Laboratory of Chemical and Biological Probes

Our research, at the interface of chemistry and biology, draws from the areas of organic synthesis, physical organic chemistry, biophysics, and molecular biology to figure out the molecular mechanisms of specific biological processes.

Selected publications

Z. Thiel, J. Nguyen, P. Rivera-Fuentes, Angew. Chem. Int. Ed. 2020, 59, 7669–7677.
Genetically Encoded Activators of Small Molecules for Imaging and Drug Delivery

Z. Thiel, P. Rivera-Fuentes, Angew. Chem. Int. Ed. 2019, 53, 11474–11478.
Single‐Molecule Imaging of Active Mitochondrial Nitroreductases using a Photo‐Crosslinking Fluorescent Sensor

E. A. Halabi, D. Pinotsi, P. Rivera-Fuentes, Nat. Commun. 2019, 10, 1232.
Photoregulated Fluxional Fluorophores for Live-Cell Super-Resolution Microscopy with no Apparent Photobleaching.

G. Bassolino, C. Nançoz, Z. Thiel, E. Bois, E. Vauthey, P. Rivera-Fuentes, Chem. Sci. 2018, 9, 387–391.
Photolabile Coumarins with Improved Efficiency through Azetidinyl Substitution.

E. A. Halabi, Z. Thiel, N. Trapp, D. Pinotsi, P. Rivera-Fuentes, J. Am. Chem. Soc. 2017, 139, 13200–13207.
A Photoactivatable Probe for Super-Resolution Imaging of Enzymatic Activity in Live Cells.

A. Tirla, P. Rivera-Fuentes, Angew. Chem. Int. Ed. 2016, 55, 14709–14712.
Development of a Photoactivatable Phosphine Probe for Induction of Intracellular Reductive Stress with Single-Cell Precision.