Return of the Native? Endogenous lipid signaling electrophiles pass two of the three tests required to be classed as bona fide messengers.

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Our invited contribution — a ‘problems & paradigms’ article — is now available on BioEssays (Wiley) Click here for the Video Abstract (by Jesse) Getting the message? Native reactive electrophiles pass two out of three thresholds to be bona fide signaling mediators Jesse R. Poganik#, Marcus J. C. Long#, and Yimon Aye* (#, co-first authors, (...)

Second (February) and two (papers)! Alexandra and Yi’s double teaming paper accepted in Current Protocols in Chemical Biology

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Seeing as it is the superbowl… Second (February) and two (papers)! Alexandra and Yi’s double teaming paper accepted in Current Protocols in Chemical Biology Single-protein-specific redox targeting in live mammalian cells and C. elegans Alexandra Van Hall-Beauvais#, Yi Zhao, Daniel A. Urul, Marcus J. C. Long, and Yimon Aye* (#, first author. *, corresponding author) (...)

A new first responder has its finger on the pulse of evolutionary sensing and disease – Sanjna, Marcus, and Daniel et al’s team work just accepted to be featured in Biosensors Special Issue of ACS Chemical Biology

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A new first responder has its finger on the pulse of evolutionary sensing and disease – Sanjna, Marcus, and Daniel et al’s team work on cardiovascular small heat shock protein just accepted! Cardiovascular small heat shock protein HSPB7 is a kinetically-privileged reactive electrophilic species (RES) sensor Invited contribution to the 2018 “Biosensors” Special Issue of (...)

Party like it’s 1799! A new Rosetta Stone discovered: Yi’s paper (detailing how a specific sensor translates electrophile messages to ubiquitin signaling for genome protection) welcomes 2018! —in ACS Central Science

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Ube2V2 is a Rosetta Stone bridging redox and ubiquitin codes, coordinating DNA damage responses Synopsis: G-REX and T-REX double tap strategy identifies privileged electrophile responsivity of Ube2V2 to promote genome protection Yi Zhao#, Marcus J. C. Long, Yiran Wang, Sheng Zhang, and Yimon Aye* (#, first author. *, corresponding author) Highlight in Cornell Chronicle We thank (...)

Jesse won an “impressive talk award” at the 3rd Annual Cornell Biophysics Symposium!

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Jesse, our 4th year graduate student member and an AHA predoctoral fellow (and a former fellow of the Cornell NIH CBI program), was honored by an “impressive talk award” for his oral presentation at the Cornell University Annual Biophysics Symposium! Photo: Jesse led a recent Aye Lab outreach workshop session for the Masters Program Teachers (...)