1. The mechanistic basis for chromatin invasion and remodeling by the yeast pioneer transcription factor Rap1, Mivelaz, M., Cao, A.-M., Kubik, S., Zencir, , Hovius, R., Boichenko, I., Stachowicz, A.M., Kurat, C.F., Shore, D., Fierz B.*, preprint in BioRxiv, doi:
  1. KAP1 is an antiparallel dimer with a natively functional asymmetry. Fonti, G., Marcaida, M.J., Bryan, L.C., Traeger, S., Kalantzi, A.S., Helleboid, P-Y.J.L., Demurtas, D., Tully, M.D., Grudini, S., Trono, D., Fierz, B., Dal Peraro, M.,  preprint in BioRxiv, doi:
  1. Revealing chromatin organization in metaphase chromosomes, Fierz, B., EMBO JournalDOI 10.15252/embj.2019101699
  1. Chemical and biophysical methods to explore dynamic mechanisms of chromatin silencing, Boichenko, I., & Fierz, B.*, Curr Opin Chem Biol 2019, Volume 51, p. 1-10.
  1. A modular ligation strategy for asymmetric bivalent nucleosomes trimethylated at K36 and K27, Guidotti, N., Lechner, C.C., Bachmann, A.L., Fierz, B.*, ChemBioChem
  1. Biophysics of Chromatin Dynamics, Fierz, B.* & Poirier M.*, Annual Reviews in Biophysics, invited review,
  1. Single-molecule dynamics and genome-wide transcriptomics reveal that NF-κB-p65 binding times can be decoupled from transcriptional activation, Callegari, A., Sieben, C., Suter, D. M., Fierz, B., Mazza, D., Manley, S., PLOS Genet., 2019, 15(1):e1007891. doi: 10.1371/journal.pgen.1007891


  1. Kilic, S., Boichenko, I., Lechner C. and Fierz B., A bi-terminal protein ligation strategy to probe chromatin structure during DNA damage, Chemical Science, 2018, DOI: 10.1039/C8SC00681D
  1. Kilic, S., Felekyan S., Doroshenko O., Boichenko I., Dimura M., Vardanyan H, Bryan LC., Arya G, Seidel, CAM* & Fierz B.*, Single-molecule FRET reveals multiscale chromatin dynamics modulated by HP1α, Nature Commun., 2018, 9(1):235. Recommended in Faculty of 1000 (F1000 prime) as being of special significance in its field. 
  1. Delachat AMF, Pick H, Lechner CC., Guidotti N., Meireles-Filho ACA, Deluz C., Deplancke B., Suter DM, Fierz B., Engineered multivalent sensors to detect coexisting histone modifications in living stem cells, Cell Chem. Biol., 2018, 18;25(1):51-56Highlighted in Cell Chem. Biol., 2018, 25


  1. Choi J. #, Bachmann AL#., Tauscher K., Benda C., Fierz B.* and Müller J.*, DNA binding by Polycomblike proteins prolongs the residence time of PRC2 on chromatin and thereby stimulates H3K27 methylation, Nature Struct. & Mol. Biol., 2017, 24(12):1039-1047 (#: co-first authors, *: co-corresponding authors) Highlighted in Science 2017, 358, Editor’s choice section
  1. Guidotti N., Lechner CC., Fierz B., Controlling the supramolecular assembly of nucleosomes asymmetrically modified on H4, Commun., 2017, 53(74):10267-10270.
  1. Bryan, LC., Weilandt, DR., Bachmann, AL., Kilic, S, Lechner, CC., et al., & Fierz, B., Single-molecule kinetic analysis of HP1-chromatin binding reveals a dynamic network of histone modification and DNA interactions, Nucleic Acids Research, 2017, 45(18):10504-10517.
  1. Cuvier O., & Fierz, B., Dynamic chromatin technologies: from individual molecules to epigenomic regulation in cells, Nature Reviews Genetics, 2017, 18(8):457-472


  1. Lechner CC., Agashe N., Fierz B., Traceless synthesis of asymmetrically modified bivalent nucleosomes, Angew Chem Int Ed Engl 2016, 55(8):2903-6
  1. Müller M., Fierz B., Bittova L., Liszczak G & Muir TW., A two-state activation mechanism controls the histone methyltransferase Suv39h1, Nature Chem. Biol., 2016, 12(3):188-93
  1. 2016 International Symposium on Chemical Biology of the NCCR Chemical Biology Campus Biotech, Geneva 13-15.1.2016. Hantschel O, Fierz B., Chimia (Aarau). 2016 Mar;70(3):215-9.


  1. Fierz B., Dynamic chromatin regulation from a single molecule perspective, ACS Chemical Biology, 2015, 11(3):609-20
  1. Molecular and Chemical Mechanism in Epigenetics – Swiss Summer School 2015 July 12-17, 2015, Hotel Kurhaus, Arolla, Switzerland. Bryan LC, Bachmann AL, Fierz B., Chimia (Aarau). 2015;69(10):624-6
  1. Kilic S, Bachmann AL, Bryan LC, Fierz B., Multivalency governs HP1α association dynamics with the silent chromatin state, Nature Commun., 2015, 6, 7313; Highlighted in ACS Chemical Biology, July 17th 2015


  1. Dhall, A., Wei, S., Fierz, B., Woodcock, C.L., Lee, T.H. and Chatterjee, C., Sumoylated human histone H4 prevents chromatin compaction by inhibiting long-range internucleosomal interactions, Biol. Chem., 2014, Dec 5;289(49):33827-37
  1. Nguyen, U.T-T, Bittova, L., Müller, M.M., Fierz, B., David, Y., Houck-Loomis, B., Dann G.D. & Muir, T.W., Accelerated Chromatin Effector Profiling Using Barcoded ‘Designer’ Nucleosome Libraries, Nature Methods, 2014, 11(8):834-40
  1. Pick, H., Kilic, S. & Fierz, B., Engineering chromatin states: Chemical and synthetic biology approaches to investigate histone modification function, Biophysica Biochimica acta: Gene regulatory mechanisms, 2014, 1839(8):644-56
  1. Fierz, B., Synthetic chromatin approaches to probe writing and erasing of histone marks, ChemMedChem, 2014 Mar; 9(3):495-504


  1. Kim, D.-H. Tang, Z., Shimada, M., Fierz, B., Houck-Loomis, B., Bar-Dagen, M., Lee, S., Lee, S-K K, Muir, T.W., Roeder, R.G., Lee, J.W., Histone H3K27 Trimethylation Inhibits H3 Binding and Function of SET1-Like H3K4 Methyltransferase Complexes. Mol Cell Biol, 2013, 33, 4936–4946.
  1. Rauch, S., Reiner, A., Büttner, M., Fierz, B. & Kiefhaber, T., Testing the Diffusing Boundary Model for the Helix-Coil Transition in Peptides, Natl. Acad. Sci. U.S.A., 2013, Aug 6, 110(32):12905-10.


  1. Fierz, B., Kilic, S., Hieb, A., Luger, K. and Muir, TW., Stability of nucleosomes containing homogenously ubiquitylated H2A and H2B prepared using semisynthesis, J Am Chem Soc, 2012 Dec 5;134(48):19548-51
  1. Whitcomb, SJ., Fierz, B., McGinty, RK., Holt, M., Ito, T., Muir TW., Allis CD., Histone monoubiquitylation position determines specificity and direction of enzymatic crosstalk with histone methyltransferases Dot1L and PRC2, J Biol Chem, 2012;287(28):23718-25
  1. Fierz B. & Muir T. W., Chromatin as an expansive canvas for chemical biology, Nature Chemical Biology. 2012 Apr 17;8(5):417-27


  1. Fierz, B., Chatterjee, C., McGinty R., Bar-Dagan, M., Raleigh, DP. & Muir, TW., Histone H2B Ubiquity-lation inhibits local and higher order chromatin compaction, Nature Chemical Biology, 2011 Feb;7(2): 113-9.


  1. Chatterjee, C., McGinty R., Fierz, B., Muir, TW., Disulfide- directed histone ubiquitylation reveals plasticity in hDot1L activation, Nature Chemical Biology, 2010, 6(4): 267-9


  1. Fierz, B., Reiner A. & Kiefhaber, T. Local Conformational Dynamics in α-Helices Measured by Fast Triplet Transfer, Natl. Acad. Sci. USA, 2009, 106(4): p. 1057-62


  1. Fierz, B., Satzger, H., Root, C., Zinth, W. & Kiefhaber, T., Loop Formation in Unfolded Polypeptide Chains on the Picoseconds to Microseconds Time Scale, Natl. Acad. Sci. USA, 2007, 104(7), 2163-8
  1. Fierz, B., Joder, K., Krieger, F. & Kiefhaber, T., Using Triplet-Triplet Energy Transfer to Measure Conformational Dynamics in Polypeptide Chains, in Methods Mol. 2007, 350: p. 169-87 
  1. Fierz, B. & Kiefhaber, T., End-to-End vs. Interior Loop Formation Kinetics in Unfolded Polypeptide Chains, Am. Chem. Soc., 2007, 129, 672-79
  1. Heinz, B., Schmidt, B., Root, C., Milota, F., Fierz, B., Kiefhaber, T., Zinth, W., Gilch, P., Slow fluorescence and fast intersystem crossing – The xanthone anomaly, Ultrafast Phenomena XV, Springer Series in Chemical Physics, Corkum, P., Jonas, , Miller, RJD., Weiner AM., Editors. 2007, Springer-Verlag, Berlin, Vol. 88, p. 513-515


  1. Heinz, B., Schmidt, B., Root, C., Satzger, H., Milota, F., Fierz, B., Kiefhaber, T., Zinth, W. & Gilch, P., On the Unusual Fluorescence Properties of Xanthone in Water, Phys Chem Chem Phys., 2006, 8(29): p 3432-9

  1. Fierz, B. & Kiefhaber, T., Dynamics of Unfolded Polypeptide Chains, in Protein Folding Handbook, J. Buchner and T. Kiefhaber, Editors. 2005, WILEY-VCH: Weinheim. p. 809-855.
  1. Satzger, H., Schmidt, B., Root, C., Zinth, W., Fierz, B., Krieger, F., Kiefhaber, T. & Gilch, P., Ultrafast Quenching of the Xanthone Triplet by Energy Transfer: New Insight into the Intersystem Crossing Kinetics. Phys. Chem. A, 2004. 108(46): p. 10072-10079.


  1. Krieger, F., Fierz, B., Axthelm, F., Joder, K., Meyer, D. & Kiefhaber, T., Intrachain diffusion in a protein loop fragment from carp parvalbumin. Phys., 2004. 307: p. 209-215.


  1. Krieger, F., Fierz, B., Bieri, O., Drewello, M. & Kiefhaber, T. Dynamics of Unfolded Polypeptide Chains as a Model for the Earliest Steps in Protein Folding. J Mol Biol, 2003. 332: p. 265-274.