Switzerland has a strong manufacturing economy, which serves as a model for how manufacturing can thrive despite high labor costs. Yet, Switzerland faces challenges from emerging manufacturing nations and also from technological advances that reduce the edge that Swiss technical skill and expertise bring to its manufacturing economy. In order to strengthen Switzerland manufacturing activities, significant investment in science and R&D is required. Other technologically advanced countries are also taking action to strengthen their manufacturing activities and the European Commission has identified Advanced Manufacturing Systems (AMS) as the sixth crosscutting Key Enabling Technology (KET) besides five other technologies of current critical relevance. The M2C responds to the need of the Swiss Industry in the frame of the strategic initiative of the ETH Board on advanced manufacturing for 2017-2020.