At the end of the production cycle, numerous drugs undergo terminal sterilization, by either heat or irradiation. These treatments can induce reactive dangling bonds and free radicals. Their concentrations and lifetimes can be precisely measured by ESR, allowing a better understanding of their role in the human body, and helping physicians to better diagnose certain diseases.
In this context:
- ESR quantifies the presence of dangling bonds and free radicals in drugs;
- ESR measurements provide precise guidance in determining the appropriate dose of radiation;
- Monitoring of the irradiation-induced dangling bonds/free radicals provide benefits for the drug production and product safety management.