. X. Y. Ven; H. A. Eskandarian; C. Toniolo; A. P. D. Nievergelt et al. 

Single-cell studies of Mycobacterium smegmatis cell cycle using time-lapse fluorescence microscopy

Fluorescent Benzothiazinone Analogues Efficiently and Selectively Label Dpre1 in Mycobacteria and Actinobacteria

R. Sommer; J. Neres; J. Piton; N. Dhar; A. van der Sar et al. 

Maturing Mycobacterium smegmatis peptidoglycan requires non-canonical crosslinks to maintain shape

C. Baranowski; M. A. Welsh; L-T. Sham; H. A. Eskandarian; H. C. Lim et al. 

Revealing Bacterial Surface Physiology using Dual Atomic Force and Optical Time-Lapse Microscopy

H. A. Eskandarian 

A microfluidic cell-trapping device to study dynamic host-microbe interactions at the single-cell level

Tip connector for fluidic and electrical connection

D. V. Bonzon; J-P. Bonzon; G. H. Muller; J-B. Bureau; Y. Barrandon et al. 

Single-cell division and killing dynamics of bacteria exposed to isocratic and time-dependent concentrations of antibiotic

Elucidating the role of (p)ppGpp in mycobacterial persistence against antibiotics

A. Bhaskar; C. De Piano; E. Gelman; J. McKinney; N. Dhar 

The studies of ParA and ParB dynamics reveal asymmetry of chromosome segregation in mycobacteria

K. Ginda; I. Santi; D. Bousbaine; J. Zakrzewska-Czerwinska; D. Jakimowicz et al. 

An Amidase_3 domain-containing N-acetylmuramyl-L-alanine amidase is required for mycobacterial cell division

S. Senzani; D. Li; A. Bhaskar; C. Ealand; J. Chang et al. 

Dielectrophoresis as a single cell characterization method for bacteria

M. Elitas; N. Dhar; K. Schneider; A. Valero; T. Braschler et al. 

Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria

V. Singh; N. Dhar; J. Pato; G. S. Kolly; J. Kordulakova et al. 

The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis

V. Singh; S. Donini; A. Pacitto; C. Sala; R. C. Hartkoorn et al. 

A Microfluidic Platform Enables Large-Scale Single-Cell Screening to Identify Genes Involved in Bacterial Persistence

Mycobacterium tuberculosis Resists Stress by Regulating PE19 Expression

P. Ramakrishnan; A. M. Aagesen; J. D. Mckinney; A. D. Tischler 

Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor

M. Martinez-Hoyos; E. Perez-Herran; G. Gulten; L. Encinas; D. Alvarez-Gomez et al. 

Mycobacterium tuberculosis Phosphate Uptake System Component PstA2 Is Not Required for Gene Regulation or Virulence

A. D. Tischler; R. L. Leistikow; P. Ramakrishnan; M. I. Voskuil; J. D. Mckinney 

A microfluidic cell-trapping device for single-cell tracking of host-microbe interactions

M. J. Delince; J-B. Bureau; A. T. Lopez-Jimenez; P. Cosson; T. Soldati et al. 

A rheostat mechanism governs the bifurcation of carbon flux in mycobacteria

P. Murima; M. Zimmermann; T. Chopra; F. Pojer; G. Fonti et al. 

Devices, systems and methods for dispensing and analysing particles

D. V. Bonzon; G. H. Muller; P. Renaud; Y. Barrandon; J-b. Bureau et al. 

Quantitative Single-Cell Analysis of Host-Pathogen Interactions

Antiviral drug resistance as an adaptive process

K. K. Irwin; N. Renzette; T. F. Kowalik; J. D. Jensen 

Next-generation antimicrobials: from chemical biology to first-in-class drugs

M. L. T. Ang; P. Murima; K. Pethe 

Whole Cell Target Engagement Identifies Novel Inhibitors of Mycobacterium tuberculosis Decaprenylphosphoryl-beta-D-ribose Oxidase

S. M. Batt; M. Cacho Izquierdo; J. Castro Pichel; C. J. Stubbs; L. Vela-Glez Del Peral et al. 

Single-Cell Tracking Reveals Antibiotic-Induced Changes in Mycobacterial Energy Metabolism

Z. Maglica; E. Oezdemir; J. D. Mckinney 

Chromosome Organization and Replisome Dynamics in Mycobacterium smegmatis

I. Santi; J. D. Mckinney 

Rapid Cytolysis of Mycobacterium tuberculosis by Faropenem, an Orally Bioavailable beta-Lactam Antibiotic

N. Dhar; V. Dubee; L. Ballell; G. Cuinet; J-E. Hugonnet et al. 

Combinations of beta-Lactam Antibiotics Currently in Clinical Trials Are Efficacious in a DHP-I-Deficient Mouse Model of Tuberculosis Infection

J. Rullas; N. Dhar; J. D. Mckinney; A. Garcia-Perez; J. Lelievre et al. 

Dielectrophoresis-based purification of antibiotic-treated bacterial subpopulations

M. Elitas; R. Martinez-Duarte; N. Dhar; J. D. Mckinney; P. Renaud 

Delayed bactericidal response of Mycobacterium tuberculosis to bedaquiline involves remodelling of bacterial metabolism

A. Koul; L. Vranckx; N. Dhar; H. W. H. Gohlmann; M. E. Özdemir et al. 

Targeting Bacterial Central Metabolism for Drug Development

P. Murima; J. D. Mckinney; K. Pethe 

Quantitative Mass Spectrometry Reveals Plasticity of Metabolic Networks in Mycobacterium smegmatis

T. Chopra; R. Hamelin; F. Armand; D. Chiappe; M. Moniatte et al. 

Antibiotic-Induced Killing and Persistence of Mycobacteria

BactImAS: a platform for processing and analysis of bacterial time-lapse microscopy movies

I. Mekterovic; D. Mekterovic; Z. Maglica 

Pathogenesis of Mycobacterium tuberculosis and its Interaction with the Host Organism Preface

4-Aminoquinolone Piperidine Amides: Noncovalent Inhibitors of DprE1 with Long Residence Time and Potent Antimycobacterial Activity

M. Naik; V. Humnabadkar; S. J. Tantry; M. Panda; A. Narayan et al. 

Establishment and Validation of Whole-Cell Based Fluorescence Assays to Identify Anti-Mycobacterial Compounds Using the Acanthamoeba castellanii – Mycobacterium marinum Host-Pathogen System

S. Kicka; V. Trofimov; C. Harrison; H. Ouertatani-Sakouhi; J. McKinney et al. 

A Single-Cell Perspective on Non-Growing but Metabolically Active (NGMA) Bacteria

Metabolic modeling and experimental studies on carbon and energy metabolism of Mycobacterium tuberculosis

A problem of persistence: still more questions than answers?

N. Q. Balaban; K. Gerdes; K. Lewis; J. D. McKinney 

Dynamic Persistence of Antibiotic-Stressed Mycobacteria

Y. Wakamoto; N. Dhar; R. Chait; K. E. Schneider; F. Signorino-Gelo et al. 

The Phosphate Specific Transport (Pst) System in Fast- and Slow-Growing Mycobacteria

Adaptive Response of Group B Streptococcus to High Glucose Conditions: New Insights on the CovRS Regulation Network

B. Di Palo; V. Rippa; I. Santi; C. Brettoni; A. Muzzi et al. 

Tuberculosis biomarkers discovery: developments, needs, and challenges

R. S. Wallis; P. Kim; S. Cole; D. Hanna; B. B. Andrade et al. 

Single-cell dynamics of the chromosome replication and cell division cycles in mycobacteria

I. Santi; N. Dhar; D. Bousbaine; Y. Wakamoto; J. D. McKinney 

The DprE1 enzyme, one of the most vulnerable targets of Mycobacterium tuberculosis

G. Riccardi; M. R. Pasca; L. R. Chiarelli; G. Manina; A. Mattevi et al. 

A vitamin B-12 transporter in Mycobacterium tuberculosis

K. Gopinath; C. Venclovas; T. R. Ioerger; J. C. Sacchettini; J. D. McKinney et al. 

Mycobacterium tuberculosis Requires Phosphate-Responsive Gene Regulation To Resist Host Immunity

A. D. Tischler; R. L. Leistikow; M. A. Kirksey; M. I. Voskuil; J. D. McKinney 

Drug-resistant tuberculosis: time for visionary political leadership

I. Abubakar; M. Zignol; D. Falzon; M. Raviglione; L. Ditiu et al. 

Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium tuberculosis

J. Neres; F. Pojer; E. Molteni; L. R. Chiarelli; N. Dhar et al. 

Streptomycin-Starved Mycobacterium tuberculosis 18b, a Drug Discovery Tool for Latent Tuberculosis

M. Zhang; C. Sala; R. C. Hartkoorn; N. Dhar; A. Mendoza-Losana et al. 

Single-Cell Analysis of Mycobacterial Persistence Using Microfabricated Tools

Malachite Green Interferes with Postantibiotic Recovery of Mycobacteria

E. Gelman; J. D. McKinney; N. Dhar 

Cholesterol Catabolism by Mycobacterium tuberculosis Requires Transcriptional and Metabolic Adaptations

J. E. Griffin; A. K. Pandey; S. A. Gilmore; V. Mizrahi; J. D. Mckinney et al. 

EspD Is Critical for the Virulence-Mediating ESX-1 Secretion System in Mycobacterium tuberculosis

J. M. Chen; S. Boy-Röttger; N. Dhar; N. Sweeney; R. S. Buxton et al. 

Dispensability of Surfactant Proteins A and D in Immune Control of Mycobacterium tuberculosis Infection following Aerosol Challenge of Mice

M. P. Lemos; J. McKinney; K. Y. Rhee 

Bacterial strategies for survival in the host

Spontaneous phthiocerol dimycocerosate-deficient variants of Mycobacterium tuberculosis are susceptible to gamma interferon-mediated immunity

M. A. Kirksey; A. D. Tischler; R. Siméone; K. B. Hisert; S. Uplekar et al. 

A community effort towards a knowledge-base and mathematical model of the human pathogen Salmonella Typhimurium LT2

I. Thiele; D. R. Hyduke; B. Steeb; G. Fankam; D. K. Allen et al. 

Nanoparticle conjugation and pulmonary delivery enhance the protective efficacy of Ag85B and CpG against tuberculosis

M. Ballester; C. Nembrini; N. Dhar; A. de Titta; C. de Piano et al. 

Expression of the leptin receptor outside of bone marrow-derived cells regulates tuberculosis control and lung macrophage MHC expression

M. P. Lemos; K. Y. Rhee; J. D. McKinney 

Mycobacterium tuberculosis persistence mutants identified by screening in isoniazid-treated mice

N. Dhar; J. D. McKinney 

Decaprenylphosphoryl-beta-D-Ribose 2 ‘-Epimerase from Mycobacterium tuberculosis is a Magic Drug Target

G. Manina; M. R. Pasca; S. Buroni; E. De Rossi; G. Riccardi 

Contrasting persistence strategies in Salmonella and Mycobacterium

A. D. Tischler; J. D. McKinney 

Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis

V. Makarov; G. Manina; K. Mikusova; U. Möllmann; O. Ryabova et al. 

Functional characterization of a vitamin B12-dependent methylmalonyl pathway in Mycobacterium tuberculosis: implications for propionate metabolism during growth on fatty acids

S. Savvi; D. F. Warner; B. D. Kana; J. D. McKinney; V. Mizrahi et al. 

Role of the methylcitrate cycle in propionate metabolism and detoxification in Mycobacterium smegmatis

A. M. Upton; J. D. McKinney 

Microbial phenotypic heterogeneity and antibiotic tolerance

N. Dhar; J. D. McKinney 

M. tuberculosis Rv2252 encodes a diacylglycerol kinase involved in the biosynthesis of phosphatidylinositol mannosides (PIMs)

R. M. Owens; F. F. Hsu; B. C. VanderVen; G. E. Purdy; E. Hesteande et al. 

A multidrug-resistant, acr1-deficient clinical isolate of Mycobacterium tuberculosis is unimpaired for replication in macrophages

J. Timm; N. Kurepina; B. N. Kreiswirth; F. A. Post; G. B. Walther et al. 

Dual role of isocitrate lyase 1 in the glyoxylate and methylcitrate cycles in Mycobacterium tuberculosis

T. A. Gould; H. van de Langemheen; E. J. Muñoz-Elías; J. D. McKinney; J. C. Sacchettini 

Role of the methylcitrate cycle in Mycobacterium tuberculosis metabolism, intracellular growth, and virulence

E. J. Muñoz-Elías; A. M. Upton; J. Cherian; J. D. McKinney 

Carbon metabolism of intracellular bacteria

E. J. Muñoz-Elías; J. D. McKinney 

Consumed in the city Observing tuberculosis at century‘s end

J. E. Gomez; J. D. McKinney 

Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence

E. Munoz-Elias; J. McKinney 

Identification of Mycobacterium tuberculosis counterimmune (cim) mutants in immunodeficient mice by differential screening

K. B. Hisert; M. A. Kirksey; J. E. Gomez; A. O. Sousa; J. S. Cox et al. 

Persistence and drug tolerance

Role of KatG catalase-peroxidase in mycobacterial pathogenesis: countering the phagocyte oxidative burst

V. H. Ng; J. S. Cox; A. O. Sousa; J. D. MacMicking; J. D. McKinney 

Replication dynamics of Mycobacterium tuberculosis in chronically infected mice

E. J. Muñoz-Elías; J. Timm; T. Botha; W-T. Chan; J. E. Gomez et al. 

Life on the inside for Mycobacterium tuberculosis

J. D. McKinney; J. E. Gomez 

Macrophage immunity and Mycobacterium Tuberculosis

Differential expression of iron-, carbon-, and oxygen-responsive mycobacterial genes in the lungs of chronically infected mice and tuberculosis patients

J. Timm; F. A. Post; L-G. Bekker; G. B. Walther; H. C. Wainwright et al. 

M. tuberculosis persistence, latency, and drug tolerance

J. E. Gomez; J. D. McKinney 

Ribonucleotide reduction in Mycobacterium tuberculosis: function and expression of genes encoding class Ib and class II ribonucleotide reductases

S. S. Dawes; D. F. Warner; L. Tsenova; J. Timm; J. D. McKinney et al. 

Immune control of tuberculosis by IFN-gamma-inducible LRG-47

J. D. MacMicking; G. A. Taylor; J. D. McKinney 

Bacterial persistence: strategies for survival

Infection of mice with aerosolized Mycobacterium tuberculosis: use of a nose-only apparatus for delivery of low doses of inocula and design of an ultrasafe facility

J. R. Schwebach; B. Chen; A. Glatman-Freedman; A. Casadevall; J. D. McKinney et al. 

Tuberculosis and leprosy

Recombinant bacillus Calmette-Guérin as a potential vector for preventive HIV type 1 vaccines

L. A. Falk; K. L. Goldenthal; J. Esparza; M. T. Aguado; S. Osmanov et al. 

Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase

J. D. McKinney; K. Höner zu Bentrup; E. J. Muñoz-Elías; A. Miczak; B. Chen et al. 

In vivo veritas: the search for TB drug targets goes live

J. D. McKinney 

Structure of isocitrate lyase, a persistence factor of Mycobacterium tuberculosis

V. Sharma; S. Sharma; K. Hoener zu Bentrup; J. D. McKinney; D. G. Russell et al. 

The death and resurrection of tuberculosis

B. R. Bloom; J. D. McKinney 

Persisting problems in tuberculosis

Ste12 and Mcm1 regulate cell cycle-dependent transcription of FAR1.

L. J. Oehlen; J. D. McKinney; F. R. Cross 

FAR1 and the G1 phase specificity of cell cycle arrest by mating factor in Saccharomyces cerevisiae.

J. D. McKinney; F. R. Cross 

Identification of bacteriophage T4 prereplicative proteins on two-dimensional polyacrylamide gels

E. M. Kutter; K. d’Acci; R. H. Drivdahl; J. Gleckler; J. C. McKinney et al. 

Effects on host genome and structure

Role of Swi4 in cell cycle regulation of CLN2 expression.

F. R. Cross; M. Hoek; J. D. McKinney; A. H. Tinkelenberg 

Negative regulation of FAR1 at the Start of the yeast cell cycle.

J. D. McKinney; F. Chang; N. Heintz; F. R. Cross 

A switch-hitter at the Start of the cell cycle

J. McKinney; F. Cross 

Is START a switch?

F. Cross; J. McKinney 

Transcriptional regulation in the eukaryotic cell cycle

J. D. McKinney; N. Heintz 

Histone H1 subtype-specific consensus elements mediate cell cycle-regulated transcription in vitro

F. La Bella; P. Gallinari; J. McKinney; N. Heintz 

Expression of cloned rpoB gene of Escherichia coli: a genetic system for the isolation of dominant negative mutations and overproduction of defective beta subunit of RNA polymerase.

J. Y. Lee; K. Zalenskaya; Y. K. Shin; J. D. McKinney; J. H. Park et al. 

Overexpression and purification of a biologically active rifampicin-resistant beta subunit of Escherichia coli RNA polymerase

J. D. McKinney; J. Y. Lee; R. E. O’Neill; A. Goldfarb