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Latest Publications

Unintended specificity of an engineered ligand-binding protein facilitated by unpredicted plasticity of the protein fold

A. L. Day; P. Greisen; L. Doyle; A. Schena; N. Stella et al. 

Protein Engineering Design & Selection. 2018-10-01. Vol. 31, num. 10, p. 375-387. DOI : 10.1093/protein/gzy031.

Semisynthetic sensor proteins enable metabolic assays at the point of care

Q. Yu; L. Xue; J. Hiblot; R. Griss; S. Fabritz et al. 

Science. 2018-09-14. Vol. 361, num. 6407, p. 1122-1125. DOI : 10.1126/science.aat7992.

SNAP-Tagged Nanobodies Enable Reversible Optical Control of a G Protein-Coupled Receptor via a Remotely Tethered Photoswitchable Ligand

H. Farrants; V. A. Gutzeit; A. Acosta-Ruiz; D. Trauner; K. Johnsson et al. 

Acs Chemical Biology. 2018-09-01. Vol. 13, num. 9, p. 2682-2688. DOI : 10.1021/acschembio.8b00628.

Semisynthetic biosensors for mapping cellular concentrations of nicotinamide adenine dinucleotides

O. Sallin; L. Reymond; C. Gondrand; F. Raith; B. Koch et al. 

eLife. 2018-05-29. Vol. 7. DOI : 10.7554/eLife.32638.

Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor (vol 8, 1862, 2017)

M. Berry; A. Holt; J. Levitz; J. Broichhagen; B. Gaub et al. 

Nature Communications. 2018. Vol. 9. DOI : 10.1038/s41467-018-03585-2.

Control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-positive sensory neurons

R. Dhandapani; C. Arokiaraj; F. Taberner; P. Pacifico; S. Raja et al. 

Nature Communications. 2018. Vol. 9. DOI : 10.1038/s41467-018-04049-3.

A New Fluorogenic Small-Molecule Labeling Tool for Surface Diffusion Analysis and Advanced Fluorescence Imaging of beta-site Amyloid Precursor Protein-Cleaving Enzyme 1 Based on Silicone Rhodamine: SiR-BACE1

S. Karch; J. Broichhagen; J. Schneider; D. Boning; S. Hartmann et al. 

JOURNAL OF MEDICINAL CHEMISTRY. 2018. Vol. 61, num. 14, p. 6121-6139. DOI : 10.1021/acs.jmedchem.8b00387.

Sampling and Energy Evaluation Challenges in Ligand Binding Protein Design

J. Dou; L. Doyle; P. J. Greisen; A. Schena; H. Park et al. 

Protein Science. 2017. Vol. 26, num. 12, p. 2426-2437. DOI : 10.1002/pro.3317.