2019

Journal Articles

An autism-linked missense mutation in SHANK3 reveals the modularity of Shank3 function

L. Wang; K. Pang; K. Han; C. J. Adamski; W. Wang et al.

Molecular Psychiatry. 2019-01-04. DOI : 10.1038/s41380-018-0324-x.

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2018

Journal Articles

Reprogramming G protein coupled receptor structure and function

D. Keri; P. Barth

Current Opinion in Structural Biology. 2018-07-25. Vol. 51, p. 187-194. DOI : 10.1016/j.sbi.2018.07.008.

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Computational design of orthogonal membrane receptor-effector switches for rewiring signaling pathways

M. Young; T. Dahoun; B. Sokrat; C. Arber; K. M. Chen et al.

Proceedings of the National Academy of Sciences. 2018-07-13. Vol. 115, num. 27, p. 7051-7056. DOI : 10.1073/pnas.1718489115.

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Conference Papers

Computational design of GPCR structure, stability and function

P. Barth

2018-03-18. 255th National Meeting and Exposition of the American-Chemical-Society (ACS) – Nexus of Food, Energy, and Water, New Orleans, LA, Mar 18-22, 2018.

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2017

Journal Articles

Reprogramming cellular functions with engineered membrane proteins

C. Arber; M. Young; P. Barth

Current Opinion in Biotechnology. 2017-10-01. Vol. 47, p. 92-101. DOI : 10.1016/j.copbio.2017.06.009.

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Computational design of ligand-binding membrane receptors with high selectivity

X. Feng; J. Ambia; K-Y. M. Chen; M. Young; P. Barth

Nature Chemical Biology. 2017-07-13. Vol. 13, num. 7, p. 715-723. DOI : 10.1038/nchembio.2371.

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Enhancing Structure Prediction and Design of Soluble and Membrane Proteins with Explicit Solvent-Protein Interactions

J. K. Lai; J. Ambia; Y. Wang; P. Barth

Structure. 2017. Vol. 25, num. 11, p. 1758-+. DOI : 10.1016/j.str.2017.09.002.

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2016

Journal Articles

Toward high-resolution computational design of the structure and function of helical membrane proteins

P. Barth; A. Senes

Nature Structural & Molecular Biology. 2016-06-07. Vol. 23, num. 6, p. 475-480. DOI : 10.1038/nsmb.3231.

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Introduction of a polar core into the de novo designed protein Top7

B. Basanta; K. K. Chan; P. Barth; T. King; T. R. Sosnick et al.

Protein Science. 2016-07-26. Vol. 25, num. 7, p. 1299-1307. DOI : 10.1002/pro.2899.

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A topological and conformational stability alphabet for multipass membrane proteins

X. Feng; P. Barth

Nature Chemical Biology. 2016-03-12. Vol. 12, num. 3, p. 167-173. DOI : 10.1038/nchembio.2001.

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2015

Journal Articles

Evolutionary-guided de novo structure prediction of self-associated transmembrane helical proteins with near-atomic accuracy

Y. Wang; P. Barth

Nature Communications. 2015-05-21. Vol. 6, num. 1. DOI : 10.1038/ncomms8196.

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Survivin-specific T cell receptor targets tumor but not T cells

C. Arber; X. Feng; H. Abhyankar; E. Romero; M-F. Wu et al.

Journal of Clinical Investigation. 2015-01-01. Vol. 125, num. 1, p. 157-168. DOI : 10.1172/JCI75876.

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2014

Journal Articles

High-Resolution Modeling of Transmembrane Helical Protein Structures from Distant Homologues

A. Schlessinger; K-Y. M. Chen; J. Sun; J. S. Salvo; D. Baker et al.

PLoS Computational Biology. 2014-05-22. Vol. 10, num. 5, p. e1003636. DOI : 10.1371/journal.pcbi.1003636.

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Advances in GPCR Modeling Evaluated by the GPCR Dock 2013 Assessment: Meeting New Challenges

I. Kufareva; V. Katritch; R. Stevens; R. Abagyan

Structure. 2014-08-05. Vol. 22, num. 8, p. 1120-1139. DOI : 10.1016/j.str.2014.06.012.

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2013

Journal Articles

Novel Conserved Genotypes Correspond to Antibiotic Resistance Phenotypes of E. coli Clinical Isolates

W. van Schaik; M. C. Swick; M. A. Evangelista; T. J. Bodine; J. R. Easton-Marks et al.

PLoS ONE. 2013-06-18. Vol. 8, num. 6, p. e65961. DOI : 10.1371/journal.pone.0065961.

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2012

Journal Articles

Naturally evolved G protein-coupled receptors adopt metastable conformations

K-Y. M. Chen; F. Zhou; B. G. Fryszczyn; P. Barth

Proceedings of the National Academy of Sciences. 2012-08-04. Vol. 109, num. 33, p. 13284-13289. DOI : 10.1073/pnas.1205512109.

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2011

Journal Articles

Status of GPCR Modeling and Docking as Reflected by Community-wide GPCR Dock 2010 Assessment

I. Kufareva; M. Rueda; V. Katritch; R. Stevens; R. Abagyan

Structure. 2011-08-10. Vol. 19, num. 8, p. 1108-1126. DOI : 10.1016/j.str.2011.05.012.

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2009

Journal Articles

Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008

M. Michino; E. Abola; C. L. Brooks; J. S. Dixon; J. Moult et al.

Nature Reviews Drug Discovery. 2009-06-08. Vol. 8, num. 6, p. 455-463. DOI : 10.1038/nrd2877.

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The Structure of a Receptor with Two Associating Transmembrane Domains on the Cell Surface: Integrin αIIbβ3

J. Zhu; B-H. Luo; P. Barth; J. Schonbrun; D. Baker et al.

Molecular Cell. 2009-04-24. Vol. 34, num. 2, p. 234-249. DOI : 10.1016/j.molcel.2009.02.022.

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Prediction of membrane protein structures with complex topologies using limited constraints

P. Barth; B. Wallner; D. Baker

Proceedings of the National Academy of Sciences. 2009-02-03. Vol. 106, num. 5, p. 1409-1414. DOI : 10.1073/pnas.0808323106.

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2008

Journal Articles

Targeting Metastable Coiled-Coil Domains by Computational Design

P. Barth; A. Schoeffler; T. Alber

Journal of the American Chemical Society. 2008-08-13. Vol. 130, num. 36, p. 12038-12044. DOI : 10.1021/ja802447e.

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2007

Journal Articles

Closing In on the Resting State of the Shaker K+ Channel

M. M. Pathak; V. Yarov-Yarovoy; G. Agarwal; B. Roux; P. Barth et al.

Neuron. 2007-10-04. Vol. 56, num. 1, p. 124-140. DOI : 10.1016/j.neuron.2007.09.023.

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Toward high-resolution prediction and design of transmembrane helical protein structures

P. Barth; J. Schonbrun; D. Baker

Proceedings of the National Academy of Sciences. 2007-10-02. Vol. 104, num. 40, p. 15682-15687. DOI : 10.1073/pnas.0702515104.

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Accurate, conformation-dependent predictions of solvent effects on protein ionization constants

P. Barth; T. Alber; P. B. Harbury

Proceedings of the National Academy of Sciences. 2007-03-20. Vol. 104, num. 12, p. 4898-4903. DOI : 10.1073/pnas.0700188104.

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Reviews

Modulating membrane protein stability and association by design

P. Barth

Current Opinion in Structural Biology. 2007-09-17. Vol. 17, num. 4, p. 460-466. DOI : 10.1016/j.sbi.2007.08.006.

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2004

Journal Articles

Protein–Protein Interactions Governing Septin Heteropentamer Assembly and Septin Filament Organization in Saccharomyces cerevisiae

M. Versele; B. Gullbrand; M. J. Shulewitz; V. J. Cid; S. Bahmanyar et al.

Molecular Biology of the Cell. 2004-07-28. Vol. 15, num. 10, p. 4568-4583. DOI : 10.1091/mbc.e04-04-0330.

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2002

Journal Articles

Solution NMR Structure and Backbone Dynamics of the PsaE Subunit of Photosystem I fromSynechocystissp. PCC 6803†,‡

P. Barth; P. Savarin; B. Gilquin; B. Lagoutte; F. Ochsenbein

Biochemistry. 2002-10-30. Vol. 41, num. 47, p. 13902-13914. DOI : 10.1021/bi0259599.

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2000

Journal Articles

Essential Role of a Single Arginine of Photosystem I in Stabilizing the Electron Transfer Complex with Ferredoxin

P. Barth; I. Guillouard; P. Sétif; B. Lagoutte

Journal of Biological Chemistry. 2000-03-10. Vol. 275, num. 10, p. 7030-7036. DOI : 10.1074/jbc.275.10.7030.

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1998

Journal Articles

Ferredoxin Reduction by Photosystem I fromSynechocystissp. PCC 6803: Toward an Understanding of the Respective Roles of Subunits PsaD and PsaE in Ferredoxin Binding

P. Barth; B. Lagoutte; P. Sétif

Biochemistry. 1998-11-17. Vol. 37, num. 46, p. 16233-16241. DOI : 10.1021/bi981379t.

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