Three is not a crowd!

  • (W)Hu ‘R’ you? A key transcription factor in a druggable pathway is regulated by two mRNA-binding proteins in a mechanism conserved from humans to zebrafish:
Poganik et al. Just Accepted
FASEB Journal
  • Gotta get with my friends!: in this invited opinion piece (in Current Opinion in Chem Biology), we draw together the latest data in the field to provide insight on how genetics, biochemistry, and chemical biology are shedding light onto novel signaling functions of the enzyme RNR, acquired selectively through RNR-oligomerization and new partner association:

The more the merrier: How homo-oligomerization alters the interactome and function of ribonucleotide reductase

  • Mind your P’s and Q’s, but don’t focus on the pKa’s!: in this invited forum review (in Antioxidant & Redox Signaling), we evaluate kinetic and thermodynamic terms of known electrophile adduction events to offer a new lens into what it takes to be an electrophile sensor:

Getting the right grip: How understanding electrophile selectivity profiles could illuminate our understanding of redox signaling

We thank all of our past and present team members and collaborators, and funding agencies, that collectively make these contributions possible