Reproducibility of Scientific Claims in Drosophila Immunity: A Retrospective Analysis of 400 Publications

H. Westlake; F. David; Y. Tian; K. Krakovic; A. Dolgikh et al. 

A retrospective analysis of 400 publications reveals patterns of irreproducibility across an entire life sciences research field

J. Lemaitre; D. Popelka; B. Ribotta; H. Westlake; S. Chakrabarti et al. 

The Antimicrobial and Host Defense Peptides of Drosophila melanogaster

M. A. Hanson; H. E. Westlake; P. Bulet; B. Lemaitre 

Functional Characterization of Paillotin: an Immune Peptide Regulated by the Immune Deficiency (imd) Pathway with Pathogen-specific Roles in drosophila Immunity

Y. Tian; X. Yue; R. Jiao; M. A. Hanson; B. Lemaitre 

The secreted Nimrod protein NimB1 negatively regulates early steps of apoptotic cell phagocytosis in Drosophila

A. Dolgikh; S. Rommelaere; A. Ghanem; B. Petrignani; M. Poidevin et al. 

Gut commensal bacteria-derived methionine is required for host reproduction by modulating RNA m6A methylation of the insulin receptor

Q. Zhang; Z. R. Deng; X. Li; J. Qiao; Z. Li et al. 

SAM transmethylation pathway and adenosine recycling to ATP are essential for systemic regulation and immune response

B. Lemaître 

Bacterial-induced Duox-ROS regulates the Imd immune pathway in the gut by modulating the peritrophic matrix

S. Bai; Z. Yao; Z. Cai; Q. Ma; Q. Guo et al. 

An updated proteomic analysis of Drosophila haemolymph after bacterial infection

S. Rommelaere; F. Schüpfer; F. Armand; R. Hamelin; B. Lemaitre 

Insights into Phagocytic Regulation in Drosophila: Understanding the Role of NimBs

A Controlled Test of Risk-Dependent Immune Investment in a Clonal Ant

Z. Li; T. H. Ng; J. Keller; F. Masson; G. Grabenweger et al. 

Drosophila host defense mechanisms against filamentous fungal pathogens with diverse lifestyles

G. Liu; Y. Tian; M. A. Hanson; J. Li; B. Lemaitre 

Layers of immunity: Deconstructing the Drosophila effector response

F. Ryckebusch; Y. Tian; M. Rapin; F. Schüpfer; M. A. Hanson et al. 

Dietary L-Glu sensing by enteroendocrine cells adjusts food intake via modulating gut PYY/NPF secretion

J. Gao; S. Zhang; P. Deng; Z. Wu; B. Lemaitre et al. 

Duox activation in Drosophila Malpighian tubules stimulates intestinal epithelial renewal through a countercurrent flow

Z. Liu; H. Zhang; B. Lemaitre; X. Li 

The conceptual foundations of innate immunity: Taking stock 30 years later

Pradeu Thomas; Thomma Bart T.P.H.; Girarding Stephen; B. Lemaitre 

A humoral stress response protects Drosophila tissues from antimicrobial peptides

S. Rommelaere; A. Carboni; J. F. Bada Juarez; J-P. Boquete; L. A. Abriata et al. 

Pathobiont and symbiont contribute to microbiota homeostasis through Malpighian tubules–gut countercurrent flow in Bactrocera dorsalis

Y. Liu; R. Luo; S. Bai; B. Lemaitre; H. Zhang et al. 

The Drosophila immunity handbook

H. Westlake; M. A. Hanson; B. Lemaitre 

Intestinal commensal bacteria promote Bactrocera dorsalis larval development through vitamin B6 synthesis pathway

J. Gu; Z. Yao; B. Lemaitre; Z. Cai; H. Zhang et al. 

Protein target highlights in CASP15: Analysis of models by structure providers

L. T. Alexander; J. Durairaj; A. Kryshtafovych; L. A. Abriata; Y. Bayo et al. 

Ecology-relevant bacteria drive the evolution of host antimicrobial peptides in Drosophila

M. A. Hanson; L. Grollmus; B. Lemaitre 

CERT1 mutations perturb human development by disrupting sphingolipid homeostasis

C. Gehin; M. A. Lone; W. Lee; L. Capolupo; S. Ho et al. 

Antimicrobial peptides do not directly contribute to aging in Drosophila, but improve lifespan by preventing dysbiosis

M. A. Hanson; B. Lemaitre 

Functional characterization of Drosophila melanogaster immune effectors

Compartmentalized PGRP expression along the dipteran Bactrocera dorsalis gut forms a zone of protection for symbiotic bacteria

Z. Yao; Z. Cai; Q. Ma; S. Bai; Y. Wang et al. 

Disproportionate investment in Spiralin B production limits in-host growth and favors the vertical transmission of Spiroplasma insect endosymbionts

F. Masson; S. Rommelaere; F. Schupfer; J-P. Boquete; B. Lemaitre 

Drosophila immunity: the Drosocin gene encodes two host defence peptides with pathogen-specific roles

M. A. Hanson; S. Kondo; B. Lemaitre 

Repeated truncation of a modular antimicrobial peptide gene for neural context

M. Hanson; B. Lemaitre 

Cecropins contribute to Drosophila host defense against a subset of fungal and Gram-negative bacterial infection

A. L. Carboni; M. A. Hanson; S. A. Lindsay; S. A. Wasserman; B. Lemaitre 

The role of the Nimrod proteins in the Drosophila immune system

A systematic CRISPR approach to understanding the role of Drosophila antimicrobial peptides in immunity in vivo

The wall-less bacterium Spiroplasma poulsonii builds a polymeric cytoskeleton composed of interacting MreB isoforms

F. Masson; X. Pierrat; B. Lemaitre; A. Persat 

A secreted factor NimrodB4 promotes the elimination of apoptotic corpses by phagocytes in Drosophila

B. M. Petrignani; S. Rommelaere; K. Hakim‐Mishnaevski; F. F. Masson; E. J. V. Ramond et al. 

The Drosophila Baramicin polypeptide gene protects against fungal infection

M. A. Hanson; L. B. Cohen; A. Marra; I. Iatsenko; S. A. Wasserman et al. 

Drosophila Antimicrobial Peptides and Lysozymes Regulate Gut Microbiota Composition and Abundance

A. Marra; M. A. Hanson; S. Kondo; B. Erkosar; B. Lemaitre 

The iron transporter Transferrin 1 mediates homeostasis of the endosymbiotic relationship between Drosophila melanogaster and Spiroplasma poulsonii

A. Marra; F. Masson; B. Lemaitre 

Dual proteomics of Drosophila melanogaster hemolymph infected with the heritable endosymbiont Spiroplasma poulsonii

F. F. Masson; S. Rommelaere; A. Marra; F. Schüpfer; B. Lemaitre 

Rapid molecular evolution of Spiroplasma symbionts of Drosophila

M. Gerth; H. Martinez-Montoya; P. Ramirez; F. Masson; J. S. Griffin et al. 

Autophagy as a Gatekeeper of Intestinal Homeostasis

X. Li; B. Lemaitre 

Steroid‐dependent switch of OvoL/Shavenbaby controls self‐renewal versus differentiation of intestinal stem cells

S. Al Hayek; A. Alsawadi; Z. Kambris; J. P. Boquete; J. Bohère et al. 

The role of immune effectors in controlling Drosophila-microbes interactions

Transformation of the Drosophila Sex-Manipulative Endosymbiont Spiroplasma poulsonii and Persisting Hurdles for Functional Genetic Studies

F. Masson; F. Schuepfer; C. Jollivet; B. Lemaitre 

Comparative RNA-Seq analyses ofDrosophilaplasmatocytes reveal gene specific signatures in response to clean injury and septic injury

E. Ramond; J. P. Dudzic; B. Lemaitre 

Machiavellian males with high emotional intelligence exhibit fewer depressive symptoms

R. Bianchi; N. Patthey; D. Mirkovic; B. Lemaitre; K. Schlegel 

Iron sequestration by transferrin 1 mediates nutritional immunity in Drosophila melanogaster

I. Iatsenko; A. Marra; J-P. Boquete; J. Pena; B. Lemaitre 

Renal Purge of Hemolymphatic Lipids Prevents the Accumulation of ROS-Induced Inflammatory Oxidized Lipids and Protects Drosophila from Tissue Damage

X. Li; S. Rommelaere; S. Kondo; B. Lemaitre 

The adipokine NimrodB5 regulates peripheral hematopoiesis in Drosophila

E. Ramond; B. Petrignani; J. P. Dudzic; J-P. Boquete; M. Poidevin et al. 

Blind killing of both male and female Drosophila embryos by a natural variant of the endosymbiotic bacterium Spiroplasma poulsonii

F. Masson; S. Calderon-Copete; F. Schuepfer; A. Vigneron; S. Rommelaere et al. 

New insights on Drosophila antimicrobial peptide function in host defense and beyond

M. A. Hanson; B. Lemaitre 

Growing Ungrowable Bacteria: Overview and Perspectives on Insect Symbiont Culturability

F. Masson; B. Lemaitre 

Role of Nimrod receptors in the Drosophila melanogaster cellular immune response

Adult Drosophila Lack Hematopoiesis but Rely on a Blood Cell Reservoir at the Respiratory Epithelia to Relay Infection Signals to Surrounding Tissues

P. S. Bosch; K. Makhijani; L. Herboso; K. S. Gold; R. Baginsky et al. 

Dynamic Evolution of Antimicrobial Peptides Underscores Trade-Offs Between Immunity and Ecological Fitness

M. A. Hanson; B. Lemaitre; R. L. Unckless 

The antimicrobial peptide defensin cooperates with tumour necrosis factor to drive tumour cell death in Drosophila

J-P. Parvy; Y. Yu; A. Dostalova; S. Kondo; A. Kurjan et al. 

Two Nimrod receptors, NimC1 and Eater, synergistically contribute to bacterial phagocytosis in Drosophila melanogaster

C. Melcarne; E. Ramond; J. Dudzic; A. J. Bretscher; E. Kurucz et al. 

Phagocytosis in Drosophila: From molecules and cellular machinery to physiology

C. Melcarne; B. Lemaitre; E. Kurant 

More Than Black or White: Melanization and Toll Share Regulatory Serine Proteases in Drosophila

J. P. Dudzic; M. A. Hanson; I. Iatsenko; S. Kondo; B. Lemaitre 

The Exchangeable Apolipoprotein Nplp2 Sustains Lipid Flow and Heat Acclimation in Drosophila

S. Rommelaere; J-P. Boquete; J. Piton; S. Kondo; B. Lemaitre 

Functional analysis of RIP toxins from the Drosophila endosymbiont Spiroplasma poulsonii

M. G. Garcia-Arraez; F. Masson; J. C. P. Escobar; B. Lemaitre 

Synergy and remarkable specificity of antimicrobial peptides in vivo using a systematic knockout approach

M. A. Hanson; A. Dostálová; C. Ceroni; M. Poidevin; B. Lemaitre 

Evolution of longevity improves immunity in Drosophila

D. K. Fabian; K. Garschall; P. Klepsatel; G. Santos-Matos; E. Sucena et al. 

Microbiota-Derived Lactate Activates Production of Reactive Oxygen Species by the Intestinal NADPH Oxidase Nox and Shortens Drosophila Lifespan

I. Iatsenko; J-P. Boquete; B. Lemaitre; I. Iatsenko; J-P. Boquete et al. 

Male-killing toxin in a bacterial symbiont of Drosophila

T. Harumoto; B. Lemaitre 

Cell-Specific Imd-NF-κB Responses Enable Simultaneous Antibacterial Immunity and Intestinal Epithelial Cell Shedding upon Bacterial Infection

Z. Zhai; J-P. Boquete; B. Lemaitre; Z. Zhai; J-P. Boquete et al. 

Common and unique strategies of male killing evolved in two distinct Drosophila symbionts

T. Harumoto; T. Fukatsu; B. Lemaitre 

In Vitro Culture of the Insect Endosymbiont Spiroplasma poulsonii Highlights Bacterial Genes Involved in Host-Symbiont Interaction

F. Masson; S. Calderon Copete; F. Schüpfer; G. Garcia-Arraez; B. Lemaitre et al. 

Anatomy and Physiology of the Digestive Tract of Drosophila melanogaster

I. Miguel-Aliaga; H. Jasper; B. Lemaitre 

The double-edged toxins : how Spiroplasma Ribosome-Inactivating Proteins affect Drosophila melanogaster life history traits

The melanization reaction in Drosophila: More than black or white

La montée du narcissisme ?

A. Albertelli; B. Lemaitre 

Protection from within

F. Masson; B. Lemaitre 

A genetic framework controlling the differentiation of intestinal stem cells during regeneration in Drosophila

Z. Zhai; J-P. Boquete; B. Lemaitre 

Science, narcissism and the quest for visibility

B. Lemaitre 

The gram-negative sensing receptor PGRP-LC contributes to grooming induction in Drosophila

A. Yanagawa; C. Neyen; B. Lemaitre; F. Marion-Poll 

Transforming Growth Factor beta/Activin signaling in neurons increases susceptibility to starvation

W-B. A. Chng; R. Koch; X. Li; S. Kondo; E. Nagoshi et al. 

Thioester-containing proteins regulate the Toll pathway and play a role in Drosophila defence against microbial pathogens and parasitoid wasps

A. Dostalova; S. Rommelaere; M. Poidevin; B. Lemaitre 

Physiological Adaptations to Sugar Intake: New Paradigms from Drosophila melanogaster

W-B. A. Chng; V. Hietakangas; B. Lemaitre 

The Role of Lipid Competition for Endosymbiont-Mediated Protection against Parasitoid Wasps in Drosophila

J. C. Paredes; J. K. Herren; F. Schüpfer; B. Lemaitre 

Chemometric Analysis of Bacterial Peptidoglycan Reveals Atypical Modifications That Empower the Cell Wall against Predatory Enzymes and Fly Innate Immunity

A. Espaillat; O. Forsmo; K. El Biari; R. Björk; B. Lemaitre et al. 

The dual oxidase gene BdDuox regulates the intestinal bacterial community homeostasis of Bactrocera dorsalis

Z. Yao; A. Wang; Y. Li; Z. Cai; B. Lemaitre et al. 

Remote Control of Intestinal Stem Cell Activity by Haemocytes in Drosophila

S. Chakrabarti; J. P. Dudzic; X. Li; E. J. Collas; J-P. Boquete et al. 

The regulatory isoform rPGRP-LC induces immune resolution via endosomal degradation of receptors

C. Neyen; C. Runchel; F. Schüpfer; P. Meier; B. Lemaitre 

Connecting the obesity and the narcissism epidemics

B. Lemaitre 

PGRP-SD, an Extracellular Pattern-Recognition Receptor, Enhances Peptidoglycan-Mediated Activation of the Drosophila Imd Pathway

I. Iatsenko; S. Kondo; D. Mengin-Lecreulx; B. Lemaitre 

Male-killing symbiont damages host’s dosage-compensated sex chromosome to induce embryonic apoptosis

T. Harumoto; H. Anbutsu; B. Lemaitre; T. Fukatsu 

Cell Division by Longitudinal Scission in the Insect Endosymbiont

E. Ramond; C. Maclachlan; S. Clerc-Rosset; G. W. Knott; B. Lemaitre 

Sensing Gram-negative bacteria: a phylogenetic perspective

C. Neyen; B. Lemaitre 

The Drosophila gut response to infection : a systems approach

Gut physiology mediates a trade-off between adaptation to malnutrition and susceptibility to food-borne pathogens

R. K. Vijendravarma; S. Narasimha; S. Chakrabarti; A. Babin; S. Kolly et al. 

Different flavors of Toll guide olfaction

C. Neyen; B. Lemaitre 

Infection Dynamics and Immune Response in a Newly Described Drosophila-Trypanosomatid Association

P. T. Hamilton; J. Votypka; A. Dostalova; V. Yurchenko; N. H. Bird et al. 

The Nimrod transmembrane receptor Eater is required for hemocyte attachment to the sessile compartment in Drosophila melanogaster

A. J. Bretscher; V. Honti; O. Binggeli; O. Burri; M. Poidevin et al. 

From Embryo to Adult: Hematopoiesis along the Drosophila Life Cycle

E. Ramond; M. Meister; B. Lemaitre 

The Black cells phenotype is caused by a point mutation in the Drosophila pro-phenoloxidase 1 gene that triggers melanization and hematopoietic defects

C. Neyen; O. Binggeli; P. Roversi; L. Bertin; M. B. Sleiman et al. 

Determination of the structure of the O-antigen and the lipid A from the entomopathogenic bacterium Pseudomonas entomophila lipopolysaccharide along with its immunological properties

I. Speciale; I. Paciello; L. L. Fazio; L. Sturiale; A. Palmigiano et al. 

X-ray and Cryo-electron Microscopy Structures of Monalysin Pore-forming Toxin Reveal Multimerization of the Pro-form

P. Leone; C. Bebeacua; O. Opota; C. Kellenberger; B. Klaholz et al. 

Drosophila innate immunity: regional and functional specialization of prophenoloxidases

J. P. Dudzic; S. Kondo; R. Ueda; C. M. Bergman; B. Lemaitre 

Genome Sequence of the Drosophila melanogaster Male-Killing Spiroplasma Strain MSRO Endosymbiont

J. C. Paredes; J. K. Herren; F. Schuepfer; R. Marin; S. Claverol et al. 

Genetic, molecular and physiological basis of variation in Drosophila gut immunocompetence

M. S. B. Sleiman; D. Osman; A. Massouras; A. A. Hoffmann; B. Lemaitre et al. 

Accumulation of differentiating intestinal stem cell progenies drives tumorigenesis

Z. Zhai; S. Kondo; N. Ha; J-P. Boquete; M. Brunner et al. 

Redefining the metabolic landscape through TGF-beta/Activin signaling in Drosophila melanogaster

Insect endosymbiont proliferation is limited by lipid availability

J. K. Herren; J. C. Paredes; F. Schuepfer; K. Arafah; P. Bulet et al. 

The Drosophila MAPK p38c Regulates Oxidative Stress and Lipid Homeostasis in the Intestine

S. Chakrabarti; M. Poidevin; B. Lemaitre 

Transforming Growth Factor beta/Activin Signaling Functions as a Sugar-Sensing Feedback Loop to Regulate Digestive Enzyme Expression

W-B. A. Chng; M. S. B. Sleiman; F. Schuepfer; B. Lemaitre 

Prophenoloxidase Activation Is Required for Survival to Microbial Infections in Drosophila

O. Binggeli; C. Neyen; M. Poidevin; B. Lemaitre 

Methods to study Drosophila immunity

C. Neyen; A. J. Bretscher; O. Binggeli; B. Lemaitre 

Microbiota-Induced Changes in Drosophila melanogaster Host Gene Expression and Gut Morphology

N. A. Broderick; N. Buchon; B. Lemaitre 

The useful gate-crasher : molecular interactions between Drosophila and Spiroplasma

The Effectual Hitchhiker : Mechanisms and Consequences of Interactions Between Endosymbiotic Spiroplasma and Host Drosophila

Pseudomonas entomophila: A Versatile Bacterium with Entomopathogenic Properties

G. Dieppois; O. Opota; J. Lalucat; B. Lemaitre 

Vertical transmission of a Drosophila endosymbiont via cooption of the yolk transport and internalization machinery

J. K. Herren; J. C. Paredes; F. Schüpfer; B. Lemaitre 

dRYBP Contributes to the Negative Regulation of the Drosophila Imd Pathway

R. Aparicio; C. Neyen; B. Lemaitre; A. Busturia 

Morphological and Molecular Characterization of Adult Midgut Compartmentalization in Drosophila

N. Buchon; D. Osman; F. P. A. David; H. Y. Fang; J-P. Boquete et al. 

Functional Analysis of PGRP-LA in Drosophila Immunity

M. Gendrin; A. Zaidman-Remy; N. A. Broderick; J. Paredes; M. Poidevin et al. 

Crystallization and preliminary X-ray analysis of monalysin, a novel beta-pore-forming toxin from the entomopathogen Pseudomonas entomophila

M. Blemont; R. Vincentelli; C. Kellenberger; O. Opota; B. Lemaitre et al. 

Translation inhibition and metabolic stress pathways in the host response to bacterial pathogens

B. Lemaitre; S. E. Girardin 

Gut homeostasis in a microbial world: insights from Drosophila melanogaster

N. Buchon; N. A. Broderick; B. Lemaitre 

The Digestive Tract of Drosophila melanogaster

B. Lemaitre; I. Miguel-Aliaga 

The contribution of the host stress response to the pathogenesis of Pseudomonas entomophila in the Drosophila intestine

Role and regulation of the melanization reaction in Drosophila immune response

Gut-associated microbes of Drosophila melanogaster

N. A. Broderick; B. Lemaitre 

Tissue- and ligand-specific sensing of gram-negative infection in drosophila by PGRP-LC isoforms and PGRP-LE

C. Neyen; M. Poidevin; A. Roussel; B. Lemaitre 

Autocrine and paracrine unpaired signalling regulate intestinal stem cell maintenance and division

D. Osman; N. Buchon; S. Chakrabarti; Y-T. Huang; W-C. Su et al. 

Insect-microbe interactions: the good, the bad and the others

J. Herren; B. Lemaitre 

Taxonomic characterisation of Pseudomonas strain L48 and formal proposal of Pseudomonas entomophila sp nov.

M. Mulet; M. Gomila; B. Lemaitre; J. Lalucat; E. Garcia-Valdes 

Infection-induced host translational blockage inhibits immune responses and epithelial renewal in the Drosophila gut

S. Chakrabarti; P. Liehl; N. Buchon; B. Lemaitre 

Distinguishing dead from alive – a novel intracellular receptor mediates ligand-specific regulation of Relish-dependent immune activation in Drosophila

C. Neyen; B. Lemaitre 

The drosophila gut: A new paradigm for epithelial immune response

B. Lemaitre 

Genetic evidence for a protective role of the peritrophic matrix against intestinal bacterial infection in Drosophila melanogaster

T. Kuraishi; O. Binggeli; O. Opota; N. Buchon; B. Lemaitre 

Drosophila immunity: analysis of PGRP-SB1 expression, enzymatic activity and function

A. Zaidman-Rémy; M. Poidevin; M. Hervé; D. P. Welchman; J. C. Paredes et al. 

Spiroplasma and host immunity: activation of humoral immune responses increases endosymbiont load and susceptibility to certain Gram-negative bacterial pathogens in Drosophila melanogaster

J. K. Herren; B. Lemaitre 

Mercury is a direct and potent γ-secretase inhibitor affecting Notch processing and development in Drosophila

J-R. Alattia; T. Kuraishi; M. Dimitrov; I. Chang; B. Lemaitre et al. 

Monalysin, a novel ß-pore-forming toxin from the Drosophila pathogen Pseudomonas entomophila, contributes to host intestinal damage and lethality

O. Opota; I. Vallet-Gély; R. Vincentelli; C. Kellenberger; I. Iacovache et al. 

Negative Regulation by Amidase PGRPs Shapes the Drosophila Antibacterial Response and Protects the Fly from Innocuous Infection

J. C. Paredes; D. P. Welchman; M. Poidevin; B. Lemaitre 

Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection

N. Buchon; N. A. Broderick; T. Kuraishi; B. Lemaitre 

A secondary metabolite acting as a signalling molecule controls Pseudomonas entomophila virulence

I. Vallet-Gely; O. Opota; A. Boniface; A. Novikov; B. Lemaitre 

Association of hemolytic activity of Pseudomonas entomophila, a versatile soil bacterium, with cyclic lipopeptide production

I. Vallet-Gely; A. Novikov; L. Augusto; P. Liehl; G. Bolbach et al. 

Toll-like receptors – an evolutionary perspective

B. Lemaitre 

Insect immunity: from pattern recognition to symbiont-mediated host defense

D. P. Welchman; S. Aksoy; F. Jiggins; B. Lemaitre 

Long-range activation of systemic immunity through peptidoglycan diffusion in Drosophila

M. Gendrin; D. P. Welchman; M. Poidevin; M. Hervé; B. Lemaitre 

Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferation

N. Buchon; N. A. Broderick; M. Poidevin; S. Pradervand; B. Lemaitre 

Genetic ablation of Drosophila phagocytes reveals their contribution to both development and resistance to bacterial infection

A. Defaye; I. Evans; M. Crozatier; W. Wood; B. Lemaitre et al. 

Proteolytic cascade for the activation of the insect toll pathway induced by the fungal cell wall component

K-B. Roh; C-H. Kim; H. Lee; H-M. Kwon; J-W. Park et al. 

Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila

N. Buchon; N. A. Broderick; S. Chakrabarti; B. Lemaitre 

A non-redundant role for Drosophila Mkk4 and hemipterous/Mkk7 in TAK1-mediated activation of JNK

P. Geuking; R. Narasimamurthy; B. Lemaitre; K. Basler; F. Leulier 

A single modular serine protease integrates signals from pattern-recognition receptors upstream of the Drosophila Toll pathway

N. Buchon; M. Poidevin; H-M. Kwon; A. Guillou; V. Sottas et al. 

Recognition and response to microbial infection in Drosophila

N. A. Broderick; B. Lemaitre 

PIMS modulates immune tolerance by negatively regulating Drosophila innate immune signaling

N. Lhocine; P. S. Ribeiro; N. Buchon; A. Wepf; R. Wilson et al. 

Animal models for host-pathogen interactions

B. Lemaitre; F. M. Ausubel 

Evf, a virulence factor produced by the Drosophila pathogen Erwinia carotovora, is an S-palmitoylated protein with a new fold that binds to lipid vesicles

S. Quevillon-Cheruel; N. Leulliot; C. A. Muniz; M. Vincent; J. Gallay et al. 

Drosophila Serpin-28D regulates hemolymph phenoloxidase activity and adult pigmentation

C. Scherfer; H. Tang; Z. Kambris; N. Lhocine; C. Hashimoto et al. 

Drosophila immunity: methods for monitoring the activity of Toll and Imd signaling pathways

Y. Romeo; B. Lemaitre 

A serpin that regulates immune melanization in the respiratory system of Drosophila

H. Tang; Z. Kambris; B. Lemaitre; C. Hashimoto 

Cyanogenesis in Pseudomonas entomophila: an entomopathogenic bacterium

B. Ryall; H. Nasser; B. Lemaitre; D. Mossialos; H. D. Williams 

Toll-like receptors–taking an evolutionary approach

F. Leulier; B. Lemaitre 

Bacterial strategies to overcome insect defences

I. Vallet-Gely; B. Lemaitre; F. Boccard 

The host defense of Drosophila melanogaster

B. Lemaitre; J. Hoffmann 

Drosophila immunity: a large-scale in vivo RNAi screen identifies five serine proteases required for Toll activation

Z. Kambris; S. Brun; I-H. Jang; H-J. Nam; Y. Romeo et al. 

The Drosophila inhibitor of apoptosis protein DIAP2 functions in innate immunity and is essential to resist gram-negative bacterial infection

F. Leulier; N. Lhocine; B. Lemaitre; P. Meier 

The MAPKKK Mekk1 regulates the expression of Turandot stress genes in response to septic injury in Drosophila

S. Brun; S. Vidal; P. Spellman; K. Takahashi; H. Tricoire et al. 

Insect immunity: the post-genomic era

J. Bangham; F. Jiggins; B. Lemaitre 

The Drosophila amidase PGRP-LB modulates the immune response to bacterial infection

A. Zaidman-Rémy; M. Hervé; M. Poidevin; S. Pili-Floury; M-S. Kim et al. 

A Spätzle-processing enzyme required for toll signaling activation in Drosophila innate immunity

I-H. Jang; N. Chosa; S-H. Kim; H-J. Nam; B. Lemaitre et al. 

Prevalence of local immune response against oral infection in a Drosophila/Pseudomonas infection model

P. Liehl; M. Blight; N. Vodovar; F. Boccard; B. Lemaitre 

The Toll immune-regulated Drosophila protein Fondue is involved in hemolymph clotting and puparium formation

C. Scherfer; M. R. Qazi; K. Takahashi; R. Ueda; M. S. Dushay et al. 

Erwinia carotovora Evf antagonizes the elimination of bacteria in the gut of Drosophila larvae

C. Acosta Muniz; D. Jaillard; B. Lemaitre; F. Boccard 

Two proteases defining a melanization cascade in the immune system of Drosophila

H. Tang; Z. Kambris; B. Lemaitre; C. Hashimoto 

Complete genome sequence of the entomopathogenic and metabolically versatile soil bacterium Pseudomonas entomophila

N. Vodovar; D. Vallenet; S. Cruveiller; Z. Rouy; V. Barbe et al. 

Drosophila host defense after oral infection by an entomopathogenic Pseudomonas species

N. Vodovar; M. Vinals; P. Liehl; A. Basset; J. Degrouard et al. 

Inhibitor of apoptosis 2 and TAK1-binding protein are components of the Drosophila Imd pathway

A. Kleino; S. Valanne; J. Ulvila; J. Kallio; H. Myllymäki et al. 

Structure and metabolism of peptidoglycan and molecular requirements allowing its detection by the Drosophila innate immune system

D. Mengin-Lecreulx; B. Lemaitre 

Peptidoglycan molecular requirements allowing detection by the Drosophila immune deficiency pathway

C. R. Stenbak; J-H. Ryu; F. Leulier; S. Pili-Floury; C. Parquet et al. 

A Drosophila pattern recognition receptor contains a peptidoglycan docking groove and unusual L,D-carboxypeptidase activity

C-I. Chang; S. Pili-Floury; M. Hervé; C. Parquet; Y. Chelliah et al. 

In vivo RNA interference analysis reveals an unexpected role for GNBP1 in the defense against Gram-positive bacterial infection in Drosophila adults

S. Pili-Floury; F. Leulier; K. Takahashi; K. Saigo; E. Samain et al. 

The road to Toll

B. Lemaitre 

Drosophila: a polyvalent model to decipher host-pathogen interactions

N. Vodovar; C. Acosta; B. Lemaitre; F. Boccard 

Sensing microbes by diverse hosts. Workshop on pattern recognition proteins and receptors.

S. E. Girardin; D. J. Philpott; B. Lemaitre 

The Drosophila immune system detects bacteria through specific peptidoglycan recognition

F. Leulier; C. Parquet; S. Pili-Floury; J-H. Ryu; M. Caroff et al. 

A single gene that promotes interaction of a phytopathogenic bacterium with its insect vector, Drosophila melanogaster

A. Basset; P. Tzou; B. Lemaitre; F. Boccard 

Directed expression of the HIV-1 accessory protein Vpu in Drosophila fat-body cells inhibits Toll-dependent immune responses

F. Leulier; C. Marchal; I. Miletich; B. Limbourg-Bouchon; R. Benarous et al. 

Immunology. Pathogen surveillance–the flies have it.

R. S. Khush; F. Leulier; B. Lemaitre 

Inducible expression of double-stranded RNA reveals a role for dFADD in the regulation of the antibacterial response in Drosophila adults

F. Leulier; S. Vidal; K. Saigo; R. Ueda; B. Lemaitre 

The mosquito genome: the post-genomic era opens

E. De Gregorio; B. Lemaitre 

A ubiquitin-proteasome pathway represses the Drosophila immune deficiency signaling cascade

R. S. Khush; W. D. Cornwell; J. N. Uram; B. Lemaitre 

27 Methods for studying infection and immunity in Drosophila

P. Tzou; M. Meister; B. Lemaitre 

The Toll and Imd pathways are the major regulators of the immune response in Drosophila

E. De Gregorio; P. T. Spellman; P. Tzou; G. M. Rubin; B. Lemaitre 

Constitutive expression of a single antimicrobial peptide can restore wild-type resistance to infection in immunodeficient Drosophila mutants

P. Tzou; J-M. Reichhart; B. Lemaitre 

An immune-responsive Serpin regulates the melanization cascade in Drosophila

E. De Gregorio; S-J. Han; W-J. Lee; M-J. Baek; T. Osaki et al. 

How Drosophila combats microbial infection: a model to study innate immunity and host-pathogen interactions

P. Tzou; E. De Gregorio; B. Lemaitre 

Drosophila immunity: two paths to NF-kappaB

R. S. Khush; F. Leulier; B. Lemaitre 

Genome-wide analysis of the Drosophila immune response by using oligonucleotide microarrays

E. De Gregorio; P. T. Spellman; G. M. Rubin; B. Lemaitre 

Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-kappaB-dependent innate immune responses

S. Vidal; R. S. Khush; F. Leulier; P. Tzou; M. Nakamura et al. 

Stop press: genes that fight infections: what the drosophila genome says about animal immunity

R. Khush; B. Lemaitre 

The phytopathogenic bacteria Erwinia carotovora infects Drosophila and activates an immune response

A. Basset; R. S. Khush; A. Braun; L. Gardan; F. Boccard et al. 

Gram-negative bacteria-binding protein, a pattern recognition receptor for lipopolysaccharide and beta-1,3-glucan that mediates the signaling for the induction of innate immune genes in Drosophila melanogaster cells

Y. S. Kim; J. H. Ryu; S. J. Han; K. H. Choi; K. B. Nam et al. 

The Drosophila caspase Dredd is required to resist gram-negative bacterial infection

F. Leulier; A. Rodriguez; R. S. Khush; J. M. Abrams; B. Lemaitre 

Comparative genomics of the eukaryotes

G. M. Rubin; M. D. Yandell; J. R. Wortman; G. L. Gabor Miklos; C. R. Nelson et al. 

Tissue-specific inducible expression of antimicrobial peptide genes in Drosophila surface epithelia

P. Tzou; S. Ohresser; D. Ferrandon; M. Capovilla; J. M. Reichhart et al. 

Genes that fight infection: what the Drosophila genome says about animal immunity

R. S. Khush; B. Lemaitre 

Le génome de la mouche du vinaigre

B. Lemaitre 

La drosophile : un modèle pour l’étude de la réponse immunitaire innée

B. Lemaitre 

A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF

P. Manfruelli; J. M. Reichhart; R. Steward; J. A. Hoffmann; B. Lemaitre 

In vivo regulation of the IkappaB homologue cactus during the immune response of Drosophila

E. Nicolas; J. M. Reichhart; J. A. Hoffmann; B. Lemaitre 

Two distinct pathways can control expression of the gene encoding the Drosophila antimicrobial peptide metchnikowin

E. A. Levashina; S. Ohresser; B. Lemaitre; J. L. Imler 

A drosomycin-GFP reporter transgene reveals a local immune response in Drosophila that is not dependent on the Toll pathway

D. Ferrandon; A. C. Jung; M. Criqui; B. Lemaitre; S. Uttenweiler-Joseph et al. 

Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms

B. Lemaitre; J. M. Reichhart; J. A. Hoffmann 

Drosophila immunity: analysis of larval hemocytes by P-element-mediated enhancer trap

A. Braun; B. Lemaitre; R. Lanot; D. Zachary; M. Meister 

Antimicrobial peptide defense in Drosophila

M. Meister; B. Lemaitre; J. A. Hoffmann 

Expression of antimicrobial peptide genes after infection by parasitoid wasps in Drosophila

E. Nicolas; A. J. Nappi; B. Lemaitre 

The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults

B. Lemaitre; E. Nicolas; L. Michaut; J. M. Reichhart; J. A. Hoffmann 

Functional analysis and regulation of nuclear import of dorsal during the immune response in Drosophila

B. Lemaitre; M. Meister; S. Govind; P. Georgel; R. Steward et al. 

A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense

B. Lemaitre; E. Kromer-Metzger; L. Michaut; E. Nicolas; M. Meister et al. 

Drosophila P element: transposition, regulation and evolution

D. Coen; B. Lemaitre; M. Delattre; H. Quesneville; S. Ronsseray et al. 

Expression and nuclear translocation of the rel/NF-kappa B-related morphogen dorsal during the immune response of Drosophila

J. M. Reichhart; P. Georgel; M. Meister; B. Lemaitre; C. Kappler et al. 

Maternal inheritance of P cytotype in Drosophila melanogaster: a “pre-P cytotype” is strictly extra-chromosomally transmitted

S. Ronsseray; B. Lemaitre; D. Coen 

Maternal repression of the P element promoter in the germline of Drosophila melanogaster: a model for the P cytotype

B. Lemaitre; S. Ronsseray; D. Coen 

Insect immunity: the diptericin promoter contains multiple functional regulatory sequences homologous to mammalian acute-phase response elements

P. Georgel; M. Meister; C. Kappler; B. Lemaitre; J. M. Reichhart et al. 

L’element P de drosophila melanogaster : mecanismes controlant la transposition

P regulatory products repress in vivo the P promoter activity in P-lacZ fusion genes

B. Lemaitre; D. Coen