Publications

2025

Orthogonally Functionalizable Redox-Responsive Polymer Brushes: Catch and Release Platform for Proteins and Cells

A. Degirmenci; R. Sanyal; H-A. Klok; A. Sanyal 

Journal of the American Chemical Society. 2025. DOI : 10.1021/jacs.5c05856.

Chemically Recyclable, Hydroxycinnamic Acid‐Derived Semi‐Aromatic Polycarbonates

G. Tekleab; P. A. Schouwink; H. Klok 

Journal of Polymer Science. 2025. DOI : 10.1002/pol.20250028.

Biodegradable Polymers for Plant Nutrient Delivery and Recovery

A. Boarino; N. Carrara; E. Padoan; L. Celi; H-A. Klok 

MACROMOLECULAR BIOSCIENCE. 2025. DOI : 10.1002/mabi.202500042.

Supramolecular Polymer Brushes Grafted via Atom Transfer Radical Polymerization from Surfaces Presenting Non-covalent, Host-Guest Complex-Based Initiators

F. K. Metze; H-A. Klok 

Macromolecules. 2025. DOI : 10.1021/acs.macromol.5c00058.

Spontaneously Pyro- and Piezoelectric Polymer Thin Films Generated by Surface-initiated Polymerization

F. Hu / H-A. Klok (Dir.)  

Lausanne, EPFL, 2025. 

Nanoparticle-modified bacteria for agricultural applications

M. M. Marcinek / H-A. Klok (Dir.)  

Lausanne, EPFL, 2025. 

2024

Swelling and Degrafting of Poly(3-sulfopropyl methacrylate) Brushes

S. Sant; K. Kaur; H-A. Klok 

Langmuir. 2024. Vol. 40, num. 41, p. 21656 – 21662. DOI : https://doi.org/10.1021/acs.langmuir.4c02714.

Synthesis of Amino Acid-Based Aromatic Poly(Ester Urea)s Using 4-Hydroxycinnamic Acid-Derived Diols

G. Tekleab; H-A. Klok 

Macromolecular Rapid Communications. 2024. DOI : https://doi.org/10.1002/marc.202400507.

The Structural Dispersity of Oligoethylene Glycol-Containing Polymer Brushes Determines Their Interfacial Properties

C. Pavon; A. Ongaro; I. Filipucci; S. N. Ramakrishna; A. Mattarei et al. 

Journal Of The American Chemical Society. 2024. DOI : 10.1021/jacs.4c05565.

Disulfide-Cross-Linked Tetra-PEG Gels

Z. Meng; L. Loeser; K. Saalwaechter; U. Gasser; H-A. Klok 

Macromolecules. 2024. Vol. 57, num. 7, p. 3058 – 3065. DOI : 10.1021/acs.macromol.3c02514.

Linear, Y- and Ψ-shaped poly(2-(dimethylamino)ethyl methacrylate) and poly(methyl methacrylate) brushes prepared by surface-initiated polymerization from a homologous series of ATRP initiators

S. Sant; H-A. Klok 

European Polymer Journal. 2024. Vol. 205, p. 112706. DOI : 10.1016/j.eurpolymj.2023.112706.

Pyroelectric Polyelectrolyte Brushes

J. Wang; F. Hu; S. Sant; K. Chu; L. Riemer et al. 

Advanced Materials. 2024. DOI : 10.1002/adma.202307038.

Soft Mechanochemistry of Disulfide-Crosslinked Polymer Networks

Z. Meng / H-A. Klok (Dir.)  

Lausanne, EPFL, 2024. 

New Polymers from Biomass-Derived Hydroxycinnamic Acid Derivatives

G. Tekleab / H-A. Klok (Dir.)  

Lausanne, EPFL, 2024. 

Aqueous Dispersion of Aramid Nanofibers Achieved by Using Tannic Acid for Ultrahigh Strength Films

Y. Zhao; R. Fu; F. Hu; B. Yan; Q. Yang et al. 

ACS Applied Materials & Interfaces. 2024. DOI : 10.1021/acsami.4c00851.

2023

Ductile, High-Lignin-Content Thermoset Films and Coatings

A. Boarino; J. Charmillot; M. B. Figueiredo; T. T. H. Le; N. Carrara et al. 

Acs Sustainable Chemistry & Engineering. 2023. Vol. 11, num. 46, p. 16442 – 16452. DOI : 10.1021/acssuschemeng.3c03030.

Supramolecular Polymer Brushes Grown by Surface-Initiated Atom Transfer Radical Polymerization from Cucurbit[7]uril-based Non-Covalent Initiators

F. K. Metze; I. Filipucci; H-A. Klok 

Angewandte Chemie International Edition. 2023. Vol. 62, num. 34, p. e202305930. DOI : 10.1002/anie.202305930.

Fluorinated Poly(aryl piperidinium) Membranes for Anion Exchange Membrane Fuel Cells

X. Wu; N. Chen; C. Hu; H-A. Klok; Y. M. Lee et al. 

Advanced Materials. 2023. Vol. 35, num. 26, p. 2210432. DOI : 10.1002/adma.202210432.

Swelling-Activated, Soft Mechanochemistry in Polymer Materials

F. K. Metze; S. Sant; Z. Meng; H-A. Klok; K. Kaur 

Langmuir. 2023. DOI : 10.1021/acs.langmuir.2c02801.

Supramolecular Polymer Brushes

F. K. Metze; H. -A. Klok 

Acs Polymers Au. 2023. DOI : 10.1021/acspolymersau.2c00067.

Opportunities and Challenges for Lignin Valorization in Food Packaging, Antimicrobial, and Agricultural Applications

A. Boarino; H-A. Klok 

Biomacromolecules. 2023. DOI : 10.1021/acs.biomac.2c01385.

Lignin, from biomass waste to sustainable materials for food packaging, antiviral coatings and agriculture

A. Boarino / H-A. Klok (Dir.)  

Lausanne, EPFL, 2023. 

Chemical Approaches for the Preparation of Bacteria – Nano/Microparticle Hybrid Systems

L. P. E. Bader; H-A. Klok 

Macromolecular Bioscience. 2023. Vol. 23, num. 8, p. 2200440. DOI : 10.1002/mabi.202200440.

Supramolecular Polymer Brushes

F. K. Metze / H-A. Klok (Dir.)  

Lausanne, EPFL, 2023. 

Architecturally Diverse Polymer Brushes Prepared via Surface-Initiated Atom Transfer Radical Polymerization

S. Sant / H-A. Klok (Dir.)  

Lausanne, EPFL, 2023. 

2022

Mechanical Acceleration of Ester Bond Hydrolysis in Polymers

J. Wang; X. Gao; A. Boarino; F. Celerse; C. Corminboeuf et al. 

Macromolecules. 2022. Vol. 55, num. 22, p. 10145 – 10152. DOI : 10.1021/acs.macromol.2c01789.

Lignin: A Sustainable Antiviral Coating Material

A. Boarino; H. Wang; F. Olgiati; F. Artusio; M. Ozkan et al. 

Acs Sustainable Chemistry & Engineering. 2022. DOI : 10.1021/acssuschemeng.2c04284.

Sustainable polyesters via direct functionalization of lignocellulosic sugars

L. P. Manker; G. R. Dick; A. Demongeot; M. A. Hedou; C. Rayroud et al. 

Nature Chemistry. 2022. Vol. 14, p. 976 – 984. DOI : 10.1038/s41557-022-00974-5.

Specific Counterion Effects on the Swelling Behavior of Strong Polyelectrolyte Brushes

K. Ehtiati; S. Z. Moghaddam; H-A. Klok; A. E. Daugaard; E. Thormann 

Macromolecules. 2022. Vol. 55, num. 12, p. 5123 – 5130. DOI : 10.1021/acs.macromol.2c00411.

Uniformly Dispersed Poly(lactic acid)-Grafted Lignin Nanoparticles Enhance Antioxidant Activity and UV-Barrier Properties of Poly(lactic acid) Packaging Films

A. Boarino; A. Schreier; Y. Leterrier; H-A. Klok 

Acs Applied Polymer Materials. 2022. DOI : 10.1021/acsapm.2c00420.

Macromolecular engineering via polyhomologation

F. Li; H-A. Klok 

European Polymer Journal. 2022. Vol. 171, p. 111195. DOI : 10.1016/j.eurpolymj.2022.111195.

Biodegradation of water-soluble and water-dispersible polymers for agricultural, consumer, and industrial applications-Challenges and opportunities for sustainable materials solutions

G. W. M. Vandermeulen; A. Boarino; H-A. Klok 

Journal Of Polymer Science. 2022. Vol. 60, num. 12, p. 1797 – 1813. DOI : 10.1002/pol.20210922.

Preparation and Analysis of Bacteria Surface-Modified with Polymer Nanoparticles

L. P. E. Bader / H-A. Klok (Dir.)  

Lausanne, EPFL, 2022. 

Branched Poly(Aryl Piperidinium) Membranes for Anion-Exchange Membrane Fuel Cells

X. Wu; N. Chen; H-A. Klok; Y. M. Lee; X. Hu 

Angewandte Chemie International Edition. 2022.  p. e202114892. DOI : 10.1002/anie.202114892.

2021

Reduction-Sensitive Protein Nanogels Enhance Uptake of Model and Tumor Lysate Antigens In Vitro by Mouse- and Human-Derived Dendritic Cells

C. Berti; A. Boarino; M. Graciotti; L. P. E. Bader; L. E. Kandalaft et al. 

Acs Applied Bio Materials. 2021. Vol. 4, num. 12, p. 8291 – 8300. DOI : 10.1021/acsabm.1c00828.

Polymer Nanoparticle-Mediated Delivery of Oxidized Tumor Lysate-Based Cancer Vaccines

C. Berti; M. Graciotti; A. Boarino; C. Yakkala; L. E. Kandalaft et al. 

Macromolecular Bioscience. 2021.  p. 2100356. DOI : 10.1002/mabi.202100356.

Polymethylene Brushes via Surface-Initiated C1 Polyhomologation

F. Li; S. Thiele; H-A. Klok 

Journal Of The American Chemical Society. 2021. Vol. 143, num. 47, p. 19873 – 19880. DOI : 10.1021/jacs.1c09187.

Covalent and Noncovalent Conjugation of Degradable Polymer Nanoparticles to T Lymphocytes

T. Thomsen; R. Reissmann; E. Kaba; B. Engelhardt; H-A. Klok 

Biomacromolecules. 2021. Vol. 22, num. 8, p. 3416 – 3430. DOI : 10.1021/acs.biomac.1c00488.

Succinimidyl Carbonate-Based Amine-Reactive Polymer Brushes: Facile Fabrication of Functional Interfaces

T. N. Gevrek; A. Degirmenci; R. Sanyal; H-A. Klok; A. Sanyal 

Acs Applied Polymer Materials. 2021. Vol. 3, num. 5, p. 2507 – 2517. DOI : 10.1021/acsapm.1c00107.

A minimalistic cyclic ice-binding peptide from phage display

C. A. Stevens; F. Bachtiger; X. Kong; L. A. Abriata; G. C. Sosso et al. 

Nature Communications. 2021. Vol. 12, num. 1, p. 2675. DOI : 10.1038/s41467-021-22883-w.

Self-assembly of protein-polymer conjugates for drug delivery

C. A. Stevens; K. Kaur; H-A. Klok 

Advanced Drug Delivery Reviews. 2021. Vol. 174, p. 447 – 460. DOI : 10.1016/j.addr.2021.05.002.

Structural Basis of Ligand Selectivity by a Bacterial Adhesin Lectin Involved in Multispecies Biofilm Formation

S. Guo; T. D. R. Vance; H. Zahiri; R. Eves; C. A. Stevens et al. 

Mbio. 2021. Vol. 12, num. 2, p. e00130 – 21. DOI : 10.1128/mBio.00130-21.

Biotin-NeutrAvidin Mediated Immobilization of Polymer Micro- and Nanoparticles on T Lymphocytes

M. Ayer; O. Burri; R. Guiet; A. Seitz; E. Kaba et al. 

Bioconjugate Chemistry. 2021. Vol. 32, num. 3, p. 541 – 552. DOI : 10.1021/acs.bioconjchem.1c00026.

Chemical Cell Surface Modification and Analysis of Nanoparticle-Modified Living Cells

T. Thomsen; H-A. Klok 

Acs Applied Bio Materials. 2021. Vol. 4, num. 3, p. 2293 – 2306. DOI : 10.1021/acsabm.0c01619.

Fluorescence-Based and Fluorescent Label-Free Characterization of Polymer Nanoparticle Decorated T Cells

T. Thomsen; A. B. Ayoub; D. Psaltis; H-A. Klok 

Biomacromolecules. 2021. Vol. 22, num. 1, p. 190 – 200. DOI : 10.1021/acs.biomac.0c00969.

Mechanical Activation of Chemical Bonds at Polymer Interfaces

J. N. Bleich / H-A. Klok (Dir.)  

Lausanne, EPFL, 2021. 

Enhancing T-cell response in cancer immunotherapy using nanoparticles

C. Berti / H-A. Klok (Dir.)  

Lausanne, EPFL, 2021. 

2020

T Cell-Mediated Transport of Polymer Nanoparticles across the Blood-Brain Barrier

M. Ayer; M. Schuster; I. Gruber; C. Blatti; E. Kaba et al. 

Advanced Healthcare Materials. 2020.  p. 2001375. DOI : 10.1002/adhm.202001375.

Reversibly Cross-Linking Polymer Brushes Using Interchain Disulfide Bonds

P. Mocny; H-A. Klok 

Macromolecules. 2020. Vol. 53, num. 231, p. 731 – 740. DOI : 10.1021/acs.macromol.9b02199.

Chemistry and Analysis of Nanoparticle-Modified Living Cells

T. Thomsen / H-A. Klok (Dir.)  

Lausanne, EPFL, 2020. 

Surface engineering of T cells with polymer nanoparticles to enhance drug delivery to the brain

M. Schuster / H-A. Klok (Dir.)  

Lausanne, EPFL, 2020. 

Light-Activated, Bioadhesive, Poly(2-hydroxyethyl methacrylate) Brush Coatings

J. Wang; P. Karami; N. C. Ataman; D. P. Pioletti; T. W. J. Steele et al. 

Biomacromolecules. 2020. Vol. 21, num. 1, p. 240 – 249. DOI : 10.1021/acs.biomac.9b01196.

Complex polymer topologies and polymer-nanoparticle hybrid films prepared via surface-initiated controlled radical polymerization

P. Mocny; H-A. Klok 

Progress In Polymer Science. 2020. Vol. 100, p. 101185. DOI : 10.1016/j.progpolymsci.2019.101185.

Functional and Responsive Polymers via Controlled Radical Polymerization

J. Wang / H-A. Klok (Dir.)  

Lausanne, EPFL, 2020. 

2019

Synthesis of Loop Poly(Methyl Methacrylate) Brushes via Chain-End Postpolymerization Modification

P. Mocny; M. Menetrey; H-A. Klok 

Macromolecules. 2019. Vol. 52, num. 21, p. 8394 – 8403. DOI : 10.1021/acs.macromol.9b01527.

Mechanoresponsive Micro- and Nanoparticles

F. K. Metze; H-A. Klok 

Chimia. 2019. Vol. 73, num. 1, p. 35 – 38. DOI : 10.2533/chimia.2019.35.

Polymer brush interfaces for protein biosensing prepared by surface-initiated controlled radical polymerization

M. Badoux; M. Billing; H-A. Klok 

Polymer Chemistry. 2019. Vol. 10, num. 23, p. 2925 – 2951. DOI : 10.1039/C9PY00163H.

Future Directions at the Frontier of Polymer Science and Biology

S. Lecommandoux; H-A. Klok; Z. Zhong; T. J. Deming 

Biomacromolecules. 2019. Vol. 20, num. 1, p. 1 – 3. DOI : 10.1021/acs.biomac.8b01785.

Swelling-Induced Chain Stretching Enhances Hydrolytic Degrafting of Hydrophobic Polymer Brushes in Organic Media

J. Wang; H-A. Klok 

Angewandte Chemie International Edition. 2019. Vol. 58, p. 1 – 6. DOI : 10.1002/anie.201904436.

Cellular Uptake and Intracellular Trafficking of Poly(N-(2-Hydroxypropyl) Methacrylamide)

C. Battistella; R. Guiet; O. Burri; A. Seitz; S. Escrig et al. 

Biomacromolecules. 2019. Vol. 20, num. 1, p. 231 – 242. DOI : 10.1021/acs.biomac.8b01372.

Controlling topology, dynamics and function of polymer brushes via post-polymerization modification

P. Mocny / H-A. Klok (Dir.)  

Lausanne, EPFL, 2019. 

2018

Trace element and isotope labels to study uptake and intracellular trafficking of polymer conjugates

H. Klok 

2018. 256th National Meeting and Exposition of the American-Chemical-Society (ACS) – Nanoscience, Nanotechnology and Beyond, Boston, MA, Aug 19-23, 2018.

Polymers at Interfaces

H. Klok 

2018. 256th National Meeting and Exposition of the American-Chemical-Society (ACS) – Nanoscience, Nanotechnology and Beyond, Boston, MA, Aug 19-23, 2018.

Structure and functionality of polyelectrolyte brushes, a surface force perspective

X. Xu; M. Billing; M. Ruths; H-A. Klok; J. Yu 

Chemistry – An Asian Journal. 2018. Vol. 13, num. 22, p. 3411 – 3436. DOI : 10.1002/asia.201800920.

Synthesis and Postpolymerization Modification of Fluorine-End-Labeled Poly(Pentafluorophenyl Methacrylate) Obtained via RAFT Polymerization

C. Battistella; Y. Yang; J. Chen; H-A. Klok 

Acs Omega. 2018. Vol. 3, num. 8, p. 9710 – 9721. DOI : 10.1021/acsomega.8b01654.

An Acid Test: Facile SI-ARGET-ATRP of Methacrylic Acid

T. D. Michl; D. Jung; A. Pertoldi; A. Schulte; P. Mocny et al. 

Macromolecular Chemistry and Physics. 2018. Vol. 219, num. 15, p. 1800182. DOI : 10.1002/macp.201800182.

Polymers from Nature and for Nature

H. Sun; H-A. Klok; Z. Zhong 

Biomacromolecules. 2018. Vol. 19, num. 6, p. 1697 – 1700. DOI : 10.1021/acs.biomac.8b00830.

Stimuli-Sensitive and -Responsive Polymer Biomaterials

T. W. J. Steele; H-A. Klok 

Biomacromolecules. 2018. Vol. 19, num. 5, p. 1375 – 1377. DOI : 10.1021/acs.biomac.8b00145.

pH-Sensitive Coiled-Coil Peptide-Cross-Linked Hyaluronic Acid Nanogels: Synthesis and Targeted Intracellular Protein Delivery to CD44 Positive Cancer Cells

L. Ding; Y. Jiang; J. Zhang; H-A. Klok; Z. Zhong 

Biomacromolecules. 2018. Vol. 19, num. 2, p. 555 – 562. DOI : 10.1021/acs.biomac.7b01664.

Surface modification of living cells with synthetic polymer nano- and microparticles

H. Klok 

2018. 

Polymers at the Interface with Biology

T. Deming; H-A. Klok; S. Armes; M. Becker; J. Champion et al. 

Biomacromolecules. 2018. Vol. 19, num. 8, p. 3151 – 3162. DOI : 10.1021/acs.biomac.8b01029.

Polymer-Brush-Templated Three-Dimensional Molybdenum Sulfide Catalyst for Hydrogen Evolution

L-A. Stern; P. Mocny; H. Vrubel; T. Bilgic; H-A. Klok et al. 

ACS Applied Materials & Interfaces. 2018. Vol. 10, num. 7, p. 6253 – 6261. DOI : 10.1021/acsami.7b16679.

2017

The era of bioengineering: how will this affect the next generation of cancer immunotherapy?

M. Graciotti; C. Berti; H-A. Klok; L. Kandalaft 

Journal Of Translational Medicine. 2017. Vol. 15, p. 142. DOI : 10.1186/s12967-017-1244-2.

Cellulose Nanocrystals with Tethered Polymer Chains: Chemically Patchy versus Uniform Decoration

J. O. Zoppe; A. V. M. Dupire; T. G. G. Lachat; P. Lemal; L. Rodriguez-Lorenzo et al. 

ACS Macro Letters. 2017. Vol. 6, num. 9, p. 892 – 897. DOI : 10.1021/acsmacrolett.7b00383.

Reversion of P-gp-Mediated Drug Resistance in Ovarian Carcinoma Cells with PHPMA-Zosuquidar Conjugates

C. Battistella; H-A. Klok 

Biomacromolecules. 2017. Vol. 18, num. 6, p. 1855 – 1865. DOI : 10.1021/acs.biomac.7b00291.

Selective Peptide-Mediated Enhanced Deposition of Polymer Fragrance Delivery Systems on Human Hair

K. A. Gunay; D. L. Berthier; H. K. Jerri; D. Benczedi; H-A. Klok et al. 

ACS Applied Materials & Interfaces. 2017. Vol. 9, num. 28, p. 24238 – 24249. DOI : 10.1021/acsami.7b06569.

Microcomputed Tomography Technique for In Vivo Three-Dimensional Fat Tissue Volume Evaluation After Polymer Injection

S. Berndt; I. Konz; D. Colin; S. Germain; B. Pittet-Cuenod et al. 

Tissue Engineering Part C-Methods. 2017. Vol. 23, num. 12, p. 964 – 970. DOI : 10.1089/ten.tec.2017.0207.

Surface-Initiated Controlled Radical Polymerization: State-of-the-Art, Opportunities, and Challenges in Surface and Interface Engineering with Polymer Brushes

J. O. Zoppe; N. C. Ataman; P. Mocny; J. Wang; J. Moraes et al. 

Chemical Reviews. 2017. Vol. 117, num. 3, p. 1105 – 1318. DOI : 10.1021/acs.chemrev.6b00314.

Controlling and Monitoring Intracellular Delivery of Anticancer Polymer Nanomedicines

C. Battistella; H-A. Klok 

Macromolecular Bioscience. 2017. Vol. 17, num. 10, p. 1700022. DOI : 10.1002/mabi.201700022.

Peptide-Enhanced Selective Surface Deposition of Polymer-Based Fragrance Delivery Systems

K. A. Guenay; D. Benczedi; A. Herrmann; H-A. Klok 

Advanced Functional Materials. 2017. Vol. 27, num. 2, p. 1603843. DOI : 10.1002/adfm.201603843.

Cell-mediated delivery of synthetic nano- and microparticles funding

M. Ayer; H-A. Klok 

Journal of Controlled Release. 2017. Vol. 259, p. 92 – 104. DOI : 10.1016/j.jconrel.2017.01.048.

Controlling and Monitoring Intracellular Drug Delivery Using PHPMA-Based Polymer Nanomedicines

C. Battistella / H-A. Klok (Dir.)  

Lausanne, EPFL, 2017. 

T-cell surface modification with synthetic nanomaterials for cell-mediated delivery to the central nervous system

M. Ayer / H-A. Klok (Dir.)  

Lausanne, EPFL, 2017. 

Site-Specific Polymer Attachment to HR2 Peptide Fusion Inhibitors against HIV-1 Decreases Binding Association Rates and Dissociation Rates Rather Than Binding Affinity

M. Danial; A. N. Stauffer; F. R. Wurm; M. J. Root; H-A. Klok 

Bioconjugate Chemistry. 2017. Vol. 28, num. 3, p. 701 – 712. DOI : 10.1021/acs.bioconjchem.6b00540.

Caspofungin on ARGET-ATRP grafted PHEMA polymers: Enhancement and selectivity of prevention of attachment of Candida albicans

T. D. Michl; C. Giles; P. Mocny; K. Futrega; M. R. Doran et al. 

Biointerphases. 2017. Vol. 12, num. 5, p. 05G602. DOI : 10.1116/1.4986054.

2016

Impact of polymer-modified gold nanoparticles on brain endothelial cells: exclusion of endoplasmic reticulum stress as a potential risk factor

L. Anspach; R. E. Unger; C. Brochhausen; M. I. Gibson; H-A. Klok et al. 

Nanotoxicology. 2016. Vol. 10, num. 9, p. 1341 – 1350. DOI : 10.1080/17435390.2016.1214761.

Influence of Block versus Random Monomer Distribution on the Cellular Uptake of Hydrophilic Copolymers

J. Moraes; R. Peltier; G. Gody; M. Blum; S. Recalcati et al. 

ACS Macro Letters. 2016. Vol. 5, num. 12, p. 1416 – 1420. DOI : 10.1021/acsmacrolett.6b00652.

Bioinspired Selective Surface Deposition of Fragrance Delivery Systems

K. A. Günay / H-A. Klok (Dir.)  

Lausanne, EPFL, 2016. 

Synthesis of cyclic peptide disulfide-PHPMA conjugates via sequential active ester aminolysis and CuAAC coupling

K. A. Guenay; H-A. Klok 

Polymer Chemistry. 2016. Vol. 7, num. 4, p. 970 – 978. DOI : 10.1039/c5py01817j.

Swelling Behavior and Nanomechanical Properties of (Peptide-Modified) Poly(2-hydroxyethyl methacrylate) and Poly(poly(ethylene glycol) methacrylate) Brushes

S. Desseaux; J. P. Hinestrosa; N. Schuwer; B. S. Lokitz; J. F. Ankner et al. 

Macromolecules. 2016. Vol. 49, num. 12, p. 4609 – 4618. DOI : 10.1021/acs.macromol.6b00881.

Tribology of surface-grafted polymer brushes

P. Mocny; H-A. Klok 

Molecular Systems Design & Engineering. 2016. Vol. 1, num. 2, p. 141 – 154. DOI : 10.1039/c5me00010f.

Effect of Surface Charge on Surface-Initiated Atom Transfer Radical Polymerization from Cellulose Nanocrystals in Aqueous Media

J. O. Zoppe; X. Xu; C. Kaenel; P. Orsolini; G. Siqueira et al. 

Biomacromolecules. 2016. Vol. 17, num. 4, p. 1404 – 1413. DOI : 10.1021/acs.biomac.6b00011.

Effects of Grafting Density and Film Thickness on the Adhesion of Staphylococcus epidermidis to Poly(2-hydroxy ethyl methacrylate) and Poly(poly(ethylene glycol)methacrylate) Brushes

S-A. Ibanescu; J. Nowakowska; N. Khanna; R. Landmann; H-A. Klok 

Macromolecular Bioscience. 2016. Vol. 16, num. 5, p. 676 – 685. DOI : 10.1002/mabi.201500335.

Mechanochemically Responsive Surfaces and Soft Tissue Adhesive Interfaces Generated via Controlled Radical Polymerization

N. Çavuşoǧlu Ataman / H-A. Klok (Dir.)  

Lausanne, EPFL, 2016. 

Degrafting of Poly(poly(ethylene glycol) methacrylate) Brushes from Planar and Spherical Silicon Substrates

N. C. Ataman; H-A. Klok 

Macromolecules. 2016. Vol. 49, num. 23, p. 9035 – 9047. DOI : 10.1021/acs.macromol.6b01445.

Click Chemistry in Biomaterials, Nanomedicine, and Drug Delivery

K. S. Anseth; H-A. Klok 

Biomacromolecules. 2016. Vol. 17, num. 1, p. 1 – 3. DOI : 10.1021/acs.biomac.5b01660.

2015

Fibroblast adhesion on ECM-derived peptide modified poly(2-hydroxyethyl methacrylate) brushes: Ligand co-presentation and 3D-localization

S. Desseaux; H-A. Klok 

Biomaterials. 2015. Vol. 44, p. 24 – 35. DOI : 10.1016/j.biomaterials.2014.12.011.

Peptide-Polymer Conjugates for Therapeutic Applications

A. M. Răduţă / H-A. Klok (Dir.)  

Lausanne, EPFL, 2015. 

Oligonucleotide Immobilization and Hybridization on Aldehyde-Functionalized Poly(2-hydroxyethyl methacrylate) Brushes

T. Bilgic; H-A. Klok 

Biomacromolecules. 2015. Vol. 16, num. 11, p. 3657 – 3665. DOI : 10.1021/acs.biomac.5b01116.

Polymeric Anti-HIV Therapeutics

M. Danial; H-A. Klok 

Macromolecular Bioscience. 2015. Vol. 15, num. 1, p. 9 – 35. DOI : 10.1002/mabi.201400298.

Expanding the Polymer Mechanochemistry Toolbox through Surface-Initiated Polymerization

H-A. Klok; J. Genzer 

ACS Macro Letters. 2015. Vol. 4, num. 6, p. 636 – 639. DOI : 10.1021/acsmacrolett.5b00295.

Surface Grafted Polymer Brushes : A Versatile Platform for Antibacterial Applications

S. A. Ibanescu / H-A. Klok (Dir.)  

Lausanne, EPFL, 2015. 

Avoiding compositional drift during the RAFT copolymerization of N-(2-hydroxypropyl)methacrylamide and N-acryloxysuccinimide: towards uniform platforms for post-polymerization modification

J. Moraes; I-M. Simionca; H. Ketari; H-A. Klok 

Polymer Chemistry. 2015. Vol. 6, num. 17, p. 3245 – 3251. DOI : 10.1039/c5py00253b.

Avoiding compositional drift during the RAFT copolymerization of N-(2-hydroxypropyl)-methacrylamide and N-acryloxysuccinimide: towards uniform platforms for post-polymerization modification (vol 6, pg 3245, 2015)

J. Moraes; I-M. Simionca; H. Ketari; H-A. Klok 

Polymer Chemistry. 2015. Vol. 6, num. 42, p. 7480 – 7483. DOI : 10.1039/c5py90156a.

Identification of Soft Matter Binding Peptide Ligands Using Phage Display

K. A. Guenay; H-A. Klok 

Bioconjugate Chemistry. 2015. Vol. 26, num. 10, p. 2002 – 2015. DOI : 10.1021/acs.bioconjchem.5b00377.

Shape-Persistent, Thermoresponsive Polypeptide Brushes Prepared by Vapor Deposition Surface-Initiated Ring-Opening Polymerization of alpha-Amino Acid N-Carboxyanhydrides

Y. Shen; S. Desseaux; B. Aden; B. S. Lokitz; Z. Li et al. 

Macromolecules. 2015. Vol. 48, num. 8, p. 2399 – 2406. DOI : 10.1021/acs.macromol.5b00017.

Surface-initiated controlled radical polymerization enhanced DNA biosensing

T. Bilgic; H-A. Klok 

European Polymer Journal. 2015. Vol. 62, p. 281 – 293. DOI : 10.1016/j.eurpolymj.2014.07.037.

Polymer Brush Guided Formation of Conformal, Plasmonic Nanoparticle-Based Electrodes for Microwire Solar Cells

C. Sugnaux; A. D. Mallorqui; J. Herriman; H-A. Klok; A. Fontcuberta I Morral 

Advanced Functional Materials. 2015. Vol. 25, num. 25, p. 3958 – 3965. DOI : 10.1002/adfm.201404235.

Glucose Monitoring Using a Polymer Brush Modified Polypropylene Hollow Fiber-based Hydraulic Flow Sensor

N. Fortin; H-A. Klok 

ACS Applied Materials & Interfaces. 2015. Vol. 7, num. 8, p. 4631 – 4640. DOI : 10.1021/am507927w.

Polymer Brushes – Engineered Model Interfaces and Functional Surface Coatings for DNA Biosensing and Electrocatalysis

T. Bilgiç Tune / H-A. Klok (Dir.)  

Lausanne, EPFL, 2015. 

Polypeptide brushes grown via surface-initiated ring-opening polymerization of alpha-amino acid N-carboxyanhydrides

Y. Shen; Z. Li; H-A. Klok 

Chinese Journal Of Polymer Science. 2015. Vol. 33, num. 7, p. 931 – 946. DOI : 10.1007/s10118-015-1654-7.

2014

Temperature-Controlled Masking/Unmasking of Cell-Adhesive Cues with Poly(ethylene glycol) Methacrylate Based Brushes

S. Desseaux; H-A. Klok 

Biomacromolecules. 2014. Vol. 15, num. 10, p. 3859 – 3865. DOI : 10.1021/bm501233h.

Polymer Brush Gradients Grafted from Plasma-Polymerized Surfaces

B. R. Coad; T. Bilgic; H-A. Klok 

Langmuir. 2014. Vol. 30, num. 28, p. 8357 – 8365. DOI : 10.1021/la501380m.

Responsive polymer and peptide-polymer hybrid microgels

V. Kolesov / H-A. Klok (Dir.)  

Lausanne, EPFL, 2014. 

Poly[N-(2-hydroxypropyl)methacrylamide] nanogels by RAFT polymerization in inverse emulsion

H. Wutzel; F. H. Richter; Y. Li; S. S. Sheiko; H-A. Klok 

Polymer Chemistry. 2014. Vol. 5, num. 5, p. 1711 – 1719. DOI : 10.1039/c3py01280h.

Functional polypeptide and hybrid materials: Precision synthesis via alpha-amino acid N-carboxyanhydride polymerization and emerging biomedical applications

C. Deng; J. Wu; R. Cheng; F. Meng; H-A. Klok et al. 

Progress In Polymer Science. 2014. Vol. 39, num. 2, p. 330 – 364. DOI : 10.1016/j.progpolymsci.2013.10.008.

Glucose-Sensitive QCM-Sensors Via Direct Surface RAFT Polymerization

C. Sugnaux; H-A. Klok 

Macromolecular Rapid Communications. 2014. Vol. 35, num. 16, p. 1402 – 1407. DOI : 10.1002/marc.201400217.

Gating, sensing and templating with polymer brushes

C. Sugnaux / H-A. Klok (Dir.)  

Lausanne, EPFL, 2014. 

Modulating Cell-Surface Interactions with Polymer Brushes

S. Desseaux / H-A. Klok; K. Voitchovsky (Dir.)  

Lausanne, EPFL, 2014. 

Squaric acid mediated bioconjugation expanded to polymers prepared by ATRP

T. Steinbach; F. Wurm; H-A. Klok 

Polymer Chemistry. 2014. Vol. 5, num. 13, p. 4039 – 4047. DOI : 10.1039/c4py00168k.

Controlled release from a mechanically-stimulated thermosensitive self-heating composite hydrogel

M. Nassajian Moghadam; V. Kolesov; H-A. Klok; D. Pioletti 

Biomaterials. 2014. Vol. 35, p. 450 – 455. DOI : 10.1016/j.biomaterials.2013.09.065.

Maleimide-Functionalized Thiol Reactive Copolymer Brushes: Fabrication and Post-Polymerization Modification

T. N. Gevrek; T. Bilgic; H-A. Klok; A. Sanyal 

Macromolecules. 2014. Vol. 47, num. 22, p. 7842 – 7851. DOI : 10.1021/ma5015098.

Copolymerization of 2,2,3,3,4,4,4-heptafluorobutyl acrylate with butyl acrylate via RAFT polymerization

B. P. Koiry; H-A. Klok; N. K. Singha 

Journal Of Fluorine Chemistry. 2014. Vol. 165, p. 109 – 115. DOI : 10.1016/j.jfluchem.2014.06.016.

2013

Be squared: expanding the horizon of squaric acid-mediated conjugations

F. R. Wurm; H-A. Klok 

Chemical Society Reviews. 2013. Vol. 42, num. 21, p. 8220 – 8236. DOI : 10.1039/c3cs60153f.

Postpolymerization Modification of Poly(glycidyl methacrylate) Brushes: An XPS Depth-Profiling Study

R. Barbey; V. Laporte; S. Alnabulsi; H-A. Klok 

Macromolecules. 2013. Vol. 46, num. 15, p. 6151 – 6158. DOI : 10.1021/ma400819a.

Multifaceted polymer coated, gold nanoparticles

L. Chen; H-A. Klok 

Soft Matter. 2013. Vol. 9, num. 45, p. 10678 – 10688. DOI : 10.1039/c3sm51789f.

Functional Polymers by Post-Polymerization Modification: Concepts, Guidelines, and Applications

P. Theato; H. A. Klok 

wiley, 2013.

Dual and multi-stimuli responsive polymeric nanoparticles for programmed site-specific drug delivery

R. Cheng; F. Meng; C. Deng; H-A. Klok; Z. Zhong 

Biomaterials. 2013. Vol. 34, num. 14, p. 3647 – 3657. DOI : 10.1016/j.biomaterials.2013.01.084.

Towards the Synthesis of Uniform Polymers by Template Polymerization

G. G. Sahin Kurtuldu / H-A. Klok (Dir.)  

Lausanne, EPFL, 2013. 

Aqueous Fabrication of pH-Gated, Polymer-Brush-Modified Alumina Hybrid Membranes

C. Sugnaux; L. Lavanant; H-A. Klok 

Langmuir. 2013. Vol. 29, num. 24, p. 7325 – 7333. DOI : 10.1021/la304949h.

One-pot squaric acid diester mediated aqueous protein conjugation

F. Wurm; T. Steinbach; H-A. Klok 

Chemical Communications (ChemComm). 2013. Vol. 49, num. 71, p. 7815 – 7817. DOI : 10.1039/c3cc44039g.

Standing on the shoulders of hermann staudinger: Post-polymerization modification from past to present

K. A. Guenay; P. Theato; H-A. Klok 

Journal Of Polymer Science Part A-Polymer Chemistry. 2013. Vol. 51, num. 1, p. 1 – 28. DOI : 10.1002/pola.26333.

2012

Polyvalent Side Chain Peptide-Synthetic Polymer Conjugates as HIV-1 Entry Inhibitors

M. Danial; M. J. Root; H-A. Klok 

Biomacromolecules. 2012. Vol. 13, p. 1438 – 1447. DOI : 10.1021/bm300150q.

Comparative Study on the In Vitro Cytotoxicity of Linear, Dendritic, and Hyperbranched Polylysine Analogues

Z. Kadlecova; L. Baldi; D. Hacker; F. M. Wurm; H-A. Klok 

Biomacromolecules. 2012. Vol. 13, num. 10, p. 3127 – 3137. DOI : 10.1021/bm300930j.

Squaric Acid Mediated Chemoselective PEGylation of Proteins: Reactivity of Single-Step-Activated alpha-Amino Poly(ethylene glycol)s

C. Dingels; F. Wurm; M. Wagner; H-A. Klok; H. Frey 

Chemistry-A European Journal. 2012. Vol. 18, num. 52, p. 16828 – 16835. DOI : 10.1002/chem.201200182.

Site-Specific PEGylation of HR2 Peptides: Effects of PEG Conjugation Position and Chain Length on HIV-1 Membrane Fusion Inhibition and Proteolytic Degradation

M. Danial; V. Dulmen; H. H. Tim; J. Aleksandrowicz; A. J. G. Poetgens et al. 

Bioconjugate Chemistry. 2012. Vol. 23, num. 8, p. 1648 – 1660. DOI : 10.1021/bc3002248.

Assessment of transferrin recycling by Triplet Lifetime Imaging in living cells

M. Geissbuehler; Z. Kadlecova; H-A. Klok; T. Lasser 

Biomedical Optics Express. 2012. Vol. 3, num. 10, p. 2526 – 2536. DOI : 10.1364/BOE.3.002526.

Squaric Acid Mediated Synthesis and Biological Activity of a Library of Linear and Hyperbranched Poly(Glycerol)-Protein Conjugates

F. Wurm; C. Dingels; H. Frey; H-A. Klok 

Biomacromolecules. 2012. Vol. 13, p. 1161 – 1171. DOI : 10.1021/bm300103u.

Functional, Hyperbranched Polyesters Via Baylis-Hillman Polymerization

S. Ji; B. Bruchmann; F. Wurm; H-A. Klok 

Journal Of Polymer Science Part A-Polymer Chemistry. 2012. Vol. 50, p. 25 – 34. DOI : 10.1002/pola.24954.

Size- and Coating-Dependent Uptake of Polymer-Coated Gold Nanoparticles in Primary Human Dermal Microvascular Endothelial Cells

C. Freese; M. I. Gibson; H-A. Klok; R. E. Unger; C. J. Kirkpatrick 

Biomacromolecules. 2012. Vol. 13, p. 1533 – 1543. DOI : 10.1021/bm300248u.

Synthesis and post-polymerization modification of poly(pentafluorophenyl methacrylate) brushes

K. A. Guenay; N. Schuewer; H-A. Klok 

Polymer Chemistry. 2012. Vol. 3, p. 2186 – 2192. DOI : 10.1039/c2py20162c.

Osteoconductive surfaces generated from peptide functionalized poly(2-hydroxyethyl methacrylate-co-2-(methacryloyloxy)ethyl phosphate) brushes

D. Paripovic; H. Hall-Bozic; H-A. Klok 

Journal of Materials Chemistry. 2012. Vol. 22, num. 37, p. 19570 – 19578. DOI : 10.1039/c2jm31568h.

Voltammetric Detection of Hg2+ Using Peptide-Functionalized Polymer Brushes

N. Schuewer; M-L. Tercier-Waeber; M. Danial; H-A. Klok 

Australian Journal Of Chemistry. 2012. Vol. 65, num. 8, p. 1104 – 1109. DOI : 10.1071/Ch12177.

Poly(ethyleneimine)-Mediated Large-Scale Transient Gene Expression: Influence of Molecular Weight, Polydispersity and N-Propionyl Groups

Z. Kadlecova; S. Nallet; D. L. Hacker; L. Baldi; H-A. Klok et al. 

Macromolecular Bioscience. 2012. Vol. 12, p. 628 – 636. DOI : 10.1002/mabi.201100404.

Hyperbranched Polylysine: A Versatile, Biodegradable Transfection Agent for the Production of Recombinant Proteins by Transient Gene Expression and the Transfection of Primary Cells

Z. Kadlecova; Y. Rajendra; M. Matasci; D. Hacker; L. Baldi et al. 

Macromolecular Bioscience. 2012. Vol. 12, p. 794 – 804. DOI : 10.1002/mabi.201100519.

2011

Aqueous solution self-assembly of polystyrene-b-poly(L-lysine) diblock oligomers

H. Nuhn; H-A. Klok 

European Polymer Journal. 2011. Vol. 47, p. 782 – 791. DOI : 10.1016/j.eurpolymj.2010.09.026.

Diagnostic and Sensory Polymer Brushes

N. Schuewer; R. Barbey; H-A. Klok 

CHIMIA. 2011. Vol. 65, p. 276 – 276. DOI : 10.2533/chimia.2011.276.

Conformational consequences of cooperative binding of a coiled-coil peptide motif to poly(N-(2-hydroxypropyl) methacrylamide) HPMA copolymers

P. C. Griffiths; A. Paul; B. Apostolovic; H-A. Klok; E. de Luca et al. 

Journal Of Controlled Release. 2011. Vol. 153, p. 173 – 179. DOI : 10.1016/j.jconrel.2011.03.030.

Assessing the cellular uptake pathway for poly-Lysine analogues using triplet lifetime imaging

M. Geissbuehler; Z. Kadlecova; I. Märki; M. Matasci; D. Van De Ville et al. 

Biophysical Society 55th Annual Meeting, Baltimore, Maryland, USA, March 5-9, 2011.

Interactive Surfaces Based on Polymer Brushes

D. Paripovic / H-A. Klok (Dir.)  

Lausanne, EPFL, 2011. 

Synthesis of Functional Polyesters via Baylis-Hillman Polymerization

S. Ji / H-A. Klok (Dir.)  

Lausanne, EPFL, 2011. 

Polymer Coiled-Coil Conjugates: Potential for Development as a New Class of Therapeutic “Molecular Switch”

S. P. E. Deacon; B. Apostolovic; R. J. Carbajo; A-K. Schott; K. Beck et al. 

Biomacromolecules. 2011. Vol. 12, num. 1, p. 19 – 27. DOI : 10.1021/bm100843e.

Combating HIV Type 1 with Peptide – Synthetic Polymer Conjugates

M. Danial / H-A. Klok (Dir.)  

Lausanne, EPFL, 2011. 

Polymers Interfacing with Biology

F. Wurm; H-A. Klok 

CHIMIA. 2011. Vol. 65, p. 659 – 662. DOI : 10.2533/chimia.2011.659.

Sequentially Modified, Polymer-Stabilized Gold Nanoparticle Libraries: Convergent Synthesis and Aggregation Behavior

M. I. Gibson; M. Danial; H-A. Klok 

Acs Combinatorial Science. 2011. Vol. 13, p. 286 – 297. DOI : 10.1021/co100099r.

Gene Delivery with Hyperbranched Polylysine

Z. Kadlecova / H-A. Klok (Dir.)  

Lausanne, EPFL, 2011. 

Arginine-specific protein modification using alpha-oxo-aldehyde functional polymers prepared by atom transfer radical polymerization

M. A. Gauthier; M. Ayer; J. Kowal; F. R. Wurm; H-A. Klok 

Polymer Chemistry. 2011. Vol. 2, p. 1490 – 1498. DOI : 10.1039/c0py00422g.

Side-Chain Peptide-Synthetic Polymer Conjugates via Tandem “Ester-Amide/Thiol-Ene” Post-Polymerization Modification of Poly(pentafluorophenyl methacrylate) Obtained Using ATRP

N. K. Singha; M. I. Gibson; B. P. Koiry; M. Danial; H-A. Klok 

Biomacromolecules. 2011. Vol. 12, p. 2908 – 2913. DOI : 10.1021/bm200469a.

Synthesis of Side-Chain Functional Polyesters via Baylis-Hillman Polymerization

S. Ji; B. Bruchmann; H-A. Klok 

Macromolecules. 2011. Vol. 44, p. 5218 – 5226. DOI : 10.1021/ma2006238.

Tuning the pH Sensitivity of Poly(methacrylic acid) Brushes

N. Schuewer; H-A. Klok 

Langmuir. 2011. Vol. 27, p. 4789 – 4796. DOI : 10.1021/la200347u.

Neutron Reflectivity Study on the Postpolymerization Modification of Poly(2-hydroxyethyl methacrylate) Brushes

N. Schuewer; T. Geue; J. P. Hinestrosa; H-A. Klok 

Macromolecules. 2011. Vol. 44, p. 6868 – 6874. DOI : 10.1021/ma201069d.

Improving the Stability in Aqueous Media of Polymer Brushes Grafted from Silicon Oxide Substrates by Surface-Initiated Atom Transfer Radical Polymerization

D. Paripovic; H-A. Klok 

Macromolecular Chemistry And Physics. 2011. Vol. 212, p. 950 – 958. DOI : 10.1002/macp.201000729.

Cell Uptake and Trafficking Behavior of Non-covalent, Coiled-coil Based Polymer-Drug Conjugates

B. Apostolovic; S. P. E. Deacon; R. Duncan; H-A. Klok 

Macromolecular Rapid Communications. 2011. Vol. 32, num. 1, p. 11 – 18. DOI : 10.1002/marc.201000434.

Exploring the Scope of the Baylis-Hillman Reaction for the Synthesis of Side-Chain Functional Polyesters

S. Ji; B. Bruchmann; H-A. Klok 

Macromolecular Chemistry And Physics. 2011. Vol. 212, p. 2612 – 2618. DOI : 10.1002/macp.201100482.

Arginine-Specific Modification of Proteins with Polyethylene Glycol

M. A. Gauthier; H-A. Klok 

Biomacromolecules. 2011. Vol. 12, num. 2, p. 482 – 493. DOI : 10.1021/bm101272g.

Synthesis of Responsive Polymer Brushes for Sensing Applications

N. B. Schüwer / H-A. Klok (Dir.)  

Lausanne, EPFL, 2011. 

2010

Size-Dependent LCST Transitions of Polymer-Coated Gold Nanoparticles: Cooperative Aggregation and Surface Assembly

M. I. Gibson; D. Paripovic; H-A. Klok 

Advanced Materials. 2010. Vol. 22, num. 42, p. 4721 – 4725. DOI : 10.1002/adma.201001382.

Copolymerization Behavior of N-(2-Hydroxypropyl)methacrylamide and methacrylated coiled-coil peptide derivative

B. Apostolovic; H-A. Klok 

Biomacromolecules. 2010. Vol. 11, num. 7, p. 1891 – 1895. DOI : 10.1021/bm100533g.

A facile strategy for the modification of polyethylene substrates with non-fouling, bioactive poly(poly(ethylene glycol) methacrylate) brushes

L. Lavanant; B. Pullin; J. A. Hubbell; H-A. Klok 

Macromolecular bioscience. 2010. Vol. 10, num. 1, p. 101 – 8. DOI : 10.1002/mabi.200900205.

Hybrid Polymer Therapeutics Incorporating Bioresponsive, Coiled Coil Peptide Linkers

B. Apostolovic; S. P. E. Deacon; R. Duncan; H-A. Klok 

Biomacromolecules. 2010. Vol. 11, num. 5, p. 1187 – 1195. DOI : 10.1021/bm901313c.

Polymer–protein conjugates: an enzymatic activity perspective

M. A. Gauthier; H-A. Klok 

Polymer Chemistry. 2010. Vol. 1, num. 9, p. 1352 – 1373. DOI : 10.1039/c0py90001j.

Synthesis of Functional Polydepsipeptides via Direct Ring-Opening Polymerization and Post-Polymerization Modification

N. Franz; H-A. Klok 

Macromolecular Chemistry and Physics. 2010. Vol. 211, num. 7, p. 809 – 820. DOI : 10.1002/macp.200900521.

Polymer Brushes as Substrates for Microarray Applications

R. Barbey / H-A. Klok (Dir.)  

Lausanne, EPFL, 2010. 

Coiled coils: attractive protein folding motifs for the fabrication of self-assembled, responsive and bioactive materials

B. Apostolovic; M. Danial; H-A. Klok 

Chemical Society Reviews. 2010. Vol. 39, num. 9, p. 3541. DOI : 10.1039/b914339b.

Protein Microarrays Based on Polymer Brushes Prepared via Surface-Initiated Atom Transfer Radical Polymerization

R. Barbey; E. Kauffmann; M. Ehrat; H-A. Klok 

Biomacromolecules. 2010. Vol. 11, num. 12, p. 3467 – 3479. DOI : 10.1021/bm101297w.

Room Temperature, Aqueous Post-Polymerization Modification of Glycidyl Methacrylate-Containing Polymer Brushes Prepared via Surface-Initiated Atom Transfer Radical Polymerization

R. Barbey; H-A. Klok 

Langmuir. 2010. Vol. 26, num. 23, p. 18219 – 18230. DOI : 10.1021/la102400z.

Hybrid Polymer Therapeutics Incorporating Bioresponsive, Coiled Coil Peptide Linkers

B. Apostolovic / H-A. Klok (Dir.)  

Lausanne, EPFL, 2010. 

A Potassium-Selective Quartz Crystal Microbalance Sensor Based on Crown-Ether Functionalized Polymer Brushes

N. Schüwer; H-A. Klok 

Advanced Materials. 2010. Vol. 22, num. 30, p. 3251 – 3255. DOI : 10.1002/adma.201000377.

Polymer Conjugates

H-A. Klok 

Macromolecular Rapid Communications. 2010. Vol. 31, num. 14, p. 1230 – 1230. DOI : 10.1002/marc.201000182.

2009

Synthesis of functional polymers by post-polymerization modification

M. A. Gauthier; M. I. Gibson; H-A. Klok 

Angewandte Chemie. 2009. Vol. 121, num. 1, p. 50 – 60. DOI : 10.1002/ange.200801951.

Nonfouling Polypeptide Brushes via Surface-initiated Polymerization of N-epsilon-oligo(ethylene glycol)succinate-L-lysine N-carboxyanhydride

J. Wang; M. I. Gibson; R. Barbey; S-J. Xiao; H-A. Klok 

Macromolecular Rapid Communications. 2009. Vol. 30, num. 9-10, p. 845 – 850. DOI : 10.1002/marc.200800744.

Dendritic and hyperbranched polyamides

M. Scholl; Z. Kadlecova; H-A. Klok 

Progr. Polym. Sci. 2009. Vol. 34, p. 24 – 61. DOI : 10.1016/j.progpolymsci.2008.09.001.

Surface Modification of Polydimethylsiloxane Substrates with Nonfouling Poly(Poly(ethylene glycol)methacrylate) Brushes

S. Tugulu; H-A. Klok 

Macromolecular Symposia. 2009. Vol. 279, num. 1, p. 103 – 109. DOI : 10.1002/masy.200950516.

Degradable Polymer Brushes Prepared via Surface-Initiated Controlled Radical Polymerization

C. Riachi; N. Schüwer; H-A. Klok 

Macromolecules. 2009. Vol. 42, num. 21, p. 8076 – 8081. DOI : 10.1021/ma901537x.

Synthesis of sequence-defined oligomers and polymers

N. Franz / H-A. Klok (Dir.)  

Lausanne, EPFL, 2009. 

Potential novel drug carriers for inner ear treatment: hyperbranched polylysine and lipid nanocapsules

V. Scheper; M. Wolf; M. Scholl; Z. Kadlecova; T. Perrier et al. 

Nanomedicine. 2009. Vol. 4, num. 6, p. 623 – 635. DOI : 10.2217/nnm.09.41.

A post-modification approach to peptide foldamers

N. Franz; L. Menin; H-A. Klok 

Organic & Biomolecular Chemistry. 2009. Vol. 7, num. 24, p. 5207 – 5218. DOI : 10.1039/b912313j.

Postpolymerization modification of poly(pentafluorophenyl methacrylate): Synthesis of a diverse water-soluble polymer library

M. I. Gibson; E. Fröhlich; H-A. Klok 

Journal of Polymer Science Part A: Polymer Chemistry. 2009. Vol. 47, num. 17, p. 4332 – 4345. DOI : 10.1002/pola.23486.

Polymer Brushes via Surface-Initiated Controlled Radical Polymerization: Synthesis, Characterization, Properties, and Applications

R. Barbey; L. Lavanant; D. Paripovic; N. Schüwer; C. Sugnaux et al. 

Chemical Reviews. 2009. Vol. 109, num. 11, p. 5437 – 5527. DOI : 10.1021/cr900045a.

Peptide/Protein−Synthetic Polymer Conjugates: Quo vadis

H-A. Klok 

Macromolecules. 2009. Vol. 42, num. 21, p. 7990 – 8000. DOI : 10.1021/ma901561t.

A Post-Modification Strategy for the Synthesis of Uniform, Hydrophilic/Hydrophobic Patterned α-Hydroxy Acid Oligomers

N. Franz; L. Menin; H-A. Klok 

European Journal of Organic Chemistry. 2009. num. 31, p. 5390 – 5405. DOI : 10.1002/ejoc.200900663.

Synthesis of functional polymers by post-polymerization modification

M. A. Gauthier; M. I. Gibson; H-A. Klok 

Angewandte Chemie International Edition. 2009. Vol. 48, p. 48 – 58. DOI : 10.1002/anie.200801951.

2008

Secondary structure formation and LCST behaviour of short, elastin-like peptides

H. Nuhn; H-A. Klok 

Biomacromolecules. 2008. Vol. 9, p. 2755 – 2763. DOI : 10.1021/bm800784y.

Peptide/protein – polymer conjugates: synthetic strategies and design concepts

M. A. Gauthier; H-A. Klok 

Chemical Communications (ChemComm). 2008. num. 23, p. 2591 – 2611. DOI : 10.1039/b719689j.

Stability and nonfouling properties of poly(poly(ethylene glycol) methacrylate) brushes under cell culture conditions

S. Tugulu; H-A. Klok 

Biomacromolecules. 2008. Vol. 9, p. 906 – 912. DOI : 10.1021/bm701293g.

Biofunctional and biomimetic polymer brushes prepared via surface-initiated atom transfer radical polymerization

L. Lavanant; H-A. Klok 

CHIMIA. 2008. Vol. 62, num. 10, p. 793 – 798. DOI : 10.2533/chimia.2008.793.

pH-Sensitivity of the E3/K3 heterodimeric coiled coil

B. Apostolovic; H-A. Klok 

Biomacromolecules. 2008. Vol. 9, p. 3173 – 3180. DOI : 10.1021/bm800746e.

Solution behavior of peptide and peptide-hybrid materials

H. Nuhn / H-A. Klok (Dir.)  

Lausanne, EPFL, 2008. 

Self-organization on multiple length scales in “hairy rod”- coil block copolymer supramolecular complexes

M. R. Hammond; H-A. Klok; R. Mezzenga 

Macromol. Rapid. Commun. 2008. Vol. 29, p. 299 – 303. DOI : 10.1002/marc.200700666.

Investigation of the Release of Bioactive Volatiles from Amphiphilic Multiarm Star-Block Copolymers by Thermogravimetry and Dynamic Headspace Analysis

C. Ternat; L. Ouali; H. Sommer; W. Fieber; M. I. Velazco et al. 

Macromolecules. 2008. Vol. 41, p. 7079 – 7089. DOI : 10.1021/ma801366m.

2007

NMR diffusion and relaxation studies of the encapsulation of fragrances by amphiphilic multiarm star block copolymers

W. Fieber; A. Herrmann; L. Ouali; M. I. Velazco; G. Kreutzer et al. 

Macromolecules. 2007. Vol. 40, num. 15, p. 5372 – 5378. DOI : 10.1021/ma070222i.

The thermal polymerization of amino acids revisited; Synthesis and structural characterization of hyperbranched polymers from L-lysine

M. Scholl; T. Nguyen; B. Bruchmann; H-A. Klok 

Journal of Polymer Science Part A: Polymer Chemistry. 2007. Vol. 45, p. 5494 – 5508. DOI : 10.1002/pola.22295.

Synthesis of poly(methacrylic acid) brushes via surface-initiated atom transfer radical polymerization of sodium methacrylate and their use as substrates for the mineralization of calcium carbonate

S. Tugulu; R. Barbey; M. Harms; M. Fricke; D. Volkmer et al. 

Macromolecules. 2007. Vol. 40, num. 2, p. 168 – 177. DOI : 10.1021/ma060739e.

Dark curing kinetics of UV printing inks by real-time ATR-FTIR spectroscopy

E. Nouzille / T. Q. Nguyen (Dir.)  

Lausanne, EPFL, 2007. 

Amphiphilic multi-arm star-block copolymers for encapsulation of fragrance molecules

C. Ternat; G. Kreutzer; C. J. Plummer; T. Q. Nguyen; A. Herrmann et al. 

Macromolecular Chemistry and Physics. 2007. Vol. 208, num. 2, p. 131 – 145. DOI : 10.1002/macp.200600449.

Controlling polymer architecture in the thermal hyperbranched polymerization of L-lysine

M. Scholl; T. Q. Nguyen; B. Bruchmann; H-A. Klok 

Macromolecules. 2007. Vol. 40, num. 16, p. 5726 – 5734. DOI : 10.1021/ma070494l.

Macromolecular engineering of polypeptides using the ring-opening polymerization of alpha-amino acid N-carboxyanhydrides

H-A. Klok; T. Deming 

Macromolecular Engineering. Precise Synthesis, Materials Properties, Applications; Wiley-VCH Verlag, 2007. p. 519 – 540.

Functional polymer brushes via surface-initiated controlled radical polymerizations

S. Tugulu / H-A. Klok (Dir.)  

Lausanne, EPFL, 2007. 

Thermotropic ionic liquid crystals via self-assembly of cationic hyperbranched polypeptides and anionic surfactants

N. Canilho; M. Scholl; H-A. Klok; R. Mezzenga 

Macromolecules. 2007. Vol. 40, num. 23, p. 8374 – 8383. DOI : 10.1021/ma071558v.

RGD-Functionalized polymer brushes as substrates for the integrin specific adhesion of human umbilical vein endothelial cells

S. Tugulu; P. Silacci; N. Stergiopulos; H-A. Klok 

Biomaterials. 2007. Vol. 28, num. 16, p. 2536 – 2546. DOI : 10.1016/j.biomaterials.2007.02.006.

Synthesis, structural characterization and applications of hyperbranched polymers based on L-lysine

M. T. Scholl / H-A. Klok (Dir.)  

Lausanne, EPFL, 2007. 

Complex coacervate core micelles with a lysozyme-modified corona

M. Danial; H-A. Klok; W. Norde; M. A. C. Stuart 

Langmuir. 2007. Vol. 23, num. 15, p. 8003 – 8009. DOI : 10.1021/la700573j.

2006

Protein function microarrays based on self-immobilizing and self-labeling fusion proteins

I. Sielaff; A. Arnold; G. Godin; S. Tugulu; H-A. Klok et al. 

ChemBioChem. 2006. Vol. 7, num. 1, p. 194 – 202. DOI : 10.1002/cbic.200500278.

Solid-state structure, organization and properties of peptide-synthetic hybrid block copolymers

H-A. Klok; S. Lecommandoux 

Advances in Polymer Science. 2006. Vol. 202, p. 75 – 111. DOI : 10.1007/12_083.

Water-soluble, unimolecular containers based on amphiphilic multiarm star block copolymers

G. Kreutzer; C. Ternat; T. Q. Nguyen; C. J. G. Plummer; J. A. E. Manson et al. 

Macromolecules. 2006. Vol. 39, num. 13, p. 4507 – 4516. DOI : 10.1021/ma060548b.

Self-assembly of linear polypeptide-based block copolymers

S. Lecommandoux; H-A. Klok; H. Schlaad 

Block Copolymers in Nanoscience; Wiley-VCH Verlag, 2006.

Thermodynamic confinement and α-helix persistence length in poly(γ-benzyl-L-glutamate)-b-poly(dimethyl siloxane)-b-poly(γ-benzyl-L-glutamate) triblock copolymers

P. Papadopoulos; G. Floudas; I. Schnell; I. Lieberwirth; T. Q. Nguyen et al. 

Biomacromolecules. 2006. Vol. 7, num. 2, p. 618 – 626. DOI : 10.1021/bm050772t.

Spontaneous condensation in DNA-polystyrene-b-poly(L-lysine) polyelectrolyte block copolymer mixtures

V. Castelletto; I. W. Hamley; S. L. H. Kerstens; S. Deacon; C. D. Thomas et al. 

European Physical Journal E. 2006. Vol. 20, num. 1, p. 1 – 6. DOI : 10.1140/epje/i2005-10074-x.

Polymer brushes as ionotropic matrices for the directed fabrication of microstructured calcite thin films

S. Tugulu; M. Harms; M. Fricke; D. Volkmer; H-A. Klok 

Angewandte Chemie International Edition. 2006. Vol. 45, num. 44, p. 7458 – 7461. DOI : 10.1002/anie.200602382.

Synthesis of uniform, non-natural oligomers

N. Franz; G. Kreutzer; H-A. Klok 

Synlett. 2006. num. 12, p. 1793 – 1815. DOI : 10.1055/s-2006-944221.

2005

Peptide mediated formation of hierarchically organized solution and solid state polymer nanostructures

H-A. Klok; H. Nuhn; G. Vandermeulen; A. Rösler; I. Hamley et al. 

Faraday Discussions. 2005. Vol. 128, p. 29 – 41. DOI : 10.1039/b402273d.

Biological-synthetic hybrid block copolymers: Combining the best from two worlds

H-A. Klok 

Journal of Polymer Science, Part A: Polymer Chemistry. 2005. Vol. 43, num. 1, p. 1 – 17. DOI : 10.1002/pola.20527.

PEG-based hybrid block copolymers containing α-helical coiled coil peptide sequences: Control of self-assembly and preliminary biological evaluation

G. Vandermeulen; C. Tziatzios; R. Duncan; H-A. Klok 

Macromolecules. 2005. Vol. 38, num. 3, p. 761 – 769. DOI : 10.1021/ma0485538.

Nonspherical assemblies generated from polystyrene-b-poly(L-lysine) polyelectrolyte block copolymers

A. Lübbert; V. Castelletto; I. W. Hamley; H. Nuhn; M. Scholl et al. 

Langmuir. 2005. Vol. 21, num. 14, p. 6582 – 6589. DOI : 10.1021/la0502600.

L-lysine dendronized polystyrene

A. Lübbert; T. Nguyen; H-A. Klok; F. Sun; S. Sheiko 

Macromolecules. 2005. Vol. 38, num. 6, p. 2064 – 2071. DOI : 10.1021/ma047621n.

Protein-Functionalized Polymer Brushes

S. Tugulu; A. Arnold; I. Sielaff; K. Johnsson; H-A. Klok et al. 

Biomacromolecules. 2005. Vol. 6, num. 3, p. 1602 – 1607. DOI : 10.1021/bm050016n.

A novel star PEG-derived surface coating for specific cell adhesion

J. Groll; J. Fiedler; E. Engelhard; T. Ameringer; S. Tugulu et al. 

Journal of Biomedical Materials Research – Part A. 2005. Vol. 74, num. 4, p. 607 – 617. DOI : 10.1002/jbm.a.30335.

Nanostructure formation in poly(γ-benzyl-L-glutamate)-poly(ethylene glycol)-poly(γ-benzyl-L-glutamate) triblock copolymers in the solid state

P. Parras; V. Castelletto; I. W. Hamley; H-A. Klok 

Soft Matter. 2005. Vol. 1, num. 4, p. 284 – 291. DOI : 10.1039/b508772b.

“Glass transition” in peptides: Temperature and pressure effects

P. Papadopoulos; G. Floudas; I. Schnell; H-A. Klok; T. Aliferis et al. 

The Journal of Chemical Physics. 2005. Vol. 122, num. 22, p. 1 – 4. DOI : 10.1063/1.1931657.

Solution self-assembly of hybrid block copolymers containing poly(ethylene glycol) and amphiphilic peptide sequences

I. Hamley; I. Ansari; V. Castelletto; H. Nuhn; A. Rösler et al. 

Biomacromolecules. 2005. Vol. 6, num. 3, p. 1310 – 1315. DOI : 10.1021/bm049286g.

Polyphenylene dendrimers as scaffolds for shape-persistent multiple peptide conjugates

G. Mihov; D. Grebel-Koehler; A. Lübbert; G. Vandermeulen; A. Herrmann et al. 

Bioconjugate Chemistry. 2005. Vol. 16, num. 2, p. 283 – 293. DOI : 10.1021/bc049839k.

Self-assembled nanostructures from peptide-synthetic hybrid block copolymers: Complex, stimuli-responsive rod-coil architectures

J. Babin; J. Rodriguez-Hernandez; S. Lecommandoux; H-A. Klok; M-F. Achard 

Faraday Discussions. 2005. Vol. 128, p. 179 – 192. DOI : 10.1039/b403203a.

2004

Ring-opening polymerization of alpha-amino acid N-carboxyanhydrides

H-A. Klok 

Encyclopledia of Polymer Science and Technology; John Wiley and Sons, 2004.

Chemical approaches for the preparation of biologically-inspired supramolecular architectures and advanced polymeric materials

H-A. Klok 

Highlights in Bioorganic Chemistry: Methods and Applications; Wiley-VCH Verlag, 2004.

Structure and dynamics of self-assembled poly(ethylene glycol) based coiled-coil nano-objects

G. Vandermeulen; D. Hinderberger; G. Jeschke; H-A. Klok; H. Xu et al. 

ChemPhysChem. 2004. Vol. 5, num. 4, p. 488 – 494. DOI : 10.1002/cphc.200301079.

Metal ion assisted folding and supramolecular organization of a De Novo designed metalloprotein

G. Vandermeulen; C. Tziatzios; D. Schubert; P. Andres; A. Alexeev et al. 

Australian Journal of Chemistry. 2004. Vol. 57, num. 1, p. 33 – 39. DOI : 10.1071/CH03260.

Materials Research Society Symposium Proceedings: Preface

J. Y. Wong; A. L. Plant; C. E. Schmidt; L. Shea; A. J. Coury et al. 

Materials Research Society Symposium Proceedings. 2004. Vol. EXS, num. 1.

Synthesis of a silk-inspired peptide-oligothiophene conjugate

H-A. Klok; A. Rösler; G. Götz; E. Mena-Osteritz; P. Bäuerle 

Organic and Biomolecular Chemistry. 2004. Vol. 2, num. 24, p. 3541 – 3544. DOI : 10.1039/b415454a.

Peptide/protein hybrid materials: Enhanced control of structure and improved performance through conjugation of biological and synthetic polymers

G. Vandermeulen; H-A. Klok 

Macromolecular Bioscience. 2004. Vol. 4, num. 4, p. 383 – 398. DOI : 10.1002/mabi.200300079.

Self-assembly and dynamics of poly(γ-benzyl-L-glutamate) peptides

P. Papadopoulos; G. Floudas; H-A. Klok; I. Schnell; T. Pakula 

Biomacromolecules. 2004. Vol. 5, num. 1, p. 81 – 91. DOI : 10.1021/bm034291q.