Category: News & announcements
Delve deeper into electrophile signaling through “proteomics and beyond” in Trends in Biochemical Sciences
To proteomics and beyond: Cell decision making shaped by reactive electrophiles Trends in Biochemical Sciences (Elsevier) — just accepted (September 2018) Link to paper Revolutionary proteomics strategies have enabled rapid profiling of the cellular targets of electrophilic small molecules. However, precise means to directly interrogate how these individual electrophilic modifications at low occupancy functionally reshape signaling (…)
Double agent exposed in Nature Chemical Biology
The large subunit of ribonucleotide reductase—the harbinger of the DNA world—downregulates replication when inside the nucleus: it plays a tug-of-war with IRBIT/importin-α1 in the cytosol and PCNA/ZRANB3 in the nucleus Springer SharedIt Link Nuclear RNR-α Antagonizes Cell Proliferation by Directly Inhibiting ZRANB3 Yuan Fu#, Marcus J. C. Long#, Somsinee Wisitpitthaya, Huma Inayet, Timothy M. Pierpont, (…)
Get the full scoop on redox signaling — accepted in Chemical Reviews!
Redox Signaling by Reactive Electrophiles and Oxidants Chemical Reviews (American Chemical Society) —just accepted Saba Parvez#, Marcus J. C. Long#, Jesse Poganik, and Yimon Aye* (#, co-first authors. *, corresponding author) The concept of cell signaling in the context of non-enzyme-assisted protein modifications by reactive electrophilic and oxidative species—broadly known as redox signaling—is a uniquely (…)
We are very excited to welcome Bo Kyoung Kim to join our team at EPFL!
Bokyoung Kim has joined us as our first PhD student at EPFL! Bokyoung has just completed the Master in Chemical Biology program at the Swiss National Center of Competence in Research (NCCR) Chemical Biology, jointly run by the University of Geneva and EPFL. Welcome Bokyoung!
Translocation in progress!
Following lab promotion, we are very excited to be moving to join EPFL in the near future ISIC EPFL — home of the Aye Lab Business will be uninterrupted as almost all of the team members are coming along. We are happy to have spent our formative years at Cornell & Weill Cornell Medicine.