Laboratory for the Neural Basis of Brain States

The Laboratory for the Neural Basis of Brain States (LNBBS) is part of EPFL Blue Brain Project, a Swiss national brain research initiative that applies advanced neuroinformatics, data analytics, high-performance computing infrastructure and simulation-based approaches to the challenge of digitally reconstructing and simulating the mouse brain.


The Laboratory for the Neural Basis of Brain States (LNBBS) is directed by Prof. Sean Hill and based at the Campus Biotech in Geneva, Switzerland. The laboratory focuses on understanding cortical and thalamocortical structure and function and the relationship to states of the brain including wakefulness, sleep and anesthesia. The group employs biophysically-detailed computational models and large-scale simulations to investigate the cellular and synaptic mechanisms underlying brain states in health and disease.

Professor Hill is primarily based in Toronto where he is the inaugural Director of the Krembil Centre for Neuroinformatics at the Centre for Addiction and Mental Health (CAMH). He is also a Director at the EPFL Blue Brain Project where he founded the Neuroinformatics team, which provides the informatics infrastructure to organize, search, access and analyze heterogeneous neuroscience data including multi-scale brain atlases, machine learning, machine vision, data and text mining, data analysis and data-driven ontologies.


Large-scale simulation, neuroinformatics, microcircuitry, neocortex, thalamus, connectome, sleep, wakefulness, anesthesia, integrated information, brain atlases, TMS, EEG


Sean Hill

Adjunct Professor