A preview on ‘sec-rets’ and an interview on ‘crossing borders with chemical biology’

— Yimon Aye

Lab contributes to a preview and an interview in Cell Chemical Biology and Trends in Biochemical Sciences (for the Trends Talk section), respectively: — “Weighing up the selenocysteome uncovers new sec-rets” – for the paper by Guo et al. 2018 Cell Chem Biol (in press) Jesse Poganik & Yimon Aye — “Crossing borders with chemical (...)

Delve deeper into electrophile signaling through “proteomics and beyond” in Trends in Biochemical Sciences

— Yimon Aye

To proteomics and beyond: Cell decision making shaped by reactive electrophiles Trends in Biochemical Sciences (Elsevier) — just accepted (September 2018) Link to paper Revolutionary proteomics strategies have enabled rapid profiling of the cellular targets of electrophilic small molecules. However, precise means to directly interrogate how these individual electrophilic modifications at low occupancy functionally reshape signaling (...)

Double agent exposed in Nature Chemical Biology

— admin

The large subunit of ribonucleotide reductase—the harbinger of the DNA world—downregulates replication when inside the nucleus: it plays a tug-of-war with IRBIT/importin-α1 in the cytosol and PCNA/ZRANB3 in the nucleus Springer SharedIt Link Nuclear RNR-α Antagonizes Cell Proliferation by Directly Inhibiting ZRANB3 Yuan Fu#, Marcus J. C. Long#, Somsinee Wisitpitthaya, Huma Inayet, Timothy M. Pierpont, (...)

Get the full scoop on redox signaling — accepted in Chemical Reviews!

— admin

Redox Signaling by Reactive Electrophiles and Oxidants Chemical Reviews (American Chemical Society) —just accepted Saba Parvez#, Marcus J. C. Long#, Jesse Poganik, and Yimon Aye* (#, co-first authors. *, corresponding author) The concept of cell signaling in the context of non-enzyme-assisted protein modifications by reactive electrophilic and oxidative species—broadly known as redox signaling—is a uniquely (...)

We are very excited to welcome Bo Kyoung Kim to join our team at EPFL!

— admin

Bokyoung Kim has joined us as our first PhD student at EPFL! Bokyoung has just completed the Master in Chemical Biology program at the Swiss National Center of Competence in Research (NCCR) Chemical Biology, jointly run by the University of Geneva and EPFL. Welcome Bokyoung!