Publications

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RECENT PUBLICATIONS (2014-2023)

  • Selected original research articles
  • Selected reviews
  • Selected commentaries

***Selected original research articles***


Ghasemi A, Martinez-Usatorre A, Li L, […], Migliorini D, Heikenwalder M, & De Palma M. Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy. Nat Cancer. 2023; 10.1038/s43018-023-00668-y.


Bernier-Latmani J, et al. Apelin-driven endothelial cell migration sustains intestinal progenitor cells and tumor growth. Nat Cardiovasc Res. 2022 May; 1(5): 476–490.

Featured Cover Article


Luck R, Karakatsani A, Shah B, Schermann G, Adler H, Kupke J, Tisch N, Jeong HW, Back MK, Hetsch F, D’Errico A, De Palma M, Wiedtke E, Grimm D, Acker-Palmer A, von Engelhardt J, Adams RH, Augustin HG, Ruiz de Almodóvar. The angiopoietin-Tie2 pathway regulates Purkinje cell dendritic morphogenesis in a cell-autonomous mannerCell Rep. 2021 Aug 17;36(7):109522.


Martinez-Usatorre, A.*, Kadioglu, E.*, Boivin, G., Cianciaruso, C., Guichard, A., Torchia, B., Zangger, N., Nassiri, S., Keklikoglou, I., Schmittnaegel., M., Ries, C.H., Meylan, E., & De Palma, MOvercoming microenvironmental resistance to PD-1 blockade in genetically engineered lung cancer modelsSci Transl Med. 2021 Aug 11;13(606):eabd1616.

Featured Cover Article


Bissinger S, Hage C, Wagner V, Maser IP, Brand V, Schmittnaegel M, Jegg AM, Cannarile M, Watson C, Klaman I, Rieder N, González Loyola A, Petrova TV, Cassier PA, Gomez-Roca C, Sibaud V, De Palma, M, Hoves S, & Ries CH. Macrophage depletion induces edema through release of matrix-degrading proteases and proteoglycan depositionSci Transl Med. 2021 Jun 16;13(598):eabd4550.

Featured Cover Article


Jahani, Y, Arvelo ER, Yesilkoy F, Koshelev K, Cianciaruso C, De Palma M, Kivshar Y, & Altug H. Imaging-based spectrometer-less optofluidic biosensors based on dielectric metasurfaces for detecting extracellular vesiclesNat Communs. 2021 May 31;12:3246.


Kashyap, A.S.*, Schmittnaegel, M.*, Rigamonti, N., Pais-Ferreira, D., Mueller, P., Buchi, M., Ooi, C.-H., Kreuzaler, M., Hirschmann, P., Guichard, A., Rieder, N., Bill, R., Herting, F., Kienast, Y., Dirnhofer, S., Klein, C., Hoves, S., Ries, C. H., Corse, E., & De Palma, M.*, Zippelius, A*. Optimized anti-angiogenic reprogramming of tumor microenvironment by VEGFA and angiopoietin-2 blockade potentiates CD40 immunotherapyProc. Natl. Acad. Sci. U.S.A. 2020 .


Ragusa, S., Prat-Luri, B., González-Loyola, A., Nassiri, S., Squadrito, M.L., Guichard, A., Cavin, S., Gjorevski, N., Barras, D., Marra, G., Lutolf, M.P., Perentes, J., Corse, E., Bianchi, R., Wetterwald, L., Kim, J., Oliver, G., Delorenzi, M., De Palma, M., & Petrova, T.V. Anti-angiogenic immunotherapy suppresses desmoplastic and chemoresistant intestinal tumors in miceJ Clin Invest., 2020 Mar 2;130(3):1199-1216.

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Commentary (Claesson-Welsh): J Clin Invest. 2020 Mar 2;130(3):1093-1095.


Cianciaruso, C.*, Beltraminelli, T.*, Duval, F.*, Nassiri, S., Hamelin, R., Mozes, A., Gallart-Ayala, H., Ceada Torres, G., Torchia, B., Ries, C.H., Ivanisevic, J., & De Palma, M. Molecular profiling and functional analysis of macrophage-derived tumor extracellular vesicles. Cell Rep. 2019 June 4;27(10):3062-3080.e11.


Keklikoglou, I.*, Cianciaruso, C.*, Güç, E., Squadrito, M.L., Spring, L.M., Tazzyman, S., Lambein, L., Poissonnier, A., Ferraro, G.B., Baer, C., Cassará, A., Guichard, A., Iruela-Arispe, M.L., Lewis, C.E., Coussens, L.M., Bardia, A., Jain, R.K., Pollard, J.W., & De Palma, M. Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer modelsNat Cell Biol. 2019 Feb;21(2):190-202.

Highlight: Nat Rev Cancer 2019 (doi: 10.1038/s41568-019-0111-2).

Highlights: F1000Prime (https://f1000.com/prime/734718811).


Neubert, N. J.*, Schmittnaegel, M.*, Bordry, N.*, Nassiri, S., Wald, N., Martignier, C., Tillé, L., Hemicsko, K., Damsky, W., Maby El-Hajjami, H., Klaman, I., Danenberg, E., Ioannidou, K., Kandalaft, L., Coukos, G., Hoves, S., Ries, C. H., Fuertes Marraco, S. A., Foukas, P. G., & De Palma, M.*, Speiser, D.E.* T cell-induced CSF1 promotes melanoma resistance to PD1 blockadeSci Transl Med. 2018 Apr 11;10(436), pii: eaan3311.

Highlight: Cancer Immunol Res. 2018 June 1;6(6):629.


Keklikoglou, I., Kadioglu, E., Bissinger, S., Langlois, B., Bellotti, A., Orend, G., Ries, C.H. & De Palma, MPeriostin limits tumor response to VEGFA inhibitionCell Rep. 2018 Mar;22(10):2530-2540.

Featured Cover Article


Squadrito, M.L., Cianciaruso, C., Hansen, S.K., & De Palma, MEVIR: Chimeric receptors that enhance dendritic cell cross-dressing with tumor antigensNat Methods. 2018 Mar;15(3):183-186.


Cortesi, F., Delfanti G., Grilli, A., Calcinotto A., Gorini, F., Pucci, F., Lucianò R., Grioni, M., Recchia, A., Benigni, F., Briganti, A., Salonia A., De Palma, M., Bicciato, S., Doglioni, C., Bellone, M., Casorati, G., Dellabona, P. Bimodal CD40/Fas-dependent crosstalk between iNKT cells and tumor-associated macrophages impairs prostate cancer progressionCell Rep. 2018 Mar;22(11):3006-3020.


Hoves, S., Ooi, C.-H., Wolter, C., Sade, H., Bissinger, S., Schmittnaegel, M., Ast, O., Giusti, A.M., Wartha, K., Runza, V., Xu, W., Kienast, Y., Cannarile, M.A., Levitsky, H., Romagnoli, S., De Palma, M., Rüttinger, D., & Ries, C.H. Rapid activation of tumor-associated macrophages boosts preexisting tumor immunityJ Exp Med. 2018 March 5;215(3):859-876

Highlight: Cancer Immunol Res. 2018 May 1;6(5):501.


Scodeller, P., Simon Gracia, L., Kopanchuk, S., Tobi, A., Kilk, K., Säälik, P., Kurm, K., Squadrito, M.L., Kotamraju, V.R., Rinken, A., De Palma, M., Ruoslahti, E., & Teesalu, T. Precision targeting of tumor macrophages with a CD206 binding peptideSci Rep 2017Nov 7;7(1):14655.


Harney, S.A., Karagiannis, G.S., Pignatelli, J., Smith, B.D., Kadioglu, E., Wise, S.C., Hood, M.M., Kaufman, M.D., Leary, C.B., Lu, W.-P., Al-Ani, G., Chen, X., Entenberg, D., Oktay, M.H., Wang, Y., Chun, L., De Palma, M., Jones, J.G., Flynn, D.L., & Condeelis, J.S. The selective Tie2 inhibitor rebastinib blocks recruitment and function of Tie2Hi macrophages in breast cancer and neuroendocrine pancreatic tumors. Mol Cancer Ther. 2017 Nov 1;16(11):2486-2501.


Schmittnaegel, M.*, Rigamonti, N.*, Kadioglu, E., Cassará, A., Wyser Rmili, C., Kiialainen, A., Kienast, Y., Mueller, H.-J., Ooi, C.-H., Laoui, D., and De Palma, MDual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockadeSci Transl Med. 2017 Apr 12;9(385). pii: eaak9670.

Highlight: Nat Rev Clin Oncol. 2017 (doi: 10.1038/nrclinonc.2017.6).

Highlight: Nat Rev Drug Discov. 2017 (doi: 10.1038/nrd.2017.103).

Highlight: Nat Rev Rev Cancer 2017 (doi: 10.1038/nrc.2017.39).

Highlight: Science Signal. 2017 (doi: 10.1126/scisignal.aan4458).

Highlight: F1000Prime (https://f1000.com/prime/727504006).

Featured Cover Article


Cianciaruso, C., Phelps, E.A., Pasquier, M., Hamelin, R., Demurtas, D., Alibashe Ahmed, M., Piemonti, L., Hirosue, S., Swartz, M., De Palma, M., Hubbell, J.A., and Baekkeskov, S. Primary human and rat beta cells release the intracellular autoantigens GAD65, IA-2 and proinsulin in exosomes together with cytokine-induced enhancers of immunityDiabetes2017 Feb;66(2):460-473.

Featured Cover Article


He, H., Mack, J., Guc, E., Warren, C., Squadrito, M.L., Kilarski, W., Baer, C., Freshman, R., McDonald, A., Ziyad, S., Swartz, M.A., De Palma, M., and Iruela-Arispe, M.L. Perivascular Macrophages Limit PermeabilityArterioscler Thromb Vasc Biol. 2016 Nov;36(11):2203-2212

Featured Cover Article


Baer, C., Squadrito, M.L., Laoui, D., Thompson, D., Hansen, S.K., Kiialainen, A., Hoves, S., Ries, C.H., Ooi, C.-H., De Palma, MSuppression of microRNA activity amplifies IFN-γ-induced macrophage activation and promotes anti-tumor immunityNat Cell Biol. 2016 Jul;18(7):790-802.

News & Views (Lee & Biswas): Nat Cell Biol. 2016 Jul;18(7):718-720.


Wallerius, M., Wallmann, T., Bartish, M., Östling, J., Mezheyeuski, A., Tobin, N.P., Nygren, E., Pangigadde, P.N., Pellegrini, P., Squadrito, M.L., Pontén, F., Hartman, J., Bergh, J., De Milito, A., De Palma, M., Ostman, A., Andersson, J., Rolny, C. Guidance molecule SEMA3A restricts tumor growth by differentially regulating the proliferation of tumor-associated macrophagesCancer Res. 2016 Jun 1;76(11):3166-78 IF: 9.329


Galletti, G., Scielzo, C., Barbaglio, F., Veliz Rodriguez, T., Riba, M., Lazarevic, D., Cittaro, D., Simonetti, G., Ranghetti, P., Scarfò, L., Ponzoni, M., Rocchi, M., Corti, A., Anselmo, A., van Rooijen, N., Klein, C., Ries, H.C., Ghia, P., De Palma, M., Caligaris-Cappio, F., Bertilaccio, M.T.S. Targeting macrophages sensitizes chronic lymphocytic leukemia to apoptosis and inhibits disease progressionCell Rep. 2016 Feb 23;14(7):1748-60


Ferri, F., Parcelier, A., Petit, V., Gallouet, A.S., Lewandowski, D., Dalloz, M., van den Heuvel, A., Kolovos P., Sole, E., Squadrito, M.L., De Palma, M., Davidson, I., Rousselet, G., & Romeo, P.H. TRIM33 switches off Ifnb1 gene transcription during the late phase of macrophage activationNat Commun. 2015 Nov 23;6:8900.


Hughes, R., Qian, B.-Z., Muthana, M., Keklikoglou, I., Olson, O.C., Tazzyman, S., Danson, S.J., Addison, C.L., Clemons, M., Gonzalez-Angulo, A.M., Joyce, J.A., De Palma, M., Pollard, J.W., & Lewis, C.E. Perivascular M2 macrophages stimulate tumor relapse after chemotherapy. Cancer Res. 2015 Sep 1;75(17):3479-91.


Keskin, D., Kim, J., Cooke, V.G., Wu, C.C., Sugimoto, H., Gu, C., De Palma, M., Kalluri, R., & LeBleu, V.S. Targeting vascular pericytes in hypoxic tumors promotes lung metastasis via angiopoietin-2Cell Rep. 2015 Feb 24;10(7):1066-81.

Featured Cover Article


Squadrito, M.L., Baer, C., Burdet, F., Maderna, C., Gilfillan, G.D., Lyle, R., Ibberson, M., & De Palma, M. Endogenous RNAs modulate microRNA sorting to exosomes and transfer to acceptor cellsCell Rep. 2014 Sep 11;8(5):1432-1446.


Rigamonti, N., Kadioglu, E., Keklikoglou, I., Wyser Rmili, C., Leow, C.C., & De Palma, M. Role of angiopoietin-2 in adaptive tumor resistance to VEGF signalling blockadeCell Rep. 2014 Aug 7;8(3):696-706.


Escobar, G., Moi, D., Ranghetti, A., Ozkal-Baydin, P., Squadrito, M.L., Kajaste-Rudnitski, A., Bondanza, A., Gentner, B., De Palma, M., Mazzieri, R., & Naldini, L. Genetic engineering of hematopoiesis for targeted IFN-α delivery inhibits breast cancer progressionSci Transl Med. 2014 Jan 1;6(217):217ra3

Featured Cover Article


***Selected reviews***


Beltraminelli, T., Perez, C.R. & De Palma, M. Disentangling the complexity of tumor-derived extracellular vesicles. Cell Rep. 2021 Apr 6;35(1):108960.


Beltraminelli, T. & De Palma, M. Biology and therapeutic targeting of tumor-associated macrophages. J Pathol. 2020 Apr;250(5):573-592.


Perez, C.R. & De Palma, M. Engineering dendritic cell vaccines to improve cancer immunotherapy. Nat Communs. 2019 Nov 27;10(1):5408.


Lapenna, A., De Palma, M. & Lewis, C.E. Perivascular macrophages in health and diseaseNat Rev Immunol. 2018 Nov;18(11):689-702.


Nowak-Sliwinska, P. et al. Consensus guidelines for the use and interpretation of angiogenesis assaysAngiogenesis 2018 Aug;21(3):425-532.


Schmittnaegel, M. & De Palma, M. Reprogramming tumor blood vessels for enhancing immunotherapyTrends Cancer 2017 Dec;3(12):809-812.


De Palma, M., Biziato, D., & Petrova, T.V. Microenvironmental regulation of tumour angiogenesisNat Rev Cancer. 2017 Aug;17(8):457-474.


***Selected commentaries***


Mohammadzadeh Y & De Palma M. Boosting dendritic cell nanovaccines. Nat Nanotechnol. 2022 Apr 11.


Martinez-Usatorre A & De Palma M. Alzheimer’s drug turns macrophages against cancer. Nat Cancer. 2021 Nov;2(11):1119-1121.


Ghasemi, A. & De Palma, M. Tweaking the DNA of myeloid cells curbs cancer spread. Nature. 2020 Mar;579(7798):196-197.


Duval, F. & De Palma, M. Lymphoma chemotherapy: Hungry macrophages strike the final blow. Cancer Discov. 2019 Jul;9(7):834-836.


De Palma, M., Nassiri, S., Cianciaruso, C. Macrophage interference on chemotherapyNat Cell Biol. 2019 Apr;21(4):411-412.


De Palma, M. & Jain, R.K. CD4+ T cell activation and vascular normalization: Two sides of the same coin? Immunity. 2017 May 16;46(5):773-775.


De Palma, M. Origins of brain tumor macrophagesCancer Cell. 2016 Dec 12;30(6):832-833.


Kadioglu, E. & De Palma, MCancer metastasis: Perivascular macrophages under watchCancer Discov. 2015 Sep;5(9):906-8.


Squadrito, M.L. & De Palma, MA niche role for periostin and macrophages in glioblastomaNat Cell Biol 2015 Jan 30;17(2):107-9.


Biziato, D. & De Palma, MAssessing metastasis risk after pre-operative anti-angiogenic therapyEMBO Mol Med. 2014 Dec12;6(12):1515-7.


Keklikoglou, I. & De Palma, M. Cancer: Metastasis risk after anti-macrophage therapyNature. 2014 Nov 6;515(7525):46-7.



EPFL PATENTS

Title: Engineered antigen-presenting cells and uses thereof.

Inventors: Michele DE PALMA, Mario Leonardo SQUADRITO

Applicant: EPFL

Publication number: WO2017134100 A1; Application number: PCT/EP2017/052145

Priority date: Feb 2, 2016