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Latest Publications

Semisynthetic sensor proteins enable metabolic assays at the point of care

Q. Yu; L. Xue; J. Hiblot; R. Griss; S. Fabritz et al. 

Science. 2018-09-14. DOI : 10.1126/science.aat7992.

SNAP-Tagged Nanobodies Enable Reversible Optical Control of a G Protein-Coupled Receptor via a Remotely Tethered Photoswitchable Ligand

H. Farrants; V. A. Gutzeit; A. Acosta-Ruiz; D. Trauner; K. Johnsson et al. 

Acs Chemical Biology. 2018-09-01. DOI : 10.1021/acschembio.8b00628.

Semisynthetic biosensors for mapping cellular concentrations of nicotinamide adenine dinucleotides

O. Sallin; L. Reymond; C. Gondrand; F. Raith; B. Koch et al. 

eLife. 2018-05-29. DOI : 10.7554/eLife.32638.

Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor (vol 8, 1862, 2017)

M. Berry; A. Holt; J. Levitz; J. Broichhagen; B. Gaub et al. 

Nature Communications. 2018. DOI : 10.1038/s41467-018-03585-2.

Control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-positive sensory neurons

R. Dhandapani; C. Arokiaraj; F. Taberner; P. Pacifico; S. Raja et al. 

Nature Communications. 2018. DOI : 10.1038/s41467-018-04049-3.

A New Fluorogenic Small-Molecule Labeling Tool for Surface Diffusion Analysis and Advanced Fluorescence Imaging of beta-site Amyloid Precursor Protein-Cleaving Enzyme 1 Based on Silicone Rhodamine: SiR-BACE1

S. Karch; J. Broichhagen; J. Schneider; D. Boning; S. Hartmann et al. 

JOURNAL OF MEDICINAL CHEMISTRY. 2018. DOI : 10.1021/acs.jmedchem.8b00387.

Sampling and Energy Evaluation Challenges in Ligand Binding Protein Design

J. Dou; L. Doyle; P. J. Greisen; A. Schena; H. Park et al. 

Protein Science. 2017. DOI : 10.1002/pro.3317.

Computational design of environmental sensors for the potent opioid fentanyl

M. J. Bick; P. J. Greisen; K. J. Morey; M. S. Antunes; D. La et al. 

eLife. 2017. DOI : 10.7554/eLife.28909.