Measurement-based Optimization of a Batch Distillation Column
Measurement-based Optimization of a Batch Reactor under Safety Constraints
This experimental project has investigated the adjustment of the feed rate to maximize the yield of a second-order reaction (2-butanol + propionic anhydride) taking place in an isothermal semi-batch reactor. For exothermic reactions, a cooling failure can lead to a runaway situation with severe consequences if no preventive measures are taken. In this context, a feed strategy has been developed to optimize productivity under safety constraints by enforcing constraints on the maximal temperature reached under cooling failure and the amount of heat produced. The optimal solution in this case corresponds to riding on the safety constraints. For its implementation, estimates of the temperature under cooling failure and the heat generation were obtained from spectroscopic and calorimetric measurements. Optimal operation of the experimental reactor was then obtained by riding along the active constraints.
Measurement-based Optimization of a Polymerization Process
Optimization of Filamentous Fungi Fermenter