Identification of a lipid oxygen radical defense pathway and its epigenetic control

F. S. Mesquita; L. Abrami; B. Kunz; C. Raclot; D. Milovanović et al. 

Injury-induced intestinal stem cell renewal requires capillary morphogenesis gene 2

L. Bracq; A. Chuat; B. Kunz; O. Burri; R. Guiet et al. 

Role of S-acylating enzymes in ciliated cells

Identification of the Lipid Oxygen Radical Defense pathway and its epigenetic control

F-G. van der Goot; F. Sarmento Mesquita; L. Abrami; R. Forey; B. Kunz et al. 

First person – Samuele Metti

S. Metti 

INTEGRATING SUSTAINABILITY IN HIGHER EDUCATION INSTITUTIONS: A CASE STUDY FROM EPFL

V. Rossi; A. Garin; S. Der Sarkissian; J. Grazioli; G. van der Goot et al. 

Mechanisms and functions of protein S-acylation

F. S. Mesquita; L. Abrami; M. E. Linder; S. X. Bamji; B. C. Dickinson et al. 

S-acylation and lipid exchange at the ER-Golgi membrane contact sites regulate pathogen entry in human cells

Dynamics of CLIMP-63 S-acylation control ER morphology

P. A. Sandoz; R. A. Denhardt-Eriksson; L. Abrami; L. A. Abriata; G. Spreemann et al. 

Refining S-acylation: Structure, regulation, dynamics, and therapeutic implications

M. U. Anwar; F. G. van der Goot 

ClimateBench v1.0: A Benchmark for Data-Driven Climate Projections

D. Watson-Parris; Y. Rao; D. Olivie; O. Seland; P. Nowack et al. 

Clinical detection of ‘cold stress’ is overlooked: an online survey of healthcare workers to explore the gap in neonatal thermal care in low-resource settings

M. Kyokan; V. Jirapaet; F. Rosa-Mangeret; G. B. Pisoni; R. E. Pfister 

Local and substrate-specific S-palmitoylation determines subcellular localization of G alpha o

G. P. Solis; A. Kazemzadeh; L. Abrami; J. Valnohova; C. Alvarez et al. 

S-acylation by ZDHHC20 targets ORAI1 channels to lipid rafts for efficient Ca2+ signaling by Jurkat T cell receptors at the immune synapse

A. Carreras-Sureda; L. Abrami; K. Ji-Hee; W-A. Wang; C. Henry et al. 

Proteome-wide analysis of protein lipidation using chemical probes: in-gel fluorescence visualization, identification and quantification of N-myristoylation, N- and S-acylation, O-cholesterylation, S-farnesylation and S-geranylgeranylation

W. W. Kallemeijn; T. Lanyon-Hogg; N. Panyain; A. G. Grocin; P. Ciepla et al. 

S-acylation controls SARS-CoV-2 membrane lipid organization and enhances infectivity

F. S. Mesquita; L. Abrami; O. Sergeeva; P. Turelli; E. Qing et al. 

Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains

L. Abrami; M. Audagnotto; S. Ho; M. J. Marcaida; F. S. Mesquita et al. 

Akt Is S-Palmitoylated: A New Layer of Regulation for Akt

M. Blaustein; E. Piegari; C. M. Calejman; A. Vila; A. Amante et al. 

ANTXR2 as a novel player in skeletal muscle stem cells

S. Metti; L. J. Bracq; F. G. van der Goot; P. Bonaldo 

Transposon-activated POU5F1B promotes colorectal cancer growth and metastasis.

L. Simo-Riudalbas; E. Planet; S. Offner; J. Duc; L. Abrami et al. 

The emerging landscape of single-molecule protein sequencing technologies

J. A. Alfaro; P. Bohländer; M. Dai; M. Filius; C. J. Howard et al. 

Harnessing the Membrane Translocation Properties of AB Toxins for Therapeutic Applications

N. Piot; G. van der Goot; O. A. Sergeeva 

A toxic palmitoylation of Cdc42 enhances NF-kappa B signaling and drives a severe autoinflammatory syndrome

B. Bekhouche; A. Tourville; Y. Ravichandran; R. Tacine; L. Abrami et al. 

Augmented mitochondrial energy metabolism is an early response to chronic glucose stress in human pancreatic beta cells

I. Chareyron; S. Christen; S. Moco; A. Valsesia; S. Lassueur et al. 

Wnt-controlled sphingolipids modulate Anthrax Toxin Receptor palmitoylation to regulate oriented mitosis in zebrafish

I. Castanon; J. T. Hannich; L. Abrami; F. Huber; M. Dubois et al. 

Ligand Binding to the Collagen VI Receptor Triggers a Talin-to-RhoA Switch that Regulates Receptor Endocytosis

J. Buergi; L. Abrami; I. Castanon; L. A. Abriata; B. Kunz et al. 

Infection with a small intestinal helminth, Heligmosomoides polygyrus bakeri, consistently alters microbial communities throughout the murine small and large intestine

A. Rapin; A. Chuat; L. Lebon; M. M. Zaiss; B. J. Marsland et al. 

Hemagglutinin of Influenza A, but not of Influenza B and C viruses is acylated by ZDHHC2, 8, 15 and 20

M. R. Gadalla; L. Abrami; F. G. van der Goot; M. Veit 

Virus-Mediated Cell-Cell Fusion

H. Leroy; M. Han; M. Woottum; L. J. M. Bracq; J. Bouchet et al. 

Mammalian membrane trafficking as seen through the lens of bacterial toxins

F. S. Mesquita; F. G. van der Goot; O. A. Sergeeva 

Use of deoxysphingolipids as anti-toxins and anti-virals

H. S. Riezman; J. T. Hannich; A. Galih; J. Gruenberg; F. G. Van Der Goot 

Image-based analysis of living mammalian cells using label-free 3D refractive index maps reveals new organelle dynamics and dry mass flux

P. Sandoz; C. C. G. Tremblay; G. van der Goot; M. Frechin 

Co-expression of CCT subunits hints at TRiC assembly

O. A. Sergeeva; C. Haase-Pettingell; J. A. King 

Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids

M. Piccolis; L. M. Bond; M. Kampmann; P. Pulimeno; C. Chitraju et al. 

Anthrax toxin requires ZDHHC5-mediated palmitoylation of its surface-processing host enzymes

O. A. Sergeeva; F. G. van der Goot 

Mechanisms protecting host cells against bacterial pore-forming toxins

C. Brito; D. Cabanes; F. S. Mesquita; S. Sousa 

Aerolysin, a Powerful Protein Sensor for Fundamental Studies and Development of Upcoming Applications

B. Cressiot; H. Ouldali; M. Pastoriza-Gallego; L. Bacri; F. G. Van der Goot et al. 

Palmitoylation mediates membrane association of hepatitis E virus ORF3 protein and is required for infectious particle secretion

J. Gouttenoire; A. Pollan; L. Abrami; N. Oechslin; J. Mauron et al. 

Active and dynamic mitochondrial S-depalmitoylation revealed by targeted fluorescent probes

R. Kathayat; Y. Cao; P. Elvira; P. Sandoz; M. Zaballa et al. 

Targeting STING with covalent small-molecule inhibitors

S. Haag; M. Gulen; L. Reymond; A. Gibelin; L. Abrami et al. 

Palmitoylation determines the subcellular localization of the hepatitis E virus ORF3 protein

J. Gouttenoire; P. Angela; A. Laurence; M. Maxime; D. T. V. Loan et al. 

The molecular era of protein S-acylation: spotlight on structure, mechanisms, and dynamics

M. Zaballa; F. van der Goot 

CMG2/ANTXR2 regulates extracellular collagen VI which accumulates in hyaline fibromatosis syndrome

J. Burgi; B. Kunz; L. Abrami; J. Deuquet; A. Piersigilli et al. 

Regulation of Endoplasmic Reticulum Architecture by Protein S-Palmitoylation

Model-Driven Understanding of Palmitoylation Dynamics: Regulated Acylation of the Endoplasmic Reticulum Chaperone Calnexin

T. Dallavilla; L. Abrami; P. A. Sandoz; G. Savoglidis; V. Hatzimanikatis et al. 

Cryo-EM structure of aerolysin variants reveals a novel protein fold and the pore-formation process

I. Iacovache; S. De Carlo; N. Cirauqui; M. Dal Peraro; F. G. van der Goot et al. 

Ubiquitin-dependent folding of the Wnt signaling coreceptor LRP6

E. Perrody; L. Abrami; M. Feldman; B. Kunz; S. Urbe et al. 

Cytoplasmic Ubiquitin-Specific Protease 19 (USP19) Modulates Aggregation of Polyglutamine-Expanded Ataxin-3 and Huntingtin through the HSP90 Chaperone

W-T. He; X-M. Zheng; Y-H. Zhang; Y-G. Gao; A-X. Song et al. 

Discrimination of oligonucleotides of different lengths with a wild-type aerolysin nanopore

C. Cao; Y-L. Ying; Z-L. Hu; D-F. Liao; H. Tian et al. 

Intrinsic Disorder in Transmembrane Proteins: Roles in Signaling and Topology Prediction

J. Burgi; B. Xue; V. N. Uversky; F. G. van der Goot 

Revealing Assembly of a Pore-Forming Complex Using Single-Cell Kinetic Analysis and Modeling

M. Bischofberger; I. Iacovache; D. Boss; F. Naef; F. G. van der Goot et al. 

The Ins and Outs of Anthrax Toxin

S. Friebe; F. G. van der Goot; J. Buergi 

Folding and Endocytosis of Anthrax Toxin Receptors

SwissPalm: Protein Palmitoylation database

M. Blanc; F. David; L. Abrami; D. Migliozzi; F. Armand et al. 

Differential dependence on N-glycosylation of anthrax toxin receptors CMG2 and TEM8

S. Friebe; J. Deuquet; F. G. van der Goot 

The SwissLipids knowledgebase for lipid biology

L. Aimo; R. Liechti; N. Hyka-Nouspikel; A. Niknejad; A. Gleizes et al. 

How many lives does CLIMP-63 have?

P. A. Sandoz; F. G. Van der Goot 

Kicking Out Pathogens in Exosomes

O. A. Sergeeva; F. G. van der Goot 

Unraveling the Physiological Role of Capillary Morphogenesis Gene 2 in Health and Disease

Monitoring the Cellular Cholesterol Distribution via nanoSIMS Imaging

M. Demir 

Monitoring the Cellular Cholesterol Distribution via NanoSIMS Imaging

M. Demir 

Live-cell multiplane three-dimensional super-resolution optical fluctuation imaging

S. Geissbuehler; A. Sharipov; A. Godinat; N. L. Bocchio; P. A. Sandoz et al. 

Novel mechanistic insights into anthrax toxin endocytosis

S. Friebe; L. Abrami; F. G. Van der Goot 

Close Encounter of the Third Kind: The ER Meets Endosomes at Fission Sites

F. G. Van Der Goot; J. Gruenberg 

In-Depth Analysis of Mutations in Hyaline Fibromatosis Syndrome (HFS)

Mechanism and Function of S-palmitoylation in Capillary Morphogenesis Gene 2

Modelling of Protein Palmitoylation Networks

T. Dallavilla 

Did Cholera Toxin Finally Get Caught?

F. Martinon; F. G. van der Goot 

Hijacking Multivesicular Bodies Enables Long-Term and Exosome-Mediated Long-Distance Action of Anthrax Toxin

L. Abrami; L. Brandi; M. Moayeri; M. J. Brown; B. A. Krantz et al. 

Biochemical Membrane Lipidomics during Drosophila Development

X. L. Guan; G. Cestra; G. Shui; A. Kuhrs; R. B. Schittenhelm et al. 

In-depth analysis of hyaline fibromatosis syndrome frameshift mutations at the same site reveal the necessity of personalized therapy

S. E. Yan; T. Lemmin; S. Salvi; E. Lausch; A. Superti-Furga et al. 

Anthrax toxin receptor 2a controls mitotic spindle positioning

I. Castanon; L. Abrami; L. Holtzer; C. P. Heisenberg; G. van der Goot et al. 

Calnexin Controls the STAT3-Mediated Transcriptional Response to EGF

A. K. Lakkaraju; G. van der Goot 

Molecular assembly of the aerolysin pore reveals a swirling membrane-insertion mechanism

M. T. Degiacomi; I. Lacovache; L. Pernot; M. Chami; M. Kudryashev et al. 

The Molecular Assembly of the Aerolysin Pore Reveals a Unique Swirling Membrane-Insertion Mechanism

M. Degiacomi; I. Iacovache; G. Van Der Goot; M. Dal Peraro 

Palmitoylation, pathogens and their host

M. Blanc; S. Blaskovic; G. van der Goot 

What does S-palmitoylation do to membrane proteins?

S. Blaskovic; M. Blanc; G. van der Goot 

Caspase-2 is an initiator caspase responsible for pore-forming toxin-mediated apoptosis

G. Imre; J. Heering; A-N. Takeda; M. Husmann; B. Thiede et al. 

Binding of Lassa virus perturbs extracellular matrix-induced signal transduction via dystroglycan

J. M. Rojek; M-L. Moraz; C. Pythoud; S. Rothenberger; G. van der Goot et al. 

Pathogenic Pore-Forming Proteins: Function and Host Response

M. Bischofberger; I. Iacovache; G. van der Goot 

The dark sides of capillary morphogenesis gene 2

J. Deuquet; E. Lausch; A. Superti-Furga; G. van der Goot 

Dual Chaperone Role of the C-Terminal Propeptide in Folding and Oligomerization of the Pore-Forming Toxin Aerolysin

I. Iacovache; M. T. Degiacomi; L. Pernot; S. Ho; M. Schiltz et al. 

Pore-forming toxins induce multiple cellular responses promoting survival

M. R. Gonzalez; M. Bischofberger; B. Freche; S. Ho; R. G. Parton et al. 

Hyaline Fibromatosis Syndrome inducing mutations in the ectodomain of anthrax toxin receptor 2 can be rescued by proteasome inhibitors

J. Deuquet; E. Lausch; N. Guex; L. Abrami; S. Salvi et al. 

Extending the aerolysin family: from bacteria to vertebrates

P. Szczesny; I. Iacovache; A. Muszewska; K. Ginalski; G. van der Goot et al. 

Dynamics of Unfolded Protein Transport through an Aerolysin Pore

M. Pastoriza-Gallego; L. Rabah; G. Gibrat; B. Thiebot; G. van der Goot et al. 

Monalysin, a novel ß-pore-forming toxin from the Drosophila pathogen Pseudomonas entomophila, contributes to host intestinal damage and lethality

O. Opota; I. Vallet-Gély; R. Vincentelli; C. Kellenberger; I. Iacovache et al. 

When cells and microbes meet in Krakow

K. Rajalingam; G. van der Goot 

Cellular Responses to Bacterial Pore-Forming Toxins

Folding and Structure of the Pore Forming Toxin Aerolysin

Molecular Mechanisms Underlying Hyaline Fibromatosis Syndrome

The 2DX robot: a membrane protein 2D crystallization Swiss Army knife

I. Iacovache; M. Biasini; J. Kowal; W. Kukulski; M. Chami et al. 

Preliminary crystallographic analysis of two oligomerization-deficient mutants of the aerolysin toxin, H132D and H132N, in their proteolyzed forms

L. Pernot; M. Schiltz; G. van der Goot 

Endocytosis of the anthrax toxin is mediated by clathrin, actin and unconventional adaptors

L. Abrami; M. Bischofberger; B. Kunz; R. Groux; F. G. van der Goot 

Anthrax toxin triggers the activation of src-like kinases to mediate its own uptake

L. Abrami; B. Kunz; F. G. van der Goot 

A model for the assembly and activation process of the pore-forming toxin Aerolysin

M. Degiacomi; I. Iacovache; G. van der Goot; M. Dal Peraro 

Structure and assembly of pore-forming proteins

I. Iacovache; M. Bischofberger; F. G. van der Goot 

Getting the Opportunity to Fly on your own

G. van der Goot 

Shigella phagocytic vacuolar membrane remnants participate in the cellular response to pathogen invasion and are regulated by autophagy

N. Dupont; S. Lacas-Gervais; J. Bertout; I. Paz; B. Freche et al. 

Systemic hyalinosis mutations in the CMG2 ectodomain leading to loss of function through retention in the endoplasmic reticulum

J. Deuquet; L. Abrami; A. Difeo; M. C. M. Ramirez; J. A. Martignetti et al. 

Membrane injury by pore-forming proteins

M. Bischofberger; M. R. Gonzalez; F. G. van der Goot 

Novel ubiquitin-dependent quality control in the endoplasmic reticulum

M. Feldman; F. G. van der Goot 

Receptors of anthrax toxin and cell entry

G. van der Goot; J. A. T. Young 

Maturation modulates caspase-1-independent responses of dendritic cells to Anthrax lethal toxin

N. Reig; A. Jiang; R. Couture; F. S. Sutterwala; Y. Ogura et al. 

Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies

V. Pons; P. P. Luyet; E. Morel; L. Abrami; F. G. van der Goot et al. 

Regulation of the V-ATPase along the endocytic pathway occurs through reversible subunit association and membrane localization

C. Lafourcade; K. Sobo; S. Kieffer-Jaquinod; J. Garin; F. G. van der Goot 

Elastic membrane heterogeneity of living cells revealed by stiff nanoscale membrane domains

C. Roduit; F. G. van der Goot; P. De Los Rios; A. Yersin; P. Steiner et al. 

Functional interactions between anthrax toxin receptors and the WNT signalling protein LRP6

L. Abrami; B. Kunz; J. Deuquet; A. Bafico; G. Davidson et al. 

Activation of the unfolded protein response is required for defenses against bacterial pore-forming toxin in vivo

L. J. Bischof; C. Y. Kao; F. C. Los; M. R. Gonzalez; Z. Shen et al. 

Palmitoylation and ubiquitination regulate exit of the Wnt signaling protein LRP6 from the endoplasmic reticulum

L. Abrami; B. Kunz; I. Iacovache; F. G. van der Goot 

Exotoxin secretion: getting out to find the way in

M. Bischofberger; F. G. van der Goot 

Bacterial pore-forming toxins: the (w)hole story?

M. R. Gonzalez; M. Bischofberger; L. Pernot; F. G. van der Goot; B. Frêche 

Palmitoylation of membrane proteins (Review)

J. Charollais; F. G. Van Der Goot 

Pore formation: an ancient yet complex form of attack

I. Iacovache; F. G. van der Goot; L. Pernot 

Involvement of a Golgi-resident GPI-anchored protein in maintenance of the Golgi structure

X. Li; D. Kaloyanova; M. van Eijk; R. Eerland; G. van der Goot et al. 

Diversity of raft-like domains in late endosomes

K. Sobo; J. Chevallier; R. G. Parton; J. Gruenberg; F. G. van der Goot 

Late endosomal cholesterol accumulation leads to impaired intra-endosomal trafficking

K. Sobo; I. Le Blanc; P. P. Luyet; M. Fivaz; C. Ferguson et al. 

Pore-forming toxins and cellular non-immune defenses (CNIDs)

R. Aroian; F. G. van der Goot 

Editorial Overview

P. L. Small; F. G. van der Goot 

The role of the inflammasome in cellular responses to toxins and bacterial effectors

B. Freche; N. Reig; F. G. van der Goot 

Dynamics of GPI-anchored proteins on the surface of living cells

A. Nohe; E. Keating; M. Fivaz; F. G. van der Goot; N. O. Petersen 

Receptor palmitoylation and ubiquitination regulate anthrax toxin endocytosis

L. Abrami; S. H. Leppla; F. G. van der Goot 

A rivet model for channel formation by aerolysin-like pore-forming toxins

I. Iacovache; P. Paumard; H. Scheib; C. Lesieur; N. Sakai et al. 

Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival

L. Gurcel; L. Abrami; S. Girardin; J. Tschopp; F. G. van der Goot 

Toxoplasma: guess who’s coming to dinner

J. Gruenberg; F. G. van der Goot 

About lipids and toxins

N. Reig; F. G. van der Goot 

Mechanisms of pathogen entry through the endosomal compartments

J. Gruenberg; F. G. van der Goot 

Intra-endosomal membrane traffic

F. G. van der Goot; J. Gruenberg 

Aerolysin and related Aeromonas toxins

L. Gurcel; I. Iacovache; F. van der Goot 

Anthrax toxin: the long and winding road that leads to the kill

L. Abrami; N. Reig; F. G. van der Goot 

Oiling the key hole

F. Lafont; F. G. van der Goot 

Bacterial invasion via lipid rafts

F. Lafont; F. G. van der Goot 

Rafts can trigger contact-mediated secretion of bacterial effectors via a lipid-based mechanism

F. G. van der Goot; G. Tran van Nhieu; A. Allaoui; P. Sansonetti; F. Lafont 

Mitogen-activated protein kinase pathways defend against bacterial pore-forming toxins

D. L. Huffman; L. Abrami; R. Sasik; J. Corbeil; F. G. van der Goot et al. 

Membrane insertion of anthrax protective antigen and cytoplasmic delivery of lethal factor occur at different stages of the endocytic pathway

L. Abrami; M. Lindsay; R. Parton; S. Leppla; F. van der Goot 

Bacterial subversion of lipid rafts

F. Lafont; L. Abrami; F. G. van der Goot 

A bacterial big-MAC attack

I. Iacovache; F. G. van der Goot 

Sensitivity of polarized epithelial cells to the pore-forming toxin aerolysin

L. Abrami; M. Fivaz; P. E. Glauser; N. Sugimoto; C. Zurzolo et al. 

Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process

L. Abrami; S. Liu; P. Cosson; S. H. Leppla; F. G. van der Goot 

Sliding doors: clathrin-coated pits or caveolae?

M. Felberbaum-Corti; V. D. Goot; F. Gisou; J. Gruenberg 

Eukaryotic cells and microbial pathogens: a familiar couple take centre stage

C. R. Roy; F. G. van der Goot 

Initial steps of Shigella infection depend on the cholesterol/sphingolipid raft-mediated CD44-IpaB interaction

F. Lafont; G. Tran Van Nhieu; K. Hanada; P. Sansonetti; F. G. van der Goot 

Requirement of N-glycan on GPI-anchored proteins for efficient binding of aerolysin but not Clostridium septicum alpha-toxin

Y. Hong; K. Ohishi; N. Inoue; J. Y. Kang; H. Shime et al. 

Oiling the wheels of the endocytic pathway

F. G. van der Goot; J. Gruenberg 

The glycan core of GPI-anchored proteins modulates aerolysin binidng but is not sufficient: the polypeptide moiety is required for the toxin-receptor interaction

L. Abrami; M-C. Velluz; H. Hong; K. Ohishi; A. Mehlert et al. 

Conversion of a transmembrane to a water-soluble protein complex by a single point mutation

Y. Tsitrin; C. J. Morton; C. el-Bez; P. Paumard; M. C. Velluz et al. 

Differential sorting and fate of endocytosed GPI-anchored proteins

M. Fivaz; F. Vilbois; S. Thurnheer; C. Pasquali; L. Abrami et al. 

Association of Helicobacter pylori vacuolating toxin (VacA) with lipid rafts

W. Schraw; Y. Li; M. S. McClain; F. G. van der Goot; T. L. Cover 

La vie sans cavéoles

L. Abrami; F. G. van der Goot; F. Lafont 

Membranolytic toxins

F. G. van der Goot; M. Fivaz; L. Abrami 

Cross-talk between caveolae and glycosylphosphatidylinositol-rich domains

L. Abrami; M. Fivaz; T. Kobayashi; T. Kinoshita; R. G. Parton et al. 

Not as simple as just punching a hole

M. Fivaz; L. Abrami; Y. Tsitrin; F. G. van der Goot 

Aerolysin from Aeromonas hydrophila and related toxins

M. Fivaz; L. Abrami; Y. Tsitrin; F. G. van der Goot 

Biosystem for epithelial cell culture and electrical characterisation

S. Hediger; A. Sayah; K. Sobo; F. Van der Goot; M. Gijs 

The bacterial toxin toolkit

G. Schiavo; F. G. van der Goot 

Raft membrane domains: from a liquid-ordered membrane phase to a site of pathogen attack

F. G. van der Goot; T. Harder 

Pore-forming toxins

Plasticity of the transmembrane beta-barrel

F. G. van der Goot 

Analysis of glycosyl phosphatidylinositol-anchored proteins by two-dimensional gel electrophoresis

M. Fivaz; F. Vilbois; C. Pasquali; F. G. van der Goot 

Sensing proteins outside of the box

F. G. van der Goot; S. Matile 

Cholesterol-rich plasma membrane microdomains promote oligomerization of the pore.forming toxin aerolysin.

L. Abrami; M. Fivaz; F. G. van der Goot 

Surface dynamics of aerolysin on the plasma membrane of living cells

L. Abrami; M. Fivaz; F. G. van der Goot 

Adventures of a pore-forming toxin at the target cell surface

L. Abrami; M. Fivaz; F. G. van der Goot 

Surface Dynamics of Aerolysin on the Plasma Membrane of Livinf Cells.

L. Abrami; M. Fivaz; F. G. van der Goot 

The staphylococcal alpha-toxin pore has a flexible conformation

B. Vecsey-Semjen; S. Knapp; R. Möllby; F. van der Goot 

Plasma membrane microdomains act as concentration platforms to facilitate intoxication by aerolysin

L. Abrami; F. van der Goot 

Increased stability upon heptamerization of the pore-forming toxin aerolysin

C. Lesieur; S. Frutiger; G. Hughes; R. Kellner; F. Pattus et al. 

The tip of a molecular syringe

M. Fivaz; F. G. van der Goot 

Landing on lipid rafts

M. Fivaz; L. Abrami; F. van der Goot 

The lectin-like domain of tumor necrosis factor-alpha increases membrane conductance in microvascular endothelial cells and peritoneal macrophages

M. Hribar; A. Bloc; F. G. van der Goot; L. Fransen; P. De Baetselier et al. 

Dimer dissociation of the pore-forming toxin aerolysin precedes receptor binding

M. Fivaz; M. C. Velluz; F. G. van der Goot 

Pathogens, toxins and lipid rafts

M. Fivaz; L. Abrami; F. van der Goot 

Membrane interaction of TNF is not sufficient to trigger increase in membrane conductance in mammalian cells

F. G. van der Goot; J. Pugin; M. Hribar; L. Fransen; Y. Dunant et al. 

Purification and analysis of authentic CLIP-170 and recombinant fragments

J. Scheel; P. Pierre; J. E. Rickard; G. S. Diamantopoulos; C. Valetti et al. 

Aerolysin induces G-protein activation and Ca2+ release from intracellular stores in human granulocytes

K. H. Krause; M. Fivaz; A. Monod; F. G. van der Goot 

Movement of a loop in domain 3 of aerolysin is required for channel formation

J. Rossjohn; S. M. Raja; K. L. Nelson; S. C. Feil; F. G. van der Goot et al. 

The pore-forming toxin proaerolysin is activated by furin

L. Abrami; M. Fivaz; E. Decroly; N. G. Seidah; F. Jean et al. 

Brucella abortus transits through the autophagic pathway and replicates in the endoplasmic reticulum of nonprofessional phagocytes

J. Pizarro-Cerda; S. Meresse; R. G. Parton; G. van der Goot; A. Sola-Landa et al. 

A pore-forming toxin interacts with a GPI-anchored protein and causes vacuolation of the endoplasmic reticulum

L. Abrami; M. Fivaz; P. E. Glauser; R. G. Parton; F. G. van der Goot 

Aerolysin–a paradigm for membrane insertion of beta-sheet protein toxins?

J. Rossjohn; S. C. Feil; W. J. McKinstry; D. Tsernoglou; G. van der Goot et al. 

Conformational Changes upon Channel Formation by Staphylococcal alpha-Toxin

B. Vecsey-Semjen; S. Knapp; R. Möllby; F. G. van der Goot 

The Pore-Forming Toxin Aerolysin Binds to Microdomains of the Plasma Membrane and Leads to Fragmentation of the Endoplasmic Reticulum.

L. Abrami; M. Fivaz; J. T. Buckley; R. G. Parton; F. G. van der Goot 

Membrane insertion: the strategy of toxins

C. Lesieur; B. Vecsey-Semjn; L. Abrami; M. Fivaz; F. van der Goot 

Separation of early steps in endocytic membrane transport

F. G. van der Goot 

The disulfide bond in the Aeromonas hydrophila lipase/acyltransferase stabilizes the structure but is not required for secretion or activity

M. J. Brumlik; F. G. van der Goot; K. R. Wong; J. T. Buckley 

Conformational changes in aerolysin during the transition from the water-soluble protoxin to the membrane channel

V. Cabiaux; J. T. Buckley; R. Wattiez; J. M. Ruysschaert; M. W. Parker et al. 

Conformational changes due to membrane binding and channel formation by staphylococcal alpha-toxin

B. Vecsey-Semjen; C. Lesieur; R. Mollby; F. G. van der Goot 

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in the subunit stoichiometry study of high mass non-covalent complexes

M. Moniatte; C. Lesieur; B. Vecsey-Semjen; J. Buckley; F. Pattus et al. 

Membrane insertion : the strategy of toxins

C. Lesieur; L. Vecsey-Semjen; L. Abrami; M. Fivaz; F. G. van der Goot 

Partial C-terminal unfolding is required for channel formation by staphylococcal alpha-toxin

B. Vecsey-Semjen; R. Mollby; F. G. van der Goot 

Characterisation of the heptameric pore-forming complex of the Aeromonas toxin aerolysin using MALDI-TOF mass spectrometry

M. Moniatte; F. G. van der Goot; J. T. Buckley; F. Pattus; A. van Dorsselaer 

Aerolysin–the ins and outs of a model channel-forming toxin

M. W. Parker; F. G. van der Goot; J. T. Buckley 

Structure and Assembly of the Channel-Forming Aeromonas Toxin Aerolysin

M. W. Parker; J. T. Buckley; F. van der Goot; D. Tsernoglou 

Membrane insertion of toxins

C. Lesieur; B. Vecsey-Semjen; M. Kruse; F. G. van der Goot 

Protonation of histidine-132 promotes oligomerization of the channel-forming toxin aerolysin

J. T. Buckley; H. U. Wilmsen; C. Lesieur; A. Schulze; F. Pattus et al. 

The C-terminal peptide produced upon proteolytic activation of the cytolytic toxin aerolysin is not involved in channel formation.

F. van der Goot; K. Hardie; M. Parker; J. Buckley 

The pore-forming toxin aerolysin: from the soluble form to the transmembrane channel

F. van der Goot; F. Pattus; J. Buckley 

The cytolytic toxin aerolysin: from the soluble form to the transmembrane channel

F. G. van der Goot; F. Pattus; M. Parker; J. T. Buckley 

All in the family: the toxic activity of pore-forming colicins

J. Lakey; F. G. van der Goot; F. Pattus 

The cytolytic aerolysin : how a Janus protein turns inside-out upon membrane insertion and pore formation ?

F. G. van der Goot; F. Pattus; H. U. Wilmsen; R. MacDonald; K. Leonard et al. 

Modèle d’étude de l’insertion des protéines membranaires

F. van der Goot; F. Pattus 

Oligomerization of the channel-forming toxin aerolysin precedes insertion into lipid bilayers

F. G. van der Goot; F. Pattus; K. R. Wong; J. T. Buckley 

Dimerization stabilizes the pore-forming toxin aerolysin in solution.

F. van der Goot; J. Ausio; K. Wong; F. Pattus; J. Buckley 

Role of acidic lipids in the translocation and channel activity of colicins A and N in Escherichia coli cells

F. G. van der Goot; N. Didat; F. Pattus; W. Dowhan; L. Letellier 

Physical and chemical characterization of the oligomerization state of the Aeromonas hydrophila lipase/acyltransferase

J. Ausio; F. G. van der Goot; J. T. Buckley 

Modèles d’études de l’insertion des protéines membranaires

F. G. van der Goot; F. Pattus 

Spectroscopic study of the activation and oligomerization of the channel-forming toxin aerolysin: identification of the site of proteolytic activation

F. G. van der Goot; J. Lakey; F. Pattus; C. M. Kay; O. Sorokine et al. 

Flow cytometry and sorting of amphibian bladder endocytic vesicles containing ADH-sensitive water channels

F. G. van der Goot; A. Seigneur; J. C. Gaucher; P. Ripoche 

Primary and secondary structure of the pore-forming peptide of pathogenic Entamoeba histolytica

M. Leippe; E. Tannich; R. Nickel; G. van der Goot; F. Pattus et al. 

The membrane insertion of colicins

J. H. Lakey; J. M. González-Mañas; F. G. van der Goot; F. Pattus 

The molten globule intermediate for protein insertion or translocation through membranes

F. G. van der Goot; J. H. Lakey; F. Pattus 

Mechanism of water transport accross the renal proximal tubule.

B. Corman; F. G. van der Goot 

Puncturing cell membranes : comparison of colicin A and Aerolysin

N. Didat; J-M. Gonzales-Manas; F. G. van der Goot; D. Jeanteur; F. Lakey et al. 

Evidence for permanent water channels in the basolateral membrane of an ADH-sensitive epithelium

F. van der Goot; B. Corman; P. Ripoche 

A ‘molten-globule’ membrane-insertion intermediate of the pore-forming domain of colicin A

F. G. van der Goot; J. M. Gonzalez-Manas; J. H. Lakey; F. Pattus 

Axial heterogeneity of apical water permeability along rabbit kidney proximal tubule

F. Van Der Goot; B. Corman 

Determination of solute reflection coefficients in kidney brush-border membrane vesicles by light scattering: influence of the refractive index

F. van der Goot; P. Ripoche; B. Corman 

Water permeabilities and salt reflection coefficients of luminal, basolateral and intracellular membrane vesicles isolated from rabbit kidney proximal tubule

F. G. van der Goot; R. A. Podevin; B. J. Corman