Publications

Selected publications

Reply to: Bridging predictive algorithms and clinical practice in DBS contact selection

M. Muller; I. U. Isaias; E. M. Moraud; M. F. Contarino 

npj Parkinson’s Disease. 2026. Vol. 12, num. 1. DOI : 10.1038/s41531-026-01534-1.

Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders

L. Cif; D. Demailly; G. A. Horvàth; J. D. Ortigoza‐Escobar; N. Dorison et al. 

Annals of Clinical and Translational Neurology. 2026. DOI : 10.1002/acn3.70474.

Artificial intelligence in deep brain stimulation for movement disorders: a systematic review and technology readiness assessment

Z. Souei; M. M. U. Rehman; H. Akram; J. Bloch; S. Chabardes et al. 

npj Digital Medicine. 2026. DOI : 10.1038/s41746-026-03015-4.

Activity-dependent adaptive deep brain stimulation improves gait in Parkinson’s disease

S. Scafa; V. de Seta; R. Wang; P. S. López; A. S. López et al. 

Nature Medicine. 2026. DOI : 10.1038/s41591-026-04432-4.

Characterising motor and cognitive contributions of cortical beta oscillations and their modulation with rTMS

S. He; J. F. Martin-Rodriguez; A. Pogosyan; E. M. Moraud; H. Tan 

NeuroImage. 2026. Vol. 331. DOI : 10.1016/j.neuroimage.2026.121893.

Neuromodulation for gait disorders

A. Balachandar; G. Sorrento; E. M. Moraud; M. Bonizzato; A. Fasano 

Nature Reviews Bioengineering. 2026. DOI : 10.1038/s44222-026-00431-9.

Proceedings of the 13th annual deep brain stimulation think tank: the evolving landscape

C. Fleeting; E. M. Moraud; K. Uǧurbil; D. D. Wang; W-J. Neumann et al. 

Frontiers in Human Neuroscience. 2026. Vol. 20. DOI : 10.3389/fnhum.2026.1770451.

Spatial propagation of movement-related basal ganglia activity predicts parkinsonian motor state

A. Averna; M. Sousa; E. Bernasconi; E. Moraud; C. Pollo et al. 

Brain. 2026. DOI : 10.1093/brain/awag019.

A Neuronal Architecture Underlying Autonomic Dysreflexia

J. E. C. Soriano; A. Y. Y. Teo; R. Hudelle; L. Mahe; M. A. Skinnider et al. 

NATURE. 2025. Vol. 646, p. 1167 – 1177. DOI : 10.1038/s41586-025-09487-w.

Toward a Unified Gait Freeze Index: a Standardized Benchmark for Clinical and Regulatory Evaluations

A. Schaer; H. Maurenbrecher; C. Mangiante; R. Sobkuliak; K. Musch et al. 

FRONTIERS IN NEUROLOGY. 2025. Vol. 16. DOI : 10.3389/fneur.2025.1528963.

GAIT: gait analysis interactive tool a pipeline for automatic detection of gait events across different motor impairments

M. Nocilli; S. Scafa; N. La Porta; M. Ghislieri; V. Agostini et al. 

SIGNAL IMAGE AND VIDEO PROCESSING. 2024. num. 12, p. 8499 – 8506. DOI : 10.1007/s11760-024-03443-3.

Exercise and gait/movement analyses in treatment and diagnosis of Parkinson’s Disease

J. Burtscher; E. M. Moraud; D. Malatesta; J. F. Bally; G. P. Millet et al. 

Ageing Research Reviews. 2023. Vol. 93, p. 102147. DOI : 10.1016/j.arr.2023.102147.

A spinal cord neuroprosthesis for locomotor deficits due to Parkinson’s disease

T. Milekovic; E. M. Moraud; N. Macellari; C. Moerman; F. Raschella et al. 

Nature Medicine. 2023. Vol. 29, num. 11, p. 2854 – +. DOI : 10.1038/s41591-023-02584-1.

Neuromodulation/neurostimulation system for mitigating locomotor deficits of parkinson’s disease, spinal cord injury (sci), stroke and/or other neurological disorders

J. Bloch; T. Milekovic; E. Martin Moraud; G. Courtine; C. Newton et al. 

WO2023209150.

2023.

Actigraphy Enables Home Screening of Rapid Eye Movement Behavior Disorder in Parkinson’s Disease

F. Raschella; S. Scafa; A. Puiatti; E. M. Moraud; P-L. Ratti 

Annals Of Neurology. 2022. DOI : 10.1002/ana.26517.

Actigraphy enables home screening of REM behavior disorder in Parkinson’s disease: Preliminary data

F. Raschella; S. Scafa; A. Puiatti; E. Martin-Moraud; P. -L. Ratti 

2022. 

Principles of gait encoding in the subthalamic nucleus of people with Parkinson’s disease

Y. Thenaisie; K. Lee; C. Moerman; S. Scafa; A. Galvez et al. 

Science Translational Medicine. 2022. Vol. 14, num. 661, p. eabo1800. DOI : 10.1126/scitranslmed.abo1800.

Adaptive, personalized closed-loop therapy for Parkinson’s disease: biochemical, neurophysiological, and wearable sensing systems

L. di Biase; G. Tinkhauser; E. M. Moraud; M. L. Caminiti; P. M. Pecoraro et al. 

Expert Review Of Neurotherapeutics. 2021. Vol. 21, num. 12, p. 1371 – 1388. DOI : 10.1080/14737175.2021.2000392.

Controlling Clinical States Governed by Different Temporal Dynamics With Closed-Loop Deep Brain Stimulation: A Principled Framework

G. Tinkhauser; E. M. Moraud 

Frontiers In Neuroscience. 2021. Vol. 15, p. 734186. DOI : 10.3389/fnins.2021.734186.

Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury

J. W. Squair; M. Gautier; L. Mahe; J. E. Soriano; A. Rowald et al. 

Nature. 2021. Vol. 590, num. 7845, p. 308 – 314. DOI : 10.1038/s41586-020-03180-w.

(* Equal contribution)

M Muller, S Scafa, I Hanafi, C Varescon, C Palmisano, S Gaag, R Zutt, NA Gaag, C FE Hoffmann, J Bloch, MC Jimenez, JF Bally, P Capetian, IU Isaias, EM Moraud* and M F Contarino* (2025).
Online prediction of optimal deep brain stimulation contacts from local field potentials in chronically implanted patients with Parkinson’s disease.
npj Parkinson’s disease   pdf

P Sanchez Lopez, R Wang, C Varescon, A Schaer, O Ergeneman, G Chatzipirpiridis, EM Moraud (2025).
A wearable neuromonitoring platform to map motor and neural biomarkers of gait dysfunction in people with Parkinson’s disease across daily life.
Proceedings of the 47th International Conference on Engineering in Medicine and Biology pdf

A Schaer, H Maurenbrecher, C Mangiante, R Sobkuliak, K Müsch, P Sanchez Lopez, EM Moraud, O Ergeneman, G Chatzipirpiridis (2025).
Toward a unified gait freeze index: a standardized benchmark for clinical and regulatory evaluations.
Frontiers in Neurology , Vol 16  pdf

C Varescon, EM Moraud, L Cif, G Courtine, J Bloch and JF Bally (2025).
Neurosurgical therapies for movement disorders in 2025.
Revue Médicale Suisse, Vol 21 pdf

M Nocilli, S Scafa, N La Porta, M Ghislieri, V Agostini, EM Moraud and A Puiatti (2024)
GAIT: gait analysis interactive tool a pipeline for automatic detection of gait events across different motor impairments.
Signal, Image and Video Processing pdf

J Burtscher, EMM Moraud, D Malatesta, GP Millet, JF Bally and A Patoz (2023)
Exercise and gait/movement analyses in treatment and diagnosis of Parkinson’s Disease.
Ageing Research Reviews pdf

T Milekovic*, EM Moraud*, N Macellari, C Moerman, F Raschellà, S Sun, MG Perich, C Varescon, R Dememaeker, A Bruel, L Boyle-Freysot, G Schiavone, E Pirondini, C YunLong, L Hao, A Gálvez, S Hernández Charpak, G Dumont, J Ravier, C Le Goff, J-B Mignardot, G Carparelli, C Harte, N Hankov, V Aurelie, A Watrin, H Lambert, D Borton, J Laurens, I Vollenweider, S Borgognon, F Bourre, M Goillandeau, W Kin, D Ko, L Petit, Qin Li, R Buschman, N Buse, M Yaroshinsky, J-B Ledoux, F Becce, M Castro Jimenez, JF Bally, T Denison, D Guehl, A Ijspeert, M Capogrosso, J Squair, L Asboth, PA Starr, DD Wang, SP Lacour, S Micera, C Qin, J Bloch*, E Bezard* and G. Courtine* (2023).
A spinal cord neuroprosthesis for locomotor deficits due to Parkinson’s disease.
Nature Medicine pdf
Media coverage: CNN , BBC, El País, RTS, France Info

F Raschellà, S Scafa, A Puiatti, EM Moraud* and P-L Ratti* (2022).
Actigraphy enables home screening of REM behavior disorder in Parkinson’s disease
Annals of Neurology  pdf

Y Thenaisie*, K Lee*, C Moerman, S Scafa, A Gálvez, E Pirondini, M Burri, J Ravier, A Puiatti, E Accolla, B Wicki, A Zacharia, M Castro Jiménez, JF Bally, G Courtine, J Bloch and EM Moraud (2022). 
Principles of gait encoding in the subthalamic nucleus of people with Parkinson’s disease
Science Translational Medicine, Vol 14 pdf

G Tinkhauser* and EM Moraud* (2021). 
Controlling clinical states governed by different temporal dynamics using closed-loop DBS : A principled framework
Frontiers in Neuroscience Vol. 21  pdf

L di Biase, G Tinkhauser, EM Moraud, ML Caminiti, PM Pecoraro and V di Lazzaro (2021)
Adaptive, personalized closed-loop therapy for Parkinson’s disease: biochemical, neurophysiological and wearable sensing systems.
Expert Review in Neurotherapeutics Vol. 21  pdf

Y Thenaisie*, C Palmisano*, A Canessa, BJ Keulen, P Capetian, MC Jiménez, JF Bally, E Manferlotti, L Beccaria, R Zutt, G Courtine, J Bloch, NA van der Gaag, CF Hoffmann, EM Moraud* IU Isaias* and MF Contarino* (2021).
Towards adaptive deep brain stimulation: clinical and technical notes on a novel commercial device for chronic brain sensing.
Journal of Neural Engineering, Vol. 18  pdf

JW Squair, M Gautier, L Mahe, JE Soriano, A Rowald, A Bichat, N Cho, MA Anderson, N.D. James, J Gandar, AV Incognito, G Schiavone, ZK Sarafis, A Laskaratos, K Bartholdi, R. Demesmaeker, S Komi, C Moerman, B. Vaseghi, B Scott, R Rosentreter, C Kathe, J Ravier, L McCracken, X Kang, N Vachicouras, F Fallegger, I Jelescu, YunLong Cheng, Qin Li, Rik Buschman, Nicolas Buse, T Denison, S Dukelow, R. Charbonneau, I Rigby, S.K. Boyd, PJ Millar, EM Moraud, M Capogrosso, FB Wagner, Q Barraud, E Bezard, SP Lacour, J Bloch, G Courtine and AA Phillips (2021).
Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury
Nature, Vol. 590 pdf

M Capogrosso*, F Wagner*, J Gandar, EM Moraud, N Wenger, T Milekovic, P Shkorbatova, N Pavlova, P Musienko, E Bezard, J Bloch and G Courtine (2018).
Configuration of spinal cord neuromodulation through real-time analysis of gait kinematics
Nature Protocols, Vol 13 pdf

EM Moraud*, G Tinkhauser*, M Agrawal, P Brown and R Bogacz (2018)
Predicting beta-bursts from local filed potentials to improve closed-loop DBS paradigms in Parkinson’s patients.
Proceedings of the 40th International Conference on Engineering in Medicine and Biology pdf

J Baufreton*, T Milekovic*, Q Li *, S McGuire , EM Moraud, G Porras, S Sun, WK Ko, M Chazalon, S Morin, E Normand, G Fargot, A Milet, J Pype, E Pioli, G Courtine and E Bezard (2018).
Inhaling Xenon ameliorates L-Dopa-induced dyskinesia in experimental parskinsonianism
Movement Disorders , Vol 33 pdf

M Capogrosso*, J Gandar*, N Greiner, EM Moraud, N Wenger, P Shkorbatova, P Musienko, I Minev, S Lacour, G Courtine (2018)
Advantages of soft subdural implants for delivery of electrochemical neuromodulation therapies to the spinal cord.
Journal of Neural Engineering, Vol 15 pdf

EM Moraud*, J von Zitzewitz*, J Miehlbradt, S Wurth, E Formento, J DiGiovana, M Capogrosso, G Courtine and S Micera (2018)
Closed-loop control of trunk posture improves locomotion through the regulation of leg proprioceptive feedback after spinal cord injury.  
Scientific Reports, Vol 8 pdf

 

JM Florez, M Shah, EM Moraud, S Wurth, L Baud, J von Zitzewitz, R Van Den Brand, S Micera, G Courtine and J Paik (2017).
Rehabilitative Soft Exoskeleton for Rodents.
IEEE Transactions on Neural Systems and Rehabilitation Engineering, Vol 99. pdf

R Bogacz, EM Moraud, A Abdi, P J Magill and J Baufreton (2016).
Properties of Neurons in External Globus Pallidus Can Support Optimal Action Selection.
PloS Computational Biology, Vol 12. pdf

M Capogrosso*, T Milekovic*, D Borton*, F Wagner‡, EM Moraud‡, JB Mignardot, N Buse, J Gandar, Q Barraud, D Xing, E Rey, S Duis, Y Jianzhong, W Ko, Q Li, P Detemple, T Denison, S Micera, E Bezard, J Bloch and G Courtine (2016).
A brain-spine interface alleviating gait deficits after spinal cord injury in primates.
Nature, Vol 539. pdf
Media coverage: BBC News, The Telegraph, MIT Technology Review, New York Times, El Pais

EM Moraud*, M Capogrosso*, E Formento, N Wenger, J DiGiovanna, G Courtine and S Micera (2016).
Mechanisms underlying the neuromodulation of spinal circuits for correcting gait and balance deficits after spinal cord injury.
Neuron.
Vol 89.
pdf
Best PostDoc Paper Award
, Swiss National Centre of Competence in Research (NCCR) Robotics 2017

N Wenger*, EM Moraud*, J Gandar*, P Musienko, M Capogrosso, L Baud, C le Goff, Q Barraud, N Pavlova, N Dominici, I Minev, L Asboth, A Hirsch, S Duis, J Kreider, A Mortera, O Haverbeck, S Kraus, F Schmitz, J DiGiovanna, R van den Brand, J Bloch, P Detemple, S P Lacour, E Bézard, S Micera and G Courtine (2016).
Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury.
Nature Medicine.
Vol 22.
pdf
Comment on this work, Nature Medicine (A. Prochazka) pdf

R van den Brand, J Mignardot, J von Zitzewitz, C Le Goff, N Fumeaux, F Wagner, M Capogrosso, EM Moraud, S Micera, B Schurch, A Curt, S Carda, J Bloch and G Courtine (2015).
Neuroprosthetic technologies to augment the impact of neurorehabilitation after spinal cord injury.
Annals of physical and rehabilitation medicine
, Vol. 58. pdf

I Minev*, P Musienko*, A Hirsch, Q Barraud, N Wenger, EM Moraud, J Gandar, M Capogrosso, T Milekovic, L Asboth, R Fajardo Torres, N Vachicouras, Q Liu, N Pavlova, S Duis, A Larmagnac, J Voros, S Micera, Z Suo, G Courtine and S P Lacour (2015).
Electronic dura mater for long-term multimodal neural interfaces.
Science, Vol 347. pdf

N Wenger*, EM Moraud*, S Raspopovic, M Bonizzato, J DiGiovanna, P Musienko, S Micera and G Courtine (2014).
Closed-loop neuromodulation of spinal sensorimotor circuits controls refined locomotion after complete spinal cord injury.
Science Translational Medicine. Vol. 6.
pdf
Media coverage: El Pais (Spanish)

D Borton, M Bonizzato, J Beauparlant, J DiGiovanna, EM Moraud, N Wenger, P Musienko, IR Minev, SP Lacour, JdR Millan and G Courtine (2014).
Corticospinal neuroprostheses to restore locomotion after spinal cord injury.
Neuroscience Research,
Vol 78. pdf

EM Moraud*, N Wenger*, J Gandar, J DiGiovanna, P Musienko, G Courtine and S Micera (2013).
A real-time platform to study the modulatory capacity of epidural stimulation after spinal-cord injury.
Proceedings of the IEEE Conference on Neural Engineering.
San Diego, CA, USA. pdf

R van den Brand, J Heutschi, Q Barraud, J DiGiovanna, K Bartholdi, M Huerlimann, L Friedli, I Vollenweider, EM Moraud, S Duis, N Dominici, S Micera, P Musienko and G Courtine (2012).
Restoring Voluntary Control of Locomotion after Paralyzing Spinal Cord Injury.
Science
Vol. 336.
pdf
Media Coverage: New York TImes, Guardian

EM Moraud and Elisabetta Chicca (2011).
Toward Neuromorphic Odor Tracking: Perspectives for Space Exploration.
Acta Futura. Vol 4.
pdf

EM Moraud and D Martinez (2010).
Effectiveness and robustness of robot infotaxis for searching in dilute conditions.
Frontiers in Neurorobotics
Vol. 4.
pdf

JG Hale, B Hohl, S-H Hyon, T Matsubara, EM Moraud and G Cheng (2008).
Highly precise dynamics simulation environment for Humanoid Robots.
Advanced Robotics Vol. 22.
pdf