Welcome to the Laboratory of Regenerative Hematopoiesis!
The research focus of our lab is to understand the regulation of the reversible transition between yellow bone marrow (adipocyitic) to red bone marrow (hematopoietic). This naturally occurring process has tremendous impact on the efficiency of hematopoietic stem cell (HSC) engraftment and hematopoiesis. Currently, all clinical approaches to increase HSC engraftment and to enhance hematopoiesis target the HSC itself. Alternatively, we focus on studying how manipulations of the HSC niche can enhance hematopoiesis. Specifically, we are developing several strategies to induce metabolic changes in the HSC niche and to regulate the function of mesenchymal stem cells, the main precursor to stromal supportive cells in the hematopoietic marrow. The relevance of this research relies on the early mortality associated to HSC transplantation. Reducing the toxicity of the preparative regimen and accelerating the time to engraftment is critical to improving the safety of bone marrow transplantation.