Srikanth Ramaswamy

Simulation Neuroscience
Cells and Circuits
Dr. Srikanth Ramaswamy is a Senior Scientist in the Cells & Circuits Section of the Simulation Neuroscience Division.

Dr. Ramaswamy leads the effort in modeling synaptic transmission and neuromodulation in the Blue Brain Project’s flagship simulations of neocortical tissue, under the direction of Prof. Henry Markram, and in close collaboration with Dr. Eilif Muller, Prof. Idan Segev (Jerusalem) and Prof. Javier DeFelipe (Madrid).

Dr. Ramaswamy joined the Blue Brain Project in 2006, as one of its first scientific team members and completed his PhD. under the supervision of Prof. Henry Markram in 2011. He then did a brief postdoc at the EPFL and the CHUV until his appointment as a Senior Scientist at the Blue Brain Project in 2014.

Dr. Ramaswamy obtained a first class honors degree in Electrical and Electronics Engineering from the National Institute of Engineering in Mysore, India in 2003. In the same year, he was awarded a British Chevening Scholarship by the Foreign and Commonwealth Office, UK to pursue a Master’s in Electrical Engineering at the University of Strathclyde in Glasgow. Following the completion of his Masters, he developed a keen interest in neuroscience and won a fellowship by the BBVA foundation in Madrid to work with Profs. Gonzalo de Polavieja and Pablo Varona at the Universidad Autonoma de Madrid between 2005 and 2006.

In 2017, he was one of the winners of the FENS – Australasian Neuroscience Society exchange award for young researchers and he won the 2017 Japan Neuroscience Society young investigator award.

Outside of work, Srikanth enjoys cooking, traveling, hiking in the mountains and reading biographies.

Selected Publications

1. H. Markram*†, E. Muller*†, S. Ramaswamy*†, M.W Reimann* et al. (2015). Reconstruction and Simulation of Neocortical Microcircuitry. Cell 163:2, 456 – 492. doi: 10.1016/j.cell.2015.09.029
* Co-first author
*Also see a commentary on this paper by Christof Koch and Michael A. Buice (2015). Koch, C., and Buice, M.A. (2015). A Biological Imitation Game. Cell 163, 277–280.

2. S. Ramaswamy and E. Muller (2015) Cell-type specific modulation of neocortical UP and DOWN states. Front. Cell. Neurosci. 9:370. doi: 10.3389/fncel.2015.00370

3. S. Ramaswamy and H. Markram (2015) Anatomy and Physiology of the Thick-tufted Layer 5 Pyramidal Neuron. Front. Cell. Neurosci. 9:233. doi: 10.3389/fncel.2015.00233

4. S. Ramaswamy†, JD Courcol†, Abdellah M, Adaszewski S, Antille N, Arsever S, Guy Antoine A, Bilgili A, Brukau Y, Chalimourda A, Chindemi G, Dumusc R, Eilemann S, Graham JW, Hernando JB, Kanari L, Keller D, King JG, Ranjan R, Reimann MW, Roessert C, Telefont M, Geit WV, Villafranca Diaz J, Walker R, Wang Y, Zaninetta S, DeFelipe J, Hill SL, Muller J, Segev I, Schürmann F, EB Muller and H Markram (2015). The Neocortical Microcircuit Collaboration Portal: A Resource for Rat Somatosensory Cortex. Front. Neural Circuits 9:44. doi: 10.3389/fncir.2015.00044*
* Listed in the top 100 most read papers published in Frontiers in 2015

5. S. Ramaswamy (2015). Exciting times for inhibition: GABAergic synaptic transmission in dentate gyrus interneuron networks. Front. Neural Circuits 9:13. doi: 10.3389/fncir.2015.00013

6. S. Ramaswamy, S. L Hill, J.G King, F. Schürmann, Y. Wang and H. Markram (2012). Intrinsic Morphological Diversity of Thick-tufted Layer 5 Pyramidal Neurons Ensures Robust and Invariant Properties of in silico Synaptic Connections. J. Physiol, 590, 737-752.*
* Listed under Editor’s choice”
* Also see a commentary on this paper by Giorgio Ascoli (2012). Potential connectomics complements the endeavour of no synapse left behind in the cortex. J. Physiol, 590 (4), 651-652