2026
Journal Articles
Distribution and evolutionary significance of the DnaK-DnaJ-GrpE (KJE) chaperone system in archaea
Cell Stress and Chaperones. 2026. Vol. 31, num. 1. DOI : 10.1016/j.cstres.2026.100145.J-domain Proteins: From Molecular Mechanisms to Diseases
CELL STRESS & CHAPERONES. 2026. Vol. 31, num. 1. DOI : 10.1016/j.cstres.2025.100142.2025
Journal Articles
Subtle variations in a client protein determine bacterial Hsp90 dependence
Journal of Molecular Biology. 2025. DOI : 10.1016/j.jmb.2025.169378.Hsp110 Nucleotide Exchange Factors may amplify Hsp70-disaggregation by enhanced entropic pulling
Journal of Biological Chemistry. 2025. DOI : 10.1016/j.jbc.2025.110450.Physics of Protein Aggregation in Normal and Accelerated Brain Aging
BioEssays. 2025. DOI : 10.1002/bies.70030.Collective Deformation Modes Promote Fibrous Self-Assembly in Deformable Particles
Physical Review X (PRX). 2025. Vol. 15, num. 1, p. 011022. DOI : 10.1103/PhysRevX.15.011022.Minimal Model for Carnot Efficiency at Maximum Power
Physical Review Letters. 2025. Vol. 134, num. 2, p. 027101. DOI : 10.1103/PhysRevLett.134.027101.Phase boundaries promote chemical reactions through localized fluxes
The Journal of chemical physics. 2025. Vol. 162, num. 2. DOI : 10.1063/5.0242782.Reviews
Stochastic thermodynamics for biological functions
QUANTITATIVE BIOLOGY. 2025. DOI : 10.1002/qub2.75.Clearing the protein clutter in human cells: the role of protein disaggregases
Transactions of the Royal Society of South Africa. 2025. p. 1 – 19. DOI : 10.1080/0035919X.2025.2515392.Theses
Non-equilibrium control of biomolecular condensates
Lausanne, EPFL, 2025.Protein Organisation at Different Scales: Amyloid Disaggregation, Chaperone Networks and Engineered Allostery
Lausanne, EPFL, 2025.Book Chapters
Protein chaperones and the protein unfolding problem
Reference Module in Life Sciences; Elsevier, 2025.Working Papers
Native, full-length, refolding-assisted purification of TDP-43 compatible with BSL-2 safety regulations
2025
Conserved intrinsically disordered region of DNAJB6 dictates its surveillance of FG-Nup condensates
2025
Controllable Protein Design via Autoregressive Direct Coupling Analysis Conditioned on Principal Components
2025
On adaptation to a mesophilic environment and the chaperone network in Archaea
2025
Discovery of a DNA-based Optical Nanotube Sensor for Glucose Using Clustering and Deep Learning Algorithms
2025
Is Hsp110 boosting the basal disaggregation activity Hsp70 by enhanced entropic pulling strokes?
2025
2024
Journal Articles
An outmoded in vitro-inferred mechanism for chaperonin-accelerated protein refolding is confirmed in cells by cryo-electron tomography
CELL STRESS & CHAPERONES. 2024. Vol. 29, num. 6. DOI : 10.1016/j.cstres.2024.11.003.Single-molecule evidence of Entropic Pulling by Hsp70 chaperones
Nature Communications. 2024. Vol. 15, num. 1, p. 8604. DOI : 10.1038/s41467-024-52674-y.Thermodynamic Bounds on Symmetry Breaking in Linear and Catalytic Biochemical Systems
Physical review letters. 2024. Vol. 132, num. 22. DOI : 10.1103/PhysRevLett.132.228402.Valence can control the nonexponential viscoelastic relaxation of multivalent reversible gels
Science Advances. 2024. Vol. 10, num. 20, p. eadl5056. DOI : 10.1126/sciadv.adl5056.Autorepression of yeast Hsp70 cochaperones by intramolecular interactions involving their J-domains
Cell Stress & Chaperones. 2024. Vol. 29, num. 2, p. 338 – 348. DOI : 10.1016/j.cstres.2024.03.008.J-domain proteins: From molecular mechanisms to diseases
Cell stress & chaperones. 2024. Vol. 29, num. 1, p. 21 – 33. DOI : 10.1016/j.cstres.2023.12.002.Theses
Fundamental Thermodynamic Constraints on Symmetry Breaking in Biochemical Systems
Lausanne, EPFL, 2024.2023
Journal Articles
Thermodynamic bounds on time-reversal asymmetry
Physical Review E. 2023. Vol. 108, num. 6, p. L062101. DOI : 10.1103/PhysRevE.108.L062101.Individual and combined benefits of different nonequilibrium proofreading mechanisms
Physical Review Research. 2023. Vol. 5, num. 4, p. 043145. DOI : 10.1103/PhysRevResearch.5.043145.Modulation of Pulsatile Left Ventricular Afterload by Renal Denervation in Heart Failure With Preserved Ejection Fraction
Circulation-Heart Failure. 2023. Vol. 16, num. 10, p. e010543. DOI : 10.1161/CIRCHEARTFAILURE.123.010543.ABC transporters are billion-year-old Maxwell Demons
Communications Physics. 2023. Vol. 6, num. 1, p. 205. DOI : 10.1038/s42005-023-01320-y.Design of an Arabidopsis thaliana reporter line to detect heat-sensing and signaling mutants
Plant Methods. 2023. Vol. 19, num. 1, p. 56. DOI : 10.1186/s13007-023-01033-x.Ricca’s factors as mobile proteinaceous effectors of electrical signaling
Cell. 2023. Vol. 186, num. 7, p. 1337 – +. DOI : 10.1016/j.cell.2023.02.006.Fluctuations of entropy production of a run-and-tumble particle
Physical Review E. 2023. Vol. 107, num. 1, p. 014129. DOI : 10.1103/PhysRevE.107.014129.Reviews
Second Virtual International Symposium on Cellular and Organismal Stress Responses, September 8-9, 2022
Cell Stress & Chaperones. 2023. Vol. 28, num. 1, p. 1 – 9. DOI : 10.1007/s12192-022-01318-5.Theses
Information Theory in Transmembrane Transport
Lausanne, EPFL, 2023.Why do we need so many proteins? A physical insight into the collaboration of Hsp70 and DnaJ
Lausanne, EPFL, 2023.2022
Journal Articles
Emergent thermophoretic behavior in chemical reaction systems
New Journal Of Physics. 2022. Vol. 24, num. 12, p. 123006. DOI : 10.1088/1367-2630/aca556.A fluorescent multi-domain protein reveals the unfolding mechanism of Hsp70
Nature Chemical Biology. 2022. DOI : 10.1038/s41589-022-01162-9.Mutual information in changing environments: Nonlinear interactions, out-of-equilibrium systems, and continuously varying diffusivities
Physical Review E. 2022. Vol. 106, num. 1, p. 014153. DOI : 10.1103/PhysRevE.106.014153.Information-driven transitions in projections of underdamped dynamics
Physical Review E. 2022. Vol. 106, num. 1, p. 014118. DOI : 10.1103/PhysRevE.106.014118.Emergence of synergistic and competitive pathogens in a coevolutionary spreading model
Physical Review E. 2022. Vol. 105, num. 3, p. 034308. DOI : 10.1103/PhysRevE.105.034308.Statistical potentials from the Gaussian scaling behaviour of chain fragments buried within protein globules
Plos One. 2022. Vol. 17, num. 1, p. e0254969. DOI : 10.1371/journal.pone.0254969.An Efficient Signal-to-noise Approximation for Eccentric Inspiraling Binaries
The Astrophysical Journal. 2022. Vol. 924, num. 2, p. 102. DOI : 10.3847/1538-4357/ac36c5.Reviews
J-domain protein chaperone circuits in proteostasis and disease
Trends In Cell Biology. 2022. Vol. 33, num. 1, p. 30 – 47. DOI : 10.1016/j.tcb.2022.05.004.2021
Journal Articles
Mutual Information Disentangles Interactions from Changing Environments
Physical Review Letters. 2021. Vol. 127, num. 22, p. 228301. DOI : 10.1103/PhysRevLett.127.228301.Relief of ParB autoinhibition by parS DNA catalysis and recycling of ParB by CTP hydrolysis promote bacterial centromere assembly
Science Advances. 2021. Vol. 7, num. 41, p. eabj2854. DOI : 10.1126/sciadv.abj2854.Inducing and optimizing Markovian Mpemba effect with stochastic reset
New Journal Of Physics. 2021. Vol. 23, num. 10, p. 103012. DOI : 10.1088/1367-2630/ac2922.Dissipation-Driven Selection under Finite Diffusion: Hints from Equilibrium and Separation of Time Scales
Entropy. 2021. Vol. 23, num. 8, p. 1068. DOI : 10.3390/e23081068.Ant behavioral maturation is mediated by a stochastic transition between two fundamental states
Current Biology. 2021. Vol. 31, num. 10, p. 2253 – 2260.e3. DOI : 10.1016/j.cub.2020.05.038.Equilibrium and non-equilibrium furanose selection in the ribose isomerisation network
Nature Communications. 2021. Vol. 12, num. 1, p. 2749. DOI : 10.1038/s41467-021-22818-5.Bidirectional propagation of low frequency oscillations over the human hippocampal surface
Nature Communications. 2021. Vol. 12, num. 1, p. 2764. DOI : 10.1038/s41467-021-22850-5.Dissipation-driven selection of states in non-equilibrium chemical networks
Communications Chemistry. 2021. Vol. 4, num. 1, p. 16. DOI : 10.1038/s42004-021-00454-w.Reviews
Repair or Degrade: the Thermodynamic Dilemma of Cellular Protein Quality-Control
Frontiers In Molecular Biosciences. 2021. Vol. 8, p. 768888. DOI : 10.3389/fmolb.2021.768888.2020
Journal Articles
Tighter thermodynamic bound on the speed limit in systems with unidirectional transitions
Physical Review E. 2020. Vol. 102, num. 6, p. 062121. DOI : 10.1103/PhysRevE.102.062121.Coarse-grained entropy production with multiple reservoirs: Unraveling the role of time scales and detailed balance in biology-inspired systems
Physical Review Research. 2020. Vol. 2, num. 4, p. 043257. DOI : 10.1103/PhysRevResearch.2.043257.Molecular dissection of amyloid disaggregation by human HSP70
Nature. 2020. Vol. 587, p. 483 – 488. DOI : 10.1038/s41586-020-2904-6.Computational pipeline to probe NaV1.7 gain-of-function variants in neuropathic painful syndromes
Scientific Reports. 2020. Vol. 10, num. 1, p. 17930. DOI : 10.1038/s41598-020-74591-y.Entropy production in systems with unidirectional transitions
Physical Review Research. 2020. Vol. 2, num. 2, p. 023011. DOI : 10.1103/PhysRevResearch.2.023011.Protein Structural Information and Evolutionary Landscape by In Vitro Evolution
Molecular Biology And Evolution. 2020. Vol. 37, num. 4, p. 1179 – 1192. DOI : 10.1093/molbev/msz256.Thermodynamics and kinetics of protonated merocyanine photoacids in water
Chemical Science. 2020. Vol. 11, num. 32, p. 8457 – 8468. DOI : 10.1039/D0SC03152F.Conference Papers
How Complex Molecules Could Possibly be Stable at the Dawn of Life: Out of Equilibrium Dissipation Shapes Selection
2020. 64th Annual Meeting of the Biophysical-Society, San Diego, CA, Feb 15-19, 2020. p. 611A – 611A. DOI : 10.1016/j.bpj.2019.11.3301.Reviews
Membraneless organelles: phasing out of equilibrium
Emerging Topics In Life Sciences. 2020. Vol. 4, num. 3, p. 331 – 342. DOI : 10.1042/ETLS20190190.2019
Journal Articles
Efficient conversion of chemical energy into mechanical work by Hsp70 chaperones
Elife. 2019. Vol. 8, p. e48491. DOI : 10.7554/eLife.48491.Hyperaccurate currents in stochastic thermodynamics
Physical Review E. 2019. Vol. 100, num. 6, p. 060102. DOI : 10.1103/PhysRevE.100.060102.Mechanics of Allostery: Contrasting the Induced Fit and Population Shift Scenarios
Biophysical Journal. 2019. Vol. 117, num. 10, p. 1954 – 1962. DOI : 10.1016/j.bpj.2019.10.002.Entropy production in master equations and Fokker-Planck equations: facing the coarse-graining and recovering the information loss
Journal of Statistical Mechanics-Theory and Experiment. 2019. Vol. 2019, num. 10, p. 104013. DOI : 10.1088/1742-5468/ab363e.DNA-segment-capture model for loop extrusion by structural maintenance of chromosome (SMC) protein complexes
Nucleic Acids Research. 2019. Vol. 47, num. 13, p. 6956 – 6972. DOI : 10.1093/nar/gkz497.Entropy production for coarse-grained dynamics
New Journal Of Physics. 2019. Vol. 21, p. 073004. DOI : 10.1088/1367-2630/ab29c0.Detailed experiments on weakly deformed cavitation bubbles
Experiments In Fluids. 2019. Vol. 60, num. 2, p. 33. DOI : 10.1007/s00348-019-2679-4.Self-organization of parS centromeres by the ParB CTP hydrolase
Science. 2019. Vol. 366, num. 6469, p. 1129 – 1133. DOI : 10.1126/science.aay3965.Reviews
Function, evolution, and structure of J-domain proteins
Cell Stress and Chaperones. 2019. Vol. 24, num. 1, p. 7 – 15. DOI : 10.1007/s12192-018-0948-4.2018
Journal Articles
Toward a unified scoring function for native state discrimination and drug-binding pocket recognition
Physical Chemistry Chemical Physics. 2018. Vol. 20, num. 25, p. 17148 – 17155. DOI : 10.1039/C7CP08170G.The cold denaturation of IscU highlights structure–function dualism in marginally stable proteins
Communications Chemistry. 2018. Vol. 1, num. 1, p. 13. DOI : 10.1038/s42004-018-0015-1.Chaperones convert the energy from ATP into the nonequilibrium stabilization of native proteins
Nature Chemical Biology. 2018. Vol. 14, num. 4, p. 388 – 395. DOI : 10.1038/s41589-018-0013-8.Interplay between cost and benefits triggers nontrivial vaccination uptake
Physical Review E. 2018. Vol. 97, num. 3, p. 032308. DOI : 10.1103/PhysRevE.97.032308.Vibrational entropy estimation can improve binding affinity prediction for non-obligatory protein complexes
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 2018. Vol. 86, num. 4, p. 393 – 404. DOI : 10.1002/prot.25454.Theses
Non equilibrium thermodynamics of protein organization
Lausanne, EPFL, 2018.Statistical Analysis of Protein Sequences: A Coevolutionary Study of Molecular Chaperones
Lausanne, EPFL, 2018.Unleashing the power of semantic text analysis: a complex systems approach
Lausanne, EPFL, 2018.2017
Journal Articles
Coevolution of Synchronization and Cooperation in Costly Networked Interactions
Physical Review Letters. 2017. Vol. 118, num. 23, p. 238301. DOI : 10.1103/PhysRevLett.118.238301.Hyperplectonemes: A Higher Order Compact and Dynamic DNA Self-Organization
Nano Letters. 2017. Vol. 17, num. 3, p. 1938 – 1948. DOI : 10.1021/acs.nanolett.6b05294.Modeling Hsp70/Hsp40 interaction by multi-scale molecular simulations and co-evolutionary sequence analysis
eLife. 2017. Vol. 6, p. e23471. DOI : 10.7554/eLife.23471.The Shape of a Stretched Polymer
Physical Review Letters. 2017. Vol. 119, num. 3, p. 037801. DOI : 10.1103/PhysRevLett.119.037801.Evolution of an intricate J-protein network driving protein disaggregation in eukaryotes
eLife. 2017. Vol. 6, p. e24560. DOI : 10.7554/eLife.24560.Thermodynamic bounds on the ultra- and infra-affinity of Hsp70 for its substrates
Biophysical Journal. 2017. Vol. 34, num. 4, p. 362 – 370. DOI : 10.1016/j.bpj.2017.06.010.New Techniques for Ancient Proteins: Direct Coupling Analysis Applied on Proteins Involved in Iron Sulfur Cluster Biogenesis
Frontiers in Molecular Biosciences. 2017. Vol. 4, p. 40. DOI : 10.3389/fmolb.2017.00040.Working Papers
Irreducible network backbones: unbiased graph filtering via maximum entropy
2017
Molecular chaperones inject energy from ATP hydrolysis into the non-equilibrium stabilisation of native proteins
2017
ScienceWISE: Topic Modeling over Scientific Literature Networks
2017